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Randomised trials are at the heart of evidence-based healthcare, but the methods and infrastructure for conducting these sometimes complex studies are largely evidence free. Trial Forge (
Positioning a patient lying-flat in the acute phase of ischaemic stroke may improve recovery and reduce disability, but such a possibility has not been formally tested in a randomised trial. We therefore initi...
Neurobehavioral disabilities occur in 5–15 % of preterm infants with an estimated 50–70 % of very low birth weight preterm infants experiencing later dysfunction, including cognitive, behavioral, and social de...
Anaemia is common in patients undergoing major surgery. The current standard of care for patients with low haemoglobin in the peri-operative period is blood transfusion. The presence of preoperative anaemia is...
The Erratum to this article has been published in Trials 2015 16:312
The advantages of patient-held portable health files (PHF) and personal health records (PHR), paper or electronic, are said to include improved health-care provider continuity-of-care and patient empowerment i...
Fibromyalgia (FM) is a syndrome most prevalent in women, in whom it is characterized mainly by chronic pain. An important issue is that many patients with FM are reported to have temporomandibular dysfunction ...
The rate of lumbar fusion surgery (LFS) is increasing. Clinical recovery often lags technical outcome. Approximately 40 % of patients undergoing LFS rate themselves as symptomatically unchanged or worse follow...
The objective of phase II cancer clinical trials is to determine if a treatment has sufficient activity to warrant further study. The efficiency of a conventional phase II trial design has been the object of c...
Laparoscopic repair of ventral and incisional hernias has gained popularity since many studies have reported encouraging results in terms of outcomee and recurrence. Choice of mesh and fixation methods are con...
Osteoarthritis of the knee is a major cause of disability among adults. Electro-acupuncture is considered a potentially useful treatment for osteoarthritis. The purpose of this study is to assess the efficacy ...
Late-life depression is associated with high rates of morbidity, premature mortality, disability, functional decline, caregiver burden and increased health care costs. While clinical and public health approach...
Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell’s palsy are limited. Acupuncture is widely used for Bell’s palsy patients in ...
The prevention of near and actual cardiopulmonary arrest in hospitalized children is a patient safety imperative. Prevention is contingent upon the timely identification, referral and treatment of children who...
Approximately 1 million individuals experience a mild traumatic brain injury (TBI) and cost the United States nearly $17 billion each year. Many trauma survivors with mild TBI have debilitating and long-term p...
The Consolidated Standards of Reporting Trials (CONSORT) Statement was published in 1996, and first introduced to China in 2001. Although CONSORT has been widely accepted in high-quality international journals...
Complex intervention trials may require health care organisations to implement new service models. In a recent cluster randomised controlled trial, some participating organisations achieved high recruitment, w...
Under a conventional two-arm randomised trial design, participants are allocated to an intervention and participating health professionals are expected to deliver both interventions. However, health profession...
Shoulder pain and dysfunction are common after oncologic neck dissection for head and neck cancer (HNC), due to traction, compression, and devascularization injuries to the spinal accessory nerve (SAN). Should...
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
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