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  1. Content type: Study protocol

    Type 2 diabetes mellitus (T2DM) and obesity are syndemic and will have a significant impact on affected individuals and healthcare services worldwide. Evidence shows that T2DM remission can be achieved with si...

    Authors: Shahrad Taheri, Odette Chagoury, Hadeel Zaghloul, Sara Elhadad, Salma Hayder Ahmed, Omar Omar, Sherryl Payra, Salma Ahmed, Neda El Khatib, Rasha Abou Amona, Katie El Nahas, Matthew Bolton, Henem Chaar, Noor Suleiman, Amin Jayyousi, Mahmoud Zirie…

    Citation: Trials 2018 19:284

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  2. Content type: Research

    Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of profe...

    Authors: Victoria Borg Debono, Lawrence Mbuagbaw, James Paul, Norman Buckley and Lehana Thabane

    Citation: Trials 2018 19:281

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  3. Content type: Study protocol

    Process evaluations are critical for interpreting and understanding outcome trial results. By understanding how interventions function across different settings, process evaluations have the capacity to inform...

    Authors: Stephanie T. Jong, Helen Elizabeth Brown, Caroline H. D. Croxson, Paul Wilkinson, Kirsten L. Corder and Esther M. F. van Sluijs

    Citation: Trials 2018 19:282

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  4. Content type: Research

    Randomised controlled trials (RCTs) are challenging to conduct in a paediatric critical-care environment. Background work, including surveys and observational studies, is often used to determine disease estima...

    Authors: Anna Liu and Kusum Menon

    Citation: Trials 2018 19:283

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  5. Content type: Study protocol

    Over the last decade, a wide range of attention-deficit/hyperactivity disorder (ADHD) treatment approaches for adults, including both pharmacological interventions and psychosocial treatments, have been propos...

    Authors: Toivo Zinnow, Tobias Banaschewski, Andreas J. Fallgatter, Carolin Jenkner, Florence Philipp-Wiegmann, Alexandra Philipsen, Wolfgang Retz, Esther Sobanski, Johannes Thome and Michael Rösler

    Citation: Trials 2018 19:280

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  6. Content type: Study protocol

    Previous studies have shown that electroacupuncture (EA) reduces the severity of acute pancreatitis. However, the effect of EA for pain relief in patients with acute pancreatitis has not been evaluated yet. Th...

    Authors: Dong Kee Jang, Chan Yung Jung, Kyung Ho Kim and Jun Kyu Lee

    Citation: Trials 2018 19:279

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  7. Content type: Study protocol

    Mindfulness has been applied in the United States and Europe to improve physical and psychological health; however, little is known about its feasibility and efficacy in a Brazilian population. Mindfulness may...

    Authors: Vera Salvo, Jean Kristeller, Jesus Montero Marin, Adriana Sanudo, Bárbara Hatzlhoffer Lourenço, Mariana Cabral Schveitzer, Vania D’Almeida, Héctor Morillo, Suely Godoy Agostinho Gimeno, Javier Garcia-Campayo and Marcelo Demarzo

    Citation: Trials 2018 19:277

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  8. Content type: Study protocol

    Physical activity is associated with a lower risk of cognitive decline in older adults. However, past studies have demonstrated that older adults tend to relapse into inactivity after completing interventions....

    Authors: Songee Jung, Sungchul Lee, Seongryu Bae, Sangyoon Lee, Keitaro Makino, Yohei Shinkai and Hiroyuki Shimada

    Citation: Trials 2018 19:276

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  9. Content type: Study protocol

    Enhanced mobility in the Intensive Care Unit (ICU) could minimize the negative effects of critical illness, such as declines in cognitive, muscular, respiratory, and functional capacity. We aim to compare the ...

    Authors: Debora Stripari Schujmann, Adriana Claudia Lunardi and Carolina Fu

    Citation: Trials 2018 19:274

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  10. Content type: Study protocol

    Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinep...

    Authors: Ai-mei Zhao, Wen-ran Qiu, Li-jun Mao, Jun-guo Ren, Li Xu, Ming-jiang Yao, Kellie Bilinksi, Dennis Chang and Jian-xun Liu

    Citation: Trials 2018 19:275

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  11. Content type: Study protocol

    Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is...

    Authors: Anna Geke Algera, Luigi Pisani, Dennis C. J. Bergmans, Sylvia den Boer, Corianne A. J. de Borgie, Frank H. Bosch, Karina Bruin, Thomas G. Cherpanath, Rogier M. Determann, Arjen M. Dondorp, Dave A. Dongelmans, Henrik Endeman, Jasper J. Haringman, Janneke Horn, Nicole P. Juffermans, David M. van Meenen…

    Citation: Trials 2018 19:272

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  12. Content type: Study protocol

    Postoperative morbidity and mortality in patients undergoing surgery is high, especially in patients who are at risk of complications and undergoing major surgery. We hypothesize that perioperative, algorithm-...

    Authors: Sandra Funcke, Bernd Saugel, Christian Koch, Dagmar Schulte, Thomas Zajonz, Michael Sander, Angelo Gratarola, Lorenzo Ball, Paolo Pelosi, Savino Spadaro, Riccardo Ragazzi, Carlo Alberto Volta, Thomas Mencke, Amelie Zitzmann, Benedikt Neukirch, Gonzalo Azparren…

    Citation: Trials 2018 19:273

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  13. Content type: Study protocol

    Dementia has a huge physical, psychological, social and economic impact upon caregivers, families and societies at large. There has been a growing impetus to utilize Internet interventions given the potential ...

    Authors: Kala M. Mehta, Dolores Gallagher-Thompson, Mathew Varghese, Santosh Loganathan, Upasana Baruah, Katrin Seeher, Diana Zandi, Tarun Dua and Anne Margriet Pot

    Citation: Trials 2018 19:271

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  14. Content type: Study protocol

    Secondary school teachers have low levels of wellbeing and high levels of depression compared with the general population. Teachers are in a key position to support students, but poor mental health may be a ba...

    Authors: Rhiannon Evans, Rowan Brockman, Jillian Grey, Sarah Bell, Sarah Harding, David Gunnell, Rona Campbell, Simon Murphy, Tamsin Ford, William Hollingworth, Kate Tilling, Richard Morris, Bryar Kadir, Ricardo Araya and Judi Kidger

    Citation: Trials 2018 19:270

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  15. Content type: Study protocol

    Recurrent patellar instability incidence is 5.8/100,000 population, and recurrent dislocations are reported in the range of 15–80%. Recurrent instability is multifactorial and can be associated with disorder o...

    Authors: Adam Tucker, Sam McMahon, Bronwyn McArdle, Bridgeen Rutherford and Danny Acton

    Citation: Trials 2018 19:268

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  16. Content type: Research

    Randomized clinical trials that have public health implications but no or low potential for commercial gain are predominantly funded by governmental (e.g., National Institutes of Health (NIH)) and not-for-prof...

    Authors: Olivia Lovegreen, Danielle Riggs, Myrlene A. Staten, Patricia Sheehan and Anastassios G. Pittas

    Citation: Trials 2018 19:267

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  17. Content type: Study protocol

    Exercise reduces the amount of visceral adipose tissue (VAT) and the risk of cardiometabolic diseases. The underlying mechanisms responsible for these exercise-induced adaptations are unclear, but they may inv...

    Authors: Regitse Højgaard Christensen, Anne-Sophie Wedell-Neergaard, Louise Lang Lehrskov, Grit Elster Legård, Emma Berndt Dorph, Stine Nymand, Maria Korf Ball, Morten Zacho, Robin Christensen, Helga Ellingsgaard, Jaya Birgitte Rosenmeier, Rikke Krogh-Madsen, Bente Klarlund Pedersen and Kristian Karstoft

    Citation: Trials 2018 19:266

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  18. Content type: Study protocol

    Acute appendicitis is one of the most common indications for emergency surgery. In patients with a complex appendicitis, prolonged antibiotic prophylaxis is recommended after appendectomy. There is no consensu...

    Authors: Anne Loes van den Boom, Elisabeth M. L. de Wijkerslooth, Joost van Rosmalen, Frédérique H. Beverdam, Evert-Jan G. Boerma, Marja A. Boermeester, Joanna W. A. M. Bosmans, Thijs A. Burghgraef, Esther C. J. Consten, Imro Dawson, Jan Willem T. Dekker, Marloes Emous, Anna A. W. van Geloven, Peter M. N. Y. H. Go, Luc A. Heijnen, Sander A. Huisman…

    Citation: Trials 2018 19:263

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  19. Content type: Study protocol

    Radical cystectomy for bladder cancer is associated with a high risk of needing red blood cell transfusion. Tranexamic acid reduces blood loss during cardiac and orthopedic surgery, but no study has yet evalua...

    Authors: Rodney H. Breau, Luke T. Lavallée, Sonya Cnossen, Kelsey Witiuk, Ilias Cagiannos, Franco Momoli, Gregory Bryson, Salmaan Kanji, Christopher Morash, Alexis Turgeon, Ryan Zarychanski, Ranjeeta Mallick, Greg Knoll and Dean A. Fergusson

    Citation: Trials 2018 19:261

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  20. Content type: Study protocol

    Smartphone-based ecological momentary assessment and intervention (EMA/I) show promise for enhancing psychological treatments for psychosis. EMA has the potential to improve assessment and formulation of exper...

    Authors: Imogen H. Bell, Sarah F. Fielding-Smith, Mark Hayward, Susan L. Rossell, Michelle H. Lim, John Farhall and Neil Thomas

    Citation: Trials 2018 19:262

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  21. Content type: Study protocol

    Catheter-related bloodstream infection (CRBSI) is one of the most frequent complications in patients with cancer who have central venous catheters (CVCs) implanted and is associated with substantial morbidity ...

    Authors: C. Gudiol, S. Nicolae, C. Royo-Cebrecos, M. Aguilar-Guisado, I. Montero, C. Martín-Gandul, M. Perayre, D. Berbel, M. Encuentra, M. Arnan, J. M. Cisneros-Herreros and J. Carratalà

    Citation: Trials 2018 19:264

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  22. Content type: Study protocol

    Acute pain is a common condition among prehospital patients and prompt management is pivotal. Opioids are the most frequently analgesics used in the prehospital setting. However, opioids are highly addictive, ...

    Authors: Clément Le Cornec, Said Lariby, Vivien Brenckmann, Jean Benoit Hardouin, Claude Ecoffey, Marion Le Pottier, Philippe Fradin, Hélène Broch, Amine Kabbaj, Yannick Auffret, Florence Deciron, Céline Longo, François Javaudin, Quentin Le Bastard, Joël Jenvrin and Emmanuel Montassier

    Citation: Trials 2018 19:260

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