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  1. Content type: Study protocol

    Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment an...

    Authors: J. Nikles, G. Keijzers, G. Mitchell, S. Schug, R. Ware, S. A. McLean, L. Connelly, S. Gibson, S. F. Farrell and M. Sterling

    Citation: Trials 2018 19:44

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  2. Content type: Study protocol

    Children who stutter (CWS) are at a high-risk of being teased and bullied in primary school because of negative peer attitudes and perceptions towards stuttering. There is little evidence to determine if class...

    Authors: Rizwana Mallick, Harsha Kathard, Lehana Thabane and Mershen Pillay

    Citation: Trials 2018 19:43

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  3. Content type: Study protocol

    Several suction techniques have been developed recently to enhance tissue acquisition when sampling solid lesions using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The aim of this study is t...

    Authors: Yun Wang, Qian Chen, Jinlin Wang, Xiaoli Wu, Yaqi Duan, Ping Yin, Qiaozhen Guo, Wei Hou and Bin Cheng

    Citation: Trials 2018 19:45

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  4. Content type: Correction

    In the original publication [1] the last sentence in the last paragraph under ‘Perspectives and implications’ in the Discussions section needs to be removed. The correct version can be found in this Erratum.

    Authors: Lee Aymar Ndounga Diakou, Francine Ntoumi, Philippe Ravaud and Isabelle Boutron

    Citation: Trials 2018 19:42

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    The original article was published in Trials 2017 18:291

  5. Content type: Study protocol

    The current state of evidence suggests that community-based exercise programs are beneficial in improving impairment, function, and health status, and are greatly needed for persons with stroke. However, limit...

    Authors: Julie Richardson, Ada Tang, Gordon Guyatt, Lehana Thabane, Feng Xie, Demetrios Sahlas, Robert Hart, Rebecca Fleck, Genevieve Hladysh and Louise Macrae

    Citation: Trials 2018 19:39

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  6. Content type: Study protocol

    This study aims to explore the safety, efficacy, and feasibility of Danggwijagyaksan (DJS) for alleviating climacteric syndrome in peri- and postmenopausal women with a blood-deficiency dominant pattern.

    Authors: Mikyung Kim, Ae-Ran Kim, Hyo-Ju Park, Ojin Kwon, Joo-Hee Kim, Eun-Ji Park, Seon-Eun Baek, Jeong-Eun Yoo and Jun-Hwan Lee

    Citation: Trials 2018 19:41

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  7. Content type: Study protocol

    Physical activity plays an important role in the management of chronic low back pain (LBP). Engaging in an active lifestyle is associated with a better prognosis. Nevertheless, there is evidence to suggest tha...

    Authors: Crystian B. Oliveira, Márcia R. Franco, Chris G. Maher, Anne Tiedemann, Fernanda G. Silva, Tatiana M. Damato, Michael K. Nicholas, Diego G. D. Christofaro and Rafael Z. Pinto

    Citation: Trials 2018 19:40

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  8. Content type: Study protocol

    Laparoscopic surgery has become the preferred surgical approach due to a reduction in postoperative pain, better recovery, shorter hospitalization, and improved esthetic outcomes. Laparoscopic surgery with sin...

    Authors: Andy Schmitt, Patrice Crochet, Karine Baumstark, Claire Tourette, Sabine Poizac, Audrey Pivano, Léon Boubli, Ludovic Cravello and Aubert Agostini

    Citation: Trials 2018 19:38

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  9. Content type: Study protocol

    Standard treatment for locally advanced rectal cancer includes 5–6 weeks of neoadjuvant chemoradiotherapy (NACRT) followed by total mesorectal excision 6–8 weeks later. NACRT improves local disease control and...

    Authors: Andria R. Morielli, Nawaid Usmani, Normand G. Boulé, Diane Severin, Keith Tankel, Tirath Nijjar, Kurian Joseph, Alysa Fairchild and Kerry S. Courneya

    Citation: Trials 2018 19:35

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  10. Content type: Study protocol

    Complex medication regimens are highly prevalent in residential aged care facilities (RACFs). Strategies to reduce unnecessary complexity may be valuable because complex medication regimens can be burdensome f...

    Authors: Janet K. Sluggett, Esa Y. H. Chen, Jenni Ilomäki, Megan Corlis, Sarah N. Hilmer, Jan Van Emden, Choon Ean Ooi, Kim-Huong Nguyen, Tracy Comans, Michelle Hogan, Tessa Caporale, Susan Edwards, Lyntara Quirke, Allan Patching and J. Simon Bell

    Citation: Trials 2018 19:37

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  11. Content type: Study protocol

    Chronic neck pain is a common musculoskeletal disease during the lifespan of an individual. With an increase in dependence on computer technology, the prevalence of chronic neck pain is expected to rise and th...

    Authors: Seungah Jun, Jung Hee Lee, Han Mi Gong, Yeon-Joong Chung, Ju-Ran Kim, Chung A. Park, Seong Hun Choi, Geon-Mok Lee, Hyun-Jong Lee and Jae Soo Kim

    Citation: Trials 2018 19:36

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  12. Content type: Research

    School-based interventions may be effective at increasing levels of physical activity (PA) among adolescents; however, there is a paucity of evidence on whether walking can be successfully promoted to increase...

    Authors: Angela Carlin, Marie H. Murphy, Alan Nevill and Alison M. Gallagher

    Citation: Trials 2018 19:31

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  13. Content type: Research

    Selective reporting of outcomes in clinical trials is a serious problem. We aimed to investigate the influence of the peer review process within biomedical journals on reporting of primary outcome(s) and stati...

    Authors: Sally Hopewell, Claudia M. Witt, Klaus Linde, Katja Icke, Olubusola Adedire, Shona Kirtley and Douglas G. Altman

    Citation: Trials 2018 19:30

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  14. Content type: Study protocol

    The Fostering Changes programme was developed by the Adoption and Fostering National Team at the Maudsley Hospital, South London, in conjunction with King’s College London. It is a 12-week group-based training...

    Authors: Gwenllian Moody, Lucy Brookes-Howell, Rebecca Cannings-John, Sue Channon, Elinor Coulman, Mandy Lau, Alyson Rees, Jonathan Scourfield, Jeremy Segrott and Michael Robling

    Citation: Trials 2018 19:34

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  15. Content type: Research

    Clinical trials conducted in Lebanon are increasing. However, little is known about the performance of research ethics committees (RECs) in charge of reviewing the research protocols. This study aimed to asses...

    Authors: David Atallah, Malak Moubarak, Nadine El Kassis and Sara Abboud

    Citation: Trials 2018 19:27

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  16. Content type: Review

    Routinely collected health data (RCD) are increasingly used for randomized controlled trials (RCTs). This can provide three major benefits: increasing value through better feasibility (reducing costs, time, an...

    Authors: Kimberly A. Mc Cord, Rustam Al-Shahi Salman, Shaun Treweek, Heidi Gardner, Daniel Strech, William Whiteley, John P. A. Ioannidis and Lars G. Hemkens

    Citation: Trials 2018 19:29

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  17. Content type: Study protocol

    Orthopedic trauma injury impacts nearly 2.8 million people each year. Despite surgical improvements and excellent survivorship rates, many patients experience poor quality of life (QOL) outcomes years later. P...

    Authors: Laura Zdziarski-Horodyski, MaryBeth Horodyski, Kalia K. Sadasivan, Jennifer Hagen, Terrie Vasilopoulos, Matthew Patrick, Robert Guenther and Heather K. Vincent

    Citation: Trials 2018 19:32

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  18. Content type: Research

    Allergic rhinitis is a common respiratory disease. Acupuncture is used to treat it in traditional Chinese medicine, and generally, the L120, ST2 and ST36 acupoints are selected in clinical practice. We report ...

    Authors: Jiaoping Mi, Xinye Chen, Xiaoyan Lin, Jianling Guo, Hongtao Chen, Liao Wei and Haiyu Hong

    Citation: Trials 2018 19:28

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  19. Content type: Study protocol

    Mortality in children remains high in sub-Saharan African hospitals. While antimalarial drugs, antibiotics and other definitive treatments are well understood, the role of emergency care with supportive therap...

    Authors: Tim Baker, Queen Dube, Josephine Langton and Helena Hildenwall

    Citation: Trials 2018 19:33

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  20. Content type: Research

    H1/IC31® is a tuberculosis (TB) subunit vaccine candidate consisting of the fusion protein of Ag85B and ESAT-6 (H1) formulated with the IC31® adjuvant. Previous trials have reported on the H1/IC31® vaccine in M. ...

    Authors: Jemal Hussein, Martha Zewdie, Lawrence Yamuah, Ahmed Bedru, Markos Abebe, Alemnew F. Dagnew, Menberework Chanyalew, Asfawesen G. Yohannes, Jemal Ahmed, Howard Engers, T. Mark Doherty, Peter Bang, Ingrid Kromann, Søren T. Hoff and Abraham Aseffa

    Citation: Trials 2018 19:24

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  21. Content type: Study protocol

    Osteoradionecrosis of the mandible is the most common serious complication of radiotherapy for head and neck malignancy. For decades, hyperbaric oxygen has been employed in efforts to prevent those cases of os...

    Authors: Richard Shaw, Christopher Butterworth, Binyam Tesfaye, Matthew Bickerstaff, Susanna Dodd, Gary Smerdon, Seema Chauhan, Peter Brennan, Keith Webster, James McCaul, Peter Nixon, Anastasios Kanatas and Paul Silcocks

    Citation: Trials 2018 19:22

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  22. Content type: Review

    Applications of causal inference methods to randomised controlled trial (RCT) data have usually focused on adjusting for compliance with the randomised intervention rather than on using RCT data to address oth...

    Authors: Ruth E. Farmer, Daphne Kounali, A. Sarah Walker, Jelena Savović, Alison Richards, Margaret T. May and Deborah Ford

    Citation: Trials 2018 19:23

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  23. Content type: Methodology

    There is an increasing demand by non-commercial funders that trialists should provide access to trial data once the primary analysis is completed. This has to take into account concerns about identifying indiv...

    Authors: Catriona Keerie, Christopher Tuck, Garry Milne, Sandra Eldridge, Neil Wright and Steff C. Lewis

    Citation: Trials 2018 19:25

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  24. Content type: Study protocol

    Proton pump inhibitors are often used in critically ill patients to prevent gastrointestinal bleeding despite limited evidence for benefit. Patients with acute kidney injury requiring renal replacement therapy...

    Authors: Joerg C. Schefold, Anders Perner, Theis Lange, Jørn Wetterslev, Matt P. Wise, Mark Borthwick, Stepani Bendel, Frederik Keus, Anne Berit Guttormsen, Søren Marker, Mette Krag and Morten Hylander Møller

    Citation: Trials 2018 19:26

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  25. Content type: Study protocol

    Chronic pelvic pain syndrome (CPPS) is a pain condition perceived in the pelvic area for at least 6 months. While evidence of the aetiology and maintenance of CPPS is still unclear and therapy options are rare...

    Authors: Christian A. Brünahl, Susanne G. R. Klotz, Christoph Dybowski, Björn Riegel, Sonja Gregorzik, Dean A. Tripp, Gesche Ketels and Bernd Löwe

    Citation: Trials 2018 19:20

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