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  1. Content type: Study protocol

    Perinatal asphyxia is, even in developed countries, one the major causes of neonatal morbidity and mortality. Therefore, if foetal distress during labour is suspected, one should try to restore foetal oxygen l...

    Authors: Lauren M. Bullens, Alexandra D. J. Hulsenboom, Suzanne Moors, Rohan Joshi, Pieter J. van Runnard Heimel, M. Beatrijs van der Hout-van der Jagt, Edwin R. van den Heuvel and S. Guid Oei

    Citation: Trials 2018 19:195

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  2. Content type: Commentary

    Multinational clinical trials are logistically complex and require close coordination between various stakeholders. They must comply with global clinical standards and are accountable to multiple regulatory an...

    Authors: George Mtove, Joshua Kimani, William Kisinza, Geofrey Makenga, Peter Mangesho, Stephan Duparc, Miriam Nakalembe, Kamija S. Phiri, Russell Orrico, Ricardo Rojo and Pol Vandenbroucke

    Citation: Trials 2018 19:190

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  3. Content type: Study protocol

    The high co-morbidity of mental disorders, particularly depression, with non-communicable diseases (NCDs) such as cardiovascular disease (CVD), is concerning given the rising burden of NCDs globally, and the r...

    Authors: Inge Petersen, Arvin Bhana, Naomi Folb, Graham Thornicroft, Babalwa Zani, One Selohilwe, Ruwayda Petrus, Ntokozo Mntambo, Daniella Georgeu-Pepper, Tasneem Kathree, Crick Lund, Carl Lombard, Max Bachmann, Thomas Gaziano, Naomi Levitt and Lara Fairall

    Citation: Trials 2018 19:192

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  4. Content type: Study protocol

    Acceptance and Commitment Therapy (ACT) is a form of cognitive behavioural therapy, which may be beneficial for people with chronic pain. The approach aims to enhance daily functioning through increased psycho...

    Authors: Máire-Bríd Casey, Keith Smart, Ricardo Segurado, Conor Hearty, Hari Gopal, Damien Lowry, Dearbhail Flanagan, Lance McCracken and Catherine Doody

    Citation: Trials 2018 19:194

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  5. Content type: Study protocol

    The scale-up of antiretroviral treatment (ART) programmes has seen HIV/AIDS transition to a chronic condition characterised by high rates of comorbidity with tuberculosis, non-communicable diseases (NCDs) and ...

    Authors: Lara Fairall, Inge Petersen, Babalwa Zani, Naomi Folb, Daniella Georgeu-Pepper, One Selohilwe, Ruwayda Petrus, Ntokozo Mntambo, Arvin Bhana, Carl Lombard, Max Bachmann, Crick Lund, Jill Hanass-Hancock, Daniel Chisholm, Paul McCrone, Sergio Carmona…

    Citation: Trials 2018 19:193

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  6. Content type: Study protocol

    Stroke patients usually suffer primary cognitive impairment related to attention, memory, and executive functions. This impairment causes a negative impact on the quality of life of patients and their families...

    Authors: Macarena Gil-Pagés, Javier Solana, Rocío Sánchez-Carrión, Jose M. Tormos, Antonia Enseñat-Cantallops and Alberto García-Molina

    Citation: Trials 2018 19:191

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  7. Content type: Study protocol

    Microembolism is a frequent pathological event during extracorporeal renal replacement therapy (RRT). Some previous data indicate that microemboli are generated in patients who are undergoing RRT and that thes...

    Authors: Gabor Erdoes, Dominik E. Uehlinger, Beatrice Kobel, Monika P. Stucki, Roland Wiest, Frank Stueber, Niklaus Fankhauser, Stephan M. Jakob and Joerg C. Schefold

    Citation: Trials 2018 19:189

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  8. Content type: Study protocol

    Among women at high risk for HIV and other sexually transmitted diseases (STIs), gender and economic issues limit the impact of behavioral prevention strategies. Women in Kazakhstan with dual risks of sex trad...

    Authors: Tara McCrimmon, Susan Witte, Gaukhar Mergenova, Assel Terlikbayeva, Sholpan Primbetova, Azamat Kuskulov, Scarlett L. Bellamy and Nabila El-Bassel

    Citation: Trials 2018 19:187

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  9. Content type: Study protocol

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by swelling and painful joints, eventually leading to joint destruction. There is still a lack of effective therapy to treat RA. The Juan...

    Authors: Qiong Wang, Yi-Ru Wang, Qing-Yun Jia, Li Liu, Chong-Qing Xu, Xiao-Yun Wang, Min Yao, Xue-Jun Cui, Qi Shi, Yong-Jun Wang and Qian-Qian Liang

    Citation: Trials 2018 19:188

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  10. Content type: Study protocol

    Specific phobias are among the most common anxiety disorders. Exposure therapy is the treatment of choice for specific phobias. However, not all patients respond equally well to it. Hence, current research foc...

    Authors: Sarah K. Schäfer, Frank R. Ihmig, Karen A. Lara H., Frank Neurohr, Stephan Kiefer, Marlene Staginnus, Johanna Lass-Hennemann and Tanja Michael

    Citation: Trials 2018 19:184

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  11. Content type: Study protocol

    PaVOS is a randomized controlled trial (RCT) which aims to address the use of whole-body vibration exercise (WBV) in combination with parathyroid hormone 1-34 fragment teriparatide (PTH 1-34) treatment in pati...

    Authors: Ditte Beck Jepsen, Jesper Ryg, Niklas Rye Jørgensen, Stinus Hansen and Tahir Masud

    Citation: Trials 2018 19:186

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  12. Content type: Study protocol

    In low- and middle-income countries (LMIC), it is uncertain whether a “dedicated” approach to integrating mental health care (wherein a community health worker (CHW) has the sole responsibility of delivering m...

    Authors: Bronwyn Myers, Crick Lund, Carl Lombard, John Joska, Naomi Levitt, Christopher Butler, Susan Cleary, Tracey Naledi, Peter Milligan, Dan J. Stein and Katherine Sorsdahl

    Citation: Trials 2018 19:185

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  13. Content type: Study protocol

    Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive re...

    Authors: Til Wykes, Eileen Joyce, Tjasa Velikonja, Andrew Watson, Gregory Aarons, Max Birchwood, Matteo Cella, Sue Dopson, David Fowler, Kathy Greenwood, Sonia Johnson, Paul McCrone, Jesus Perez, Andrew Pickles, Clare Reeder, Diana Rose…

    Citation: Trials 2018 19:183

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  14. Content type: Study protocol

    The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pha...

    Authors: Yaseen Arabi, Fahad Al-Hameed, Karen E. A. Burns, Sangeeta Mehta, Sami Alsolamy, Mohammed Almaani, Yasser Mandourah, Ghaleb A. Almekhlafi, Ali Al Bshabshe, Simon Finfer, Mohammed Alshahrani, Imran Khalid, Yatin Mehta, Atul Gaur, Hassan Hawa, Hergen Buscher…

    Citation: Trials 2018 19:182

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  15. Content type: Study protocol

    Hypertension is a serious public health problem in Singapore and is associated with significant morbidity and mortality from cardiovascular disease (CVD) with considerable implications for health-care resource...

    Authors: Tazeen H. Jafar, Ngiap Chuan Tan, John C. Allen, Eric A. Finkelstein, Paul Goh, Peter Moey, Joanne Hui Min Quah, Siew Wai Hwang, Juliana Bahadin, Anandan Gerard Thiagarajah, Jason Chan, Gary Kang and Agnes Koong

    Citation: Trials 2018 19:180

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  16. Content type: Study protocol

    There is an unprecedented rise in the prevalence of stroke in sub-Saharan Africa (SSA). Secondary prevention guidelines recommend that antihypertensive, statin and antiplatelet therapy be initiated promptly af...

    Authors: Fred Stephen Sarfo, Osei Sarfo-Kantanka, Sheila Adamu, Vida Obese, Jennifer Voeks, Raelle Tagge, Vipin Sethi and Bruce Ovbiagele

    Citation: Trials 2018 19:181

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  17. Content type: Study protocol

    Sepsis caused by complicated intra-abdominal infection is associated with high mortality. Loss of endothelial barrier integrity, inflammation, and impaired cellular oxygen have been shown to be primary contrib...

    Authors: Antonella Cotoia, Lucia Mirabella, Sabrina Altamura, Rachele Villani, Flavia Marchese, Giuseppe Ferrara, Karim Mariano, Tullo Livio and Gilda Cinnella

    Citation: Trials 2018 19:179

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  18. Content type: Study protocol

    One in ten children in Britain have been identified as experiencing a diagnosable mental health disorder. School-based humanistic counselling (SBHC) may help young people identify, address, and overcome psycho...

    Authors: Megan Rose Stafford, Mick Cooper, Michael Barkham, Jeni Beecham, Peter Bower, Karen Cromarty, Andrew J. B. Fugard, Charlie Jackson, Peter Pearce, Rebekah Ryder and Cathy Street

    Citation: Trials 2018 19:175

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  19. Content type: Study protocol

    Practicing activities improves recovery after stroke, but many people in hospital do little activity. Feedback on activity using an accelerometer is a potential method to increase activity in hospital inpatien...

    Authors: Yun Dong, Dax Steins, Shanbin Sun, Fei Li, James D. Amor, Christopher J. James, Zhidao Xia, Helen Dawes, Hooshang Izadi, Yi Cao and Derick T. Wade

    Citation: Trials 2018 19:177

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  20. Content type: Update

    Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth with short-term and long-term adverse consequences. Although the glucocorticoid dexamethasone has been proven to be beneficial ...

    Authors: Wes Onland, Maruschka P. Merkus, Debbie H. Nuytemans, Marijke C. Jansen-van der Weide, Rebecca Holman and Anton H. van Kaam

    Citation: Trials 2018 19:178

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  21. Content type: Study protocol

    Maternal and child undernutrition have adverse consequences for pregnancy outcomes and child morbidity and mortality, and they are associated with low educational attainment, economic productivity as an adult,...

    Authors: Suneetha Kadiyala, Audrey Prost, Helen Harris-Fry, Meghan O’Hearn, Ronali Pradhan, Shibananth Pradhan, Naba Kishore Mishra, Suchitra Rath, Nirmala Nair, Shibanand Rath, Prasantha Tripathy, Sneha Krishnan, Peggy Koniz-Booher, Heather Danton, Diana Elbourne, Joanna Sturgess…

    Citation: Trials 2018 19:176

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  22. Content type: Study protocol

    The reporting of adverse drug reactions (ADR) by patients represents an interesting challenge in the field of pharmacovigilance, but the reporting system is not adequately implemented in France. In 2015, only ...

    Authors: Gilles Defer, Florian Le Caignec, Sophie Fedrizzi, François Montastruc, Damien Chevanne, Jean-Jacques Parienti and Laure Peyro-Saint-Paul

    Citation: Trials 2018 19:174

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  23. Content type: Study protocol

    Multiple myeloma (MM) is a plasma cell tumour with an approximate annual incidence of 4500 in the UK. Therapeutic options for patients with MM have changed in the last decade with the arrival of proteasome inh...

    Authors: Alina Striha, A. John Ashcroft, Anna Hockaday, David A. Cairns, Karen Boardman, Gwen Jacques, Cathy Williams, John A. Snowden, Mamta Garg, Jamie Cavenagh, Kwee Yong, Mark T. Drayson, Roger Owen, Mark Cook and Gordon Cook

    Citation: Trials 2018 19:169

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  24. Content type: Study protocol

    Children’s risky play is associated with a variety of positive developmental, physical and mental health outcomes, including greater physical activity, self-confidence and risk-management skills. Children’s op...

    Authors: Mariana Brussoni, Takuro Ishikawa, Christina Han, Ian Pike, Anita Bundy, Guy Faulkner and Louise C. Mâsse

    Citation: Trials 2018 19:173

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  25. Content type: Study protocol

    Physical exercise interventions have been extensively advocated for the treatment of obesity; however, clinical trials evaluating the effectiveness of exercise interventions on weight control show controversia...

    Authors: Vitor Barreto Paravidino, Mauro Felippe Felix Mediano, Inácio Crochemore M Silva, Andrea Wendt, Fabrício Boscolo Del Vecchio, Fabiana Alves Neves, Bruno de Souza Terra, Erika Alvarenga Corrêa Gomes, Anibal Sanchez Moura and Rosely Sichieri

    Citation: Trials 2018 19:167

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