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  1. Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in antic...

    Authors: Marianne Jensen Hjermstad, Nina Aass, Sigve Andersen, Cinzia Brunelli, Olav Dajani, Herish Garresori, Hanne Hamre, Ellinor C. Haukland, Mats Holmberg, Frode Jordal, Hilde Krogstad, Tonje Lundeby, Erik Torbjørn Løhre, Svein Mjåland, Arve Nordbø, Ørnulf Paulsen…

    Citation: Trials 2020 21:303

    Content type: Study protocol

    Published on:

  2. The National Institute for Health and Care Excellence (NICE) recommends that Cognitive Behaviour Therapy for psychosis (CBTp) is offered to all patients with a psychosis diagnosis. However, only a minority of ...

    Authors: Mark Hayward, Clio Berry, Ben Cameron, Kate Arnold, Katherine Berry, Stephen Bremner, Kate Cavanagh, David Fowler, Heather Gage, Kathryn Greenwood, Cassie Hazell, Anna-Marie Jones, Sam Robertson and Clara Strauss

    Citation: Trials 2020 21:302

    Content type: Study protocol

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  3. Clinical studies looking at interventions to optimize pregnancy and long-term outcomes for women with cardiac disease and their babies are inconsistent in their reporting of clinical outcomes, making it diffic...

    Authors: Rohan D’Souza, Chelsea Hall, Mathew Sermer, Samuel Siu and Candice Silversides

    Citation: Trials 2020 21:300

    Content type: Study protocol

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  4. Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and...

    Authors: Xiaoying Sun, Xiaoyong Zhou, Yuegang Wei, Wenxin Yang, Ning Huang, Yangfeng Ding, Rongyi Hu, Shun Guo, Chunyan Yang, Huilan Weng, Ying Zhang, Xi Chen, Xiaojie Ding, Liu Liu, Qingfeng Yin, Ruiping Wang…

    Citation: Trials 2020 21:299

    Content type: Study protocol

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  5. MET-deregulated non-small cell lung cancer represents an urgent clinical need because of the lack of specific therapies. Although recent studies have suggested a potential role for crizotinib in patients harbo...

    Authors: Mototsugu Shimokawa, Kaname Nosaki, Takashi Seto, Kadoaki Ohashi, Masahiro Morise, Hidehito Horinouchi, Jun Sakakibara, Haruyasu Murakami, Seiji Yano, Miyako Satouchi, Shingo Matsumoto, Koichi Goto and Kiyotaka Yoh

    Citation: Trials 2020 21:298

    Content type: Study protocol

    Published on:

  6. After publication of our article [1] we have been notified on a mistake in the sample size.

    Authors: Ling Zhu, Xiao Shi, Suqing Yin, Jiemin Yin, Ziyu Zhu, Xiong Gao, Yingfu Jiao, Weifeng Yu and Liqun Yang

    Citation: Trials 2020 21:297

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:260

  7. After publication of our article [1] the authors have notified us of two typos in the Trial status.

    Authors: Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu and Jian Wang

    Citation: Trials 2020 21:296

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:725

  8. Women with breast cancer experience a significantly higher prevalence of sleep disturbance and insomnia than the general population. The experience of persistent sleep disturbance places these women at a highe...

    Authors: Helena R. Bean, Lesley Stafford, Ruth Little, Justine Diggens, Maria Ftanou, Marliese Alexander, Prudence A. Francis, Bei Bei and Joshua F. Wiley

    Citation: Trials 2020 21:295

    Content type: Study protocol

    Published on:

  9. Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options i...

    Authors: Ida Maria H. Borgen, Marianne Løvstad, Nada Andelic, Solveig Hauger, Solrun Sigurdardottir, Helene L. Søberg, Unni Sveen, Marit V. Forslund, Ingerid Kleffelgård, Marte Ørud Lindstad, Laraine Winter and Cecilie Røe

    Citation: Trials 2020 21:294

    Content type: Study protocol

    Published on:

  10. Postoperative complications following major abdominal surgery are frequent despite progress in surgical technique and perioperative care. Early and enhanced postoperative mobilisation has been advocated to red...

    Authors: Marius Schwab, Niall Brindl, Alexander Studier-Fischer, Thomas Tu, Julia Gsenger, Max Pilgrim, Mirco Friedrich, Pia-Elena Frey, Christina Achilles, Alexander Leuck, Thore Bürgel, Manuel Feisst, Christina Klose, Solveig Tenckhoff, Colette Dörr-Harim and André L. Mihaljevic

    Citation: Trials 2020 21:293

    Content type: Study protocol

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  11. Non-communicable chronic diseases are linked to behavioral risk factors (including smoking, poor diet and physical inactivity), so effective behavior change interventions are needed to improve population healt...

    Authors: Molly Byrne, Jenny McSharry, Oonagh Meade, Kim L. Lavoie and Simon L. Bacon

    Citation: Trials 2020 21:292

    Content type: Research

    Published on:

  12. We report the first protocol for a multicenter, randomized comparison study to compare the efficacies of periodontal scaling and root-planing treatment against that of tooth-brushing treatment for nonalcoholic...

    Authors: Yohei Kamata, Takaomi Kessoku, Tomoko Shimizu, Takashi Kobayashi, Takeo Kurihashi, Satsuki Sato, Syotaro Kuraji, Norio Aoyama, Tomoyuki Iwasaki, Shogo Takashiba, Nobushiro Hamada, Toshiro Kodama, Toshiyuki Tamura, Satoshi Ino, Takuma Higurashi, Masataka Taguri…

    Citation: Trials 2020 21:291

    Content type: Study protocol

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  13. Mindfulness has been applied to improve cancer care by enhancing psychological well-being. However, little is known about its impact on cognitive impairment experienced by cancer patients after chemotherapy. M...

    Authors: Katleen Van der Gucht, Michelle Melis, Soumaya Ahmadoun, Anneleen Gebruers, Ann Smeets, Mathieu Vandenbulcke, Hans Wildiers, Patrick Neven, Peter Kuppens, Filip Raes, Stefan Sunaert and Sabine Deprez

    Citation: Trials 2020 21:290

    Content type: Study protocol

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  14. Pragmatic trials provide the opportunity to study the effectiveness of health interventions to improve care in real-world settings. However, use of open-cohort designs with patients becoming eligible after ran...

    Authors: Jennifer F. Bobb, Hongxiang Qiu, Abigail G. Matthews, Jennifer McCormack and Katharine A. Bradley

    Citation: Trials 2020 21:289

    Content type: Research

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  15. A noticeable interest in ketamine infusion for sedation management has developed among critical care physicians for critically ill patients. The 2018 Pain, Agitation/sedation, Delirium, Immobility, and Sleep d...

    Authors: Mohammed Bawazeer, Marwa Amer, Khalid Maghrabi, Kamel Alshaikh, Rashid Amin, Muhammad Rizwan, Mohammad Shaban, Edward De Vol and Mohammed Hijazi

    Citation: Trials 2020 21:288

    Content type: Study protocol

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  16. Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary inter...

    Authors: Yongxia Wang, Xinlu Wang, Jianru Wang, Bin Li, Rui Yu, Yucai Hu, Xingyuan Li, Guangcao Peng, Mengmeng Zhang and Mingjun Zhu

    Citation: Trials 2020 21:287

    Content type: Study protocol

    Published on:

  17. Generalisability is typically only briefly mentioned in discussion sections of evaluation articles, which are unhelpful in judging whether an intervention could be implemented elsewhere, with similar effects. ...

    Authors: Helen E. D. Burchett, Dylan Kneale, Laurence Blanchard and James Thomas

    Citation: Trials 2020 21:286

    Content type: Commentary

    Published on:

  18. Frailty in elderly patients is associated with an increased risk of poor health outcomes, including falls, delirium, malnutrition, hospitalisation, and mortality. Because polypharmacy is recognised as a possib...

    Authors: Achim Mortsiefer, Stefan Wilm, Sara Santos, Susanne Löscher, Anja Wollny, Eva Drewelow, Manuela Ritzke, Petra Thürmann, Nina-Kristin Mann, Gabriele Meyer, Jens Abraham, Andrea Icks, Joseph Montalbo, Birgitt Wiese and Attila Altiner

    Citation: Trials 2020 21:285

    Content type: Study protocol

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  19. After publication of our article [1] the authors have notified us that three of the names have been incorrectly spelled.

    Authors: Litza Kiropoulos, Trevor Kilpatrick, Tomas Kalincik, Leonid Churilov, Elizabeth McDonald, Tissa Wijeratne, Jennifer Threader, Vanja Rozenblat, Neil O’Brien-Simpson, Anneke Van Der Walt and Lisa Taylor

    Citation: Trials 2020 21:284

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:100

  20. A large proportion of Syrians have been exposed to potentially traumatic events, multiple losses, and breakdown of supportive social networks and many of them have sought refuge in host countries where they al...

    Authors: Ersin Uygun, Zeynep Ilkkursun, Marit Sijbrandij, A. Tamer Aker, Richard Bryant, Pim Cuijpers, Daniela C. Fuhr, Anne M. de Graaff, Joop de Jong, David McDaid, Naser Morina, A-La Park, Bayard Roberts, Peter Ventevogel, Taylan Yurtbakan and Ceren Acarturk

    Citation: Trials 2020 21:283

    Content type: Study protocol

    Published on:

  21. After publication of our article [1], the authors have reported mathematical errors made in the sample size calculation for this cluster randomized controlled trial (cRCT) (Benzies et al. 2017).

    Authors: Karen M. Benzies, Vibhuti Shah, Khalid Aziz, Wanrudee Isaranuwatchai, Luz Palacio-Derflingher, Jeanne Scotland, Jill Larocque, Kelly Mrklas, Esther Suter, Christopher Naugler, Henry T. Stelfox, Radha Chari and Abhay Lodha

    Citation: Trials 2020 21:282

    Content type: Correction

    Published on:

    The original article was published in Trials 2017 18:467

  22. Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are bas...

    Authors: Isabelle Ettori-Ajasse, Elise Tatin, Gordon Forbes, Sandra Eldridge and Clarisse Dibao-Dina

    Citation: Trials 2020 21:281

    Content type: Research

    Published on:

  23. Globally, about 15% of newborns are born with a low birth weight (LBW) as a result of preterm birth or intrauterine growth restriction or both. Up to 70% of neonatal deaths occur in this group within the first...

    Authors:

    Citation: Trials 2020 21:280

    Content type: Study protocol

    Published on:

  24. Myopia is increasing in prevalence and is currently recognized as a significant public health issue worldwide, particularly in China. Once myopia develops, appropriate clinical interventions need to be prescri...

    Authors: Yan Li, Yafei Fu, Kai Wang, Zhiming Liu, Xiaoqing Shi and Mingwei Zhao

    Citation: Trials 2020 21:279

    Content type: Study protocol

    Published on:

  25. As a lifetime disorder, ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that affects quality of life and also demands long-term interventions. In spite of considerable side effects and sometimes...

    Authors: Forough Shayesteh, Fatemeh Haidari, Ali Akbar Shayesteh, Javad Mohammadi-Asl and Kambiz Ahmadi-Angali

    Citation: Trials 2020 21:278

    Content type: Study protocol

    Published on:

  26. There is evidence that chronic stress negatively impacts parenting among refugees and other war-affected communities. Persistent parental stress and distress may lead to unresponsive, anxious, or overly harsh ...

    Authors: Kenneth E. Miller, Maguy Arnous, Fadila Tossyeh, Alexandra Chen, Ioannis Bakolis, Gabriela V. Koppenol-Gonzalez, Nayla Nahas and Mark J. D. Jordans

    Citation: Trials 2020 21:277

    Content type: Study protocol

    Published on:

  27. Psychotherapy is highly effective and widely acknowledged for treating various mental disorders. Nevertheless, in terms of methods for teaching effective psychotherapeutic approaches and competencies, there ha...

    Authors: Franziska Kühne, Peter Eric Heinze and Florian Weck

    Citation: Trials 2020 21:276

    Content type: Study protocol

    Published on:

  28. The German guideline on psychosocial interventions for people with severe mental disorders recommends a broad spectrum of evidence-based treatments. Structured implementation of the associated patient version ...

    Authors: Johanna Breilmann, Reinhold Kilian, Steffi G. Riedel-Heller, Uta Gühne, Alkomiet Hasan, Peter Falkai, Andreas Allgöwer, Rainer Muche, Thomas Becker, Klemens Ajayi, Peter Brieger, Karel Frasch, Stephan Heres, Markus Jäger, Andreas Küthmann, Albert Putzhammer…

    Citation: Trials 2020 21:275

    Content type: Study protocol

    Published on:

  29. Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according to the Berlin definitio...

    Authors: Julien Pottecher, Eric Noll, Marie Borel, Gérard Audibert, Sébastien Gette, Christian Meyer, Elisabeth Gaertner, Vincent Legros, Raphaël Carapito, Béatrice Uring-Lambert, Erik Sauleau, Walter G. Land, Seiamak Bahram, Alain Meyer, Bernard Geny and Pierre Diemunsch

    Citation: Trials 2020 21:274

    Content type: Study protocol

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  30. After publication of our article [1], the database of IRON-CKD has undergone vigorous inspection – the authors have therefore re-examined database.

    Authors: Ahmed Ziedan, Xenophon Kassianides and Sunil Bhandari

    Citation: Trials 2020 21:273

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:194

  31. Following the publication of our article [1], the authors have notified us of a typo in the third bullet point of the Consensus Criteria section.

    Authors: Roulla Katiri, Deborah A. Hall, Nora Buggy, Nicholas Hogan, Adele Horobin, Paul van de Heyning, Jill B. Firszt, Iain A. Bruce and Pádraig T. Kitterick

    Citation: Trials 2020 21:272

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:238

  32. Low back pain is a common reason for medical care and carries a heavy social burden. The efficacy of Tuina or health care education for low back pain has been evaluated in previous systematic reviews. However,...

    Authors: Shuaipan Zhang, Lingjun Kong, Qingguang Zhu, Zhiwei Wu, Jianhua Li, Min Fang, Wuquan Sun, Yanbin Cheng, Shanda Xu, Guangxin Guo, Xin Zhou and Zhizhen Lv

    Citation: Trials 2020 21:271

    Content type: Study protocol

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  33. Dual-method use is known as the most reliable protection against unintended pregnancies and sexually transmitted infections, including HIV. However, it is not commonly used in sub-Sharan Africa, especially amo...

    Authors: Hodaka Kosugi, Akira Shibanuma, Junko Kiriya, Ken Ing Cherng Ong, Stephen Mucunguzi, Conrad Muzoora and Masamine Jimba

    Citation: Trials 2020 21:270

    Content type: Study protocol

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  34. Cognitive difficulties experienced by people with multiple sclerosis (MS) impact their quality of life and daily functioning, from childcare and work, to social and self-care activities. Despite the high preva...

    Authors: Christopher P. Dwyer, Alberto Alvarez-Iglesias, Robert Joyce, Timothy J. Counihan, Dympna Casey and Sinéad M. Hynes

    Citation: Trials 2020 21:269

    Content type: Study protocol

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  35. Physical Activity 4 Everyone (PA4E1) is a physical activity program for secondary schools located in low-socioeconomic areas. Over a 24-month period, schools in the program arm of a cluster randomised controll...

    Authors: Matthew Mclaughlin, Jed Duff, Rachel Sutherland, Elizabeth Campbell, Luke Wolfenden and John Wiggers

    Citation: Trials 2020 21:268

    Content type: Study protocol

    Published on:

  36. Coronary heart disease (CHD) is a clinical syndrome caused by coronary atherosclerosis (AS) or functional changes in coronary arteries. We have previously reported that astragaloside IV (in astragalus) and tan...

    Authors: Zhihao Luo, Yuntao Liu, Zhen Zhao, Xia Yan, Dawei Wang and Qing Liu

    Citation: Trials 2020 21:267

    Content type: Study protocol

    Published on:

  37. Generalized anxiety disorder (GAD) is a persistent and common mental disorder that entails significant impairments in role functioning and quality of life. Currently available effective interventions include p...

    Authors: Pei Chen, Hong Zhu, Yanzhe Ning, Dongqing Yin and Hongxiao Jia

    Citation: Trials 2020 21:266

    Content type: Study protocol

    Published on:

  38. Anxiety is common in autistic adults and significantly limits everyday opportunities and quality of life. Evidence-based psychological therapies offered by mental health services often fail to meet the needs o...

    Authors: Jeremy R. Parr, Samuel Brice, Patrick Welsh, Barry Ingham, Ann Le Couteur, Gemma Evans, Alexander Monaco, Mark Freeston and Jacqui Rodgers

    Citation: Trials 2020 21:265

    Content type: Study protocol

    Published on:

  39. Knee osteoarthritis (KOA) is a chronic disease with symptoms of persistent pain or resting pain, joint stiffness, numbness, limitation of activity and even disability, with significant associated costs and eff...

    Authors: Qifei Zhang, Jianqiao Fang, Lifang Chen, Jiayao Wu, Jing Ni, Fang Liu and Jing Sun

    Citation: Trials 2020 21:264

    Content type: Study protocol

    Published on:

  40. Recent studies show that changes in one of the brain areas related to empathic abilities (i.e. the ventromedial prefrontal cortex (vmPFC)) plays an important role in violent behavior in abusers of alcohol and ...

    Authors: Carmen S. Sergiou, Adam J. Woods, Ingmar H. A. Franken and Josanne D. M. van Dongen

    Citation: Trials 2020 21:263

    Content type: Study protocol

    Published on:

  41. Neonatal withdrawal secondary to in utero opioid exposure is a growing global concern stressing the psychosocial well-being of affected families and scarce hospital resources. In the ongoing search for the mos...

    Authors: Flora Shan, Sonya MacVicar, Karel Allegaert, Martin Offringa, Lauren M. Jansson, Sarah Simpson, Wendy Moulsdale and Lauren E. Kelly

    Citation: Trials 2020 21:262

    Content type: Review

    Published on:

  42. Insomnia is a global disease with a high incidence and acupuncture therapy is a well appropriate method to treat insomnia. Shenmen (HT 7) and Sanyinjiao (SP 6) are the acupoints most commonly used to treat ins...

    Authors: Pei Wu, Cisong Cheng, Xiaojun Song, Ling Yang, Dandan Deng, Zhenrong Du, Xingyu Chen, Tingting Zou, Ling Qiao, Na Li, Pingping Zhou, Li Du and Yihui Zhu

    Citation: Trials 2020 21:261

    Content type: Study protocol

    Published on:

  43. In preclinical models, recombinant human relaxin-2 (serelaxin) had anti-fibrotic effects and ameliorated portal hypertension (PH). A small exploratory study in patients with cirrhosis also suggested that serel...

    Authors: Fiona J. Gifford, Philip D. J. Dunne, Graeme Weir, Hamish Ireland, Catriona Graham, Sharon Tuck, Peter C. Hayes and Jonathan A. Fallowfield

    Citation: Trials 2020 21:260

    Content type: Research

    Published on:

  44. South Africa is home to the world’s largest antiretroviral therapy program but sustaining engagement along the HIV care continuum has proven challenging in the country and throughout the wider region. Populati...

    Authors: Kate Clouse, Tamsin K. Phillips, Carol Camlin, Sandisiwe Noholoza, Phepo Mogoba, Julian Naidoo, Richard Langford, Martin Weiss, Christopher J. Seebregts and Landon Myer

    Citation: Trials 2020 21:258

    Content type: Study protocol

    Published on:

  45. After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled.

    Authors: Roger Wahba, Rabi Raj Datta, Andrea Hedergott, Jana Bußhoff, Thomas Bruns, Robert Kleinert, Georg Dieplinger, Hans Fuchs, Caroline Gietzelt, Desdemona Möller, Martin Hellmich, Christiane J. Bruns and Dirk L. Stippel

    Citation: Trials 2020 21:257

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:299

  46. Prolonging working careers is a key policy goal in ageing populations in Europe, but reaching this goal is complex. Occupational health services are in the best position to contribute towards prolonging workin...

    Authors: Salla Atkins, Tiia Reho, Nina Talola, Markku Sumanen, Mervi Viljamaa and Jukka Uitti

    Citation: Trials 2020 21:256

    Content type: Research

    Published on:

  47. Upper crossed syndrome (UCS) refers to specific altered muscle activation and changed movement patterns along with some postural deviations in the upper quarter of the body. This syndrome might contribute to t...

    Authors: Mohammad Bayattork, Foad Seidi, Hooman Minoonejad, Lars Louis Andersen and Phil Page

    Citation: Trials 2020 21:255

    Content type: Study protocol

    Published on:

  48. Trunk function in stroke patients with hemiplegia is associated with respiration and core stability and is also found to be associated with balance and postural control and activities of daily living. LiuZiJue...

    Authors: Chen Wang, Long Yu, Jian Yang, Ren Wei Wang, Ya Nan Zheng and Ying Zhang

    Citation: Trials 2020 21:254

    Content type: Study protocol

    Published on:

  49. Adolescents and young adults (AYA) with chronic somatic conditions have an increased risk of comorbid depression and anxiety symptoms. Internet- and mobile-based cognitive behavioural therapy (iCBT) might be o...

    Authors: Frederike Lunkenheimer, Matthias Domhardt, Agnes Geirhos, Reinhold Kilian, Annabel S. Mueller-Stierlin, Reinhard W. Holl, Thomas Meissner, Kirsten Minden, Morten Moshagen, Ramona Ranz, Cedric Sachser, Doris Staab, Petra Warschburger and Harald Baumeister

    Citation: Trials 2020 21:253

    Content type: Study protocol

    Published on:

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