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Research
In the UK, routinely recorded data may benefit prospective studies including randomised controlled trials (RCTs). In an on-going study, we aim to assess the feasibility of access and agreement of routinely rec...
Trials 2017 18:389
Published on: 23 August 2017
Study protocol
The reporting of outcomes in clinical trials of subjective tinnitus indicates that many different tinnitus-related complaints are of interest to investigators, from perceptual attributes of the sound (e.g. lou...
Trials 2017 18:388
Published on: 23 August 2017
Study protocol
The additional value of perioperative antibiotic prophylaxis in preventing infectious complications after emergency cholecystectomy for acute cholecystitis is a much-debated subject in the surgical community. ...
Trials 2017 18:390
Published on: 23 August 2017
Study protocol
Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now st...
Trials 2017 18:387
Published on: 22 August 2017
Study protocol
In intensive care units (ICUs), nosocomial infections are prevalent conditions and they have been related to high mortality indexes. Some studies have suggested that inefficient oral hygiene and ventilator-ass...
Trials 2017 18:385
Published on: 22 August 2017
Study protocol
Anthracyclines, alone or in combination with other drugs, are among the most effective chemotherapeutic agents to treat breast cancer both in the adjuvant and neoadjuvant setting. Unfortunately, anthracycline-...
Trials 2017 18:386
Published on: 22 August 2017
Study protocol
There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and ...
Trials 2017 18:383
Published on: 18 August 2017
Study protocol
The number of falls experienced by people with knee osteoarthritis (OA) is almost double the number experienced by people with no OA. The neuromuscular elements required to arrest a fall are more impaired in p...
Trials 2017 18:384
Published on: 18 August 2017
Study protocol
People with anxiety disorders represent a significant part of a general practitioner’s patient population. However, there are organisational obstacles for optimal treatment, such as a lack of coordination of i...
Trials 2017 18:382
Published on: 16 August 2017
Methodology
In a cluster randomised crossover (CRXO) design, a sequence of interventions is assigned to a group, or ‘cluster’ of individuals. Each cluster receives each intervention in a separate period of time, forming ‘...
Trials 2017 18:381
Published on: 15 August 2017
Study protocol
Most health care providers do not treat tobacco dependence routinely. This may in part be due to the treatment “default.” Current treatment guidelines recommend that providers (1) ask patients if they are will...
Trials 2017 18:379
Published on: 14 August 2017
Research
Recruitment and retention of participants is crucial for statistical power and internal and external validity and participant engagement is essential for behaviour change. However, many school-based interventi...
Trials 2017 18:378
Published on: 14 August 2017
Research
The indications for conservative “best medical treatment” (BMT) versus additional renal artery stenting are a matter of ongoing debate. The RADAR study aimed to evaluate the impact of percutaneous renal artery...
Trials 2017 18:380
Published on: 14 August 2017
Study protocol
Perimenopausal insomnia is one of the core symptoms of the menopausal transition. Acupuncture is considered to exert a positive effect on restoring the normal sleep–wake cycle. However, there is little intuiti...
Trials 2017 18:377
Published on: 14 August 2017
Study protocol
In recent years, there has been a significant change in the demographics of developed countries, including an increase in the number of older people. This aging population and the associated need for medical c...
Trials 2017 18:376
Published on: 11 August 2017
Study protocol
Patients undergoing general anesthesia and mechanical ventilation during major abdominal surgery commonly develop pulmonary atelectasis and/or hyperdistention of the lungs. Recent studies show benefits of lung...
Trials 2017 18:375
Published on: 11 August 2017
Study protocol
An acquired brain injury (ABI) is a complex injury often followed by a broad range of cognitive, physical, emotional, and behavioral disabilities. Because of these disabilities, vocational rehabilitation (VR) ...
Trials 2017 18:371
Published on: 10 August 2017
Study protocol
The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention pro...
Trials 2017 18:372
Published on: 10 August 2017
Study protocol
In patients with peripheral arterial disease (PAD), walking improvements are often limited by early pain onset due to vascular claudication. It would thus appear interesting to develop noninvasive therapeutic ...
Trials 2017 18:373
Published on: 10 August 2017
Study protocol
Alcohol abuse, other substance use disorders, and risk behaviors associated with the human immunodeficiency virus (HIV) represent three of the top 10 modifiable causes of mortality in the US. Despite evidence ...
Trials 2017 18:374
Published on: 10 August 2017
Study protocol
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Whilst surgery is the mainstay of curative treatment, it is associated with significant risks. Surgical strategies for treating g...
Trials 2017 18:370
Published on: 9 August 2017
Study protocol
Concurrent epidemics of HIV, depression, alcohol abuse, and partner violence threaten maternal and child health (MCH) in South Africa. Although home visiting has been repeatedly demonstrated efficacious in res...
Trials 2017 18:368
Published on: 7 August 2017
Study protocol
Research published to date on the relationship between insulin resistance (IR) and fructose consumption is scarce, has used different methods, and has yielded sometimes contradictory results. This study aims t...
Trials 2017 18:369
Published on: 7 August 2017
Study protocol
Evidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish (guppies),...
Trials 2017 18:367
Published on: 4 August 2017
Study protocol
Orthodontic treatment is commonly undertaken in young people, with over 40% of children in the UK needing treatment and currently one third having treatment, at a cost to the National Health Service in England...
Trials 2017 18:366
Published on: 4 August 2017
