Articles

Landiolol, an ultra-short acting beta-1 blocker, for preventing postoperative lung cancer recurrence: study protocol for a phase III, multicenter randomized trial with two parallel groups of patients

Recurrence of cancer after curative surgery is a major problem after most cancer treatments. Increased sympathetic activity during the perioperative period could promote cancer cell invasion to blood vessels a...

Authors: Haruko Yamamoto, Toshimitsu Hamasaki, Kaori Onda, Takashi Nojiri, Masato Aragaki, Nao Horie, Norihiro Sato and Yasuhiro Hida

Budgeting of non-commercial clinical trials: development of a budget tool by a public funding agency

Investigator-led multicentre randomised trials are essential to generate evidence on the optimal use of medical interventions. These non-commercial trials are often hampered by underfunding, which may lead to ...

Authors: Hilde Nevens, Jillian Harrison, France Vrijens, Leen Verleye, Nelle Stocquart, Elisabeth Marynen and Frank Hulstaert

A randomized trial of a specialist palliative care intervention for patients undergoing surgery for cancer: rationale and design of the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) Trial

In medical oncology settings, early specialist palliative care interventions have demonstrated improvements in patient quality of life and survival compared with usual oncologic care. However, the effect of ea...

Authors: Myrick C. Shinall Jr, Aimee Hoskins, Alexander T. Hawkins, Christina Bailey, Alaina Brown, Rajiv Agarwal, Maria C. Duggan, Laura M. Beskow, Vyjeyanthi S. Periyakoil, David F. Penson, Ryan T. Jarrett, Rameela Chandrasekhar and E. Wesley Ely

Effectiveness of an online self-management tool, OPERAS (an On-demand Program to EmpoweR Active Self-management), for people with rheumatoid arthritis: a research protocol

Active self-management is a process where patients are fully engaged in managing their health in daily life by having access to contextualized health data and tailored guidance to support a healthy lifestyle. ...

Authors: Johnathan Tam, Diane Lacaille, Teresa Liu-Ambrose, Chris Shaw, Hui Xie, Catherine L. Backman, John M. Esdaile, Kimberly Miller, Robert Petrella and Linda C. Li

Improving the relevance of randomised trials to primary care: a qualitative study investigating views towards pragmatic trials and the PRECIS-2 tool

Pragmatic trials have been suggested as a way to improve the relevance of clinical trial results to practice. PRECIS-2 (Pragmatic Explanatory Continuum Indicator Summary-2) is a trial design tool which conside...

Authors: Gordon Forbes, Kirsty Loudon, Megan Clinch, Stephanie J. C. Taylor, Shaun Treweek and Sandra Eldridge

Efficacy and safety of dexmedetomidine for prevention of withdrawal syndrome in the pediatric intensive care unit: protocol for an adaptive, multicenter, randomized, double-blind, placebo-controlled, non-profit clinical trial

Prolonged treatment with analgesic and sedative drugs in the pediatric intensive care unit (PICU) may lead to undesirable effects such as dependence and tolerance. Moreover, during analgosedation weaning, pati...

Authors: Maria Cristina Mondardini, Francesca Sperotto, Marco Daverio, Fabio Caramelli, Dario Gregori, Maria Francesca Caligiuri, Francesca Vitale, Maria Teresa Cecini, Marco Piastra, Aldo Mancino, Andrea Pettenazzo, Giorgio Conti and Angela Amigoni

Promoting Independence in Dementia (PRIDE): protocol for a feasibility randomised controlled trial

Memory services often see people with early stage dementia who are largely independent and able to participate in community activities but who run the risk of reducing activities and social networks. PRIDE is ...

Authors: Aisha Shafayat, Emese Csipke, Lucy Bradshaw, Georgina Charlesworth, Florence Day, Phuong Leung, Esme Moniz-Cook, Alan A. Montgomery, Steve Morris, Gail Mountain, Reuben Ogollah, Kirsty Sprange, Lauren Yates and Martin Orrell

Criteria for site selection in industry-sponsored clinical trials: a survey among decision-makers in biopharmaceutical companies and clinical research organizations

Knowledge of what the pharmaceutical industry emphasizes when assessing trial sites during site selection is sparse. A better understanding of this issue can improve the collaboration on clinical trials and in...

Authors: Tilde Dombernowsky, Merete Haedersdal, Ulrik Lassen and Simon Francis Thomsen

Acupoint transcutaneous electrical nerve stimulation in hospitalized COPD patients with severe dyspnoea: study protocol for a randomized controlled trial

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a major cause of hospital admissions and dyspnoea is its main symptom. Some studies have concluded that a new modality of acupuncture, ca...

Authors: Carles Fernández-Jané and Jordi Vilaró

Electronic health record nested pragmatic randomized controlled trial of a reminder system for serum lithium level monitoring in patients with mood disorder: KONOTORI study protocol

The weaknesses of classical explanatory randomized controlled trials (RCTs) include limited generalizability, high cost, and time burden. Pragmatic RCTs nested within electronic health records (EHRs) can be us...

Authors: Tomotsugu Seki, Morio Aki, Hirotsugu Kawashima, Tomotaka Miki, Shiro Tanaka, Koji Kawakami and Toshi A. Furukawa

Measurement training and feedback system for implementation of evidence-based treatment for adolescent externalizing problems: protocol for a randomized trial of pragmatic clinician training

Innovations in clinical training and support that enhance fidelity to evidence-based treatment (EBT) for adolescent behavior problems are sorely needed. This study will develop an online training system to add...

Authors: Aaron Hogue, Molly Bobek, Alexandra MacLean, Nicole Porter, Amanda Jensen-Doss and Craig E. Henderson

GoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial

Oral hygiene is of paramount importance for the preservation of oral health, and for patients affected by periodontal disease establishing an effective oral hygiene routine is the first step of therapy. Severa...

Authors: Valentin Garyga, Florian Pochelu, Béatrice Thivichon-Prince, Walid Aouini, Julie Santamaria, France Lambert, Delphine Maucort-Boulch, Francois Gueyffier, Kerstin Gritsch and Brigitte Grosgogeat

Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma

The incidence of chronic subdural haematoma (CSDH) is increasing. Although surgery remains the mainstay of management for symptomatic patients, uncertainty remains regarding the role of steroids. Hence, the De...

Authors: Annabel Allison, Ellie Edlmann, Angelos G. Kolias, Carol Davis-Wilkie, Harry Mee, Eric P. Thelin, Carole Turner, Peter J. Hutchinson and Simon Bond

Psychosomatic therapy for patients frequently attending primary care with medically unexplained symptoms, the CORPUS trial: study protocol for a randomised controlled trial

Medically unexplained symptoms (MUS) are highly prevalent and pose a burden both on patients and on health care. In a pilot study psychosomatic therapy delivered by specialised therapists for patients with MUS...

Authors: Margreet S. H. Wortman, Johannes C. van der Wouden, Janneke P. C. Grutters, Bart Visser, Willem J. J. Assendelft, Henriëtte E. van der Horst and Tim C. olde Hartman

ELEMENT TRIAL: study protocol for a randomized controlled trial on endoscopic ultrasound-guided biliary drainage of first intent with a lumen-apposing metal stent vs. endoscopic retrograde cholangio-pancreatography in the management of malignant distal biliary obstruction

Endoscopic ultrasound guided-biliary drainage (EUS-BD) is a promising alternative to endoscopic retrograde cholangiopancreatography (ERCP); however, its growth has been limited by a lack of multicenter randomi...

Authors: Yen-I Chen, Kashi Callichurn, Avijit Chatterjee, Etienne Desilets, Donnellan Fergal, Nauzer Forbes, Ian Gan, Sana Kenshil, Mouen A. Khashab, Rastislav Kunda, Eric Lam, Gary May, Rachid Mohamed, Jeff Mosko, Sarto C. Paquin, Anand Sahai…

Correction to: Mobile Link – a theory-based messaging intervention for improving sexual and reproductive health of female entertainment workers in Cambodia: study protocol of a randomized controlled trial

After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. We would like to formally apologize and give credi...

Authors: Carinne Brody, Sovannary Tuot, Pheak Chhoun, Dallas Swendeman, Kathryn C. Kaplan and Siyan Yi

An adaptive two-arm clinical trial using early endpoints to inform decision making: design for a study of sub-acromial spacers for repair of rotator cuff tendon tears

There is widespread concern across the clinical and research communities that clinical trials, powered for patient-reported outcomes, testing new surgical procedures are often expensive and time-consuming, par...

Authors: Nick Parsons, Nigel Stallard, Helen Parsons, Philip Wells, Martin Underwood, James Mason and Andrew Metcalfe

Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy

Orthopaedic infections, such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement and a prolonged course of systemic anti...

Authors: Maria Dudareva, Michelle Kümin, Werner Vach, Klaus Kaier, Jamie Ferguson, Martin McNally and Matthew Scarborough

Cognitive-behavioral intervention via interactive multimedia online video game for active aging: study protocol for a randomized controlled trial

Due to the progressive aging of the population, programs to promote active aging have been recommended. However, older adults have difficulty accessing them. Interventions administered through online video gam...

Authors: Fernando L. Vázquez, Ángela J. Torres, Patricia Otero, Vanessa Blanco, Lara López, Antonio García-Casal and Manuel Arrojo

COMMENCE trial (Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry): a randomized controlled trial of mild vs moderate hypothermia on patient outcomes in aortic hemiarch surgery with anterograde cerebral perfusion

Aortic arch surgery remains the only viable life-saving treatment for aortic arch disease. However, the necessity for cessation of systemic blood flow with hypothermic cardiac arrest carries substantial risk o...

Authors: Habib Jabagi, George Wells and Munir Boodhwani

Principles and procedures for data and safety monitoring in pragmatic clinical trials

All clinical trial investigators have ethical and regulatory obligations to monitor participant safety and trial integrity. Specific procedures for meeting these obligations, however, may differ substantially ...

Authors: Gregory E. Simon, Susan M. Shortreed, Rebecca C. Rossom, Robert B. Penfold, Jo Ann M. Sperl-Hillen and Patrick O’Connor

Chinese pediatric Tuina on children with acute diarrhea: study protocol for a randomized sham-controlled trial

Acute pediatric diarrhea is one of the most common causes of morbidity and mortality worldwide and seriously affects the health of children. Previous studies have shown that pediatric Tuina, a traditional Chinese...

Authors: Taoying Lu, Huiyan Zhang, Lingjia Yin, Jianxiong Cai, Meiling Li, Lin Dai, Conghao Zhu, Yongping Zhang, Feng Xiang, Li Wang, Lu Li, Lixin Wang and Darong Wu

Fecal microbiome as determinant of the effect of diet on colorectal cancer risk: comparison of meat-based versus pesco-vegetarian diets (the MeaTIc study)

Convincing evidence suggests that the risk of colorectal cancer (CRC) is increased by the typical Western diet characterized by high consumption of red and processed meat. In addition, some epidemiological stu...

Authors: Francesco Sofi, Monica Dinu, Giuditta Pagliai, Fabrice Pierre, Francoise Gueraud, Jildau Bowman, Philippe Gerard, Vincenzo Longo, Lisa Giovannelli, Giovanna Caderni and Carlotta de Filippo

KONTAKT© for Australian adolescents on the autism spectrum: protocol of a randomized control trial

Individuals diagnosed with autism spectrum disorder (ASD) experience impairing challenges in social communication and interaction across multiple contexts. While social skills group training (SSGT) has shown m...

Authors: Bahareh Afsharnejad, Marita Falkmer, Melissa H. Black, Tasha Alach, Fabian Lenhard, Anna Fridell, Christina Coco, Kelly Milne, Nigel T. M. Chen, Sven Bölte and Sonya Girdler

Overcoming challenges to data quality in the ASPREE clinical trial

Large-scale studies risk generating inaccurate and missing data due to the complexity of data collection. Technology has the potential to improve data quality by providing operational support to data collector...

Authors: Jessica E. Lockery, Taya A. Collyer, Christopher M. Reid, Michael E. Ernst, David Gilbertson, Nino Hay, Brenda Kirpach, John J. McNeil, Mark R. Nelson, Suzanne G. Orchard, Kunnapoj Pruksawongsin, Raj C. Shah, Rory Wolfe and Robyn L. Woods

Acupuncture for patients with insomnia disorder using resting-state functional magnetic resonance imaging: a protocol for a randomized controlled trial

Insomnia is among the most prevalent of the sleep-related disorders. Insomnia disorder is associated with a brain hyperarousal state manifested by abnormal regional brain activity and resting state functional ...

Authors: Jing Guo, Siyi Yu, Chunhong Liu, Guiling Wang and Bin Li

A pragmatic pilot phase II randomised controlled trial of prothrombin complex concentrates (PCC) versus fresh frozen plasma (FFP) in adult patients who are undergoing heart surgery (PROPHESY)

Fresh frozen plasma (FFP) is the accepted standard treatment for clotting factor replacement in bleeding patients during or immediately after cardiac surgery. In the United Kingdom prothrombin complex concentr...

Authors: Laura Green, Neil Roberts, Jackie Cooper, Jane Field, Ravi Gill, Andrew Klein, Seema Agarwal, Simon Stanworth, Atholl Johnston, Vivienne Monk and Ben O’Brien

The effect of antibiotics on post-adenotonsillectomy morbidity in Tanzanian children: study protocol for a randomized, double-blind, placebo-controlled trial

Adenotonsillectomy is the most frequently performed operation in children worldwide. For decades, prophylactic antibiotics have been prescribed to limit postoperative complications. The effect of this antibiot...

Authors: Denis R. Katundu, Peter S. Shija, Baltazari Nyombi, Hadija Semvua, Fieke K. Oussoren and Niels van Heerbeek

Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial

Much evidence is available demonstrating that both vitamin D and omega-3 fatty acids block the development and progression of colonic carcinogenesis. The results of animal studies have shown that the consumpti...

Authors: Fatemeh Haidari, Behnaz Abiri, Masood Iravani, Seyed-Mohsen Razavi, Parvin Sarbakhsh, Kambiz Ahmadi-Angali and Mohammadreza Vafa

Investigating modifications to participant information materials to improve recruitment into a large randomized trial

Large randomized trials are the best method to test the efficacy and safety of treatments expected to have moderate effects. We observed a significant decline in potential participants’ response to mailed invi...

Authors: Richard Haynes, Fang Chen, Elizabeth Wincott, Rejive Dayanandan, Michael J. Lay, Sarah Parish, Louise Bowman, Martin J. Landray and Jane Armitage

Effects of combining functional exercises with exercise training on daily physical activities and functionality in patients with COPD: a protocol for a randomized clinical trial

Functional training has been shown to be a viable alternative for the elderly and patients with chronic obstructive pulmonary disease (COPD). However, whether the combination of this type of training with aero...

Authors: Fabiano Francisco de Lima, Carlos Augusto Camillo, Isis Grigoletto, Juliana Souza Uzeloto, Franciele Marques Vanderlei, Dionei Ramos and Ercy Mara Cipulo Ramos

Solar-powered oxygen delivery for the treatment of children with hypoxemia: protocol for a cluster-randomized stepped-wedge controlled trial in Uganda

Child mortality due to pneumonia is a major global health problem and is associated with hypoxemia. Access to safe and continuous oxygen therapy can reduce mortality; however, low-income countries may lack the...

Authors: Nicholas Conradi, Qaasim Mian, Sophie Namasopo, Andrea L. Conroy, Laura L. Hermann, Charles Olaro, Jackson Amone, Robert O. Opoka and Michael T. Hawkes

Compression therapy following ClariVein® ablation therapy: a randomised controlled trial of COMpression Therapy Following MechanO-Chemical Ablation (COMMOCA)

Endovenous treatment of varicose veins has increased in popularity over the last decade. There remains, however, a degree of uncertainty regarding the role of compression bandaging or hosiery following this in...

Authors: Doireann P. Joyce, Stewart R. Walsh, Charyl J. Q. Yap, Tze T. Chong and Tjun Y. Tang

Randomised controlled trial on vitreoretinal surgery with and without oral anticoagulants: surgical complications, visual results and perioperative thromboembolic events

Vitreoretinal surgery in anticoagulated patients is a challenging situation for vitreoretinal surgeons, who have to choose between being faced with the systemic thromboembolic risks that the interruption of an...

Authors: Jose Andonegui, Ferran Capdevila, Alicia Zubicoa and Berta Ibáñez

Reporting checklists are used as measurement tools for assessing quality, even though they have not been validated for such use

Authors: Livia Puljak

A double-masked placebo-controlled trial of azithromycin to prevent child mortality in Burkina Faso, West Africa: Community Health with Azithromycin Trial (CHAT) study protocol

Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested that the strongest effects were in the youngest childre...

Authors: Ali Sié, Mamadou Ouattara, Mamadou Bountogo, Cheik Bagagnan, Boubacar Coulibaly, Valentin Boudo, Elodie Lebas, Jessica M. Brogdon, Ying Lin, Till Bärnighausen, Travis C. Porco, Thuy Doan, Thomas M. Lietman and Catherine E. Oldenburg

Fire needle acupuncture or moxibustion for chronic plaque psoriasis: study protocol for a randomized controlled trial

Psoriasis is a chronic, immune-mediated disorder with chronic plaque psoriasis being the primary manifestation during the remission stage. Patients often have a slow course and long history of the disease. The...

Authors: Zhaoxia Chen, Dongmei Zhou, Yan Wang, Haibing Lan, Xingwu Duan, Bohua Li, Jingxia Zhao, Wei Li, Zhengrong Liu, Tingting Di, Xinwei Guo, Jinchao Zhang, Bo Li, Shuo Feng and Ping Li

Fire acupuncture for mild to moderate knee osteoarthritis: a protocol for a randomized controlled pilot trial

Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusi...

Authors: Yuan-Bo Fu, Bin Li, San-Feng Sun, Hui-Lin Liu, Xin Wang, Shao-Song Wang, Fan Zhang, Xin Du, Du-Juan Ge, Lei Shang, Rui-Li Liang, Li-Na Wang, Fang Yuan, Jing-Qing Sun and Jun-Wei Chen

Protocol for a phase III wait-listed cluster randomised controlled trial of an intervention for mental well-being through enhancing mental health literacy and improving work friendliness in Hong Kong

Mental health has long been recognised as a major global health issue. Some work-related characteristics have been identified to be associated with common mental health problems, and thus the workplace is an i...

Authors: Lawrence T. Lam, Prudence Wong and Mary K. Lam

Effectiveness of upgraded maternity waiting homes and local leader training in improving institutional births among women in the Jimma zone, Ethiopia: study protocol for a cluster-randomized controlled trial

Ethiopia is one of the ten countries in the world that together account for almost 60% of all maternal deaths. Recent reductions in maternal mortality have been seen, yet just 26% of women who gave birth in Et...

Authors: Jaameeta Kurji, Manisha A. Kulkarni, Lakew Abebe Gebretsadik, Muluemebet Abera Wordofa, Sudhakar Morankar, Kunuz Haji Bedru, Gebeyehu Bulcha, Kednapa Thavorn, Ronald Labonte and Monica Taljaard

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.

Authors: Christopher J. Lindsell, Anna McGlothlin, Samuel Nwosu, Todd W. Rice, Alex Hall, Gordon R. Bernard, Laurence W. Busse, E. Wesley Ely, Alpha A. Fowler, David F. Gaieski, Jeremiah S. Hinson, Michael H. Hooper, James C. Jackson, Gabor D. Kelen, Mark Levine, Greg S. Martin…

Completeness of reporting in abstracts of randomized controlled trials in subscription and open access journals: cross-sectional study

Open access (OA) journals are becoming a publication standard for health research, but it is not clear how they differ from traditional subscription journals in the quality of research reporting. We assessed t...

Authors: Iva Jerčić Martinić-Cezar and Ana Marušić

Improving risk perception and uptake of pre-exposure prophylaxis (PrEP) through interactive feedback-based counselling with and without community engagement in young women in Manicaland, East Zimbabwe: study protocol for a pilot randomized trial

HIV incidence in adolescent girls and young women remains high in sub-Saharan Africa. Progress towards uptake of HIV prevention methods remains low. Studies of oral pre-exposure prophylaxis (PrEP) have shown t...

Authors: Ranjeeta Thomas, Morten Skovdal, Matteo M. Galizzi, Robin Schaefer, Louisa Moorhouse, Constance Nyamukapa, Rufurwokuda Maswera, Phyllis Mandizvidza, Timothy B. Hallett and Simon Gregson

Cognitive behavioural therapy for insomnia (CBTi) as a treatment for tinnitus-related insomnia: protocol for a randomised controlled trial

A significant proportion of patients with chronic tinnitus report clinical levels of sleep disturbance (insomnia). Despite the significant health and functioning implications of this, no rigorous trials have i...

Authors: E. Marks, C. Hallsworth and L. McKenna

Healthy lifestyle consultation based on traditional Chinese medicine versus routine patient education in the treatment of idiopathic sudden sensorineural hearing loss after failure of systemic therapy: study protocol for a clinical randomised trial

Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. ...

Authors: Ying-ping Fei, Yun Zheng, Dan Lai, Ping Zhong, Jing-zhe Lu, Gang Li and Peng Liu

Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study

Crossover designs are commonly utilised in randomised controlled trials investigating treatments for long-term chronic illnesses. One problem with this design is its inherent repeated measures necessitate the ...

Authors: Julie Wych, Michael J. Grayling and Adrian P. Mander

Individualised behaviour change strategies for physical activity in multiple sclerosis (IPAC-MS): protocol for a randomised controlled trial

Multiple sclerosis (MS) is a chronic, degenerative disease of the central nervous system. Because of the long-term and unpredictable nature of the disease, the burden of MS is significant from both a patient a...

Authors: Farren L. Goulding, Charity D. Evans, Katherine B. Knox, Hyun J. Lim, Michael C. Levin and Sarah J. Donkers

Randomised controlled trial of the short-term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention-deficit/hyperactivity disorder (CIAO-II)

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder, seen in 20–30% of young adult prisoners. Pharmacoepidemiological studies, a small randomised controlled trial and open trial data...

Authors: Philip Asherson, Lena Johansson, Rachel Holland, Tom Fahy, Andrew Forester, Sheila Howitt, Stephen Lawrie, John Strang, Susan Young, Sabine Landau and Lindsay Thomson

eHealth-supported case management for patients with panic disorder or depression in primary care: Study protocol for a cRCT (PREMA)

Panic disorder (PD), frequently occurring with agoraphobia (AG), and depression are common mental disorders in primary care and associated with considerable individual and societal costs. Early detection and e...

Authors: Karoline Lukaschek, Karola Mergenthal, Dirk Heider, Alexander Hanke, Kathrein Munski, Anne Moschner, Michelle Emig, Marjan van den Akker, Antonia Zapf, Karl Wegscheider, Hans-Helmut König and Jochen Gensichen

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol

Denture-related stomatitis (DS) is chronic multifactorial inflammation, strongly related to the presence of the biofilm that is the complex structure formed by microorganisms held together by a mucus-like matr...

Authors: Adriana B. Ribeiro, Camila B. de Araújo, Luiz Eduardo V. Silva, Rubens Fazan-Junior, Helio C. Salgado, Aline B. Ribeiro, Caroline V. Fortes, Frank L. Bueno, Viviane C. de Oliveira, Helena de F. O. Paranhos, Evandro Watanabe and Cláudia H. da Silva-Lovato