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  1. Content type: Correction

    Following publication of the original article [1], the author reported the errors in the figure and in text reference in the published article. These errors are detailed below. The original article has been co...

    Authors: Sasha-Denise Grünzig, Harald Baumeister, Jürgen Bengel, David Ebert and Lena Krämer

    Citation: Trials 2018 19:393

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    The original article was published in Trials 2018 19:285

  2. Content type: Research

    With the development of painless diagnosis and treatment, remifentanil, a synthetic opioid agonist, is increasingly used in gastroscopy for its rapid, short-term, and potent analgesic effect. However, the dosa...

    Authors: Minqiang Liu, Hongyan Wu, Danling Yang, Fengxian Li, Zhichao Li, Song Wang and Renliang He

    Citation: Trials 2018 19:392

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  3. Content type: Study protocol

    Obese women have fewer oocytes retrieved, an increased cancelation rate, a higher miscarriage rate, and a lower live birth rate after assisted reproductive technology (ART) treatment compared with women with n...

    Authors: Jing Li, Ze Wang, Daimin Wei, Hong Liu, Jiangtao Zhang, Jianfeng Wang, Yuhua Shi and Zi-Jiang Chen

    Citation: Trials 2018 19:391

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  4. Content type: Study protocol

    Neuroendocrine tumors (NETs) are the second most common gastrointestinal malignancy after colon cancer. Up to 90% of patients with NETs develop liver metastases, which are a major determinant of symptoms and s...

    Authors: James X. Chen, E. Paul Wileyto and Michael C. Soulen

    Citation: Trials 2018 19:390

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  5. Content type: Study protocol

    Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus and the primary cause of end-stage renal disease. Existing therapies for DKD are not sufficiently effective. We report t...

    Authors: Mengdi Wang, Zhen Wang, Jingwei Zhou, Weiwei Sun, Ying Wang, Mei Han, Hanwen Yang, Wei Jing Liu and Yaoxian Wang

    Citation: Trials 2018 19:389

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  6. Content type: Study protocol

    Proliferative vitreoretinopathy (PVR) is the major cause for postoperative failure after vitreo-retinal surgery for primary rhegmatogenous retinal detachment (RRD). Adjunct pharmaceutical therapy was found to ...

    Authors: Friederike Schaub, Robert Hoerster, Petra Schiller, Moritz Felsch, Daria Kraus, Marouan Zarrouk, Bernd Kirchhof and Sascha Fauser

    Citation: Trials 2018 19:384

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  7. Content type: Study protocol

    Patients with type 2 diabetes mellitus (T2D) are prone to micro- and macro-vascular complications. Monomeric and oligomeric flavanols (MOF) isolated from grape seeds (Vitis vinifera) have been linked to improved ...

    Authors: Mardin Rashid, Adrie J. M. Verhoeven, Monique T. Mulder, Reinier Timman, Yvonne van Beek-Nieuwland, Athumani A. Athumani, Adrienne A. M. Zandbergen, Hans E. van der Wiel, Eric J. G. Sijbrands and Kirsten A. Berk

    Citation: Trials 2018 19:379

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  8. Content type: Study protocol

    Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the e...

    Authors: Carina de Araujo, Raquel Crespo Fitz, Daniela Albugeri Nogara, Pedro Schestatsky and Fernando Gerchman

    Citation: Trials 2018 19:386

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  9. Content type: Study protocol

    People with Parkinson’s disease (PD) commonly experience postural instability, resulting in poor balance and an increased risk of falls. Exercise-based video gaming (exergaming) is a form of physical training ...

    Authors: Dale M. Harris, Timo Rantalainen, Makii Muthalib, Liam Johnson, Rachel L. Duckham, Stuart T. Smith, Robin M. Daly and Wei-Peng Teo

    Citation: Trials 2018 19:387

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  10. Content type: Study protocol

    Although China has a large number of older people living with diabetes and hypertension, the primary care system is underdeveloped and so management of these conditions in community care settings is suboptimal...

    Authors: Qiang Tu, Lily Dongxia Xiao, Shahid Ullah, Jeffrey Fuller and Huiyun Du

    Citation: Trials 2018 19:385

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  11. Content type: Study protocol

    The surgical technique used in liver transplantation has undergone constant evolution in an effort to develop a safe, highly standardized procedure. Despite this, the initial step of recipient hepatectomy has ...

    Authors: Philipp Houben, Elias Khajeh, Ulf Hinz, Phillip Knebel, Markus K. Diener and Arianeb Mehrabi

    Citation: Trials 2018 19:380

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  12. Content type: Study protocol

    Preliminary evidence based on clinical observations suggests that meditative exercise may offer potential benefits for patients with chronic heart failure (CHF). Cardiac rehabilitation (CR), as a class-IA indi...

    Authors: Meili Yu, Siming Li, Siwei Li, Jingen Li, Hao Xu and Keji Chen

    Citation: Trials 2018 19:381

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  13. Content type: Study protocol

    To achieve the World Health Organization hepatitis C virus (HCV) elimination targets, it is essential to increase access to treatment. Direct-acting antiviral (DAA) treatment can be provided in primary healthc...

    Authors: A. J. Wade, J. S. Doyle, E. Gane, C. Stedman, B. Draper, D. Iser, S. K. Roberts, W. Kemp, D. Petrie, N. Scott, P. Higgs, P. A. Agius, J. Roney, L. Stothers, A. J. Thompson and M. E. Hellard

    Citation: Trials 2018 19:383

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  14. Content type: Study protocol

    Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and lim...

    Authors: Denise Bernhardt, Adriane Hommertgen, Daniela Schmitt, Rami El Shafie, Angela Paul, Laila König, Johanna Mair-Walther, Johannes Krisam, Christina Klose, Thomas Welzel, Juliane Hörner-Rieber, Jutta Kappes, Michael Thomas, Claus Peter Heußel, Martin Steins, Meinhard Kieser…

    Citation: Trials 2018 19:388

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  15. Content type: Study protocol

    The mechanism of the long-lasting effect and the relationship between the long-lasting effect and the deqi sensation, which is the key of achieving the acupuncture effect, has not been well investigated. This tri...

    Authors: Ruirui Sun, Xiaojuan Hong, Jing Guo, Shuai Yin, Peiming Feng, Lei Lan, Du Lei, Xiaoyan Liu, Xueling Suo, Tao Yin, Tingting Zhang, Liuyang Huang, Feifei Gao, Qiyong Gong, Fanrong Liang and Fang Zeng

    Citation: Trials 2018 19:373

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  16. Content type: Study protocol

    Overactive bladder (OAB) is defined as “urgency, with or without urge incontinence, usually with frequency and nocturia”. Acupuncture is one of the most popular alternative treatment methods for OAB. Little es...

    Authors: Yu Tat Chan, Hong Wei Zhang, Yuan Qi Guo, Tony Ngai Ho Chan, Yiu-Keung Kwan, Chun-Kam Lee, Kit Ngan and Zhi-Xiu Lin

    Citation: Trials 2018 19:376

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  17. Content type: Study protocol

    The potential of neuroprotective agents should be revisited in the era of endovascular thrombectomy (EVT) for acute large-artery occlusion because their preclinical effects have been optimized for ischemia and...

    Authors: Ji Man Hong, Mun Hee Choi, Sung-Il Sohn, Yang-Ha Hwang, Seong Hwan Ahn, Yeong-Bae Lee, Dong-Ick Shin, Ángel Chamorro and Dennis W. Choi

    Citation: Trials 2018 19:375

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  18. Content type: Study protocol

    Perthes’ disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardised outcomes makes comparisons between studie...

    Authors: Donato Giuseppe Leo, Wei Yee Leong, Tina Gambling, Andrew Long, Rebecca Murphy, Helen Jones and Daniel Christopher Perry

    Citation: Trials 2018 19:374

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  19. Content type: Study protocol

    Hand-assisted laparoscopic living donor nephrectomy (HALDN) using a periumbilical or Pfannenstiel incision was developed to improve donor outcome after a kidney transplant. The aim of this study was to investi...

    Authors: Yakup Kulu, Beat P. Müller-Stich, Omid Ghamarnejad, Elias Khajeh, Georgios Polychronidis, Mohammad Golriz, Felix Nickel, Laura Benner, Philipp Knebel, Markus Diener, Christian Morath, Martin Zeier, Markus W. Büchler and Arianeb Mehrabi

    Citation: Trials 2018 19:377

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  20. Content type: Study protocol

    Different methods are available for the treatment of venous ulcers. Most current approaches focus on a combination of topical and compressive therapy. Adjuvant low-level laser therapy may be helpful in lesions...

    Authors: Taline Bavaresco, Ananda Ughini Bertoldo Pires, Vítor Monteiro Moraes, Viviane Maria Osmarin, Denise Tolfo Silveira and Amália de Fátima Lucena

    Citation: Trials 2018 19:372

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  21. Content type: Methodology

    The important role of network meta-analysis of randomized clinical trials in health technology assessment and guideline development is increasingly recognized. This approach has the potential to obtain conclus...

    Authors: Georgia Salanti, Adriani Nikolakopoulou, Alex J. Sutton, Stephan Reichenbach, Sven Trelle, Huseyin Naci and Matthias Egger

    Citation: Trials 2018 19:365

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  22. Content type: Study protocol

    Irritable bowel syndrome (IBS) is a chronic, recurring condition, prevalent in the general population. Current medication treatments usually leave patients undertreated. Nowadays, Chinese medicine (CM) is bein...

    Authors: Qian Li, Bei-ping Zhang, Shao-gang Huang, Wen-wei Ouyang, Jian-hui Xie, Ze-huai Wen and Xiao-bo Yang

    Citation: Trials 2018 19:367

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  23. Content type: Study protocol

    In distal pancreatectomy (DP), it is customary to ligate and divide the splenic vein after isolating it from the pancreatic parenchyma. This is considered essential to prevent disruption of the stump of the sp...

    Authors: Suguru Yamada, Tsutomu Fujii, Manabu Kawai, Toshio Shimokawa, Masafumi Nakamura, Yoshiaki Murakami, Sohei Satoi, Hidetoshi Eguchi, Yuichi Nagakawa, Yasuhiro Kodera and Hiroki Yamaue

    Citation: Trials 2018 19:369

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