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  • Poster presentation
  • Open Access

Systematic review of Goal Attainment Scaling as an outcome measure in drug trials

  • 1Email author,
  • 1 and
  • 1
Trials201516 (Suppl 1) :P14

  • Published:


  • Systematic Review
  • Data Extraction
  • Critical Appraisal
  • Measurement Property
  • Rare Condition


Goal Attainment Scaling (GAS)[1] is a technique aimed to measure change induced by treatment. GAS enables patients to set goals and to determine the relative success in achieving these goals on a 5-point scale that is precisely defined beforehand. Since the goals are individually determined, goals may differ in actual content. Its individual and patient oriented approach is one of the appealing aspects of GAS when used as an outcome measure for trials, particularly in orphan diseases. GAS may be more responsive than standardised questionnaires, making it useful in smaller and more heterogeneous samples. In this systematic review, we aim to investigate whether the measurement properties of GAS have been evaluated in drug trials.


We have conducted a sensitive search in Medline, PsycINFO and Embase. Included are papers that either describe a study in which a drug intervention is tested using GAS as an outcome measure, or in which the measurement characteristics of GAS are evaluated, in terms of validity, reliability, responsiveness, and/or feasibility. Selection, data extraction and critical appraisal is performed by 2 independent reviewers.


The search yielded a total of 3271 abstracts after removal of duplicates. Of those abstracts, 296 were assessed for eligibility. The final results of this review will become available in 2015.


GAS may be a useful personalised approach to outcome measurement in rare conditions. We expect that further validation of the method will be needed.

Authors’ Affiliations

Pediatric Clinical Research Office Woman-Child Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands


  1. Kiresuk TJ, Sherman RE: Goal attainment scaling: A general method for evaluating comprehensive community mental health programs. Community Ment Health J. 1968, 4: 443-453. 10.1007/BF01530764.View ArticlePubMedGoogle Scholar


© Gaasterland et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


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