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Featured article: Planning a future randomized clinical trial based on a network of relevant past trials

Network meta-analysis is increasingly recognized as having an important role in HTA and guideline development. Here, Georgia Salanti (University of Bern, Switzerland) and colleagues describe its use in planning a future trial. They introduce a four step framework that aims to identify the optimal design for a new trial that will update the existing evidence while minimizing the required sample size.

Articles

  1. Content type: Study protocol

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    Authors: Denise Bernhardt, Adriane Hommertgen, Daniela Schmitt, Rami El Shafie, Angela Paul, Laila König, Johanna Mair-Walther, Johannes Krisam, Christina Klose, Thomas Welzel, Juliane Hörner-Rieber, Jutta Kappes, Michael Thomas, Claus Peter Heußel, Martin Steins, Meinhard Kieser…

  1. Content type: Review

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    Authors: Barbara Farrell, Sara Kenyon and Haleema Shakur

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Thematic series
Building capacity for evidence informed trial management
Edited by Dr Roberta Littleford and Prof Shaun Treweek

Thematic series
Stepped wedge randomized controlled trials
Edited by Prof David Torgerson

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Aims and scope

Trials encompasses all aspects of the performance and findings of randomized controlled trials in health. Trials encourages full and transparent reporting of all research.  We publish articles on general trial methodology as well as protocols, commentaries and traditional results papers - regardless of outcome or significance of findings.

Peer review mentoring

The Editors endorse peer review mentoring of early career researchers. Find out more here

Thank you to our peer reviewers

The editors and staff of Trials would like to warmly thank our peer reviewers whose comments have helped to shape the journal.

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Call for papers: Building capacity for evidence informed trial management

We are pleased to announce that Trials is accepting submissions for a new thematic series aimed at building the evidence base for trial management. Co-edited by Dr Roberta Littleford (University of Dundee, UK) and Prof Shaun Treweek (University of Aberdeen, UK), this series will include articles that report on what is currently known about effective trial management processes and how to make trial management more evidence-informed.

Call for papers: Big data for randomized trials

We are pleased to announce that Trials is accepting submissions for a new thematic series on using big data for randomized trials. Edited by Dr Lars Hemkens (University Hospital Basel, Switzerland), this series will consider articles that report on what is currently known about using big data or routinely collected data (such as electronic health records, registries or administrative databases) for randomized trials.

Call for papers: The future of pragmatic trials

We are pleased to announce that Trials is accepting submissions for a new thematic series on the future of pragmatic trials. Edited by Professor Marion Campbell (University of Aberdeen, UK), this series will consider articles that report on any topic relevant to the role, definition and use of the pragmatic trial design.

Jeremy Grimshaw

Jeremy Grimshaw, Editor-in-Chief

Jeremy Grimshaw is a Senior Scientist in the Clinical Epidemiology Program at the Ottawa Health Research Institute and Professor of Medicine, University of Ottawa. He holds a Tier 1 Canadian Research Chair in health knowledge transfer and uptake. Professor Grimshaw’s research interests are in implementation and knowledge translation, quality improvement, complex interventions, systematic reviews, cluster randomized trials, quasi-experimental studies and behavioral theories (and their application to professional behavior).

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Tianjing Li, Editor-in-Chief

Tianjing Li is an Associate Professor in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health (JHBSPH). Dr Li was trained as a physician and subsequently earned her PhD in Epidemiology (Clinical Trials concentration) and MHS in Biostatistics from JHBSPH. The primary goal of Dr Li's research is to develop, evaluate, and disseminate efficient methods for comparing healthcare interventions and to provide trustworthy evidence for decision making. Her core research interests include methodologies for randomized controlled trials, systematic reviews, network meta-analysis, comparative effectiveness research, and patient-centered outcomes research. Dr Li serves as the Associate Director for Cochrane United States and the Director for Research for Cochrane Eyes and Vision US Project.

Celebrating Trials' 10th anniversary

2016 marked the 10th anniversary of Trials and to coincide with publication of our 3000th article, we put together a page to celebrate the great milestones of the journal, including a timeline, opinions from those in the field, links to our most popular articles, and more.

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2017 Journal Metrics

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