Ensuring research is relevant and usable means attention must be taken to select appropriate outcomes when designing clinical trials. The COMET Initiative has developed this Handbook, collating current evidence for the development, implementation, evaluation and updating of core outcome sets, and provides researchers with the guidance needed for designing and choosing relevant outcomes for their clinical trials.

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We are pleased to announce that Trials is accepting submissions for a new thematic series aimed at building the evidence base for trial management.

Co-edited by Dr Roberta Littleford (University of Dundee, UK) and Prof Shaun Treweek (University of Aberdeen, UK), this series will include articles that report on what is currently known about effective trial management processes and how to make trial management more evidence-informed.

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Doug Altman, Editor-in-Chief

Doug Altman graduated in statistics from the University of Bath and has worked for the Medical Research Council as a statistical consultant in a wide variety of medical areas. In 1988 he became head of the newly formed Medical Statistics Laboratory (now Medical Statistics Group) at ICRF (now Cancer Research UK), and in 1995 also became founding director of the Centre for Statistics in Medicine in Oxford. In 1997, Professor Altman received the Bradford Hill Medal for his contributions to medical statistics and a DSc from the University of London, and in 1998 was made Professor of Statistics in Medicine by the University of Oxford. His varied research interests include the use and abuse of statistics in medical research, studies of prognosis, regression modelling, systematic reviews and meta-analysis, randomised trials, and studies of medical measurement.

Jeremy Grimshaw, Editor-in-Chief

Jeremy Grimshaw is the Director of the Clinical Epidemiology Program at the Ottawa Health Research Institute and the Director of the Center for Best Practice at the University of Ottawa. He holds a Tier 1 Canadian Research Chair in health knowledge transfer and uptake and was made a Professor of Medicine by the University of Ottawa. Prior to this, he held a Personal Chair in health services research at the University of Aberdeen and was the Program Director of the Effective Professional Program within health services research, one of the largest implementation research programs within the UK. Professor Grimshaw’s research interests are in knowledge translation,quality improvement,complex interventions. systematic reviews, cluster randomized trials, quasi experimental studies and behavioural theories (and their application to professional behaviour).

2016 marked the 10th anniversary of Trials and to coincide with publication of our 3000th article, we put together a page to celebrate the great milestones of the journal, including a timeline, opinions from those in the field, links to our most popular articles, and more.

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