- Poster presentation
- Open Access
BISON (Bloodstream Infections and Sepsis Outcomes measurement Network) initiative: an ESGBIS proposal
Trials volume 16, Article number: P3 (2015)
Outcome of a bloodstream infection/sepsis (BSI/S) is defined in different ways in different research projects. In this, BSI/S share the characteristics of other fields of medicine; specific issues are related to diversity of causative agents, the clinical focus of infection, severity of comorbid conditions, presence of indwelling devices, multiplicity of affected patient populations, and others. A preliminary list of putative core outcome set (COS) might be:
development/resolution of metastatic foci
adverse events of treatment
salvage of infected device
Therefore, the European Society of Clinical Microbiology and Infectious Diseases working group on bloodstream infections and sepsis (ESGBIS) is currently designing a project for the development of a COS in BSI/S.
generate a comprehensive long-list of all outcome variables reported in recent randomised controlled studies on BSI/S
refine the outcome long-list into a COS agreed by key stakeholders
define the best measurement methods of proposed COS
identify unresolved issues for further research
publish the proposed COS in the relevant scientific journals
build a COS database with standard fields easily shared across studies
monitor uptake of the selected core outcomes in future relevant publications
Overall timetable: 2 year from first meeting.
The ESGBIS group is composed by approximately 30 people with different backgrounds (infectious disease, microbiology, intensive care medicine, epidemiology and statistics). We will adopt a combination of methods: two preparatory meetings, restricted and extended Delphi rounds (via email exchanges), semi-structured interviews with patients, systematic review of the literature, final consensus conference (Figure 1).
Publication of the systematic review and of the COS in medical journals and development of a standard set of database fields, to be included in eCRF of future studies.
Marshall JC, Vincent JL, Guyatt G, et al: Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med. 2005, 33 (8): 1708-16. 10.1097/01.CCM.0000174478.70338.03.
Bettiol E, Rottier WC, Del Toro MD, Harbarth S, Bonten MJ, Rodríguez-Baño J, COMBACTE consortium: Improved treatment of multidrug-resistant bacterial infections: utility of clinical studies. Future Microbiol. 2014, 9: 757-71. 10.2217/fmb.14.35.
On behalf of the European Society of Clinical Microbiology and Infectious Diseases working group on bloodstream infections and sepsis (ESGBIS)
About this article
Cite this article
Scudeller, L., Baño, J.R. & Kern, W.V. BISON (Bloodstream Infections and Sepsis Outcomes measurement Network) initiative: an ESGBIS proposal. Trials 16, P3 (2015). https://doi.org/10.1186/1745-6215-16-S1-P3
- Bloodstream Infection
- Clinical Microbiology
- Consensus Conference
- Intensive Care Medicine
- Randomise Control Study