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  1. Visceral leishmaniasis (VL) is a parasitic disease transmitted by sandflies and is fatal if left untreated. Phase II trials of new treatment regimens for VL are primarily carried out to evaluate safety and eff...

    Authors: Annabel Allison, Tansy Edwards, Raymond Omollo, Fabiana Alves, Dominic Magirr and Neal D. E. Alexander
    Citation: Trials 2015 16:522
  2. Authors: Cherry-Ann Waldron, Emma Thomas-Jones, Debbie Harris, Vicky Shepherd, Rebecca Cannings-John, Kerry Hood, Nick Francis and Chris Butler
    Citation: Trials 2015 16(Suppl 2):P119

    This article is part of a Supplement: Volume 16 Supplement 2

  3. Authors: Piers Gaunt, Hisham Mehanna and Christina Yap
    Citation: Trials 2015 16(Suppl 2):O16

    This article is part of a Supplement: Volume 16 Supplement 2

  4. A previous study reported that arginyl-fructose may have great value as a functional food with antioxidant and antidiabetic activities. However, there have been few clinical studies on the efficacy of arginyl-...

    Authors: Su Eun Park, Ok-Hwan Kim, Jung Hyun Kwak, Kwang-Hyoung Lee, Young-In Kwon, Kwang Hoe Chung and Jong Ho Lee
    Citation: Trials 2015 16:521
  5. Interventions to decrease the burden of childhood malnutrition are urgently needed, as millions of children die annually owing to undernutrition and hundreds of millions more are left cognitively and physicall...

    Authors: Indi Trehan, Nicole S. Benzoni, Alfred Z. Wang, Lucy B. Bollinger, Theresa N. Ngoma, Ulemu K. Chimimba, Kevin B. Stephenson, Sophia E. Agapova, Kenneth M. Maleta and Mark J. Manary
    Citation: Trials 2015 16:520
  6. Atypical meningiomas are an intermediate grade brain tumour with a recurrence rate of 39–58 %. It is not known whether early adjuvant radiotherapy reduces the risk of tumour recurrence and whether the potentia...

    Authors: Michael D. Jenkinson, Mohsen Javadpour, Brian J. Haylock, Bridget Young, Helen Gillard, Jacqui Vinten, Helen Bulbeck, Kumar Das, Michael Farrell, Seamus Looby, Helen Hickey, Mattheus Preusser, Conor L. Mallucci, Dyfrig Hughes, Carrol Gamble and Damien C. Weber
    Citation: Trials 2015 16:519
  7. The LiGHT trial (Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial) is a multicentre randomised controlled trial of two treatment pathways for patients who are newly diagnosed with open-ang...

    Authors: Victoria Vickerstaff, Gareth Ambler, Catey Bunce, Wen Xing and Gus Gazzard
    Citation: Trials 2015 16:517

    The Erratum to this article has been published in Trials 2017 18:318

  8. International epidemiological research into violence against children is increasing in scope and frequency, but little has been written about practical management of the ethical aspects of conducting such rese...

    Authors: Karen M. Devries, Jennifer C. Child, Diana Elbourne, Dipak Naker and Lori Heise
    Citation: Trials 2015 16:516
  9. The COMET Initiative database is a repository of studies relevant to the development of core outcome sets (COS). Use of the website continues to increase, with more than 16,500 visits in 2014 (36 % increase ov...

    Authors: Elizabeth Gargon, Paula R. Williamson, Doug G. Altman, Jane M. Blazeby and Mike Clarke
    Citation: Trials 2015 16:515
  10. Currently, there still is no treatment that eliminates tinnitus in all patients. Recent studies have shown that Tinnitus Retraining Therapy (TRT) significantly improves quality of life for tinnitus patients. A...

    Authors: Sarah Rabau, Vincent Van Rompaey and Paul Van de Heyning
    Citation: Trials 2015 16:514
  11. Venous leg ulcers (VLUs) are the commonest cause of leg ulceration, affecting 1 in 100 adults. There is a significant health burden associated with VLUs – it is estimated that the cost of treatment for 1 ulcer...

    Authors: Helen Tilbrook, Rachael O. Forsythe, Debbie Rolfe, Laura Clark, Martin Bland, Hannah Buckley, Ian Chetter, Liz Cook, Jo Dumville, Rhian Gabe, Keith Harding, Alison Layton, Ellie Lindsay, Catriona McDaid, Christine Moffatt, Ceri Phillips…
    Citation: Trials 2015 16:513
  12. Type 2 diabetes (T2D) is projected to affect 439 million people by 2030. Medical management focuses on controlling blood glucose levels pharmacologically in a disease that is closely related to lifestyle facto...

    Authors: Kylie A. Simpson, Yorgi Mavros, Shelley Kay, Jacinda Meiklejohn, Nathan de Vos, Yi Wang, Qianyu Guo, Renru Zhao, Mike Climstein, Bernard T. Baune, Steven Blair, Anthony J. O’Sullivan, David Simar, Nalin Singh and Maria A. Fiatarone Singh
    Citation: Trials 2015 16:512
  13. Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain s...

    Authors: Manuel Pedro Pereira, Mads Utke Werner and Joergen Berg Dahl
    Citation: Trials 2015 16:511

    The Erratum to this article has been published in Trials 2016 17:41

  14. The assessment of treatment success in clinical trials when multiple (repeated) doses (courses) are involved is quite common, for example, in the case of infertility treatment with assisted reproductive techno...

    Authors: Armando H. Seuc, Iqbal H. Shah, Moazzam Ali, Claudia Diaz-Olavarrieta and Marleen Temmerman
    Citation: Trials 2015 16:510

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