Volume 16 Supplement 2

3rd International Clinical Trials Methodology Conference

Meeting abstracts

Publication of this supplement was funded by the 3rd Clinical Trials Methodology Conference.

3rd International Clinical Trials Methodology Conference. Go to conference site.

Glasgow, UK16-17 November 2015

Concatenated PDF V16 S2

Page 6 of 7

The role of cluster size and intra-cluster correlations when adjusting for covariates in the analysis of cluster randomised trials

Authors: Neil Wright

Citation: Trials 2015 16(Suppl 2):P154

Content type: Poster presentation Published on: 16 November 2015
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Factors affecting the impact of covariate adjustment for binary outcomes in randomised clinical trials (RCTS): a simulation study

Authors: Ly-Mee Yu and Douglas G Altman

Citation: Trials 2015 16(Suppl 2):P155

Content type: Poster presentation Published on: 16 November 2015
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Stratified care for patients with sciatica and suspected sciatica in primary care: the scopic trial protocol (scopic - sciatica outcomes in primary care)

Authors: Nadine Foster, Kika Konstantinou, Ruth Beardmore, Kate Dunn, Martyn Lewis, Bernadette Bartlam, Majid Artus and Elaine Hay

Citation: Trials 2015 16(Suppl 2):P156

Content type: Poster presentation Published on: 16 November 2015
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Reviewing the evidence supporting predictive biomarkers in European medicines agency indications and contraindications using visual plots

Authors: Kinga Malottki, Lucinda Billingham, Richard Riley and Jonathan Deeks

Citation: Trials 2015 16(Suppl 2):P157

Content type: Poster presentation Published on: 16 November 2015
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Identification of strata for a trial of a targeted multimodal physiotherapy intervention in patellofemoral pain patients

Authors: Chris Sutton, Paola Dey, Jessie Janssen, Michael Callaghan, Jim Richards, Maria Stokes, Denis Martin, John Dixon, Erik Witvrouw, Russell Hogarth, Vasilios Baltzopoulos, Elizabeth Ritchie, Nigel Arden, Rich Masters, Remco Polman, David Turner…

Citation: Trials 2015 16(Suppl 2):P158

Content type: Poster presentation Published on: 16 November 2015
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Trials trail a long tail

Authors: Mike Clarke

Citation: Trials 2015 16(Suppl 2):P159

Content type: Poster presentation Published on: 16 November 2015
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Physical rehabilitation interventions for adult intensive care patients across the continuum of recovery: an overview of systematic reviews

Authors: Bronwen Connolly, Kathryn McDowell, Brenda O'Neill, Lisa Salisbury and Bronagh Blackwood

Citation: Trials 2015 16(Suppl 2):P160

Content type: Poster presentation Published on: 16 November 2015
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One-step individual patient data (IPD) network meta-analysis of survival data using royston-parmar models

Authors: Suzanne Freeman, James Carpenter and Jayne Tierney

Citation: Trials 2015 16(Suppl 2):P161

Content type: Poster presentation Published on: 16 November 2015
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A novel approach to understanding outcome selection and reporting during the evaluation of innovative surgery from first in human to pragmatic RCT: an evolution review

Authors: Noah Howes, Jelena Savovic, Julian Higgins and Jane Blazeby

Citation: Trials 2015 16(Suppl 2):P162

Content type: Poster presentation Published on: 16 November 2015
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The utility of PRISMA for abstracts in two cohorts: a comparison of health technology assessment and Cochrane database of systematic reviews 2009-2014

Authors: Emma Kirkpatrick, Amanda Young, Kathy Tier and Peter Davidson

Citation: Trials 2015 16(Suppl 2):P163

Content type: Poster presentation Published on: 16 November 2015
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Systematic review of randomised and observational evidence of effects of treatments of carotid stenosis to prevent stroke

Authors: Kusal Lokuge, Alison Halliday, Richard Bulbulia, Alastair Gray and Borislava Mihaylova

Citation: Trials 2015 16(Suppl 2):P164

Content type: Poster presentation Published on: 16 November 2015
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Tweeting links to cochrane schizophrenia group reviews: a randomised controlled trial

Authors: Clive Adams, Mahesh Jayaram, Angelique Bodart, Stephanie Sampson, Sai Zhao and Alan Montgomery

Citation: Trials 2015 16(Suppl 2):P165

Content type: Poster presentation Published on: 16 November 2015
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The challenges of estimating the prevalence of child maltreatment

Authors: Gwenllian Moody, Michael Robling, Kerenza Hood, Rebecca Cannings-John and Alison Kemp

Citation: Trials 2015 16(Suppl 2):P166

Content type: Poster presentation Published on: 16 November 2015
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Process evaluation in drugs trials within adult learning disability populations: a systematic review

Authors: Elizabeth Randell and Rachel McNamara

Citation: Trials 2015 16(Suppl 2):P167

Content type: Poster presentation Published on: 16 November 2015
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A new large-scale meta-epidemiological study on bias in randomized trials using routinely collected risk-of-bias assessments by cochrane reviewers: results from the robes study

Authors: Jelena Savovic, Rebecca Turner, David Mawdsley, Julian Higgins and Jonathan Sterne

Citation: Trials 2015 16(Suppl 2):P168

Content type: Poster presentation Published on: 16 November 2015
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Systematic review and meta-analysis of the participation rates in clinical trials evaluating non-pharmacological interventions for psychosis

Authors: Paulina Szymczynska, Sophie Walsh and Stefan Priebe

Citation: Trials 2015 16(Suppl 2):P169

Content type: Poster presentation Published on: 16 November 2015
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Does ‘mapping’ the evidence usefully inform the research question prioritisation process in systematic reviews?

Authors: Caroline Main, Jayne Wilson, Martin English, Pamela Kearns, Bob Phillips, Barry Pizer, Sophie Wilne and Keith Wheatley

Citation: Trials 2015 16(Suppl 2):P170

Content type: Poster presentation Published on: 16 November 2015
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Role of NIHR HTA clinical trials on subsequent systematic reviews

Authors: James Raftery and Amanda Young

Citation: Trials 2015 16(Suppl 2):P171

Content type: Poster presentation Published on: 16 November 2015
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Methodological challenges and pragmatic design in randomised controlled trials comparing surgery and rehabilitation

Authors: Vandana Ayyar Gupta, Antony Palmer, Ines Rombach, Susan Dutton, Cushla Cooper, Karen Barker, David Beard and Sion Glyn-Jones

Citation: Trials 2015 16(Suppl 2):P172

Content type: Poster presentation Published on: 16 November 2015
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A comprehensive approach to the central monitoring of clinical trials

Authors: Julie Bakobaki, Sally Stenning, Nicola Joffe and Sarah Meredith

Citation: Trials 2015 16(Suppl 2):P173

Content type: Poster presentation Published on: 16 November 2015
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The reform study: a case study of embedded trials

Authors: Sarah Cockayne, Joy Adamson, Belen Corbacho, Caroline Fairhurst, Lisa Farndon, Kate Hicks, Anne-Maree Keenan, Sally Lamb, Lorraine Loughrey, Caroline McIntosh, Hylton Menz, Anthony Redmond, Sara Rodgers, Wesley Vernon, Jude Watson and David Torgerson

Citation: Trials 2015 16(Suppl 2):P174

Content type: Poster presentation Published on: 16 November 2015
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Site identification and selection: current practices within the trial managers network and NIHR chief investigators

Authors: Dawn Coleby, Diane Whitham and Lelia Duley

Citation: Trials 2015 16(Suppl 2):P175

Content type: Poster presentation Published on: 16 November 2015
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Can site performance be predicted? Results of an evaluation of the performance of a site selection questionnaire in five multicentre trials

Authors: Dawn Coleby, Diane Whitham and Lelia Duley

Citation: Trials 2015 16(Suppl 2):P176

Content type: Poster presentation Published on: 16 November 2015
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Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature

Authors: EJ Conroy, B Arch, S Lewis, A Lane, MR Sydes, J Norrie, G Murray, NL Harman and C Gamble

Citation: Trials 2015 16(Suppl 2):P177

Content type: Poster presentation Published on: 16 November 2015
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Overcoming a trial ‘adverse event’: impact and experiences of a temporary suspension of randomisation in clinical trials

Authors: Lynda Constable, Tracey Davidson, Samantha Wileman, Kirsty McCormack, Ruth Thomas, Alison McDonald, Cathryn Glazener and John Norrie

Citation: Trials 2015 16(Suppl 2):P178

Content type: Poster presentation Published on: 16 November 2015
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Delivering a drug study in primary care: trial management challenges and solutions

Authors: Seonaidh Cotton, Karen Innes, David Price and Graham Devereux

Citation: Trials 2015 16(Suppl 2):P179

Content type: Poster presentation Published on: 16 November 2015
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Improving quality and efficiency of trial with a novel approach to standard operating procedures (SOPS): case study from a CTU

Authors: Diane Whitham, Lelia Duley and Alex Erven

Citation: Trials 2015 16(Suppl 2):P180

Content type: Poster presentation Published on: 16 November 2015
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What are the main inefficiencies in trial conduct? A survey of staff at registered clinical trials units

Authors: Lelia Duley, Alison McDonald and Alexa Gillman

Citation: Trials 2015 16(Suppl 2):P181

Content type: Poster presentation Published on: 16 November 2015
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Do trial managers know when sites will fail to recruit? Preliminary results from the estimating site performance (ESP) study

Authors: Kirsty Shearer, Hanne Bruhn, Anne Duncan, Seonaidh Cotton and Shaun Treweek

Citation: Trials 2015 16(Suppl 2):P182

Content type: Poster presentation Published on: 16 November 2015
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Use of patient diaries in conjunction with standard reporting methods: duplication of data or a valuable resource?

Authors: Janet Dunn, Bill Harris, Gulnaz Iqbal, Jill Wood, Pankaj Mistry, Joanne O'Beirne-Elliman, Stella Bowcock and Mark Drayson

Citation: Trials 2015 16(Suppl 2):P183

Content type: Poster presentation Published on: 16 November 2015
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Impact of retrospective data verification on the results of the academic-led ICON6 trial

Authors: Andrew Embleton, Elizabeth Clark, Stephen Townsend, Laura Farrelly, Cheryl Jones and Richard Kaplan

Citation: Trials 2015 16(Suppl 2):P184

Content type: Poster presentation Published on: 16 November 2015
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Optimising intervention implementation in the DCM™ epic trial (dementia care mapping™: to enable person-centred care in care homes)

Authors: Liz Graham, Claire Surr, Sharon Jones, Amanda Farrin, Rebecca Walwyn and Robert Cicero

Citation: Trials 2015 16(Suppl 2):P185

Content type: Poster presentation Published on: 16 November 2015
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Training of staff within randomised controlled trials (RCTS) of health-care interventions: a systematic review of the literature

Authors: Athanasia Gravani, Alexandra Nicholson, Athene Lane and Chris Rogers

Citation: Trials 2015 16(Suppl 2):P186

Content type: Poster presentation Published on: 16 November 2015
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Clinical trial data visualisation

Authors: Cassie Gregson

Citation: Trials 2015 16(Suppl 2):P187

Content type: Poster presentation Published on: 16 November 2015
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Independent endpoint event review for the elimination of reporting bias in an open label phase III pharmaceutical trial

Authors: Peter Hall, Anna Waterhouse, Isabelle Smith, Julia Brown, Walter Gregory, Guenther Steger, Richard Bell and David Cameron

Citation: Trials 2015 16(Suppl 2):P188

Content type: Poster presentation Published on: 16 November 2015
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Exploring the role and functionality of trial steering committees

Authors: Nicola Harman, Elizabeth Conroy, Steff Lewis, Gordon Murray, John Norrie, Matthew Sydes, Athene Lane, Doug Altman, Colin Baigent, Judith Bliss, Marion Campbell, Diana Elbourne, Stephen Evans, Peter Sandercock and Carrol Gamble

Citation: Trials 2015 16(Suppl 2):P189

Content type: Poster presentation Published on: 16 November 2015
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Streamlining R&D permission for substantial amendments to oncology clinical trials at an NHS site: a case study

Authors: David I'Anson, Amy Smith, Natasha Aslam, Kylie Gyertson, Rajinder Sidhu, Smaragda Agathou, Ashparan Gill and Jeremy Whelan

Citation: Trials 2015 16(Suppl 2):P190

Content type: Poster presentation Published on: 16 November 2015
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Developing a global core competency framework for clinical research

Authors: Tamzin Furtado, Amélie Julé, Liam Boggs, Francois van Loggerenberg, Victoria Ewing and Trudie Lang

Citation: Trials 2015 16(Suppl 2):P191

Content type: Poster presentation Published on: 16 November 2015
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Improving communication of clinical trial results: plain English summaries in the NIHR journals library

Authors: Emma Kirkpatrick, Liz Brindley and Elaine Williams

Citation: Trials 2015 16(Suppl 2):P192

Content type: Poster presentation Published on: 16 November 2015
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Investigating possible fraudulent activity at a research site

Authors: Carol Knott, Joanne Henderson, Louise Bowman and Martin Landray

Citation: Trials 2015 16(Suppl 2):P193

Content type: Poster presentation Published on: 16 November 2015
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Remote training solutions for complex intervention trials

Authors: Rebecca Lewis, Shaista Hafeez, Helen McNair, Joanna Illambas, Charlotte Friend, Emma Hall and Robert Huddart

Citation: Trials 2015 16(Suppl 2):P194

Content type: Poster presentation Published on: 16 November 2015
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Why are all multi-centre trial sites not the same? A network analytic approach

Authors: Helen McAneney

Citation: Trials 2015 16(Suppl 2):P195

Content type: Poster presentation Published on: 16 November 2015
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Challenges of the set-up process for academic led international studies of rare diseases

Authors: Elaine McColl, Kate Bushby, Michela Guglieri, Becky Davis, Gillian Watson, Robert Griggs and Kim Hart

Citation: Trials 2015 16(Suppl 2):P196

Content type: Poster presentation Published on: 16 November 2015
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The research registry - answering the call to register every research study involving human participants

Authors: Riaz Agha, Katharine Whitehurst and Harkiran K Sagoo

Citation: Trials 2015 16(Suppl 2):P197

Content type: Poster presentation Published on: 16 November 2015
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Setting up a clinical trial in care homes: challenges encountered and recommendations for future research practice

Authors: Victoria Shepherd, Jacqui Nuttall, Kerenza Hood, Nadine Aawar and Christopher Butler

Citation: Trials 2015 16(Suppl 2):P198

Content type: Poster presentation Published on: 16 November 2015
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The impact of a delayed consent model on trial recruitment - the cream study (children with eczema antibiotic management study)

Authors: Victoria Shepherd, Emma Thomas-Jones, Katy Addison, Matthew Ridd, Christopher Butler, Kerenza Hood and Nick Francis

Citation: Trials 2015 16(Suppl 2):P199

Content type: Poster presentation Published on: 16 November 2015
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TRYMS: the ethical and practical considerations of a double-blind placebo controlled randomised clinical trial

Authors: Jayne Swain, Isabelle Smith, Alexandra Smith, Jennifer Walsh, Richard Ross and Helen Marshall

Citation: Trials 2015 16(Suppl 2):P200

Content type: Poster presentation Published on: 16 November 2015
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No drug, no trial? Think again!

Authors: Kirsty Sprange, Eleanor Mitchell, Mark Hull and Gill Bumphrey

Citation: Trials 2015 16(Suppl 2):P201

Content type: Poster presentation Published on: 16 November 2015
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Establishing a journal club to promote professional development within a trials unit

Authors: Fiona Strachan, Chris Tuck, Gina Cranswick and Lorraine Smith

Citation: Trials 2015 16(Suppl 2):P202

Content type: Poster presentation Published on: 16 November 2015
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The impact of a two or three-group RCT design on blinding of patients

Authors: Kerry Avery, Chris Metcalfe, Paul Barham, Richard Berrisford, Grant Sanders, Andrew Hollowood, Tim Wheatley, Alex Nicholson, Jenny Donovan and Jane Blazeby

Citation: Trials 2015 16(Suppl 2):P203

Content type: Poster presentation Published on: 16 November 2015
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