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Page 117 of 139

  1. Clinicians, patients, governments, third-party payers, and the public take for granted that diagnostic tests are accurate, safe and effective. However, we may be seriously misled if we are relying on robust st...

    Authors: Marc Rodger, Tim Ramsay and Dean Fergusson

    Citation: Trials 2012 13:137

    Content type: Commentary

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  2. Previous studies have documented strategies to promote off-label use of drugs using journal publications and other means. Few studies have presented internal company communications that discussed financial rea...

    Authors: S Swaroop Vedula, Palko S Goldman, Ilyas J Rona, Thomas M Greene and Kay Dickersin

    Citation: Trials 2012 13:136

    Content type: Research

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  3. State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complicati...

    Authors: Jens Soukup, Antje Selle, Andreas Wienke, Jörg Steighardt, Nana-Maria Wagner and Patrick Kellner

    Citation: Trials 2012 13:135

    Content type: Study protocol

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  4. Aging is associated with chronic low-grade inflammatory activity with an elevation of cytokine levels. An association between regular physical activity and reduction of blood levels of anti-inflammatory cytoki...

    Authors: Daniele S Pereira, Bárbara Z Queiroz, Elvis CC Mateo, Alexandra M Assumpção, Diogo C Felício, Aline S Miranda, Daniela MC Anjos, Fabianna Jesus-Moraleida, Rosângela C Dias, Danielle AG Pereira, Antônio L Teixeira and Leani SM Pereira

    Citation: Trials 2012 13:134

    Content type: Study protocol

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  5. After diagnosis of a dementing illness, patients and their spouses have many concerns related to the disease and their future. This often leads to poor psychological well-being and reduced health-related quali...

    Authors: Marja-Liisa Laakkonen, Eeva H Hölttä, Niina Savikko, Timo E Strandberg, Merja Suominen and Kaisu H Pitkälä

    Citation: Trials 2012 13:133

    Content type: Study protocol

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  6. The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to...

    Authors: Paula R Williamson, Douglas G Altman, Jane M Blazeby, Mike Clarke, Declan Devane, Elizabeth Gargon and Peter Tugwell

    Citation: Trials 2012 13:132

    Content type: Commentary

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  7. Osteoarthritis (OA) is a common health issue worldwide in the aging population who are also commonly deficient in vitamin D. Our previous study suggested that higher serum 25-(OH)D levels were associated with ...

    Authors: Yuelong Cao, Graeme Jones, Flavia Cicuttini, Tania Winzenberg, Anita Wluka, James Sharman, Kay Nguo and Changhai Ding

    Citation: Trials 2012 13:131

    Content type: Study protocol

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  8. The incidence of postoperative nausea and vomiting (PONV) is 50% to 80% after neurosurgery. The common prophylactic treatment for postoperative nausea and vomiting is a triple therapy of droperidol, promethazi...

    Authors: Sergio Bergese, Adolfo Viloria, Alberto Uribe, Alejandra Antor and Soledad Fernandez

    Citation: Trials 2012 13:130

    Content type: Study protocol

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  9. Extended smoking cessation follow-up after hospital discharge significantly increases abstinence. Hospital smoke-free policies create a period of ‘forced abstinence’ for smokers, thus providing an opportunity ...

    Authors: Jeffrey L Fellows, Richard Mularski, Lisa Waiwaiole, Kim Funkhouser, Julie Mitchell, Kathleen Arnold and Sabrina Luke

    Citation: Trials 2012 13:129

    Content type: Study protocol

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  10. Hospitalized smokers often quit smoking, voluntarily or involuntarily; most relapse soon after discharge. Extended follow-up counseling can help prevent relapse. However, it is difficult for hospitals to provi...

    Authors: Sharon Cummins, Shu-Hong Zhu, Anthony Gamst, Carrie Kirby, Kendra Brandstein, Hillary Klonoff-Cohen, Edward Chaplin, Timothy Morris, Gregory Seymann and Joshua Lee

    Citation: Trials 2012 13:128

    Content type: Study protocol

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  11. Post-discharge support is a key component of effective treatment for hospitalized smokers, but few hospitals provide it. Many hospitals and care settings fax-refer smokers to quitlines for follow-up; however, ...

    Authors: Kimber P Richter, Babalola Faseru, Laura M Mussulman, Edward F Ellerbeck, Theresa I Shireman, Jamie J Hunt, Beatriz H Carlini, Kristopher J Preacher, Candace L Ayars and David J Cook

    Citation: Trials 2012 13:127

    Content type: Study protocol

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  12. Hospitalization may be a particularly important time to promote smoking cessation, especially in the immediate post-discharge period. However, there are few studies to date that shed light on the most effectiv...

    Authors: Ellie Grossman, Donna Shelley, R Scott Braithwaite, Iryna Lobach, Ana Goffin, Erin Rogers and Scott Sherman

    Citation: Trials 2012 13:126

    Content type: Study protocol

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  13. The objectives of this smoking cessation study among hospitalized smokers are to: 1) determine provider and patient receptivity, barriers, and facilitators to implementing the nurse-administered, inpatient Tob...

    Authors: Sonia A Duffy, David L Ronis, Marita G Titler, Frederic C Blow, Neil Jordan, Patricia L Thomas, Gay L Landstrom, Lee A Ewing and Andrea H Waltje

    Citation: Trials 2012 13:125

    Content type: Study protocol

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  14. A hospital admission offers smokers an opportunity to quit. Smoking cessation counseling provided in the hospital is effective, but only if it continues for more than one month after discharge. Providing smoki...

    Authors: Sandra J Japuntich, Susan Regan, Joseph Viana, Justyna Tymoszczuk, Michele Reyen, Douglas E Levy, Daniel E Singer, Elyse R Park, Yuchiao Chang and Nancy A Rigotti

    Citation: Trials 2012 13:124

    Content type: Study protocol

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  15. E-health tools are a new mechanism to expand patient care, allowing supplemental resources to usual care, including enhanced patient-provider communication. These applications to smoking cessation have yet to ...

    Authors: Kathleen F Harrington, Julie A McDougal, Maria Pisu, Bin Zhang, Rajani S Sadasivam, Thomas K Houston and William C Bailey

    Citation: Trials 2012 13:123

    Content type: Study protocol

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  16. We describe the study design, procedures, and development of the risk counseling protocol used in a randomized controlled trial to evaluate the impact of genetic testing for diabetes mellitus (DM) on psycholog...

    Authors: Corrine I Voils, Cynthia J Coffman, David Edelman, Matthew L Maciejewski, Janet M Grubber, Azita Sadeghpour, Alex Cho, Jamiyla McKenzie, Francoise Blanpain, Maren Scheuner, Margarete Sandelowski, M Patrick Gallagher, Geoffrey S Ginsburg and William S Yancy Jr

    Citation: Trials 2012 13:121

    Content type: Study protocol

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  17. Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation ...

    Authors: Noah M Ivers, Ilana J Halperin, Jan Barnsley, Jeremy M Grimshaw, Baiju R Shah, Karen Tu, Ross Upshur and Merrick Zwarenstein

    Citation: Trials 2012 13:120

    Content type: Review

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  18. Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A t...

    Authors: Rebecca L Ashby, Jo C Dumville, Marta O Soares, Elizabeth McGinnis, Nikki Stubbs, David J Torgerson and Nicky Cullum

    Citation: Trials 2012 13:119

    Content type: Research

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  19. Luteal support with progesterone is necessary for successful implantation of the embryo following egg collection and embryo transfer in an in-vitro fertilization (IVF) cycle. Progesterone has been used for as ...

    Authors: Rafet Gazvani, Richard Russell, Yasmin Sajjad and Zarko Alfirevic

    Citation: Trials 2012 13:118

    Content type: Study protocol

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  20. Despite limited effectiveness of short-term psychotherapy for chronic depression, there is a lack of trials of long-term psychotherapy. Our study is the first to determine the effectiveness of controlled long-...

    Authors: Manfred E Beutel, Marianne Leuzinger-Bohleber, Bernhard Rüger, Ulrich Bahrke, Alexa Negele, Antje Haselbacher, Georg Fiedler, Wolfram Keller and Martin Hautzinger

    Citation: Trials 2012 13:117

    Content type: Study protocol

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  21. This article is part of a series of papers examining ethical issues in cluster randomized trials (CRTs) in health research. In the introductory paper in this series, we set out six areas of inquiry that must b...

    Authors: Antonio Gallo, Charles Weijer, Angela White, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Andrew D McRae, Raphael Saginur, Merrick Zwarenstein and Monica Taljaard

    Citation: Trials 2012 13:116

    Content type: Research

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  22. Lifestyle factors playing a role in the development of late-life disability may be modifiable. There is a need for robust evidence about the potential for prevention of disability through behavior change inter...

    Authors: Linda Clare, John V Hindle, Ian R Jones, Jeanette M Thom, Sharon M Nelis, Barry Hounsome and Christopher J Whitaker

    Citation: Trials 2012 13:115

    Content type: Study protocol

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  23. Single-limb knee extension exercises have been found to be effective at improving lower extremity exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Since the positive local physi...

    Authors: Andre Nyberg, Britta Lindström and Karin Wadell

    Citation: Trials 2012 13:114

    Content type: Study protocol

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  24. Seventy percent of women in Scotland have at least one baby, making pregnancy an opportunity to help most young women quit smoking before their own health is irreparably compromised. By quitting during pregnan...

    Authors: David M Tappin, Linda Bauld, Carol Tannahill, Linda de Caestecker, Andrew Radley, Alex McConnachie, Kathleen Boyd, Andrew Briggs, Liz Grant, Alan Cameron, Susan MacAskill, Lesley Sinclair, Brenda Friel and Tim Coleman

    Citation: Trials 2012 13:113

    Content type: Study protocol

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  25. Many postnatal women are insufficiently physically active in the year after childbirth and could benefit from interventions to increase activity levels. However, there is limited information about the efficacy...

    Authors: Alyssa S Gilinsky, Adrienne R Hughes and Rhona J McInnes

    Citation: Trials 2012 13:112

    Content type: Study protocol

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  26. There are many challenges involved in running randomised controlled dietary intervention trials that investigate health outcomes. The aim of this paper was to evaluate the recruitment process, retention of par...

    Authors: Georgina E Crichton, Peter RC Howe, Jonathan D Buckley, Alison M Coates, Karen J Murphy and Janet Bryan

    Citation: Trials 2012 13:111

    Content type: Research

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  27. Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may...

    Authors: Anne Juul Wikkelsoe, Arash Afshari, Jakob Stensballe, Jens Langhoff-Roos, Charlotte Albrechtsen, Kim Ekelund, Gabriele Hanke, Heidi Fosgrau Sharif, Anja U Mitchell, Jens Svare, Ane Troelstrup, Lars Møller Pedersen, Jeannet Lauenborg, Mette Gøttge Madsen, Birgit Bødker and Ann M Møller

    Citation: Trials 2012 13:110

    Content type: Study protocol

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  28. Chronic obstructive pulmonary disease (COPD) has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and mortality. Little attention has been paid to earlie...

    Authors: Wang Minghang, Li Jiansheng, Li Suyun, Wang Haifeng, Yu Xueqing and Zhang Hailong

    Citation: Trials 2012 13:109

    Content type: Study protocol

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  29. In The Netherlands, helmet therapy is a commonly used treatment in infants with skull deformation (deformational plagiocephaly or deformational brachycephaly). However, evidence of the effectiveness of this tr...

    Authors: Renske M van Wijk, Magda M Boere-Boonekamp, Catharina GM Groothuis-Oudshoorn, Leo A van Vlimmeren and Maarten J IJzerman

    Citation: Trials 2012 13:108

    Content type: Study protocol

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  30. Neck pain is one of the chief symptoms of cervical spondylosis (CS). Acupuncture is a well-accepted and widely used complementary therapy for the management of neck pain caused by CS. In this paper, we present...

    Authors: Zhao-Hui Liang, Zhong Di, Shuo Jiang, Shu-Jun Xu, Xiao-Ping Zhu, Wen-Bin Fu and Ai-Ping Lu

    Citation: Trials 2012 13:107

    Content type: Study protocol

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  31. Limited controlled data exist to guide treatment choices for clinicians caring for patients with major depressive disorder (MDD). Although many putative predictors of treatment response have been reported, mos...

    Authors: Boadie W Dunlop, Elisabeth B Binder, Joseph F Cubells, Mark M Goodman, Mary E Kelley, Becky Kinkead, Michael Kutner, Charles B Nemeroff, D Jeffrey Newport, Michael J Owens, Thaddeus W W Pace, James C Ritchie, Vivianne Aponte Rivera, Drew Westen, W Edward Craighead and Helen S Mayberg

    Citation: Trials 2012 13:106

    Content type: Study protocol

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  32. The Well London program used community engagement, complemented by changes to the physical and social neighborhood environment, to improve physical activity levels, healthy eating, and mental wellbeing in the ...

    Authors: Gemma Phillips, Adrian Renton, Derek G Moore, Christian Bottomley, Elena Schmidt, Shahana Lais, Ge Yu, Martin Wall, Patrick Tobi, Caroline Frostick, Angela Clow, Karen Lock, Mark Petticrew and Richard Hayes

    Citation: Trials 2012 13:105

    Content type: Research

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  33. Alcohol causes huge problems for population health and for society, which require interventions with individuals as well as populations to prevent and reduce harms. Brief interventions can be effective and inc...

    Authors: Jim McCambridge, Preben Bendtsen, Marcus Bendtsen and Per Nilsen

    Citation: Trials 2012 13:49

    Content type: Study protocol

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  34. Whether acupuncture is effective for patients with functional constipation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using acupuncture to treat functional constipa...

    Authors: Ying Li, Hui Zheng, Fang Zeng, Si-yuan Zhou, Feng Zhong, Hua-bing Zheng, Min Chen, Xiang-hong Jing, Yu-ying Cai, Bao-hui Jia, Bing Zhu and Zhi-shun Liu

    Citation: Trials 2012 13:104

    Content type: Study protocol

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  35. In clinical trials in childhood asthma, outcomes reflecting short-term disease activity are frequently measured, whilst functional status, quality of life (QoL), and long-term treatment effects are rarely asse...

    Authors: Ian P Sinha, Ruairi Gallagher, Paula R Williamson and Rosalind L Smyth

    Citation: Trials 2012 13:103

    Content type: Methodology

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  36. One of the main causes of mortality and morbidity following subarachnoid haemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Des...

    Authors: Rune Rasmussen, Jørn Wetterslev, Trine Stavngaard, Jane Skjøth-Rasmussen, Per Olof Grände, Niels Vidiendal Olsen and Bertil Romner

    Citation: Trials 2012 13:102

    Content type: Study protocol

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  37. Unplanned pregnancies and sexually transmitted infections (STIs) are important and costly public health problems in the United States resulting from unprotected sexual intercourse. Risk factors for unplanned p...

    Authors: Jennifer Clarke, Melanie A Gold, Rachel E Simon, Mary B Roberts and LAR Stein

    Citation: Trials 2012 13:101

    Content type: Study protocol

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  38. For the protection of commercial interests, licensing bodies such as the EMA and health technology assessment institutions such as NICE restrict full access to unpublished evidence. Their respective policies o...

    Authors: Daniel Strech and Jasper Littmann

    Citation: Trials 2012 13:100

    Content type: Commentary

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  39. For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from ‘bench to bedside’. Successful clinical introduction, supporting safety, ...

    Authors: Peter Donndorf, Alexander Kaminski, Gudrun Tiedemann, Guenther Kundt and Gustav Steinhoff

    Citation: Trials 2012 13:99

    Content type: Study protocol

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  40. Caregivers of relatives with Alzheimer’s disease are highly stressed and at risk for physical and psychiatric conditions. Interventions are usually focused on providing caregivers with knowledge of dementia, s...

    Authors: Sheung-Tak Cheng, Rosanna WL Lau, Emily PM Mak, Natalie SS Ng, Linda CW Lam, Helene H Fung, Julian CL Lai, Timothy Kwok and Diana TF Lee

    Citation: Trials 2012 13:98

    Content type: Study protocol

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  41. Gender based violence, including violence by an intimate partner, is a major global human rights and public health problem, with important connections with HIV risk. Indeed, the elimination of sexual and gende...

    Authors: Tanya Abramsky, Karen Devries, Ligia Kiss, Leilani Francisco, Janet Nakuti, Tina Musuya, Nambusi Kyegombe, Elizabeth Starmann, Dan Kaye, Lori Michau and Charlotte Watts

    Citation: Trials 2012 13:96

    Content type: Study protocol

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  42. A number of single case reports have suggested that the context within which intervention studies take place may challenge the assumptions that underpin randomised controlled trials (RCTs). However, the divers...

    Authors: Mary Wells, Brian Williams, Shaun Treweek, Joanne Coyle and Julie Taylor

    Citation: Trials 2012 13:95

    Content type: Research

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  43. Optic neuritis is a frequent manifestation of multiple sclerosis. Visual deficits range from a minor impairment of visual functions through to complete loss of vision. Although many patients recover almost com...

    Authors: Johann Schinzel, Lina Schwarzlose, Holger Dietze, Karolina Bartusch, Susanne Weiss, Stephanie Ohlraun, Friedemann Paul and Jan Dörr

    Citation: Trials 2012 13:94

    Content type: Study protocol

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  44. Postoperative ileus (POI) is a well-known complication of abdominal surgery and is considered to be caused by a local inflammation in the gut. Previously it has been shown that both local and systemic inflamma...

    Authors: Tim MP Berghmans, Karel WE Hulsewé, Wim A Buurman and Misha DP Luyer

    Citation: Trials 2012 13:93

    Content type: Study protocol

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  45. Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional ...

    Authors: Christopher M Callahan, Malaz A Boustani, Arlene A Schmid, Mary G Austrom, Douglas K Miller, Sujuan Gao, Carrie S Morris, Mickey Vogel and Hugh C Hendrie

    Citation: Trials 2012 13:92

    Content type: Study protocol

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  46. Cognitive Stimulation Therapy (CST) is a psychosocial evidence-based group intervention for people with dementia recommended by the UK NICE guidelines. In clinical trials, CST has been shown to improve cogniti...

    Authors: Amy Streater, Aimee Spector, Elisa Aguirre, Juanita Hoe, Zoe Hoare, Robert Woods, Ian Russell and Martin Orrell

    Citation: Trials 2012 13:91

    Content type: Study protocol

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  47. Caesarean section is a commonly performed operation worldwide. It has been found to increase rates of maternal infectious morbidities more than five times when compared to vaginal delivery. Provision of intrav...

    Authors: Fadhili M Lyimo, Anthony N Massinde, Benson R Kidenya, Evelyne Konje and Stephen E Mshana

    Citation: Trials 2012 13:89

    Content type: Study protocol

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