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  1. Distressing symptoms are common in advanced cancer. Medicinal cannabinoids are commonly prescribed for a variety of symptoms. There is little evidence to support their use for most indications in palliative ca...

    Authors: Taylan Gurgenci, Janet Hardy, Georgie Huggett, Karyn Foster, Anita Pelecanos, Ristan Greer, Jennifer Philip, Alison Haywood, Ruwani Mendis, Patsy Yates and Phillip Good
    Citation: Trials 2024 25:293
  2. Antenatal balanced energy and protein (BEP) supplements have well-documented benefits for pregnancy outcomes. However, considerable practical gaps remain in the effective and cost-effective delivery of antenat...

    Authors: Dongqing Wang, Tigest Shifraw, Janaina Calu Costa, Semira Abdelmenan, Sitota Tsegaye, Yoseph Berhane, Hanna Gulema, Hanna Berhane, Nebiyou Fasil, Firehiwot Workneh, Workagegnhu Tarekegn, Molin Wang, Nicolas A. Menzies, Alemayehu Worku, Yemane Berhane and Wafaie W. Fawzi
    Citation: Trials 2024 25:291
  3. This paper describes the protocols for a randomized controlled trial using a parallel-group trial design that includes an intervention designed to address social isolation and loneliness among people experienc...

    Authors: Benjamin F. Henwood, Bo-Kyung Elizabeth Kim, Amy Stein, Gisele Corletto, Himal Suthar, Kevin F. Adler, Madeline Mazzocchi, Julia Ip and Deborah K. Padgett
    Citation: Trials 2024 25:290
  4. Iron and folic acid (IFA) supplements are currently provided to Cambodian women during pregnancy. However, recent research has found benefits of a multiple micronutrient supplement (MMS) over just IFA alone on...

    Authors: Mai-Anh Hoang, Hou Kroeun, Rolf Klemm, Aman Sen Gupta, Ngik Rem, Sokchea Meng, Sophonneary Prak, Kim Rattana, Mary Chea, Crystal D. Karakochuk, Cassandra Sauer, Ashutosh Mishra, Diwakar Mohan and Meredith Jackson de-Graffenried
    Citation: Trials 2024 25:289
  5. Acute kidney injury (AKI) is a significant postoperative complication associated with increased mortality and hospital costs. Hemodynamic strategies, such as goal-directed therapy, might reduce AKI risk. Predi...

    Authors: Javier Ripollés-Melchor, Laura Carrasco-Sánchez, José L. Tomé-Roca, César Aldecoa, Andres Zorrilla-Vaca, Juan V. Lorente-Olazábal, María J. Colomina, Ana Pérez, Juan I. Jiménez-López, Rosalía Navarro-Pérez, Alfredo Abad-Gurumeta and Manuel I. Monge-García
    Citation: Trials 2024 25:288
  6. Neovascular glaucoma (NVG) is an irreversible blinding eye disease worldwide and is classified as one of the refractory glaucoma conditions, severely impacting visual function and vision. Unfortunately, effect...

    Authors: Shuqing Zhu, Mengtian Zhou, Haoyu Li, Shaodan Zhang, Shuxia Xu, Haishuang Lin, Yanqie Xie, Rongrong Le and Yuanbo Liang
    Citation: Trials 2024 25:287
  7. The fragility index is a statistical measure of the robustness or “stability” of a statistically significant result. It has been adapted to assess the robustness of statistically significant outcomes from rand...

    Authors: Leen Naji, Brittany Dennis, Myanca Rodrigues, Monica Bawor, Alannah Hillmer, Caroul Chawar, Eve Deck, Andrew Worster, James Paul, Lehana Thabane and Zainab Samaan
    Citation: Trials 2024 25:286
  8. Urinary incontinence is highly prevalent in women while pelvic floor muscle training is recommended as the first-line therapy. However, the exact treatment regimen is poorly understood. Also, patients with pel...

    Authors: Chunmei Chen, Jing Zhang, Hong Zhang, Haiyan Li, Jucheng Yu, Yao Pei and Yuan Fang
    Citation: Trials 2024 25:285
  9. The incidence of hemiparetic limb dysfunction reaches 85% in stroke patients, emerging as a critical factor influencing their daily lives. However, the effectiveness of current rehabilitation treatments is con...

    Authors: Wang Fu, Xiaoming Yu, Minghui Lai, Yuanli Li, Yingting Yang, Yong Qin, Min Yu, Feng Wang and Cong Wang
    Citation: Trials 2024 25:284
  10. Colorectal cancer (CRC) is the second most lethal cancer in the United States (U.S.) with the highest incidence and mortality rates among African Americans (AAs) compared to other racial groups. Despite these ...

    Authors: Olajide Williams, Tina Ting, Lisa Matthews, Gladys Block, Torin Block, Jeanne Teresi, Joseph Eimicke, Jian Kong, Stephanie Silver, Joseph Ravenell, Janhavi Mallaiah, Soujanya Jammalamadaka, Laura Maudene Nelson, Wahida Karmally and Sidney Hankerson
    Citation: Trials 2024 25:283
  11. In patients requiring general anesthesia, lung-protective ventilation can prevent postoperative pulmonary complications, which are associated with higher morbidity, mortality, and prolonged hospital stay. Appl...

    Authors: Helene Selpien, Christine Eimer, David Thunecke, Jann Penon, Dirk Schädler, Ingmar Lautenschläger, Henning Ohnesorge and Tobias Becher
    Citation: Trials 2024 25:282
  12. It is crucial to include a wide range of the population in clinical trials for the outcome to be applicable in real-world settings. Existing literature indicates that under-served groups, including disabled pe...

    Authors: Yoshiko Sakuma, Marie L. E. Miller, Daphne S. Babalis, Alex Baker, Meena Reddi, Aisha Anjum, Jane Bruton, Kathryn N Jones, Umm Zeinab Mulla and Henock Taddese
    Citation: Trials 2024 25:281
  13. Neonatal mortality in India has fallen steadily and was estimated to be 24 per 1000 live births in the year 2017. However, neonatal mortality remains high in rural parts of the country. The Community Health Pr...

    Authors: Nicholas Magill, Siddharudha Shivalli, Ila Fazzio, Diana Elbourne, Suzanne Keddie, Padmanabh Reddy, Rakhi Nair, Madan Gopal, Sridevi Karnati, Harshavardhan Reddy, Peter Boone and Chris Frost
    Citation: Trials 2024 25:280
  14. Allergic rhinitis is a chronic respiratory disorder that significantly impacts patients’ quality of life (QoL) and work performance. Pharmacists are recognized as suitable professionals to provide patient educ...

    Authors: Chii-Chii Chew, Xin-Jie Lim, Pathma Letchumanan, Doris George, Philip Rajan and Chee Ping Chong
    Citation: Trials 2024 25:279
  15. To ensure optimal coordination of the EU-funded COVID-19 platform trials, a double coordination mechanism was established. It included the Trial Coordination Board (TCB) to promote the dialogue between investi...

    Authors: Jacques Demotes, Victoria Charlotte Simensen, Keiko Ueda, Sareema Javaid, Paula Garcia, Burç Aydin and John-Arne Røttingen
    Citation: Trials 2024 25:278
  16. Mental health issues are common among patients with chronic physical conditions, affecting approximately one in five patients. Poor mental health is associated with worse disease outcomes and increased mortali...

    Authors: Anne Søjbjerg, Anna Mygind, Stinne Eika Rasmussen, Bo Christensen, Anette Fischer Pedersen, Helle Terkildsen Maindal, Viola Burau and Kaj Sparle Christensen
    Citation: Trials 2024 25:277
  17. Early, rapid, and accurate pathogen diagnosis can help clinicians select targeted treatment options, thus improving prognosis and reducing mortality rates of severe pneumonia. Metagenomic next-generation seque...

    Authors: Xiao Song, Hui Jiang, Liang Zong, Di Shi and Huadong Zhu
    Citation: Trials 2024 25:276
  18. Parkinson’s disease (PD) is a progressive, neurodegenerative illness marked by the loss of dopaminergic neurons, causing motor symptoms. Oral levodopa replacement therapy remains the gold standard in the treat...

    Authors: Chuanyu Zhong, Ning Guo, Canfang Hu, Ruilong Ni, Xiaojie Zhang, Zheying Meng, Taotao Liu, Siqi Ding, Wanhai Ding, Yuwu Zhao, Li Cao and Yuanyi Zheng
    Citation: Trials 2024 25:275
  19. Recent developments suggest that neurosteroids may achieve rapid antidepressant effects. As such, neurosteroidogenesis mediated by the translocator protein 18 kDa (TSPO) might constitute a promising option for...

    Authors: Lisa-Marie Brunner, Marco Riebel, Simon Wein, Michael Koller, Florian Zeman, Gunnar Huppertz, Tanja Emmer, Yvonne Eberhardt, Jens Schwarzbach, Rainer Rupprecht and Caroline Nothdurfter
    Citation: Trials 2024 25:274
  20. Macular edema (ME) results from hyperpermeability of retinal vessels, leading to chronic extravasation of plasma components into the retina and hence potentially severe visual acuity loss. Current standard of ...

    Authors: Bénédicte Dupas, Daniela Castro-Farias, Jean-François Girmens, Ali Eginay, Aude Couturier, Frederic Villeroy, Marie-Noëlle Delyfer, Catherine Creuzot-Garcher, Audrey Giocanti-Auregan, Laurence Béral, Carl Arndt, Charles Mesnard, Eric Vicaut, Philippe Chaumet-Riffaud, Isabelle Durand-Zaleski and Michel Paques
    Citation: Trials 2024 25:273
  21. Children with sensitization against foods have to be orally food-challenged before eating these foods for the first time. However, the waiting time for an oral food challenge (OFC) in Germany is about 3–6 mont...

    Authors: Birgit Kalb, Lara Meixner, Stephanie Heller, Sabine Dölle-Bierke, Stephanie Roll, Tatjana Tissen-Diabaté, Susanne Lau, Sofia Forslund, Ingo Marenholz, Young-Ae Lee, Andreas Thiel, Magda Babina, Jörg Scheffel, Margitta Worm and Kirsten Beyer
    Citation: Trials 2024 25:272
  22. The World Health Organization recommends universal iron supplementation for children aged 6–23 months in countries where anaemia is seen in over 40% of the population. Conventional ferrous salts have low effic...

    Authors: Mamadou Bah, Hans Verhoef, Emmanuel Okoh, Abdoulie Bah, Andrew M. Prentice and Carla Cerami
    Citation: Trials 2024 25:270
  23. Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes to reducing negative and cognitive symptoms in schizophrenia. While there is emerging cl...

    Authors: Gábor Csukly, Boglárka Orbán-Szigeti, Karolin Suri, Réka Zsigmond, Levente Hermán, Viktória Simon, Anita Kabaji, Barnabás Bata, Péter Hársfalvi, Edit Vass, Éva Csibri, Kinga Farkas and János Réthelyi
    Citation: Trials 2024 25:269
  24. Due to faster recovery and lower morbidity rates, laparoscopy has become the gold standard in elective colorectal surgery for both the benign and malignant forms of the disease. A substantial proportion of col...

    Authors: Marie T. Grönroos-Korhonen and Jyrki A. O. Kössi
    Citation: Trials 2024 25:268
  25. Complete tooth loss is a significant global oral health issue, particularly impacting older individuals with lower socioeconomic status. Computer-assisted technologies enhance oral healthcare access by the eld...

    Authors: Dana Jafarpour, Nesma El-Amier, Jocelyne Feine, Christophe Bedos, Samer Abi-Nader, Shahrokh Esfandiari, Tibor Shuster, Elizabeth Zimmermann and Raphael de Souza
    Citation: Trials 2024 25:267
  26. About one third of patients with depression are in a condition that can be termed as “difficult-to-treat”. Some evidence suggests that difficult-to-treat depression is associated with a higher frequency of chi...

    Authors: Ida-Marie T. P. Arendt, Matthias Gondan, Sophie Juul, Lene Halling Hastrup, Carsten Hjorthøj, Bo Bach, Poul Videbech, Martin Balslev Jørgensen and Stine Bjerrum Moeller
    Citation: Trials 2024 25:266
  27. Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Por...

    Authors: Vishal C. Patel, Mark J. McPhail, Ruhama Uddin, Hassan Jafari, Vanessa Lawrence, Clair Le Boutillier, James Shearer, Nahel Yaziji, Angela Cape, Haroon Ahmed, Christopher Ward, Peter Walsh, Kevin Besly, Ane Zamalloa, Joanna Kelly and Ben Carter
    Citation: Trials 2024 25:265
  28. Perinatal substance use can have significant adverse effects on maternal and child health and family stability. Few interventions are specifically designed to address this significant public health problem. Th...

    Authors: Erin J. Maher, Susan A. Stoner, Julie Gerlinger, A. C. Ferraro and Heather Lepper-Pappan
    Citation: Trials 2024 25:264
  29. n-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patients. This trial design may be considered for the evaluation of health technologies in r...

    Authors: Olivia Hawksworth, Robin Chatters, Steven Julious, Andrew Cook, Katie Biggs, Kiera Solaiman, Michael C. H. Quah and Sxe Chang Cheong
    Citation: Trials 2024 25:263
  30. Disease-related malnutrition after a hospital stay has major consequences for older adults, the healthcare system and society. This study aims to develop and test the effectiveness of an educational video to p...

    Authors: Monica Christin Hansen, Lisbeth Uhrenfeldt, Kari Ingstad and Preben U. Pedersen
    Citation: Trials 2024 25:262
  31. Although clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating evidence that the presence of symptoms of borderline personality disorder (BPD) is associ...

    Authors: Melissa G. A. Remeeus, Sharon L. Clarke, Dine J. Feenstra, Hester Van Eeren, Maaike L. Smits, Sara Debruyne, Mirjam E. J. Kouijzer, Patrick Luyten, Ron H. J. Scholte and Joost Hutsebaut
    Citation: Trials 2024 25:261
  32. Extremely preterm infants, defined as those born before 28 weeks’ gestational age, are a very vulnerable patient group at high risk for adverse outcomes, such as necrotizing enterocolitis and death. Necrotizin...

    Authors: Sofia Söderquist Kruth, Carl Willers, Emma Persad, Elisabeth Stoltz Sjöström, Susanne Rautiainen Lagerström and Alexander Rakow
    Citation: Trials 2024 25:259
  33. Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period, i.e. between 34 and < 37 weeks of gestation. Antenatal corti...

    Authors:
    Citation: Trials 2024 25:258
  34. UK national clinical guidance recommends that men with prostate cancer on androgen deprivation therapy are offered twice weekly supervised aerobic and resistance exercise to address iatrogenic harm caused by t...

    Authors: Emma McNaught, Sophie Reale, Liam Bourke, Janet E. Brown, Michelle Collinson, Florence Day, Jenny Hewison, Amanda J. Farrin, Saïd Ibeggazene, Aidan Q. Innes, Ellen Mason, David Meads, Alison Scope, Chris Taylor, Steph JC. Taylor, Rebecca R. Turner…
    Citation: Trials 2024 25:257
  35. Teleaudiology can potentially improve access to hearing healthcare services. Remote hearing aid fittings offer a new mode of service delivery that removes barriers of geography and access to an audiologist. Re...

    Authors: Craig Lett, David Welch and Rosie Dobson
    Citation: Trials 2024 25:256
  36. To establish if Black adults and adult ethnic minorities, defined as any group except White British, were represented in UK-based COVID-19 vaccination randomised controlled trials (RCTs) when compared to corre...

    Authors: Hibba Herieka, Daphne Babalis, Evangelia Tzala, Shyam Budhathoki and Nicholas A. Johnson
    Citation: Trials 2024 25:255
  37. Research to date has lacked definitive evidence to determine whether mirror therapy promotes the recovery of upper extremity function after stroke. Considering that previous studies did not stratify patients b...

    Authors: Hongzhen Liu, Yangjie Xu, Wei Jiang, Fangchao Hu, Yi Zhou, Lu Pan, Feng Zhou, Ying Yin and Botao Tan
    Citation: Trials 2024 25:254
  38. Inappropriate eating behaviors, particularly a lack of food diversity and poor diet quality, have a significant impact on the prognosis of certain chronic conditions and exacerbate these conditions in the comm...

    Authors: Zidu Xu, Xiaowei Xu, Lianglong Sun, Zhen Guo, Jianqiang Lai, Lin Kang and Jiao Li
    Citation: Trials 2024 25:252
  39. The goal of anterior cruciate ligament reconstruction (ACLR) is to restore the preinjury level of knee function to return to play (RTP). However, even after completing the rehabilitation programme, some patien...

    Authors: Michael Tim-yun Ong, Xiaomin Lu, Ben Chi-yin Choi, Siu-Wai Wan, Qianwen Wang, Gene Chi-wai Man, Pauline Po-yee Lui, Daniel Tik-Pui Fong, Daniel Kam-wah Mok and Patrick Shu-hang Yung
    Citation: Trials 2024 25:251
  40. Acute type A aortic dissection (aTAAD) is a critical and life-threatening condition. Previous research has demonstrated that the use of ketorolac not only reduces the progression, incidence, and severity of ao...

    Authors: Zhikang Lv, Tuo Pan, Haitao Zhang, Yapeng Wang, Yusanjian Matniyaz, Yuxian Tang, Lichong Lu and Dongjin Wang
    Citation: Trials 2024 25:250
  41. Malignant pleural effusion (MPE) is a debilitating condition as it commonly causes disabling breathlessness and impairs quality of life (QoL). Indwelling pleural catheter (IPC) offers an effective alternative ...

    Authors: Estee P. M. Lau, Matthew Ing, Sona Vekaria, Ai Ling Tan, Chloe Charlesworth, Edward Fysh, Ranjan Shrestha, Elaine L. C. Yap, Nicola A. Smith, Benjamin C. H. Kwan, Tajalli Saghaie, Bapti Roy, John Goddard, Sanjeevan Muruganandan, Arash Badiei, Phan Nguyen…
    Citation: Trials 2024 25:249
  42. Family Integrated Care (FICare) has demonstrated positive outcomes for sick neonates and has alleviated the psychological burden faced by families. FICare involves structured training for professionals and car...

    Authors: M. T. Alferink, B. Moreno-Sanz, M. Cabrera-Lafuente, E. Ergenekon, T. R. de Haan, A. A. M. W. van Kempen, J. Lakhwani, H. Rabe, G. C. Zaharie and A. Pellicer
    Citation: Trials 2024 25:248
  43. Brain-derived neurotrophic factor (BDNF) is essential for antidepressant treatment of major depressive disorder (MDD). Our repeated studies suggest that DNA methylation of a specific CpG site in the promoter r...

    Authors: Hannah Benedictine Maier, Alexandra Neyazi, Gabriel L. Bundies, Fiona Meyer-Bockenkamp, Stefan Bleich, Hansi Pathak, Yvonne Ziert, Barbara Neuhaus, Franz-Josef Müller, Iris Pollmann, Thomas Illig, Stefanie Mücke, Meike Müller, Brinja Kira Möller, Steffen Oeltze-Jafra, Tim Kacprowski…
    Citation: Trials 2024 25:247
  44. Insomnia and eveningness are common and often comorbid conditions in youths. While cognitive behavioural therapy for insomnia (CBT-I) has been suggested as a promising intervention, it remains unclear whether ...

    Authors: Shirley Xin Li, Forrest Tin Wai Cheung, Ngan Yin Chan, Joey Wing Yan Chan, Jihui Zhang, Albert Martin Li, Colin A. Espie, Michael Gradisar and Yun-Kwok Wing
    Citation: Trials 2024 25:246
  45. Osteoarthritis (OA) has long been considered as a degenerative disease of cartilage tissue resulting from bodily wear and tear. However, there is accumulating evidence that inflammation plays a key role in the...

    Authors: Elisabeth Höld, Sabine Chmelar, Tatjana Aubram, Gabriele Leitner, Stefan Nehrer, Oliver Neubauer, Karl-Heinz Wagner and Barbara Wondrasch
    Citation: Trials 2024 25:245
  46. Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs have been widely used in patients with macular edema (ME) secondary to retinal vein occlusion (RVO); however, recurrence is ...

    Authors: Bangtao Yao, Bei Wang, Jun Yang, Yan Geng, Hao Yu, Yuhui Liu, Gang Liu and Xiuying Wang
    Citation: Trials 2024 25:244
  47. Despite the fundamental progress in hematopoietic stem cell transplant, this treatment is also associated with complications. Graft-versus-host disease is a possible complication of HSCT. Bronchiolitis obliter...

    Authors: Naeemeh Dini, Amin Pastaki Khoshbin, Rasoul Aliannejad, Hooman Bakhshandeh, Katayoun Najafizadeh, Mahshid Mehdizadeh and Shahideh Amini
    Citation: Trials 2024 25:243

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