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  1. Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects cartilage and bone. Psychological stress can both trigger disease exacerbation and result from disease activity. As standard pha...

    Authors: Lennart Seizer, Ellis Huber, Miriam Schirmer, Sven Hilbert, Eva-Maria Wiest and Christian Schubert
    Citation: Trials 2023 24:743
  2. Both acute normovolumic hemodilution (ANH) and autologous platelet-rich plasma (aPRP) have been demonstrated blood-protective effects in cardiac aortic surgery; however, the efficacies of the two methods have ...

    Authors: Dan Zhu, Yu Li, A-yong Tian and Hong-nan Wang
    Citation: Trials 2023 24:741
  3. Preventing dropout (attrition) from clinical trials is vital for improving study validity. Dropout is particularly important in justice-involved populations as they can be very challenging to engage and recrui...

    Authors: Natalie Doring, Ye In (Jane) Hwang, Emaediong Akpanekpo, Mathew Gullotta, Bianca Ton, Lee Knight, Crosbi Knight, Peter Schofield and Tony Gerard Butler
    Citation: Trials 2023 24:740
  4. With recent growth in the conduct of pragmatic clinical trials, the reliance on frontline staff to contribute to trial-related activities has grown as well. Active partnerships with staff members are often cri...

    Authors: Lisa A. Juckett, Kimberly P. Bernard and Kali S. Thomas
    Citation: Trials 2023 24:739
  5. The hallmark symptom of heart failure (HF) is severe exercise intolerance. Fortunately, accumulated evidence suggests that exercise programs improve physical performance, enhance autonomy in daily activities a...

    Authors: Vanessa Christina Costa da Silva, Fernando Zanela da Silva Arêas, Antônio Luiz Ribeiro Boechat Lopes, Fernando Fonseca de Almeida e Val, Allyson Guimarães da Costa, Joana Colares Correa dos Santos, João Marcos Bemfica Barbosa Ferreira and Guilherme Peixoto Tinoco Arêas
    Citation: Trials 2023 24:738
  6. Extremely preterm infants have a high mortality and morbidity. Here, we present a statistical analysis plan for secondary Bayesian analyses of the pragmatic, sufficiently powered multinational, trial—SafeBoosC...

    Authors: Markus Harboe Olsen, Mathias Lühr Hansen, Theis Lange, Christian Gluud, Lehana Thabane, Gorm Greisen and Janus Christian Jakobsen
    Citation: Trials 2023 24:737
  7. Electroencephalography (EEG)-based brain-computer interfaces (BCIs) allow to modulate the sensorimotor rhythms and are emerging technologies for promoting post-stroke motor function recovery. The Promotoer stu...

    Authors: Marta Cipriani, Floriana Pichiorri, Emma Colamarino, Jlenia Toppi, Federica Tamburella, Matteo Lorusso, Alessandra Bigioni, Giovanni Morone, Francesco Tomaiuolo, Filippo Santoro, Daniele Cordella, Marco Molinari, Febo Cincotti, Donatella Mattia and Maria Puopolo
    Citation: Trials 2023 24:736
  8. Dysphagia can lead to serious complications such as aspiration and aspiration pneumonia, timely and effective rehabilitation training can improve the swallowing function of patients. However, the conventional ...

    Authors: Bohan Zhang, Cai Guo, Vivian Hui, Ka Po Wong, Yue Liu, Zihan Liu, Yanan Xu, Qian Xiao, Shu-Cheng Chen and Jing Qin
    Citation: Trials 2023 24:735
  9. Emergence agitation or emergence delirium is a common complication of unknown etiology in pediatric anesthesia. Pediatric anesthesia emergence delirium (PAED) has been reported most commonly in younger childre...

    Authors: Yasuyuki Suzuki, Kiyoyuki W. Miyasaka, Kuniyoshi Hayashi, Osamu Takahashi and Yasuko Nagasaka
    Citation: Trials 2023 24:734
  10. The Large-scale Assessment of the Key health-promoting Activities of two New mass drug administration regimens with Azithromycin (LAKANA) trial in Mali aims to evaluate the efficacy and safety of azithromycin ...

    Authors: Juho Luoma, Laura Adubra, Dagmar Alber, Per Ashorn, Ulla Ashorn, Elaine Cloutman-Green, Fatoumata Diallo, Camilla Ducker, Riku Elovainio, Yue-Mei Fan, Lily Gates, Gwydion Gruffudd, Tiia Haapaniemi, Fadima Haidara, Lotta Hallamaa, Rikhard Ihamuotila…
    Citation: Trials 2023 24:733
  11. Disrupted sleep is believed to contribute to short- and long-term neurodevelopmental problems in very preterm infants (VPIs). This study presents a protocol for an evaluator-blinded, randomized crossover trial...

    Authors: Xiaoli Tang, Sha Sha, Nanping Shen, Zhiyu Zhu, Yanmin Qin, Junyi Shen and Fei Bei
    Citation: Trials 2023 24:732
  12. Upper limb lymphedema (ULLy) is an external (and/or internal) manifestation of lymphatic system insufficiency and deranged lymph transport for more than 3 months and frequently affects people as a consequence ...

    Authors: Federico Arippa, Andrea Scribante, Barbara Rocca and Marco Monticone
    Citation: Trials 2023 24:731
  13. Peritoneal dialysis (PD)-related infections, such as peritonitis, exit site, and tunnel infections, substantially impair the sustainability of PD. Accordingly, PD-related infection is the top-priority research...

    Authors: Josephine S. F. Chow, Neil Boudville, Yeoungjee Cho, Suetonia Palmer, Elaine M. Pascoe, Carmel M. Hawley, Donna M. Reidlinger, Laura E. Hickey, Ruth Stastny, Andrea Valks, Liza Vergara, Ramya Movva, Charani Kiriwandeniya, Hayley Candler, Gabor Mihala, Bernadette Buisman…
    Citation: Trials 2023 24:730
  14. The rising prevalence of knee osteoarthritis is placing a considerable strain on the global healthcare system. To address this issue, telemedicine-supported multicomponent exercise therapy has emerged as a pro...

    Authors: Yuan Feng, Yan Wu, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang, Jielei Huang, Yiwei Jiang, Chengqi He and Siyi Zhu
    Citation: Trials 2023 24:729
  15. Type 2 diabetes (T2D), a major risk factor for cardiovascular disease and other adverse health conditions, is on the rise in Singapore. TRIPOD is a randomized controlled trial aimed to determine whether comple...

    Authors: Joann Bairavi, Daphne Su-Lyn Gardner, Ester Yeoh, Kwang Wei Tham, Mihir Gandhi, Ngiap Chuan Tan, Phong Ching Lee, Robyn Su May Lim, Thofique Adamjee, Yin Bun Cheung, Yong Mong Bee and Eric Andrew Finkelstein
    Citation: Trials 2023 24:728
  16. The VenUS 6 parallel-group randomised controlled trial (RCT) will compare the clinical and cost-effectiveness of compression wraps, two-layer compression bandage and evidence-based compression therapy, compris...

    Authors: Maartje Kletter, Jane Griffiths, Catherine Arundel and Jo Dumville
    Citation: Trials 2023 24:727
  17. Authors: D. Molina-Morant, M. L. Fernández, P. Bosch-Nicolau, E. Sulleiro, M. Bangher, F. Salvador, A. Sanchez-Montalva, A. L. P. Ribeiro, A. M. B. de Paula, S. Eloi, R. Correa-Oliveira, J. C. Villar, S. Sosa-Estani and I. Molina
    Citation: Trials 2023 24:726

    The original article was published in Trials 2020 21:328

  18. Early blood transfusion improves survival in patients with life-threatening bleeding, but the optimal transfusion strategy in the pre-hospital setting has yet to be established. Although there is some evidence...

    Authors: Jason E. Smith, Ed B. G. Barnard, Charlie Brown-O’Sullivan, Rebecca Cardigan, Jane Davies, Annie Hawton, Emma Laing, Joanne Lucas, Richard Lyon, Gavin D. Perkins, Laura Smith, Simon J. Stanworth, Anne Weaver, Tom Woolley and Laura Green
    Citation: Trials 2023 24:725
  19. Preoperative anxiety management is gaining particular attention in paediatric anaesthesia. Pharmacological and non-pharmacological resorts can be implemented to address this special issue. Despite the various ...

    Authors: Meng-Qiu Zhang, Ming-Zhe Xu, Yi He, Yong-Wei Su, Jun Ma and Yun-Xia Zuo
    Citation: Trials 2023 24:724
  20. Australia persistently has one of the highest rates of colorectal cancer (CRC) in the world. Australia’s National Bowel Cancer Screening Program (NBCSP) sends a biennial Faecal Immunochemical Test (FIT)—the ‘N...

    Authors: Jennifer G. McIntosh, Jon D. Emery, Anna Wood, Patty Chondros, Belinda C. Goodwin, Judy Trevena, Carlene Wilson, Shanton Chang, Jane Hocking, Tina Campbell, Finlay Macrae, Kristi Milley, Jie-Bin Lew, Claire Nightingale, Ian Dixon, Makala Castelli…
    Citation: Trials 2023 24:723
  21. Migraine is a complex, chronic, and debilitating multifactorial disorder characterized by recurrent episodes of headache and related symptoms. It typically begins in early ages and is more prevalent in women t...

    Authors: Mahdi Vajdi, Fariborz Khorvash, Mohammad Hossein Rouhani, Abed Ghavami, Cain C. T. Clark and Gholamreza Askari
    Citation: Trials 2023 24:722
  22. Cervical facet joint disease is a common source of neck pain and its prevalence increases with aging. Conservative multimodal management options (e.g., strengthening of neck muscles, non-steroidal anti-inflamm...

    Authors: Abeer Alomari, Guilherme Ferreira-Dos-Santos, Mandeep Singh, Taylor Burnham, Xingshan Cao, Zachary McCormick, David Flamer, Pranab Kumar, Yasmine Hoydonckx, James S. Khan, Paul S. Tumber, Danielle Alvares and Anuj Bhatia
    Citation: Trials 2023 24:721
  23. In the severe forms of COVID-19 and many other infectious diseases, the patients develop a cytokine storm syndrome (CSS) where pro-inflammatory cytokines such as IL-6 and TNF-α play a key role in the developme...

    Authors: Maryam Hafizi, Somayeh Kalanaky, Saideh Fakharzadeh, Pegah Karimi, Atefeh Fakharian, Somayeh Lookzadeh, Esmaeil Mortaz, Maryam Sadat Mirenayat, Jalal Heshmatnia, Mehrdad Bakhshayesh Karam, Homa Zamani, Alireza Nadji, Mihan Pourabdollah Toutkaboni, Saeed Oraee-Yazdani, Mohammad Esmaeil Akbari, Hamidreza Jamaati…
    Citation: Trials 2023 24:720
  24. The physiologic and anthropometric characteristics changes associated with obesity may result in the alternation of pharmacologic management. Remimazolam tosylate is a new type of ultra-short-acting benzodiaze...

    Authors: Wenwen Ni, Xiuwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu, Yuan Han, Ji’e Jia and Wenxian Li
    Citation: Trials 2023 24:719
  25. Protein malnutrition after bariatric surgery is a severe complication and leads to significant morbidity. Previous studies have shown that protein intake and physical activity are the most important factors in...

    Authors: A. E. Taselaar, A. J. Boes, R. W. F. de Bruin, T. M. Kuijper, K. Van Lancker, E. van der Harst and R. A. Klaassen
    Citation: Trials 2023 24:717
  26. Blinding drugs through simulation techniques is an important means to control the subjective bias of investigators and subjects. However, clinical trials face significant challenges in the placebo production o...

    Authors: Qingna Li, Mengli Xiao, Xingfang Liu, Yang Zhao, Haoling Zhang, Yundong Yin, Panbo Qiu, Fang Lu and Rui Gao
    Citation: Trials 2023 24:716
  27. Mood disorders (anxiety, depression), sleep disorders, and catastrophizing lead to increased post-operative pain perception, increase in postoperative opioid consumption, decreased engagement with physical act...

    Authors: A. Murat Kaynar, Charles Lin, Andrea Gomez Sanchez, Danielle R. Lavage, Amy Monroe, Nicole Zharichenko, Meredith Strassburger, Katheryn Saucier, Yram J. Groff, Brian A. Klatt, Michael J. O’Malley, Eva Szigethy, Ajay D. Wasan and Jacques E. Chelly
    Citation: Trials 2023 24:715
  28. People who have undergone anterior cruciate ligament reconstruction have an increased risk of osteoarthritis. Abnormality of lower limb kinematics will occur after the operation. This may be related to lower l...

    Authors: Zhao Xiaojun, Ma Ming, Guo Jianye, Sun Wudong, Qu Yi, Cui Jun, Huang Ningqinq and Feng Panpan
    Citation: Trials 2023 24:714
  29. The university years are a developmentally crucial phase and a peak period for the onset of mental disorders. The beliefs about the changeability of negative emotion may play an important role in help-seeking....

    Authors: Shimin Zhu, Yuxi Hu, Di Qi, Nan Qin, Xinli Chi, Jiawen Luo, Jie Wu, Hua Huang, Qiaobing Wu, Lu Yu, Shiguang Ni, Kyra Hamilton and Samson Tse
    Citation: Trials 2023 24:713
  30. Genetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and promoting empowerment and adaptation to genetic information. Increasing de...

    Authors: Laura E. Forrest, Erin Tutty, Anurika P. De Silva, Lara Petelin, Amy Ruscigno, Rebecca Purvis, Katrina Monohan, Maira Kentwell, Adrienne Sexton, Lesley Stafford and Paul A. James
    Citation: Trials 2023 24:712
  31. The prevalence of mental health problems in childhood and adolescence has increased significantly, not least due to the COVID-19 pandemic in Germany and other countries worldwide. Although holistic school inte...

    Authors: Lisa Fischer, Katharina Liegmann, Matthis Morgenstern and Kevin Dadaczynski
    Citation: Trials 2023 24:711
  32. High participant retention enhances the validity of clinical trials. A monetary incentive can increase retention, but it is not known if when it is provided and if it is conditional matters. We aimed to determ...

    Authors: Johanna Cook, Jonathan A. Cook, Emily Bongard, Carl Heneghan and Chris C. Butler
    Citation: Trials 2023 24:710
  33. Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks’ gestation and is associated with an increased risk of adverse neuro...

    Authors: Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath and Brett J Manley
    Citation: Trials 2023 24:709
  34. Overall survival is the “gold standard” endpoint in cancer clinical trials. It plays a key role in determining the clinical- and cost-effectiveness of a new intervention and whether it is recommended for use i...

    Authors: Kara-Louise Royle, David Meads, Jennifer K. Visser-Rogers, Ian R. White and David A. Cairns
    Citation: Trials 2023 24:708
  35. Clinical trial evidence underpins evidence-based medicine and the improvement of healthcare worldwide. In Australasia, a significant proportion of clinical trials are conducted by geographically dispersed and ...

    Authors: Megan Sanders, Karen Goulding, Ed Oakley, Donna Reidlinger and Katie M Groom
    Citation: Trials 2023 24:707
  36. The management of respiratory distress syndrome (RDS) in premature newborns is based on different types of non-invasive respiratory support and on surfactant replacement therapy (SRT) to avoid mechanical venti...

    Authors: Iuri Corsini, Javier Rodriguez-Fanjul, Francesco Raimondi, Luca Boni, Alberto Berardi, Victoria Aldecoa-Bilbao, Almudena Alonso-Ojembarrena, Gina Ancora, Salvatore Aversa, Renzo Beghini, Nerea Bilbao Meseguer, Letizia Capasso, Francesca Chesi, Martina Ciarcià, Ana Concheiro, Luigi Corvaglia…
    Citation: Trials 2023 24:706
  37. Oral HIV pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but uptake remains low in Africa, especially among young women who are a priority population for HIV prevention services. HIV se...

    Authors: Njeri Wairimu, Rachel C. Malen, Adriana M. Reedy, Peter Mogere, Irene Njeru, Carlos Culquichicón, Maureen McGowan, Fei Gao, Jared M. Baeten, Kenneth Ngure and Katrina F. Ortblad
    Citation: Trials 2023 24:705
  38. Vector control tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), have significantly contributed to malaria prevention efforts in sub-Saharan Africa. However, insecticide resista...

    Authors: Raphael N’Guessan, Serge-Brice Assi, Alphonsine Koffi, Phamien Ludovic Ahoua Alou, Anatole Mian, Nicole L. Achee, Benedicte Fustec, John P. Grieco, Fang Liu, Santosh Kumar, Matthew Noffsinger, Ashley Hudson, Tim W. R. Möhlmann and Marit Farenhorst
    Citation: Trials 2023 24:704
  39. School-based universal social and emotional learning (SEL) interventions implemented during the transition to adolescence may be efficacious in preventing the development of mental health difficulties. This pr...

    Authors: Annie O’Brien, Suzanne Hamilton, Neil Humphrey, Pamela Qualter, Jan R. Boehnke, Joao Santos, Ola Demkowicz, Margarita Panayiotou, Alex Thompson, Jennifer Lau, Lauren Burke and Yizhuo Lu
    Citation: Trials 2023 24:703

    The Correction to this article has been published in Trials 2024 25:36

  40. Supraspinatus tendon reconstruction (STR) was recently introduced as a new treatment option for irreparable posterosuperior massive rotator cuff tears (IPMRCT). STR was thought to be more advantageous than sup...

    Authors: Lin Ma, Xiaoli Gou and Binghua Zhou
    Citation: Trials 2023 24:702
  41. Achilles tendon tenotomy is an integral part of the Ponseti method, aimed at correcting residual equinus and lack of dorsiflexion after correction of the adductus deformity in clubfoot. Percutaneous tenotomy u...

    Authors: Manon Pigeolet, Jabbar Ghufran Syed, Sadia Ahmed, Muhammad Amin Chinoy and Mansoor Ali Khan
    Citation: Trials 2023 24:701
  42. Cardiovascular diseases are a leading cause of mortality worldwide. A significant contributing factor to this mortality is the lack of engagement in preventive activities. Consequently, strategies for enhancin...

    Authors: Fernanda Laís Loro, Riane Martins, Cintia Laura Pereira de Araújo, Lucio Rene Prade, Denis Lima do Rosário, Marcos César da Rocha Seruffo, Italo Adriano Moraes de Freitas, Jéferson Nobre, Cristiano Bonato Both and Pedro Dal Lago
    Citation: Trials 2023 24:700
  43. Authors: Aleksi Laajala, Paulus Tokola, Timo J. Autio, Timo Koskenkorva, Mikko Tastula, Pasi Ohtonen, Esa Läärä and Olli-Pekka Alho
    Citation: Trials 2023 24:699

    The original article was published in Trials 2021 22:617

  44. Chronic Obstructive Pulmonary Disease (COPD) is a chronic, noncommunicable disease characterized by hypoxemia, with altered lung function, dyspnea on mild exertion, limited tolerance to physical exertion, and ...

    Authors: Wilder Villamil-Parra, Édgar Cristancho-Mejía, Joan Ramon Torrella and Erica Mabel Mancera-Soto
    Citation: Trials 2023 24:698
  45. Rheumatoid arthritis (RA) considerably impacts patients’ lives. Patients’ confidence in their ability to manage this impact, or self-efficacy, can be supported with self-management interventions. One approach ...

    Authors: Michaël Doumen, Elias De Meyst, Cedric Lefevre, Sofia Pazmino, Johan Joly, Delphine Bertrand, Mieke Devinck, René Westhovens and Patrick Verschueren
    Citation: Trials 2023 24:697
  46. The SafeBoosC project aims to test the clinical value of non-invasive cerebral oximetry by near-infrared spectroscopy in newborn infants. The purpose is to establish whether cerebral oximetry can be used to sa...

    Authors: Maria Linander Vestager, Mathias Lühr Hansen, Marie Isabel Rasmussen, Gitte Holst Hahn, Simon Hyttel-Sørensen, Adelina Pellicer, Anne Marie Heuchan, Cornelia Hagmann, Eugene Dempsey, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Hans Fuchs, Jakub Tkaczyk, Jonathan Mintzer, Monica Fumagalli…
    Citation: Trials 2023 24:696
  47. Cystic fibrosis (CF) is an autosomal recessive disorder caused by abnormal function of the chloride ion channels and characterized by pancreatic insufficiency and chronic endobronchial airway infection. Pulmon...

    Authors: Nadia Hamedi, Mehrnaz Kajbafvala, Shabnam ShahAli, MohammadReza Pourahmadi, Alireza Eshghi and MohammadReza Modaresi Estahbanati
    Citation: Trials 2023 24:695
  48. Multidrug-resistant Gram-negative bacterial (MRGNB) infections represent a major public health threat. Cancer patients and, among them, hematological patients are most vulnerable to these infections. Gut colon...

    Authors: Ainhoa Fernández Moreno, Lucía Lavín-Alconero, Paula López de Ugarriza, Laura Solán Blanco, Sara Cáceres Hernández, Juan Miguel Bergua Burgués, María Izquierdo de Miguel, Ana Julia González Huerta, Marta Polo Zarzuela, Blanca Boluda, Karem Humala, Maria Luisa Calabuig, Maria Luz Amigo, Marián Cuesta Casas, María del Mar García-Saiz, Ana Fernández Verdugo…
    Citation: Trials 2023 24:694
  49. The Government of Cambodia established the village health support groups (VHSGs) in 2003 to facilitate primary healthcare activities, including maternal and child health (MCH) services. However, VHSGs face sev...

    Authors: Chan Hang Saing, Mengieng Ung, Sovanthida Suy, Sreymom Oy, Chhavarath Dary, Esabelle Lo Yan Yam, Sophea Chhorn, Michiko Nagashima-Hayashi, Dyna Khuon, Sovatha Mam, Rattana Kim, Vonthanak Saphonn and Siyan Yi
    Citation: Trials 2023 24:692

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