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  1. The physiologic and anthropometric characteristics changes associated with obesity may result in the alternation of pharmacologic management. Remimazolam tosylate is a new type of ultra-short-acting benzodiaze...

    Authors: Wenwen Ni, Xiuwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu, Yuan Han, Ji’e Jia and Wenxian Li
    Citation: Trials 2023 24:719
  2. Protein malnutrition after bariatric surgery is a severe complication and leads to significant morbidity. Previous studies have shown that protein intake and physical activity are the most important factors in...

    Authors: A. E. Taselaar, A. J. Boes, R. W. F. de Bruin, T. M. Kuijper, K. Van Lancker, E. van der Harst and R. A. Klaassen
    Citation: Trials 2023 24:717
  3. Blinding drugs through simulation techniques is an important means to control the subjective bias of investigators and subjects. However, clinical trials face significant challenges in the placebo production o...

    Authors: Qingna Li, Mengli Xiao, Xingfang Liu, Yang Zhao, Haoling Zhang, Yundong Yin, Panbo Qiu, Fang Lu and Rui Gao
    Citation: Trials 2023 24:716
  4. Mood disorders (anxiety, depression), sleep disorders, and catastrophizing lead to increased post-operative pain perception, increase in postoperative opioid consumption, decreased engagement with physical act...

    Authors: A. Murat Kaynar, Charles Lin, Andrea Gomez Sanchez, Danielle R. Lavage, Amy Monroe, Nicole Zharichenko, Meredith Strassburger, Katheryn Saucier, Yram J. Groff, Brian A. Klatt, Michael J. O’Malley, Eva Szigethy, Ajay D. Wasan and Jacques E. Chelly
    Citation: Trials 2023 24:715
  5. People who have undergone anterior cruciate ligament reconstruction have an increased risk of osteoarthritis. Abnormality of lower limb kinematics will occur after the operation. This may be related to lower l...

    Authors: Zhao Xiaojun, Ma Ming, Guo Jianye, Sun Wudong, Qu Yi, Cui Jun, Huang Ningqinq and Feng Panpan
    Citation: Trials 2023 24:714
  6. The university years are a developmentally crucial phase and a peak period for the onset of mental disorders. The beliefs about the changeability of negative emotion may play an important role in help-seeking....

    Authors: Shimin Zhu, Yuxi Hu, Di Qi, Nan Qin, Xinli Chi, Jiawen Luo, Jie Wu, Hua Huang, Qiaobing Wu, Lu Yu, Shiguang Ni, Kyra Hamilton and Samson Tse
    Citation: Trials 2023 24:713
  7. Genetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and promoting empowerment and adaptation to genetic information. Increasing de...

    Authors: Laura E. Forrest, Erin Tutty, Anurika P. De Silva, Lara Petelin, Amy Ruscigno, Rebecca Purvis, Katrina Monohan, Maira Kentwell, Adrienne Sexton, Lesley Stafford and Paul A. James
    Citation: Trials 2023 24:712
  8. The prevalence of mental health problems in childhood and adolescence has increased significantly, not least due to the COVID-19 pandemic in Germany and other countries worldwide. Although holistic school inte...

    Authors: Lisa Fischer, Katharina Liegmann, Matthis Morgenstern and Kevin Dadaczynski
    Citation: Trials 2023 24:711
  9. High participant retention enhances the validity of clinical trials. A monetary incentive can increase retention, but it is not known if when it is provided and if it is conditional matters. We aimed to determ...

    Authors: Johanna Cook, Jonathan A. Cook, Emily Bongard, Carl Heneghan and Chris C. Butler
    Citation: Trials 2023 24:710
  10. Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks’ gestation and is associated with an increased risk of adverse neuro...

    Authors: Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath and Brett J Manley
    Citation: Trials 2023 24:709
  11. Overall survival is the “gold standard” endpoint in cancer clinical trials. It plays a key role in determining the clinical- and cost-effectiveness of a new intervention and whether it is recommended for use i...

    Authors: Kara-Louise Royle, David Meads, Jennifer K. Visser-Rogers, Ian R. White and David A. Cairns
    Citation: Trials 2023 24:708
  12. Clinical trial evidence underpins evidence-based medicine and the improvement of healthcare worldwide. In Australasia, a significant proportion of clinical trials are conducted by geographically dispersed and ...

    Authors: Megan Sanders, Karen Goulding, Ed Oakley, Donna Reidlinger and Katie M Groom
    Citation: Trials 2023 24:707
  13. The management of respiratory distress syndrome (RDS) in premature newborns is based on different types of non-invasive respiratory support and on surfactant replacement therapy (SRT) to avoid mechanical venti...

    Authors: Iuri Corsini, Javier Rodriguez-Fanjul, Francesco Raimondi, Luca Boni, Alberto Berardi, Victoria Aldecoa-Bilbao, Almudena Alonso-Ojembarrena, Gina Ancora, Salvatore Aversa, Renzo Beghini, Nerea Bilbao Meseguer, Letizia Capasso, Francesca Chesi, Martina Ciarcià, Ana Concheiro, Luigi Corvaglia…
    Citation: Trials 2023 24:706
  14. Oral HIV pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but uptake remains low in Africa, especially among young women who are a priority population for HIV prevention services. HIV se...

    Authors: Njeri Wairimu, Rachel C. Malen, Adriana M. Reedy, Peter Mogere, Irene Njeru, Carlos Culquichicón, Maureen McGowan, Fei Gao, Jared M. Baeten, Kenneth Ngure and Katrina F. Ortblad
    Citation: Trials 2023 24:705
  15. Vector control tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), have significantly contributed to malaria prevention efforts in sub-Saharan Africa. However, insecticide resista...

    Authors: Raphael N’Guessan, Serge-Brice Assi, Alphonsine Koffi, Phamien Ludovic Ahoua Alou, Anatole Mian, Nicole L. Achee, Benedicte Fustec, John P. Grieco, Fang Liu, Santosh Kumar, Matthew Noffsinger, Ashley Hudson, Tim W. R. Möhlmann and Marit Farenhorst
    Citation: Trials 2023 24:704
  16. School-based universal social and emotional learning (SEL) interventions implemented during the transition to adolescence may be efficacious in preventing the development of mental health difficulties. This pr...

    Authors: Annie O’Brien, Suzanne Hamilton, Neil Humphrey, Pamela Qualter, Jan R. Boehnke, Joao Santos, Ola Demkowicz, Margarita Panayiotou, Alex Thompson, Jennifer Lau, Lauren Burke and Yizhuo Lu
    Citation: Trials 2023 24:703

    The Correction to this article has been published in Trials 2024 25:36

  17. Supraspinatus tendon reconstruction (STR) was recently introduced as a new treatment option for irreparable posterosuperior massive rotator cuff tears (IPMRCT). STR was thought to be more advantageous than sup...

    Authors: Lin Ma, Xiaoli Gou and Binghua Zhou
    Citation: Trials 2023 24:702
  18. Achilles tendon tenotomy is an integral part of the Ponseti method, aimed at correcting residual equinus and lack of dorsiflexion after correction of the adductus deformity in clubfoot. Percutaneous tenotomy u...

    Authors: Manon Pigeolet, Jabbar Ghufran Syed, Sadia Ahmed, Muhammad Amin Chinoy and Mansoor Ali Khan
    Citation: Trials 2023 24:701
  19. Cardiovascular diseases are a leading cause of mortality worldwide. A significant contributing factor to this mortality is the lack of engagement in preventive activities. Consequently, strategies for enhancin...

    Authors: Fernanda Laís Loro, Riane Martins, Cintia Laura Pereira de Araújo, Lucio Rene Prade, Denis Lima do Rosário, Marcos César da Rocha Seruffo, Italo Adriano Moraes de Freitas, Jéferson Nobre, Cristiano Bonato Both and Pedro Dal Lago
    Citation: Trials 2023 24:700
  20. Authors: Aleksi Laajala, Paulus Tokola, Timo J. Autio, Timo Koskenkorva, Mikko Tastula, Pasi Ohtonen, Esa Läärä and Olli-Pekka Alho
    Citation: Trials 2023 24:699

    The original article was published in Trials 2021 22:617

  21. Chronic Obstructive Pulmonary Disease (COPD) is a chronic, noncommunicable disease characterized by hypoxemia, with altered lung function, dyspnea on mild exertion, limited tolerance to physical exertion, and ...

    Authors: Wilder Villamil-Parra, Édgar Cristancho-Mejía, Joan Ramon Torrella and Erica Mabel Mancera-Soto
    Citation: Trials 2023 24:698
  22. Rheumatoid arthritis (RA) considerably impacts patients’ lives. Patients’ confidence in their ability to manage this impact, or self-efficacy, can be supported with self-management interventions. One approach ...

    Authors: Michaël Doumen, Elias De Meyst, Cedric Lefevre, Sofia Pazmino, Johan Joly, Delphine Bertrand, Mieke Devinck, René Westhovens and Patrick Verschueren
    Citation: Trials 2023 24:697
  23. The SafeBoosC project aims to test the clinical value of non-invasive cerebral oximetry by near-infrared spectroscopy in newborn infants. The purpose is to establish whether cerebral oximetry can be used to sa...

    Authors: Maria Linander Vestager, Mathias Lühr Hansen, Marie Isabel Rasmussen, Gitte Holst Hahn, Simon Hyttel-Sørensen, Adelina Pellicer, Anne Marie Heuchan, Cornelia Hagmann, Eugene Dempsey, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Hans Fuchs, Jakub Tkaczyk, Jonathan Mintzer, Monica Fumagalli…
    Citation: Trials 2023 24:696
  24. Cystic fibrosis (CF) is an autosomal recessive disorder caused by abnormal function of the chloride ion channels and characterized by pancreatic insufficiency and chronic endobronchial airway infection. Pulmon...

    Authors: Nadia Hamedi, Mehrnaz Kajbafvala, Shabnam ShahAli, MohammadReza Pourahmadi, Alireza Eshghi and MohammadReza Modaresi Estahbanati
    Citation: Trials 2023 24:695
  25. Multidrug-resistant Gram-negative bacterial (MRGNB) infections represent a major public health threat. Cancer patients and, among them, hematological patients are most vulnerable to these infections. Gut colon...

    Authors: Ainhoa Fernández Moreno, Lucía Lavín-Alconero, Paula López de Ugarriza, Laura Solán Blanco, Sara Cáceres Hernández, Juan Miguel Bergua Burgués, María Izquierdo de Miguel, Ana Julia González Huerta, Marta Polo Zarzuela, Blanca Boluda, Karem Humala, Maria Luisa Calabuig, Maria Luz Amigo, Marián Cuesta Casas, María del Mar García-Saiz, Ana Fernández Verdugo…
    Citation: Trials 2023 24:694
  26. Postoperative anaemia is common in older cardiac surgery patients and often caused by iron deficiency. Anaemia may negatively affect recovery after cardiac surgery. This study aims to determine the efficacy of...

    Authors: R. M. Smoor, T. C. D. Rettig, L. M. Vernooij, E. M. Groenewegen, H. P. A. van Dongen and P. G. Noordzij
    Citation: Trials 2023 24:693
  27. The Government of Cambodia established the village health support groups (VHSGs) in 2003 to facilitate primary healthcare activities, including maternal and child health (MCH) services. However, VHSGs face sev...

    Authors: Chan Hang Saing, Mengieng Ung, Sovanthida Suy, Sreymom Oy, Chhavarath Dary, Esabelle Lo Yan Yam, Sophea Chhorn, Michiko Nagashima-Hayashi, Dyna Khuon, Sovatha Mam, Rattana Kim, Vonthanak Saphonn and Siyan Yi
    Citation: Trials 2023 24:692
  28. The recruitment process in a randomized trial can be challenging. Poor recruitment can have a negative impact on the allocated budget and estimated completion date of the study and may result in an underpowere...

    Authors: M. Elfghi, F. Jordan, S. Sultan and W. Tawfick
    Citation: Trials 2023 24:691
  29. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in females characterized by ovulatory dysfunction, hyperandrogenism, and other metabolic disorders. Both intermittent fasting and ...

    Authors: Sepide Talebi, Sakineh Shab-Bidar, Hamed Mohammadi, Ashraf Moini and Kurosh Djafarian
    Citation: Trials 2023 24:690
  30. A significant proportion of Canadian adults is impacted by chronic noncommunicable diseases. These conditions may be improved by peer-led health promotion interventions that target modifiable risk factors; how...

    Authors: Margherita Cameranesi, Rebecca Mollard, Robert Balshaw and Dylan MacKay
    Citation: Trials 2023 24:689
  31. Type 2 diabetes (T2D) poses a growing public health burden, especially in low- and middle-income countries (LMICs). Task-shifting to lay village health workers (VHWs) and the use of digital clinical decision s...

    Authors: Felix Gerber, Ravi Gupta, Thabo Ishmael Lejone, Thesar Tahirsylaj, Tristan Lee, Maurus Kohler, Maria Ines Haldemann, Fabian Räber, Mamakhala Chitja, Molulela Manthabiseng, Makhebe Khomolishoele, Mota Mota, Matumaole Bane, Pauline Mamorontsane Sematle, Retselisitsoe Makabateng, Madavida Mphunyane…
    Citation: Trials 2023 24:688
  32. Authors: Mathieu Pecqueux, Marius Distler, Olga Radulova-Mauersberger, Ulrike Neckmann, Sandra Korn, Christian Praetorius, Johannes Fritzmann, Anna Klimova, Jürgen Weitz and Christoph Kahlert
    Citation: Trials 2023 24:687

    The original article was published in Trials 2023 24:641

  33. Existing treatments for young people with severe depression have limited effectiveness. The aim of the Study of Ketamine for Youth Depression (SKY-D) trial is to determine whether a 4-week course of low-dose s...

    Authors: Orli S. Schwartz, Paul Amminger, Bernard T. Baune, Gillinder Bedi, Michael Berk, Sue M. Cotton, Rothanthi Daglas-Georgiou, Nick Glozier, Ben Harrison, Daniel F. Hermens, Emma Jennings, Jim Lagopoulos, Colleen Loo, Sumudu Mallawaarachchi, Donel Martin, Bethany Phelan…
    Citation: Trials 2023 24:686
  34. Diabetic macular edema (DME) is the main cause of vision loss in diabetic patients. Currently, anti-vascular endothelial growth factor (VEGF) intravitreal injection stands as the first-line therapy for DME. Ho...

    Authors: Haoxin Guo, Wenbo Li, Zetong Nie, Xiang Zhang, Mingfei Jiao, Siqiong Bai, Naxin Duan, Xiaorong Li and Bojie Hu
    Citation: Trials 2023 24:685
  35. With regard to the esthetics and comfort of orthodontic treatment, the requirement for removable clear aligners (CAs) is increasing. Unlike conventional fixed orthodontic appliances, CAs were made of thermopla...

    Authors: Chuangchuang Mu, Bingjing Sun, Zhicheng Gong, Yuanyuan Wei, Li Chen, Wei Zhang, Haimiao Wu and Bingjiao Zhao
    Citation: Trials 2023 24:684
  36. The autonomic nervous system can be responsible for the initiation and maintenance of arrhythmias. Low-level tragus stimulation (LLTS), a noninvasive form of autonomic neuromodulation, has been shown to be eff...

    Authors: Cheng Cai, Nan Wu, Gang Yang, Shu Yang, Wenjie Liu, Minglong Chen and Sunny S. Po
    Citation: Trials 2023 24:683
  37. Hundreds of youth psychotherapy randomized trials have generated scores of helpful empirically supported treatments (ESTs). However, the standardized structure of many ESTs and their focus on a single disorder...

    Authors: Abby Bailin, Evelyn Cho, Ariel Sternberg, Spencer C. Evans, Nathan L. Hollinsaid, Sarah Kate Bearman and John R. Weisz
    Citation: Trials 2023 24:682
  38. CommunityRx is an evidence-based social care intervention delivered to family and friend caregivers (“caregivers”) at the point of healthcare to address health-related social risks (HRSRs). Two CommunityRx ran...

    Authors: Emily M. Abramsohn, MariaDelSol De Ornelas, Soo Borson, Cristianne R. M. Frazier, Charles M. Fuller, Mellissa Grana, Elbert S. Huang, Jyotsna S. Jagai, Jennifer A. Makelarski, Doriane Miller, Dena Schulman-Green, Eva Shiu, Katherine Thompson, Victoria Winslow, Kristen Wroblewski and Stacy Tessler Lindau
    Citation: Trials 2023 24:681
  39. In this commentary, we discuss a recent article in Trials that raised concerns about the number of poorly performed randomised trials in the medical literature and discuss the trials literature more widely. Altho...

    Authors: Fergus Hamilton, David Arnold and Richard Lilford
    Citation: Trials 2023 24:680
  40. Type 2 diabetes mellitus (T2D) is a serious global health problem, and exercise is considered an essential non-pharmacological tool in T2D prevention and treatment. During periods of social isolation experienc...

    Authors: Samara Nickel Rodrigues, Rodrigo Sudatti Delevatti, Mauricio Tatsch Ximenes Carvalho, Valentina Bullo, Marco Bergamin and Cristine Lima Alberton
    Citation: Trials 2023 24:679
  41. The Unified Protocol (UP) is a transdiagnostic intervention based on emotional regulation for the treatment of emotional disorders. Its application in individual and group formats has been studied worldwide, o...

    Authors: Milagros Celleri, Camila F. Cremades, Martin J. Etchevers and Cristian J. Garay
    Citation: Trials 2023 24:678
  42. Patients with stroke frequently experience walking dysfunction. Core training can help improve balance and walking function in patients with stroke. However, core training movements in clinical practice are nu...

    Authors: Jianqing Su, Yunrong Ding, Yanjun Cao, Zengqiao Zhang, Mengxue Sun, Yajuan Zhang, Kunpeng Li and Wu Wang
    Citation: Trials 2023 24:677
  43. Approximately ten percent of US military veterans suffer from posttraumatic stress disorder (PTSD). Cognitive processing therapy (CPT) is a highly effective, evidence-based, first-line treatment for PTSD that ...

    Authors: Rebecca K. Sripada, Cassaundra L. Peterson, John J. Dziak, Inbal Nahum-Shani, Erika M. Roberge, Amber A. Martinson, Katherine Porter, Peter Grau, Diana Curtis, Sydney McElroy, Sarah Bryant, Isabel Gracy, Cosette Pryor, Heather M. Walters, Karen Austin, Carolina Ehlinger…
    Citation: Trials 2023 24:676
  44. Chronic prostatitis/chronic pelvic pain syndrome is a highly prevalent syndrome. Previous studies showed that extracorporeal shockwave therapy and myofascial release therapy could improve the quality of life i...

    Authors: Ningqing Huang, Zhi Qin, Wudong Sun, Kaiming Bao, Jingxian Zha, Peng Zhang, Panpan Feng, Xiaojun Zhao, Mengqian Liu, Jinjun Shi and Ming Ma
    Citation: Trials 2023 24:675
  45. Myopia prevalence has been increasing in the last decades, and its pathological consequences, including myopic maculopathy and high myopia-associated optic neuropathy, are now one of the most common causes of ...

    Authors: Cristina Alvarez-Peregrina, Miguel Angel Sanchez-Tena, Clara Martinez-Perez, Cesar Villa-Collar and Arne Ohlendorf
    Citation: Trials 2023 24:674
  46. Diabetes self-management education (DSME) helps patients self-manage their condition and improve outcomes/quality of life. However, access to DSME is limited, particularly in low-income areas. This study aims ...

    Authors: Jitender Nagpal, Swapnil Rawat, Lovely Gupta, Avantika Negi and Divya Shashi Oraon
    Citation: Trials 2023 24:673
  47. Running is the most common cardiovascular exercise in the military. However, there is a high incidence of running-related overuse injuries that reduces military readiness. Gait retraining is a common intervent...

    Authors: Michael S. Crowell, Richard A. Brindle, Erin M. Miller, Nicholas Reilly, Kevin R. Ford and Donald L. Goss
    Citation: Trials 2023 24:672
  48. Older patients often experience safety issues when transitioning from hospital to home. The ‘Your Care Needs You’ (YCNY) intervention aims to support older people to ‘know more’ and ‘do more’ whilst in hospita...

    Authors: Rebecca Lawton, Jenni Murray, Ruth Baxter, Gerry Richardson, Sarah Cockayne, Kalpita Baird, Laura Mandefield, Stephen Brealey, Jane O’Hara, Robbie Foy, Laura Sheard, Alison Cracknell, Edmund Breckin and Catherine Hewitt
    Citation: Trials 2023 24:671
  49. The LOw RISk DCIS (LORIS) study was set up to compare conventional surgical treatment with active monitoring in women with ductal carcinoma in situ (DCIS). Recruitment to trials with a surveillance arm is kno...

    Authors: Sally Wheelwright, Lucy Matthews, Valerie Jenkins, Shirley May, Daniel Rea, Pat Fairbrother, Claire Gaunt, Jennie Young, Sarah Pirrie, Matthew G. Wallis and Lesley Fallowfield
    Citation: Trials 2023 24:670

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