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Page 6 of 129

  1. Screening substantially reduces cervical cancer incidence and mortality. More than half of invasive cervical cancers are attributable to infrequent screening or not screening at all. The current study, My Body...

    Authors: Lisa P. Spees, Andrea C. Des Marais, Stephanie B. Wheeler, Michael G. Hudgens, Sarah Doughty, Noel T. Brewer and Jennifer S. Smith

    Citation: Trials 2019 20:788

    Content type: Study protocol

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  2. High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation...

    Authors: Camila L. P. Oliveira, Normand G. Boulé, Arya M. Sharma, Sarah Elliott, Mario Siervo, Sunita Ghosh, Aloys Berg and Carla M. Prado

    Citation: Trials 2019 20:787

    Content type: Study protocol

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  3. Posttraumatic stress disorder (PTSD) rarely remits over time, and if left untreated, leads to significant distress, functional impairment, and increased health care costs. Fortunately, effective evidence-based...

    Authors: Anouk L. Grubaugh, Ursula S. Myers, Stephanie M. Keller, Bethany C. Wangelin, Brian E. Lozano and Peter W. Tuerk

    Citation: Trials 2019 20:786

    Content type: Study protocol

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  4. People with migraine often experience disability with serious consequences for their social life and work productivity. The pharmacological prophylactic management of migraine is effective in reducing migraine...

    Authors: Andreas Leonard Amons, Rene Franciscus Castien, Johannes C. van der Wouden, Willem De Hertogh, Joost Dekker and Henriëtte Eveline van der Horst

    Citation: Trials 2019 20:785

    Content type: Study protocol

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  5. The current treatment paradigm for type 2 diabetes mellitus (T2D) typically involves use of multiple medications to lower glucose levels in hope of reducing long-term complications. However, such treatment doe...

    Authors: Cody Durrer, Sean McKelvey, Joel Singer, Alan M. Batterham, James D. Johnson, Jay Wortman and Jonathan P. Little

    Citation: Trials 2019 20:781

    Content type: Study protocol

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  6. Nutrition plays a major role in intensive care unit (ICU) treatment, influencing ICU length of stay and patient’s survival. If preferable enteral nutrition administration is not feasible, ESPEN and ASPEN guide...

    Authors: Paweł Piwowarczyk, Paweł Kutnik, Michał Borys, Elżbieta Rypulak, Beata Potręć-Studzińska, Justyna Sysiak-Sławecka, Tomasz Czarnik and Mirosław Czuczwar

    Citation: Trials 2019 20:777

    Content type: Study protocol

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  7. Following an acquired brain injury, individuals frequently experience anxiety and/or depressive symptoms. However, current treatments for these symptoms are not very effective. A promising treatment is accepta...

    Authors: Johanne Rauwenhoff, Frenk Peeters, Yvonne Bol and Caroline Van Heugten

    Citation: Trials 2019 20:773

    Content type: Study protocol

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  8. Psychotic experiences, social functioning and general psychopathology are important targets for early intervention in individuals with Ultra-High-Risk state (UHR) and a first-episode psychosis (FEP). Acceptanc...

    Authors: Ulrich Reininghaus, Annelie Klippel, Henrietta Steinhart, Thomas Vaessen, Martine van Nierop, Wolfgang Viechtbauer, Tim Batink, Zuzana Kasanova, Evelyne van Aubel, Ruud van Winkel, Machteld Marcelis, Therese van Amelsvoort, Mark van der Gaag, Lieuwe de Haan and Inez Myin-Germeys

    Citation: Trials 2019 20:769

    Content type: Study protocol

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  9. Individuals with cystic fibrosis (CF) may develop CF-related diabetes (CFDR). This comorbidity is related to a poorer quality of life, microvascular complications, a decline in lung function, and an increase i...

    Authors: Karolinne Souza Monteiro, Matheus de Paiva Azevedo, Lucas Menescal Jales, Fernanda Elizabeth Pereira da Silva, Ricardo Fernando Arrais and Karla Morganna Pereira Pinto de Mendonça

    Citation: Trials 2019 20:768

    Content type: Study protocol

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  10. Consultations in primary care for symptoms of urinary tract infections (UTIs) are common and patients are frequently treated with antibiotics. Given increasing antimicrobial resistance, there has been interest...

    Authors: Oghenekome Gbinigie, Julie Allen, Anne-Marie Boylan, Alastair Hay, Carl Heneghan, Michael Moore, Nicola Williams and Chris Butler

    Citation: Trials 2019 20:767

    Content type: Study protocol

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  11. Labor pain is one of the leading causes of fear of childbirth. Acupressure is a non-pharmacological pain relief method that has shown promising results in relieving this pain. The present study is designed to ...

    Authors: Zainab Alimoradi, Farideh Kazemi, Mahboubeh Valiani and Maryam Gorji

    Citation: Trials 2019 20:766

    Content type: Study protocol

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  12. There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled ...

    Authors: Stuart G. Nicholls, Kelly Carroll, Merrick Zwarenstein, Jamie C. Brehaut, Charles Weijer, Spencer P. Hey, Cory E. Goldstein, Ian D. Graham, Jeremy M. Grimshaw, Joanne E. McKenzie, Dean A. Fergusson and Monica Taljaard

    Citation: Trials 2019 20:765

    Content type: Research

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  13. Stroke has emerged as a leading cause of death in rural India. However, well-tested healthcare interventions to reduce stroke mortality in rural under-resourced settings are lacking. The aim of this study is t...

    Authors: Yogeshwar Kalkonde, Mahesh Deshmukh, Sindhu Nila, Sunil Jadhao and Abhay Bang

    Citation: Trials 2019 20:764

    Content type: Study protocol

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  14. A 2014 Cochrane review evaluating the effect of anabolic steroids after hip fracture concluded that the quality of the studies was insufficient to draw conclusions on the effects and recommended further high-q...

    Authors: Signe Hulsbæk, Ilija Ban, Tobias Kvanner Aasvang, Jens-Erik Beck Jensen, Henrik Kehlet, Nicolai Bang Foss, Thomas Bandholm and Morten Tange Kristensen

    Citation: Trials 2019 20:763

    Content type: Study protocol

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  15. Low back pain (LBP) is the most frequent complaint in clinical practice. Electroacupuncture treatment may be effective; however, the supporting evidence is still limited, especially in older adults.

    Authors: Sarina Francescato Torres, Ana Carolina Brandt de Macedo, Mateus Dias Antunes, Ingred Merllin Batista de Souza, Francisco Dimitre Rodrigo Pereira Santos, Adriana de Sousa do Espírito Santo, Flávia Ribeiro Jacob, Ariela Torres Cruz, Priscila de Oliveira Januário and Amélia Pasqual Marques

    Citation: Trials 2019 20:762

    Content type: Study protocol

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  16. Hypertension is present in more than 50% of patients with type 2 diabetes mellitus. Dietary salt restriction is recommended for the management of high blood pressure. Instructions on dietary salt restriction, ...

    Authors: Emi Ushigome, Chikako Oyabu, Makoto Shiraishi, Nobuko Kitagawa, Aya Kitae, Keiko Iwai, Hidetaka Ushigome, Isao Yokota, Masahide Hamaguchi, Masahiro Yamazaki and Michiaki Fukui

    Citation: Trials 2019 20:761

    Content type: Study protocol

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  17. The Cardiovascular Health Awareness Program (CHAP) uses volunteers to provide cardiovascular disease (CVD) and diabetes screening in a community setting, referrals to primary care providers, and locally availa...

    Authors: Gina Agarwal, Magali Girard, Ricardo Angeles, Melissa Pirrie, Marie-Thérèse Lussier, Francine Marzanek, Lisa Dolovich, J. Michael Paterson, Lehana Thabane and Janusz Kaczorowski

    Citation: Trials 2019 20:760

    Content type: Study protocol

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  18. In the Dutch breast cancer screening program, women recalled with a BI-RADS 0 score are referred for additional imaging, while those with BI-RADS 4/5 scores are also directed to an outpatient breast clinic. Ap...

    Authors: L. M. F. H. Neeter, I. P. L. Houben, P. J. Nelemans, T. J. A. Van Nijnatten, R. M. Pijnappel, C. Frotscher, M. Osinga-de Jong, F. Sanders, T. Van Dalen, H. P. J. Raat, B. A. B. Essers, J. E. Wildberger, M. L. Smidt and M. B. I. Lobbes

    Citation: Trials 2019 20:759

    Content type: Study protocol

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  19. Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal cancer. Currently, transthoracic and abdominal esophagectomy with cervical anastomosis (McKeown esophagect...

    Authors: Taro Oshikiri, Gosuke Takiguchi, Susumu Miura, Nobuhisa Takase, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Yoshiko Matsuda, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki and Yoshihiro Kakeji

    Citation: Trials 2019 20:758

    Content type: Study protocol

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  20. Social anxiety disorder (SAD) is a common disorder in adolescence associated with extensive distress and long-term impairment. Generic cognitive behavior therapy (CBT) programs for anxiety disorders have shown...

    Authors: Nanna Fensman Lassen, Esben Hougaard, Kristian Bech Arendt and Mikael Thastum

    Citation: Trials 2019 20:757

    Content type: Study protocol

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  21. Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease and has become a heavy economic and social burden due to its high prevalence and morbidity. The most effective strategy is that patie...

    Authors: De Jin, Wen-Jing Huang, Xiang Meng, Fan Yang, Qi Bao, Mei-zhen Zhang, Ya-nan Yang, Qing Ni, Feng-Mei Lian and Xiao-Lin Tong

    Citation: Trials 2019 20:756

    Content type: Study protocol

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  22. Allergic diseases in infants have dramatically increased in developed countries during the past few decades. To date, extensive research has been done on risk factors for allergies in infancy, and preventive m...

    Authors: Rie Nakamura, Nao Ishiguro, Eiji Naru, Yukiko Ishitsuka, Masato Nakade and Yoko Nezu

    Citation: Trials 2019 20:755

    Content type: Study protocol

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  23. Current international guidelines recommend the use of a daily topical exit-site antimicrobial to prevent peritoneal dialysis (PD)-related infections. Although nonantibiotic-based therapies are appealing becaus...

    Authors: Surapon Nochaiwong, Chidchanok Ruengorn, Kajohnsak Noppakun, Setthapon Panyathong, Phongsak Dandecha, Manish M. Sood, Chalermpong Saenjum, Ratanaporn Awiphan, Sasithorn Sirilun, Pajaree Mongkhon, Wilaiwan Chongruksut and Kednapa Thavorn

    Citation: Trials 2019 20:754

    Content type: Study protocol

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  24. Neoadjuvant immunotherapy targeting immune checkpoint programmed death-1 (PD-1) is under investigation in various tumour settings including non-small-cell lung cancer (NSCLC). Preclinical models demonstrate th...

    Authors: Elizabeth Ahern, Annette Cubitt, Emma Ballard, Michele W. L. Teng, William C. Dougall, Mark J. Smyth, David Godbolt, Rishendran Naidoo, Amanda Goldrick and Brett G. M. Hughes

    Citation: Trials 2019 20:753

    Content type: Study protocol

    Published on:

  25. Severe burn injuries result in relevant restrictions of physical capacity as well as psychological and social integrity and require a specialized rehabilitation. There is a common agreement, among national as ...

    Authors: Hubert Neubauer, Annette Stolle, Sabine Ripper, Felix Klimitz, Hans Ziegenthaler, Mareike Strupat, Ulrich Kneser and Leila Harhaus

    Citation: Trials 2019 20:752

    Content type: Study protocol

    Published on:

  26. Regorafenib is an oral multikinase inhibitor for metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidines, irinotecan, oxaliplatin, monoclonal antibodies targeting vascular endothelial gro...

    Authors: Cheng-Jen Ma, Tsung-Kun Chang, Hsiang-Lin Tsai, Wei-Chih Su, Ching-Wen Huang, Yung-Sung Yeh, Yu-Tang Chang and Jaw-Yuan Wang

    Citation: Trials 2019 20:751

    Content type: Study protocol

    Published on:

  27. The FITNET-NHS Trial is a UK, national, trial investigating whether an online cognitive behavioural therapy program (FITNET-NHS) for treating chronic fatigue syndrome/ME in adolescents is clinically effective ...

    Authors: Emma Anderson, Daisy Gaunt, Chris Metcalfe, Manmita Rai, William Hollingworth, Nicola Mills, Lucy Beasant, Roxanne Parslow, David Kessler, John Macleod, Paul Stallard, Hans Knoop, Elise Van de Putte, Sanne Nijhof, Gijs Bleijenberg and Esther Crawley

    Citation: Trials 2019 20:750

    Content type: Update

    Published on:

    The Study protocol to this article has been published in Trials 2018 19:136

  28. Deep-brain stimulation targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in the advanced stages of Parkinson’s disease (PD). High-frequency stimulation (HFS) of the STN...

    Authors: Fumin Jia, Jianguo Zhang, Huimin Wang, Zhanhua Liang, Weiguo Liu, Xuelian Wang, Yiming Liu, Yi Guo, Zhipei Ling, Xiaodong Cai, Xi Wu, Jianjun Wu, Wen Lv, Xin Xu, Wenbin Zhang and Luming Li

    Citation: Trials 2019 20:749

    Content type: Study protocol

    Published on:

  29. While the efficacy of cognitive therapy (CT) has been well established for social anxiety disorder (SAD) in several randomized controlled trials, there are still large differences between trials with respect t...

    Authors: Celina Clément, Jihong Lin and Ulrich Stangier

    Citation: Trials 2019 20:748

    Content type: Study protocol

    Published on:

  30. Current guidelines for the management of bronchiectasis (BE) highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum removal as part of s...

    Authors: Judy Martina Bradley, Rohan Anand, Brenda O’Neill, Kathryn Ferguson, Mike Clarke, Mary Carroll, James Chalmers, Anthony De Soyza, Jamie Duckers, Adam T. Hill, Michael R. Loebinger, Fiona Copeland, Evie Gardner, Christina Campbell, Ashley Agus, Alistair McGuire…

    Citation: Trials 2019 20:747

    Content type: Study protocol

    Published on:

  31. Infants born extremely preterm are at high risk of dying or suffering from severe brain injuries. Treatment guided by monitoring of cerebral oxygenation may reduce the risk of death and neurologic complication...

    Authors: Mathias Lühr Hansen, Adelina Pellicer, Christian Gluud, Eugene Dempsey, Jonathan Mintzer, Simon Hyttel-Sorensen, Anne Marie Heuchan, Cornelia Hagmann, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Guoqiang Cheng, Ana Vilan, Jakub Tkaczyk, Karen B. Kreutzer, Monica Fumagalli…

    Citation: Trials 2019 20:746

    Content type: Update

    Published on:

    The Study protocol to this article has been published in Trials 2019 20:811

  32. This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeti...

    Authors: Rieke van der Graaf and Phaik Yeong Cheah

    Citation: Trials 2019 20(Suppl 2):705

    Content type: Editorial

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    This article is part of a Supplement: Volume 20 Supplement 2

  33. Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the de...

    Authors: Meriel Raymond, Malick M. Gibani, Nicholas P. J. Day and Phaik Yeong Cheah

    Citation: Trials 2019 20(Suppl 2):704

    Content type: Commentary

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 2

  34. Stepped-wedge cluster randomized trials (SW-CRTs) are increasingly popular in health-related research in both high- and low-resource settings. There may be specific ethical issues that researchers face when de...

    Authors: Kaustubh Joag, Guillermo Ambrosio, Edgar Kestler, Charles Weijer, Karla Hemming and Rieke Van der Graaf

    Citation: Trials 2019 20(Suppl 2):703

    Content type: Commentary

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 2

  35. Human challenge trials (HCTs) deliberately infect participants in order to test vaccines and treatments in a controlled setting, rather than enrolling individuals with natural exposure to a disease. HCTs are t...

    Authors: Ricardo Palacios and Seema K. Shah

    Citation: Trials 2019 20(Suppl 2):702

    Content type: Commentary

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 2

  36. Alternative clinical trial designs and methods are increasingly being used in place of the conventional individually randomised controlled trial (RCT) in high-income and in low-income and middle-income country...

    Authors: Adrienne Hunt, Carla Saenz and Katherine Littler

    Citation: Trials 2019 20(Suppl 2):701

    Content type: Meeting report

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 2

  37. Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics ...

    Authors: Luca F. Roggeveen, Lucas M. Fleuren, Tingjie Guo, Patrick Thoral, Harm Jan de Grooth, Eleonora L. Swart, Thomas L. T. Klausch, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman and Paul W. G. Elbers

    Citation: Trials 2019 20:745

    Content type: Study protocol

    Published on:

  38. Breast cancer is the most common cancer and the leading cause of cancer mortality among Latinas. As more is learned about the association between mammographic breast density (MBD) and breast cancer risk, a num...

    Authors: Bhavika K. Patel, Jennifer L. Ridgeway, Karthik Ghosh, Deborah J. Rhodes, Bijan Borah, Sarah Jenkins, Vera J. Suman, Aaron Norman, Matt Jewett, Davinder Singh, Celine M. Vachon and Carmen Radecki Breitkopf

    Citation: Trials 2019 20:744

    Content type: Study protocol

    Published on:

  39. In a cluster randomised controlled trial in Mumbai slums, we will test the effects on the prevalence of violence against women and girls of community mobilisation through groups and individual volunteers. One ...

    Authors: Nayreen Daruwalla, Unnati Machchhar, Shanti Pantvaidya, Vanessa D’Souza, Lu Gram, Andrew Copas and David Osrin

    Citation: Trials 2019 20:743

    Content type: Study protocol

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  40. The aging population is associated with increased multimorbidity and polypharmacy. Older adults are at a higher risk of adverse events and reduced therapeutic response. This phenomenon is partially explained b...

    Authors: Karina Giassi, Vanessa Piccoli, Ticiana da Costa Rodrigues and Renato Gorga Bandeira de Mello

    Citation: Trials 2019 20:742

    Content type: Study protocol

    Published on:

  41. Chemotherapy after surgery for breast cancer plays a fundamental role in reducing the risk of distant and local recurrence. An increasing number of patients seek traditional Chinese medicine (TCM) during adjuv...

    Authors: Chien-Ting Liu, Yen-Hao Chen, Yu-Chuen Huang, Shih-Yu Chen and Ming-Yen Tsai

    Citation: Trials 2019 20:741

    Content type: Study protocol

    Published on:

  42. Despite their marginal benefit, about 60% of acute lower respiratory tract infections (ALRTIs) are currently treated with antibiotics in Catalonia. This study aims to evaluate the effectiveness and efficiency ...

    Authors: Rafa Ruiz, Ana Moragas, Marta Trapero-Bertran, Antoni Sisó, Anna Berenguera, Glòria Oliva, Alícia Borràs-Santos, Ana García-Sangenís, Jaume Puig-Junoy, Josep M. Cots, Rosa Morros, Toni Mora, Anna Lanau-Roig, Ramon Monfà, Amelia Troncoso, Rosa M. Abellana…

    Citation: Trials 2019 20:740

    Content type: Study protocol

    Published on:

  43. Cutaneous microcystic lymphatic malformations (CMLMs) are rare conditions in children and adults. They present as clusters of vesicles full of lymph and blood to various extents, inducing maceration, esthetic ...

    Authors: Sophie Leducq, Agnès Caille, Sébastien Barbarot, Nathalie Bénéton, Didier Bessis, Olivia Boccara, Anne-Claire Bursztejn, Christine Chiaverini, Anne Dompmartin, Catherine Droitcourt, Valérie Gissot, Dominique Goga, Laurent Guibaud, Denis Herbreteau, Anne Le Touze, Christine Léauté-Labrèze…

    Citation: Trials 2019 20:739

    Content type: Study protocol

    Published on:

  44. Breastfeeding provides ideal infant nutrition, conferring several health benefits to children and their mothers. Women with inverted nipples, however, face difficulties that force them to prematurely terminate...

    Authors: Mona Nabulsi, Rayan Ghanem, Marlie Abou-Jaoude and Ali Khalil

    Citation: Trials 2019 20:737

    Content type: Study protocol

    Published on:

  45. The incidence, mortality, and prevalence of chronic obstructive pulmonary disease (COPD) are high in China. Acute exacerbations of COPD (AECOPD) are important events in the management of COPD because they nega...

    Authors: Hailong Zhang, Jiansheng Li, Xueqing Yu, Suyun Li, Haifeng Wang, Huanrong Ruan, Yimei Si, Yang Xie and Minghang Wang

    Citation: Trials 2019 20:735

    Content type: Study protocol

    Published on:

  46. Despite a steady world-wide decline over recent decades, rates of smoking remain high in developed countries. In Japan, 30% of men and 10% of women are smokers. Based on these rates, 18.8 million (14.06 millio...

    Authors: Yuka Ozaki, Maki Komiyama, Kenji Ueshima, Hiroyasu Iso, Satoko Sakata, Ayumi Morino, Mitsuyoshi Takahara, Satoshi Noguchi, Yoshihiro Kuwabara, Yuko Takahashi and Koji Hasegawa

    Citation: Trials 2019 20:734

    Content type: Study protocol

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  47. In patients submitted to major pulmonary resection, the postoperative length of stay is mainly influenced by the duration of air leaks and chest tube removal. The measurement of air leaks largely relies on tra...

    Authors: Giuseppe Marulli, Giovanni M. Comacchio, Mario Nosotti, Lorenzo Rosso, Paolo Mendogni, Giuseppe Natale, Luigi Andriolo, Giovanna Imbriglio, Valentina Larocca, Debora Brascia and Federico Rea

    Citation: Trials 2019 20:730

    Content type: Study protocol

    Published on:

  48. A considerable amount of randomized controlled trials (RCTs) have been published on statins and/or fibrates for diabetic retinopathy, a clinical condition associated with high social and economic burden. Adher...

    Authors: Vânia Mozetic, Letícia Leonel, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca, Taís Guimarães, Patricia Logullo and Rachel Riera

    Citation: Trials 2019 20:729

    Content type: Research

    Published on:

  49. Chronic obstructive pulmonary disease (COPD) is a major public health issue affecting approximately 4% to 7% of the Swiss population. According to current inpatient guidelines, systemic corticosteroids are imp...

    Authors: Pascal Urwyler, Maria Boesing, Kristin Abig, Marco Cattaneo, Thomas Dieterle, Andreas Zeller, Herbert Bachler, Stefan Markun, Oliver Senn, Christoph Merlo, Stefan Essig, Elke Ullmer, Jonas Rutishauser, Macé M Schuurmans and Joerg Daniel Leuppi

    Citation: Trials 2019 20:727

    Content type: Study protocol

    Published on:

  50. Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits ...

    Authors: Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu and Jian Wang

    Citation: Trials 2019 20:725

    Content type: Study protocol

    Published on:

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