Skip to main content

Articles

Page 2 of 206

  1. Authors: Russell J. McCulloh, Paul M. Darden, Jessica Snowden, Songthip Ounpraseuth, Jeannette Lee, Martina Clarke, Sophia R. Newcomer, Linda Fu, DeAnn Hubberd, Jaime Baldner, Maryam Garza and Ellen Kerns
    Citation: Trials 2024 25:111

    The original article was published in Trials 2022 23:911

  2. Preterm and term small for gestational age (SGA) babies are at high risk of experiencing malnutrition and impaired neurodevelopment. Standalone interventions have modest and sometimes inconsistent effects on g...

    Authors: Ranadip Chowdhury, Rukman Manapurath, Ingvild Fossgard Sandøy, Ravi Prakash Upadhyay, Neeta Dhabhai, Saijuddin Shaikh, Harish Chellani, Tarun Shankar Choudhary, Abhinav Jain, Jose Martines, Nita Bhandari, Tor A. Strand and Sunita Taneja
    Citation: Trials 2024 25:110
  3. Improving retention within randomised controlled trials is important. The effectiveness of different strategies can be assessed using a Study Within A Trial (SWAT). Previous research has shown personalised tex...

    Authors: Esther Herbert, Diana Papaioannou, Amanda Loban, Nikki Totton, Marie Hyslop, Robert Bolt and Christopher Deery
    Citation: Trials 2024 25:108
  4. Multicenter trials in orthopedic trauma are costly, yet crucial to advance the science behind clinical care. The number of sites is a key cost determinant. Each site has a fixed overhead cost, so more sites co...

    Authors: Lauren Allen, Robert V. O’Toole, Michael J. Bosse, William T. Obremskey, Kristin R. Archer, Lisa K. Cannada, Jaimie Shores, Lisa M. Reider, Katherine P. Frey, Anthony R. Carlini, Elena D. Staguhn and Renan C. Castillo
    Citation: Trials 2024 25:107
  5. Robotic spinal surgery may result in better pedicle screw placement accuracy, and reduction in radiation exposure and length of stay, compared to freehand surgery. The purpose of this randomized controlled tri...

    Authors: Nicolas Aurouer, Patrick Guerin, Arnaud Cogniet, Nicolas Gangnet, Morad Pedram, Pierre-Thierry Piechaud and Paolo Mangione
    Citation: Trials 2024 25:106
  6. Many research funders have invested billions of US dollars in building research capacity in sub-Saharan Africa (SSA). Despite these colossal investments, many well-intentioned and designed clinical research pr...

    Authors: Yauba Saidu, Sangwe Clovis Nchinjoh, Amani Adidja, Andreas Frambo Besong, Palmer Masumbe Netongo, Paul Ndom and Marya Liebermann
    Citation: Trials 2024 25:105
  7. Neuroimaging studies suggest an association between apathy after deep brain stimulation (DBS) and stimulation of the ventral part of the subthalamic nucleus (STN) due to the associative fibers connected to the...

    Authors: T. J. C. Zoon, G. van Rooijen, M. F. Contarino, S. van der Gaag, R. Zutt, J. T. van Asseldonk, P. van den Munckhof, P. R. Schuurman, D. A. J. P. Denys and R. M. A. de Bie
    Citation: Trials 2024 25:104
  8. Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The cur...

    Authors: Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin…
    Citation: Trials 2024 25:103
  9. Among older people undiagnosed and untreated vision impairment and blindness are common. The leading causes are uncorrected refractive errors and cataracts. Vision problems are associated with a lower quality ...

    Authors: Vera Rooth, Hilde van der Aa, Robert P. L. Wisse, Otto R. Maarsingh, Marc Koopmanschap, Jan E. E. Keunen, Hester Vermeulen, Caroline C. W. Klaver, Gabriëlle Janssen, Ger H. M. B. van Rens and Ruth M. A. van Nispen
    Citation: Trials 2024 25:102
  10. Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compound...

    Authors: Emily B. Hill, Minghua Tang, Julie M. Long, Jennifer F. Kemp, Jamie L. Westcott, Audrey E. Hendricks, Nichole A. Reisdorph, Wayne W. Campbell and Nancy F. Krebs
    Citation: Trials 2024 25:101
  11. Type 2 diabetes mellitus (T2DM) is a common metabolic disease that requires long-term management and treatment. Digital intervention, as an emerging medical model, has been widely used in the treatment of T2DM...

    Authors: Shao Zhong, Jingyi Jiang, Hongying Liu and Ying Pan
    Citation: Trials 2024 25:100
  12. Most cardiac arrest survivors are classified with mild to moderate cognitive impairment; roughly, 50% experience long-term neurocognitive impairment. Postarrest challenges complicate participation in society a...

    Authors: Jan Christensen, Bo Gregers Winkel, Lilli Kirkeskov, Fredrik Folke, Matilde Winther-Jensen, Christine Eckhardt-Bentsen, Jesper Kjærgaard, Christian Hassager and Mette Kirstine Wagner
    Citation: Trials 2024 25:99
  13. Digital interventions offer many possibilities for improving health, as remote interventions can enhance reach and access to underserved groups of society. However, research evaluating digital health intervent...

    Authors: Rebecca A. Krukowski, Kathryn M. Ross, Max J. Western, Rosie Cooper, Heide Busse, Cynthia Forbes, Emmanuel Kuntsche, Anila Allmeta, Anabelle Macedo Silva, Yetunde O. John-Akinola and Laura M. König
    Citation: Trials 2024 25:98
  14. Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on th...

    Authors: Ming-Hui Lai, Xiao-Ming Yu, Yan Lu, Hong-Lin Wang, Wang Fu, Huan-Xia Zhou, Yuan-Li Li, Jun Hu, Jiayi Xia, Zekai Hu, Chun-Lei Shan, Feng Wang and Cong Wang
    Citation: Trials 2024 25:97
  15. Despite the critical importance of clinical trials to provide evidence about the effects of intervention for children and youth, a paucity of published high-quality pediatric clinical trials persists. Sub-opti...

    Authors: Ami Baba, Maureen Smith, Beth K. Potter, An-Wen Chan, David Moher and Martin Offringa
    Citation: Trials 2024 25:96
  16. Healthcare systems data (HSD) has the potential to optimise the efficiency of randomised controlled trials (RCTs), by decreasing trial-specific data demands. Therefore, the use of HSD in trials is expected to ...

    Authors: Alice-Maria Toader, Carrol L. Gamble, Susanna Dodd and Paula R. Williamson
    Citation: Trials 2024 25:95
  17. Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, iss...

    Authors: Alice-Maria Toader, Marion K. Campbell, Jennifer K. Quint, Michael Robling, Matthew R Sydes, Joanna Thorn, Alexandra Wright-Hughes, Ly-Mee Yu, Tom. E. F. Abbott, Simon Bond, Fergus J. Caskey, Madeleine Clout, Michelle Collinson, Bethan Copsey, Gwyneth Davies, Timothy Driscoll…
    Citation: Trials 2024 25:94
  18. The menstrual cycle and its impact on training and performance are of growing interest. However, evidence is lacking whether periodized exercise based on the menstrual cycle is beneficial. The primary purpose ...

    Authors: Linda Ekenros, Philip von Rosen, Jessica Norrbom, Hans-Christer Holmberg, Carl Johan Sundberg, Cecilia Fridén and Angelica Lindén Hirschberg
    Citation: Trials 2024 25:93
  19. Procedural sedation is essential for optimizing upper gastrointestinal endoscopy, particularly in high-risk patients with multiple underlying diseases. Respiratory and circulatory complications present signifi...

    Authors: Zhi Li, Daming Yuan, Yu Yu, Jie Xu, Weili Yang, Li Chen and Nanbo Luo
    Citation: Trials 2024 25:92
  20. Antimicrobial resistance (AMR) is a rising threat in low-resource settings, largely driven by transmission in the community, outside health facilities. Inappropriate antibiotic use is one of the main modifiabl...

    Authors:
    Citation: Trials 2024 25:91
  21. Retinitis pigmentosa (RP) is an inherited disease characterized by a progressive loss of rod photoreceptors of the eye, leading to irreversible blindness. To date, to our knowledge, no clinical prospective stu...

    Authors: Wei Zhou, Ziyang Huang, Kai Xu, Yamin Li, Xiaoyu Li, Jiaxian Li, Yu Jin, Torkel Snellingen and Lina Liang
    Citation: Trials 2024 25:89
  22. Respiratory viral illness (RVI)—e.g., influenza, COVID-19—is a serious threat in long-term care (LTC) facilities. Standard infection control measures are suboptimal in LTC facilities because of residents’ cogn...

    Authors: Hayden P. Nix, Samantha Meeker, Caroline E. King, Melissa Andrew, Ian R. C. Davis, Prosper S. Koto, Meaghan Sim, Jennifer Murdoch, Glenn Patriquin, Chris Theriault, Stephanie Reidy, Michael Rockwood, Tara Sampalli, Samuel D. Searle and Kenneth Rockwood
    Citation: Trials 2024 25:88
  23. Despite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years of age in sub-Saharan Africa. Cerebral malaria (CM), defined as Plasmodi...

    Authors: Nginache Nampota-Nkomba, Osward M. Nyirenda, Jane Mallewa, Yamikani Chimalizeni, Nettie Dzabala, Michael P. Fay, Mathangi Gopalakrishnan, Matthew B. Laurens, Nicole F. O’Brien, Louis H. Miller, Susan K. Pierce, Brittany A. Riggle and Douglas G. Postels
    Citation: Trials 2024 25:87
  24. Lower respiratory tract infections (LRTIs) are among the most frequent infections and a significant contributor to inappropriate antibiotic prescription. Currently, no single diagnostic tool can reliably ident...

    Authors: Cécile Bessat, Roland Bingisser, Markus Schwendinger, Tim Bulaty, Yvan Fournier, Vincent Della Santa, Magali Pfeil, Dominique Schwab, Jörg D. Leuppi, Nicolas Geigy, Stephan Steuer, Friedemann Roos, Michael Christ, Adriana Sirova, Tanguy Espejo, Henk Riedel…
    Citation: Trials 2024 25:86
  25. A high concentration of inspired supplemental oxygen may possibly cause hypercapnia and acidosis and increase mortality in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Ev...

    Authors: Arne Sylvester Rønde Jensen, Jan Brink Valentin, Mathilde Gundgaard Mulvad, Victor Hagenau, Søren Helbo Skaarup, Søren Paaske Johnsen, Ulla Væggemose and Martin Faurholdt Gude
    Citation: Trials 2024 25:85
  26. Dermatitis is a skin condition caused by multiple causes, including radiotherapy treatment. Pharmacological treatments can become chronic and are not exempt from side effects. The latest recommendations of the...

    Authors: Celia Jimenez-Garcia, Luis Angel Perula-de Torres, Enrique Villegas-Becerril, Juan Jose Muñoz-Gavilan, Maria Espinosa-Calvo, Gertrudis Montes-Redondo and Esperanza Romero-Rodriguez
    Citation: Trials 2024 25:84
  27. For the potential benefits of trials to reach all that they should, trials must be designed to ensure that those taking part reflect the population who will receive the intervention. However, adults with impai...

    Authors: Victoria Shepherd, Katherine Joyce, Amanda Lewis, Samantha Flynn, Madeleine Clout, Brittany Nocivelli, Jeremy Segrott and Shaun Treweek
    Citation: Trials 2024 25:83
  28. Cognitive impairments are prevalent across mood disorders and psychosis spectrum disorders, but there is a lack of real-life-like cognitive training programmes. Fully immersive virtual reality has the potentia...

    Authors: Andreas E. Jespersen, Anders Lumbye, Maj Vinberg, Louise Glenthøj, Merete Nordentoft, Eva E. Wæhrens, Gitte M. Knudsen, Guido Makransky and Kamilla W. Miskowiak
    Citation: Trials 2024 25:82
  29. Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmenta...

    Authors: Corinna Engel, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Ana Vilan, Mari Falck, Isabella Mauro, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht…
    Citation: Trials 2024 25:81
  30. In an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, pro...

    Authors: Elmir Omerovic, Mark Petrie, Björn Redfors, Stephen Fremes, Gavin Murphy, Guillaume Marquis-Gravel, Alexandra Lansky, Eric Velazquez, Divaka Perera, Christopher Reid, Julian Smith, Peter van der Meer, Eric Lipsic, Peter Juni, John McMurray, Johann Bauersachs…
    Citation: Trials 2024 25:80
  31. In early 2021, the Department of Health and Social Care in the UK called for research on the safety and immunogenicity of concomitant administration of COVID-19 and influenza vaccines. Co-administration of the...

    Authors: Rosie Harris, Russell Thirard, Sarah Baos, Rajeka Lazarus, Rachel Todd, Jana Kirwan, Katherine Joyce, David Hutton, Maddie Clout, Heike Cappel-Porter, Lucy Culliford and Chris A. Rogers
    Citation: Trials 2024 25:79
  32. Unplanned hospital presentations may occur post-stroke due to inadequate preparation for transitioning from hospital to home. The Recovery-focused Community support to Avoid readmissions and improve Participation...

    Authors: Monique F. Kilkenny, Muideen T. Olaiya, Janette Cameron, Natasha A. Lannin, Nadine E. Andrew, Amanda G. Thrift, Maree Hackett, Ian Kneebone, Avril Drummond, Vincent Thijs, Olivia Brancatisano, Joosup Kim, Megan Reyneke, Shaun Hancock, Liam Allan, Fiona Ellery…
    Citation: Trials 2024 25:78
  33. Severe acute respiratory syndrome coronavirus 2 will coexist with humans for a long time, and it is therefore important to develop effective treatments for coronavirus disease 2019 (COVID-19). Recent studies h...

    Authors: Xinlun Tian, Yan Xu, Luo Wang, Chongya Dong, Xiaoyan Yan, Junping Fan, Huaiya Xie, Hong Zhang, Jinglan Wang, Yongjian Liu, Yaqi Wang, Siqi Pan, Aohua Wu, Xueqi Liu, Chen Yao and Mengzhao Wang
    Citation: Trials 2024 25:77
  34. Physical activity levels are low in people with Parkinson’s disease (PD) and have proved difficult to increase with exercise programs alone. Intervention approaches that address both the capacity to engage in ...

    Authors: Sandra G. Brauer, Robyn M. Lamont and John D. O’Sullivan
    Citation: Trials 2024 25:76
  35. The onset of disability in bathing is particularly important for older adults as it can be rapidly followed by disability in other daily activities; this may represent a judicious time point for intervention i...

    Authors: Phillip J. Whitehead, Stuart Belshaw, Samantha Brady, Elizabeth Coleman, Alexandra Dean, Laura Doherty, Caroline Fairhurst, Sandra Francis-Farrell, Miriam Golding-Day, Joanne Gray, Maisie Martland, Jennifer McAnuff, Andrew McCarthy, Peter McMeekin, Natasha Mitchell, Melanie Narayanasamy…
    Citation: Trials 2024 25:75
  36. Postoperative pulmonary complications (PPCs) extend the length of stay of patients and increase the perioperative mortality rate after video-assisted thoracoscopic (VATS) pulmonary surgery. Thoracic paraverteb...

    Authors: Jiayu Zhu, Biyu Wei, Lili Wu, He Li, Yi Zhang, Jinfeng Lu, Shaofei Su, Chunhua Xi, Wei Liu and Guyan Wang
    Citation: Trials 2024 25:74
  37. Maternal oxygen supplementation is usually used as an intrauterine resuscitation technique to prevent fetal hypoxia and acidemia during delivery. However, there has been a great deal of controversy regarding t...

    Authors: Yun-Hui Li, Gui-Yu Lei, Jun Guo, Meng Yi, Yu-Jing Fu and Gu-Yan Wang
    Citation: Trials 2024 25:73
  38. Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that delivers oxygen pressures in proportion to electrical signals of the diaphragm. The proportional assistance can be adjusted ...

    Authors: Grace Poole, Christopher Harris, Sandeep Shetty, Theodore Dassios, Allan Jenkinson and Anne Greenough
    Citation: Trials 2024 25:72

    The Correction to this article has been published in Trials 2024 25:109

  39. In mental health care, the number of patients with diverse cultural backgrounds is growing. Nevertheless, evaluated training programs for transcultural competence are missing. Barriers for engaging in transcul...

    Authors: Selina Studer, Maria Kleinstäuber, Ulrike von Lersner and Cornelia Weise
    Citation: Trials 2024 25:71
  40. Delamanid and bedaquiline are two of the most recently developed antituberculosis (TB) drugs that have been extensively studied in patients with multidrug-resistant TB. There is currently a need for more poten...

    Authors: Rodney Dawson, Andreas H. Diacon, Simbarashe Takuva, Yongge Liu, Bo Zheng, Vatsala Karwe and Jeffrey Hafkin
    Citation: Trials 2024 25:70
  41. The perioperative antibiotic prophylaxis with 1st or 2nd generation cephalosporins is evidence-based in orthopedic surgery. There are, however, situations with a high risk of prophylaxis-resistant surgical sit...

    Authors: Ilker Uçkay, Hagen Bomberg, Markus Risch, Daniel Müller, Michael Betz and Mazda Farshad
    Citation: Trials 2024 25:69
  42. Uterine leiomyomas are common for reproductive-aged women and affect women’s quality of life due to heavy menstrual bleeding or dysmenorrhea. Leiomyomas grow according to estradiol exposure and decrease after ...

    Authors: Naoki Kawahara, Ryuji Kawaguchi, Konosuke Yamamoto, Kyohei Nishikawa, Motoki Matsuoka, Tomoka Maehana, Yosuke Fukui, Shoichiro Yamanaka, Sumire Sugimoto, Kana Iwai, Yuki Yamada, Hiroyuki Kurakami, Takumi Hirata, Ryuzo Takashima, Shota Suzuki, Kiyoshi Asada…
    Citation: Trials 2024 25:68
  43. Mastectomies are commonly performed and strongly associated with chronic postsurgical pain (CPSP), more specifically termed postmastectomy pain syndrome (PMPS), with 25–60% of patients reporting pain 3 months ...

    Authors: Jing Wang, Lisa V. Doan, Deborah Axelrod, John Rotrosen, Binhuan Wang, Hyung G. Park, Robert R. Edwards, Michele Curatolo, Carina Jackman and Raven Perez
    Citation: Trials 2024 25:67
  44. Robotic-assisted bronchoscopy has recently emerged as an alternative to electromagnetic navigational bronchoscopy for the evaluation of peripheral pulmonary lesions. While robotic-assisted bronchoscopy is prop...

    Authors: Rafael Paez, Robert J. Lentz, Cristina Salmon, Justin K. Siemann, See-Wei Low, Jonathan D. Casey, Heidi Chen, Sheau-Chiann Chen, Sameer Avasarala, Samira Shojaee, Otis B. Rickman, Christopher J. Lindsell, Cheryl L. Gatto, Todd W. Rice and Fabien Maldonado
    Citation: Trials 2024 25:66
  45. Minimally invasive direct coronary artery bypass (MIDCAB) surgery offers an effective option for coronary artery disease (CAD) patients with the avoidance of median sternotomy and fast postoperative recovery. ...

    Authors: Ling Xin, Lu Wang and Yi Feng
    Citation: Trials 2024 25:65
  46. Atelectasis after anesthesia induction in most patients undergoing general anesthesia may lead to postoperative pulmonary complications (PPCs) and affect postoperative outcomes. However, there is still no exis...

    Authors: Di Zhang, Yi Liang, Di Bao, Wei Xiong, Lu Li, Yaxin Wang, Bin Liu and Xu Jin
    Citation: Trials 2024 25:64
  47. Rectovaginal fistula (RVF) is an abnormal channel formed by epithelial tissue between the anterior wall of the rectum and the posterior wall of the vagina, which manifests as vaginal gassing and defecation. It...

    Authors: Dao-xiong Ye, Sheng-hui Huang, Yu Lin, Ying-Huang and Pan Chi
    Citation: Trials 2024 25:63
  48. The Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i) trial is being conducted to establish whether ‘screening and intervention’, consisting of usual school practice plus a p...

    Authors: Susan Ball, Tessa Reardon, Cathy Creswell, Lucy Taylor, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence…
    Citation: Trials 2024 25:62

Annual Journal Metrics

  • 2022 Citation Impact
    2.5 - 2-year Impact Factor
    2.5 - 5-year Impact Factor
    0.827 - SNIP (Source Normalized Impact per Paper)
    0.814 - SJR (SCImago Journal Rank)

    2022 Speed
    50 days submission to first editorial decision for all manuscripts (Median)
    188 days submission to accept (Median)

    2022 Usage 
    6,130,958 downloads
    28,089 Altmetric mentions