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  1. Child health and development can be promoted by strengthening and supporting parents. Research on parental support programs based on positive psychology and a health-promoting approach aimed at all parents, an...

    Authors: Lisa Blom, Anna Edenius, Pia Enebrink, Anders Hjern, Sven Arne Silfverdal, Johan Åhlén, Malin Bergström and Lene Lindberg
    Citation: Trials 2023 24:184
  2. Clinical psychomotor skills training is a core component of undergraduate nursing education. Performing technical skills competently involves the use of cognitive and motor function. The training of these tech...

    Authors: Orlaith Hernon, Edel McSharry, Andrew Simpkin, Iain MacLaren and Peter J. Carr
    Citation: Trials 2023 24:182
  3. Adolescents in the U.S. experience significant negative sexual health outcomes, representing a public health priority in the U.S. Research shows that while parents play an influential role in shaping adolescen...

    Authors: Vincent Guilamo-Ramos, Adam Benzekri and Marco Thimm-Kaiser
    Citation: Trials 2023 24:181
  4. Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms.

    Authors: Mark E. McClure, Seerapani Gopaluni, James Wason, Robert B. Henderson, Andre Van Maurik, Caroline C.O. Savage, Charles D. Pusey, Alan D. Salama, Paul A. Lyons, Jacinta Lee, Kim Mynard, David R. Jayne and Rachel B. Jones
    Citation: Trials 2023 24:180
  5. Around one-third of workdays lost in Norway are due to musculoskeletal conditions, with persistent (chronic) pain being the most frequent cause of sick leave and work disability. Increasing work participation ...

    Authors: Pål André Amundsen, Martin Underwood, Kim Burton, Margreth Grotle, Ira Malmberg-Heimonen, Adnan Kisa, Milada Cvancarova Småstuen, Thor Einar Holmgard, Amy Martinsen, Jakob Lothe, Pernille Marie Stähr Irgens, Magnus Højen, Sølvi Spilde Monsen and Robert Froud
    Citation: Trials 2023 24:179
  6. Immunosuppression in transplantation continues to be associated with a multitude of adverse effects. Induction of immune tolerance may be a viable strategy to reduce dependence on immunosuppression. Various tr...

    Authors: Sam Kant, Dixon B. Kaufman, Lenuta Micsa and Daniel C. Brennan
    Citation: Trials 2023 24:178
  7. Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases globally. Pharmacological treatments for NAFLD are still limited. Silymarin, a compound extracted from Silybum marianum, is an...

    Authors: Camila Ribeiro de Avelar, Beatriz Vieira Coelho Nunes, Betina da Silva Sassaki, Mariana dos Santos Vasconcelos, Lucivalda Pereira Magalhães de Oliveira, André Castro Lyra, Allain Amador Bueno and Rosângela Passos de Jesus
    Citation: Trials 2023 24:177
  8. Oesophageal cancer (EC) is the sixth leading cause of cancer death worldwide. Oesophageal resection is the only curative treatment option for EC which is frequently performed via an abdominal and right thoraci...

    Authors: Rosa Klotz, Markus K. Diener, Thomas Schmidt, Thilo Hackert, Sandra Graf, Hans F. Fuchs, Peter Grimminger, Jan-Hendrick Egberts, Ines Gockel, Pieter C. van der Sluis, Colette Doerr-Harim, Christina Klose, Manuel Feißt and Andre L. Mihaljevic
    Citation: Trials 2023 24:175
  9. Research reveals a high prevalence of stressors in adolescence. Mental health in adolescence is highly related to life-stressors exposure and difficulties in adjusting to stressors. Therefore, interventions fo...

    Authors: Paulina Zelviene, Agniete Kairyte, Austeja Dumarkaite, Augustė Nomeikaite and Evaldas Kazlauskas
    Citation: Trials 2023 24:174
  10. Pulmonary rehabilitation (PR) is a core component of management people with chronic obstructive pulmonary disease (COPD); yet, people with COPD face significant barriers to attending centre-based PR programs. ...

    Authors: Narelle S Cox, Anne E Holland, Arwel W Jones, Christine F McDonald, Paul O’Halloran, Ajay Mahal, Graham Hepworth and Natasha A Lannin
    Citation: Trials 2023 24:173
  11. Gait disorders and cognitive impairments are prime causes of disability and institutionalization after stroke. We hypothesized that relative to single-task gait rehabilitation (ST GR), cognitive-motor dual-tas...

    Authors: Sophie Tasseel-Ponche, Martine Roussel, Monica N. Toba, Thibaud Sader, Vincent Barbier, Arnaud Delafontaine, Jonathan Meynier, Carl Picard, Jean-Marc Constans, Alexis Schnitzler, Olivier Godefroy and Alain Pierre Yelnik
    Citation: Trials 2023 24:172
  12. Underrepresentation of disabled groups in clinical trials results in an inadequate evidence base for their clinical care, which drives health inequalities. This study aims to review and map the potential barri...

    Authors: Sameed Shariq, Alexandra M Cardoso Pinto, Shyam Sundar Budhathoki, Marie Miller and Suzie Cro
    Citation: Trials 2023 24:171
  13. Autism spectrum disorder is a developmental disability with first signs appearing in children aged 3 years and younger. Given that autism spectrum disorder is accompanied by a broad range of symptoms such as i...

    Authors: Mahrokh Dehghani, Amir Ali Jafarnezhadgero, Mohamad Abdollahpour Darvishani, Shirin Aali and Urs Granacher
    Citation: Trials 2023 24:170
  14. Blind/low vision (BLV) severely limits information about our three-dimensional world, leading to poor spatial cognition and impaired navigation. BLV engenders mobility losses, debility, illness, and premature ...

    Authors: Mahya Beheshti, Tahereh Naeimi, Todd E. Hudson, Chen Feng, Pattanasak Mongkolwat, Wachara Riewpaiboon, William Seiple, Rajesh Vedanthan and John-Ross Rizzo
    Citation: Trials 2023 24:169
  15. The incidence of colorectal cancer among the middle-aged and elderly is gradually increasing in China. Colonoscopy is an effective method for the early diagnosis of colorectal cancer, and bowel preparation is ...

    Authors: Xing Wang Zhu, Jun Yan, Long Miao, Ying Li He, Hai Ping Wang and Xun Li
    Citation: Trials 2023 24:168
  16. The primary objective is to determine the proportion of men with suspected prostate cancer (PCA) in whom the management plans are changed by additive gallium-68 prostate-specific membrane antigen positron emis...

    Authors: P. Krausewitz, R. A. Bundschuh, F. C. Gaertner, M. Essler, U. Attenberger, J. Luetkens, G. Kristiansen, M. Muders, C-H. Ohlmann, S. Hauser, J. Ellinger and M. Ritter
    Citation: Trials 2023 24:167
  17. Aspirin is widely used for cardioprotection with its antiplatelet effects due to the blocking of thromboxane A2 production. However, it has been suggested that platelet abnormalities in those with diabetes pre...

    Authors: Sarah Parish, Georgina Buck, Theingi Aung, Marion Mafham, Sarah Clark, Michael R. Hill, Rory Collins, Louise Bowman and Jane Armitage
    Citation: Trials 2023 24:166
  18. Alternatively to conventional treatments, chemo-mechanical caries removal agents can be used. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orell...

    Authors: Luiz Filipe Barbosa Martins, Leandro Rodrigues de Sena, Diego Martins de Paula, Victor Pinheiro Feitosa, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Lara Jansiski Motta, Marcela Leticia Leal Gonçalves and Sandra Kalil Bussadori
    Citation: Trials 2023 24:165
  19. Recruitment of participants is crucial to the success of randomised control trials (RCTs) but can be challenging and expensive. Current research on trial efficiency is often focused at the patient-level with a...

    Authors: Michelle Tew, Max Catchpool, John Furler, Katie De La Rue, Philip Clarke, Jo-Anne Manski-Nankervis and Kim Dalziel
    Citation: Trials 2023 24:164
  20. Causes and consequences of chronic stress levels in the context of healthcare work are well examined. Nevertheless, the implementation and evaluation of high-quality interventions to reduce stress of healthcar...

    Authors: Hannes Baumann, Luis Heuel, Laura L. Bischoff and Bettina Wollesen
    Citation: Trials 2023 24:163
  21. The lateral ankle sprain (LAS) is the most common injury in the field of everyday and sports-related activities. There is a high rate of patients with LAS who will develop chronic ankle instability (CAI). A po...

    Authors: Janina Tennler, Christian Raeder, Arthur Praetorius, Tobias Ohmann and Christian Schoepp
    Citation: Trials 2023 24:162
  22. Administration of Janus kinase (JAK) inhibitors and biological disease-modifying antirheumatic drugs has dramatically improved even the clinical outcomes in patients with rheumatoid arthritis (RA) and an inade...

    Authors: Toshimasa Shimizu, Shin-ya Kawashiri, Shimpei Morimoto, Yurika Kawazoe, Shohei Kuroda, Rina Kawasaki, Yasuko Ito, Rieko Kiya, Shuntaro Sato, Hiroshi Yamamoto and Atsushi Kawakami
    Citation: Trials 2023 24:161
  23. Treatment fidelity (TF) refers to methodological strategies used to monitor and enhance the reliability and validity of interventions. We evaluated TF in a pragmatic RCT of music therapy (MT) for premature inf...

    Authors: Tora Söderström Gaden, Christian Gold, Jörg Assmus, Ingrid Kvestad, Andreas Størksen Stordal, Łucja Bieleninik and Claire Ghetti
    Citation: Trials 2023 24:160
  24. Recruiting participants for lifestyle programmes is known to be challenging. Insights into recruitment strategies, enrolment rates and costs are valuable but rarely reported. We provide insight into the costs ...

    Authors: Josine M. Stuber, Beryl A. C. E. van Hoek, Anne L. Vos, Edith G. Smit, Jeroen Lakerveld, Joreintje D. Mackenbach and Joline W. J. Beulens
    Citation: Trials 2023 24:159
  25. Clinical trial participants have a right to be informed throughout the entire process of human subject research. As part of this pillar of research ethics, participants and other stakeholders should be made aw...

    Authors: Colleen E. Shelly, Caroline Logan, Beth Skorochod, Alison Wiyeh, Duduzile Ndwandwe, Augustine Choko, Innocent Valea and Boghuma K. Titanji
    Citation: Trials 2023 24:158
  26. Trials in pre-hospital trauma care are relatively uncommon. There are logistical and methodological challenges related to designing and delivering trials in this setting. Previous studies have assessed challen...

    Authors: Louisa Lawrie, Eilidh M. Duncan, Robert Lendrum, Victoria Lebrec and Katie Gillies
    Citation: Trials 2023 24:157
  27. So far, the recovery quality after general anesthesia is still unsatisfied. Nalmefene is a drug to treat opioid overdose and reverse opioid actions. We aim to investigate the efficacy of nalmefene on optimizin...

    Authors: Xiaowen Ma, Jueying Liu, Ying Tang, Qiueyue Lian, Xiaorong Huai, Wanfeng Liu and Diansan Su
    Citation: Trials 2023 24:156
  28. Chronic daily headaches (CDH) are common and associated with significant morbidity, poor quality of life, and substantial burden on the healthcare system. CDH tends to be refractory to conventional medical man...

    Authors: Yasmine Hoydonckx, Mandeep Singh, Ian Gilron, James Khan, Samer Narouze, Albert Dahan, Kathryn Curtis, Xingshan Cao, Jamal Kara and Anuj Bhatia
    Citation: Trials 2023 24:155
  29. There is growing evidence that Internet-based cognitive behavioral therapy (ICBT) is as effective as a stand-alone treatment and helps facilitating access to treatment. Given the complexity of the treatment, w...

    Authors: Jan Marius Schittenhelm, Christoph von Borell, Celina Clément, Johanna Schüller, Ulrich Stangier and Juergen Hoyer
    Citation: Trials 2023 24:154
  30. Intermittent exotropia (IXT) is the most common type of strabismus in China, but the best treatment and optimal timing of intervention for IXT remain controversial, particularly for children with moderate IXT ...

    Authors: Tao Shen, Jingchang Chen, Ying Kang, Daming Deng, Xiaoming Lin, Heping Wu, Jinrong Li, Zhonghao Wang, Xuan Qiu, Ling Jin and Jianhua Yan
    Citation: Trials 2023 24:153
  31. Minimally invasive surgery has become popular as a surgical approach for colorectal cancer because it has fewer complications related to the abdominal incision and perioperative complications. However, the inc...

    Authors: Soo Yeun Park, Gi Won Ha, Soo Young Lee, Chang Hyun Kim and Gyung Mo Son
    Citation: Trials 2023 24:152
  32. Informed consent is considered a fundamental requirement for participation in trials, yet obtaining consent is challenging in a number of populations and settings. This may be due to participants having commun...

    Authors: Amy M. Russell, Victoria Shepherd, Kerry Woolfall, Bridget Young, Katie Gillies, Anna Volkmer, Mark Jayes, Richard Huxtable, Alexander Perkins, Nurulamin M. Noor, Beverley Nickolls and Julia Wade
    Citation: Trials 2023 24:151
  33. The perimenopausal transition is accompanied by psychiatric symptoms in over 10% of women. Symptoms commonly include depressed mood and anhedonia and less commonly include psychosis. Psychiatric symptoms have ...

    Authors: Melissa J. M. Walsh, Kathryn Gibson, Megan Hynd, Tory A. Eisenlohr-Moul, Erin C. Walsh, Lauren Schiff, Fred Jarskog, David Lalush, Gabriel S. Dichter and Crystal E. Schiller
    Citation: Trials 2023 24:150
  34. Research into life-threatening illnesses which require emergency hospitalisation is essential. This group of patients is unique in that they are experiencing an unfolding emergency when they are approached, en...

    Authors: David S. Lawrence, Agnes Ssali, Joseph N. Jarvis and Janet Seeley
    Citation: Trials 2023 24:149
  35. There is a current lack of knowledge regarding optimal rehabilitation and duration of sling immobilization after an open Latarjet procedure. A shift towards immediate self-rehabilitation protocols in shoulder ...

    Authors: Patrick Goetti, Tiago Martinho, Antoine Seurot, Hugo Bothorel and Alexandre Lädermann
    Citation: Trials 2023 24:148
  36. People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is...

    Authors: Fiona E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. Smith, Katherine Lloyd, Edward W. Richfield, Danielle E. Brazier, Mícheál Ó Breasail, Agnes J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh…
    Citation: Trials 2023 24:147
  37. Postoperative cognitive dysfunction (POCD) refers to a neurological dysfunction after a major surgery and anesthesia. It is common in elderly patients and is characterized by impairment in consciousness, orien...

    Authors: Xiaoyi Zhang, Yuwen Chen, Ying Tang, Yizhe Zhang, Xiao Zhang and Diansan Su
    Citation: Trials 2023 24:146
  38. The seemingly simple tasks of standing and walking require continuous integration of complex spinal reflex circuits between descending motor commands and ascending sensory inputs. Spinal cord injury greatly im...

    Authors: Andreas Skiadopoulos, Grace O. Famodimu, Shammah K. Solomon, Parul Agarwal, Noam Y. Harel and Maria Knikou
    Citation: Trials 2023 24:145
  39. Perioperative pain management is one of the most challenging issues for patients with spinal neoplasms. Inadequate postoperative analgesia usually leads to severe postsurgical pain, which could cause patients ...

    Authors: Wanchen Sun, Juan Wang, Jing Wang, Jingyi Fan, Yang Zhou, Yunzhen Wang and Ruquan Han
    Citation: Trials 2023 24:144
  40. To explore the effects of Ving Tsun (VT) sticking-hand training on knee joint proprioception and leg muscular performance among community-dwelling middle-aged and older adults.

    Authors: Shirley S. M. Fong, Louisa M. Y. Chung, Timothy T. T. Yam, Joanne W. Y. Chung, Young-Hyeon Bae, Yang Gao, Jessie S. M. Chan and Hsing-Kuo Wang
    Citation: Trials 2023 24:143
  41. In parallel to the traditional symptomatology, deficits in cognition (memory, attention, reasoning, social functioning) contribute significantly to disability and suffering in individuals with schizophrenia. C...

    Authors: Clément Dondé, Julien Bastin, Arnaud Pouchon, Nicolas Costes, Eric Fakra, Filipe Galvão, Aurélia Gay, Frédéric Haesebaert, Laurent Lamalle, Inès Mérida, Maxence Rigon, Fabien Schneider, Irène Troprès, Jérôme Brunelin and Mircea Polosan
    Citation: Trials 2023 24:141
  42. Haemorrhoids are common and frequently occurring diseases in the clinical setting, and severe haemorrhoids require surgical treatment. There are various surgical methods to treat haemorrhoids, but each has adv...

    Authors: Keqiang Yu, Haijun Li, Ping Xue, Zhidi Xie, Minghui Tang, Hongbo He and Jing Wu
    Citation: Trials 2023 24:140
  43. Periodontal disease and lung function impairment were found to be associated with low-grade systemic or local inflammation, and it might be that gingival/periodontal inflammation triggers lung function due to ...

    Authors: Jan Kühnisch, Tianyu Zhao, Randi J. Bertelsen, Rudolf A. Jörres, Dennis Nowak and Joachim Heinrich
    Citation: Trials 2023 24:139
  44. Child maltreatment (CM) is a pervasive public health problem and there is a critical need for brief, effective, scalable prevention programs. Problematic parent-child relationships lie at the heart of CM. Pare...

    Authors: Samantha Schilling, Byron J. Powell, Paul W. Stewart and Joanne N. Wood
    Citation: Trials 2023 24:138
  45. The OPTIMIZE trial is a multi-site, comparative effectiveness research (CER) study that uses a Sequential Multiple Assessment Randomized Trial (SMART) designed to examine the effectiveness of complex health in...

    Authors: Julie M. Fritz, Tom Greene, Gerard P. Brennan, Kate Minick, Elizabeth Lane, Stephen T. Wegener and Richard L. Skolasky
    Citation: Trials 2023 24:137

    The Study protocol to this article has been published in BMC Musculoskeletal Disorders 2020 21:293

  46. Adults with intellectual disabilities have a higher prevalence of unhealthy eating habits, stress, low levels of mobility, and comparable drug consumption as the general population. Consequently, they suffer f...

    Authors: Stephan Nadolny, Dirk Bruland, Marie Grunwald, Annika Gröndahl, Jessica Grammatico, Miriam Tariba Richter, Christian Grebe and Änne-Dörte Latteck
    Citation: Trials 2023 24:136
  47. Induction of labour (IOL) at 39 weeks has been shown to decrease maternal and neonatal adverse outcomes. Given the growing demand for 39-week IOL, it is imperative that effective methods be assessed for induct...

    Authors: Sarah M. Nicholson, Orla Smith, Susan Hatt, Zara Molphy, Patrick Dicker, Karen Flood and Fergal Malone
    Citation: Trials 2023 24:135
  48. Breast cancer (BC) is the most common invasive cancer in women, and exercise can significantly improve the outcomes of BC survivors. MoviS (Movement and Health Beyond Care) is a randomized controlled trial aim...

    Authors: Valentina Natalucci, Carlo Ferri Marini, Mauro De Santi, Giosuè Annibalini, Francesco Lucertini, Luciana Vallorani, Andrea Rocco Panico, Davide Sisti, Roberta Saltarelli, Sabrina Donati Zeppa, Deborah Agostini, Marco Gervasi, Giulia Baldelli, Eugenio Grassi, Alessandra Nart, Massimo Rossato…
    Citation: Trials 2023 24:134
  49. Deep inspiration breath hold (DIBH) reduces radiotherapy cardiac dose for left-sided breast cancer patients. The primary aim of the BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Hear...

    Authors: Hilary L. Byrne, Elisabeth Steiner, Jeremy Booth, Gillian Lamoury, Marita Morgia, Kylie Richardson, Leigh Ambrose, Kuldeep Makhija, Cameron Stanton, Benjamin Zwan, Regina Bromley, John Atyeo, Shona Silvester, Natalie Plant and Paul Keall
    Citation: Trials 2023 24:132

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