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  1. Moderately severe or major trauma (injury severity score (ISS) > 8) is common, often resulting in physical and psychological problems and leading to difficulties in returning to work. Vocational rehabilitation...

    Authors: Denise Kendrick, Rebecca Lindley, Lauren Blackburn, Cristina Roadevin, Ellen Thompson, Isabel Andrews, Fahim Anwar, Adam Brooks, Edd Carlton, Robert Crouch, Florence Day, Steve Fallon, Amanda Farrin, Laura Graham, Karen Hoffman, Rebekah Howell…
    Citation: Trials 2024 25:439
  2. Colon cancer is a global health concern, ranking fifth in both new diagnoses and deaths among tumors worldwide. Surgical intervention remains the primary treatment for localized cases, with a historical evolut...

    Authors: Vladimir Balaban, Mikhail Mutyk, Nikolay Bondarenko, Stanislav Zolotukhin, Oleg Sovpel, Igor Sovpel, Dmitriy Zykov, Igor Rublevskiy, Mikhail Klochkov, Alfredo Ponce Prado, Mingze He and Petr Tsarkov
    Citation: Trials 2024 25:438
  3. Compared to traditional thoracotomy, transapical transcatheter aortic valve implantation (TAVI) surgery offers reduced trauma and faster recovery, fostering the adoption of enhanced recovery after surgery (ERA...

    Authors: Cheng Xiao, Fang Chen, Lei Cao, Ming Yang, Yuting Tan, Guoyun Lin, Guiying Yang, Sheng Jing and Hong Li
    Citation: Trials 2024 25:436
  4. Hypertensive disorders of pregnancy (HDP) pose significant risks to both maternal and fetal health, contributing to global morbidity and mortality. Management of HDP is complex, particularly because of concern...

    Authors: Ju-Seung Kwun, Jina Choi, Yeonyee E. Yoon, Hong-Mi Choi, Jee Yoon Park, Hyeon Ji Kim, Min Jung Lee, Bo Young Choi, Sooyoung Yoo and Jung-Won Suh
    Citation: Trials 2024 25:435
  5. Postoperative delirium (POD) is a common complication that is characterized by acute onset of impaired cognitive function and is associated with an increased mortality, a prolonged duration of hospital stay, a...

    Authors: Yi Cheng, Ying Gao, Gu-Yue Liu, Fu‑Shan Xue and Mu Jin
    Citation: Trials 2024 25:434
  6. Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surfactant administration are to reduce the duration of mechanic...

    Authors: Giovanni Vento, Angela Paladini, C. Aurilia, S. Alkan Ozdemir, V. P. Carnielli, F. Cools, S. Costa, F. Cota, C. Dani, P. G. Davis, S. Fattore, C. Fè, N. Finer, F. P. Fusco, C. Gizzi, E. Herting…
    Citation: Trials 2024 25:433
  7. Use of sedatives and analgesics is associated with the occurrence of delirium in critically ill patients receiving mechanical ventilation. Dexmedetomidine reduces the occurrence of delirium but may cause hypot...

    Authors: Wenhui Zhang, Jinjin You, Jing Hu, Xiangding Chen, Han Wang, Nan Li, Chen Wei, Wanchun Tang and Xiangrong Zuo
    Citation: Trials 2024 25:431
  8. Rural African people living with HIV face significant challenges in entering and remaining in HIV care. In rural Uganda, for example, there is a threefold higher prevalence of HIV compared to the national aver...

    Authors: Radhika Sundararajan, Misha Hooda, Yifan Lai, Denis Nansera, Carolyn Audet, Jennifer Downs, Myung Hee Lee, Margaret McNairy, Winnie Muyindike and Juliet Mwanga-Amumpaire
    Citation: Trials 2024 25:430
  9. Randomised trials are essential to reliably assess medical interventions. Nevertheless, interpretation of such studies, particularly when considering absolute effects, is enhanced by understanding how the tria...

    Authors: Guilherme Pessoa-Amorim, Raphael Goldacre, Charles Crichton, Will Stevens, Michelle Nunn, Andy King, Dave Murray, Richard Welsh, Heather Pinches, Andrew Rees, Eva J. A. Morris, Martin J. Landray, Richard Haynes, Peter Horby, Karl Wallendszus, Leon Peto…
    Citation: Trials 2024 25:429
  10. Isolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive dysfunctions predict earlier phenotypic conversion from iRBD to Parki...

    Authors: Anja Ophey, Sinah Röttgen, Julia Pauquet, Kim-Lara Weiß, Daniel Scharfenberg, Christopher E. J. Doppler, Aline Seger, Clint Hansen, Gereon R. Fink, Michael Sommerauer and Elke Kalbe
    Citation: Trials 2024 25:428
  11. Acute leukaemias (AL) are life-threatening blood cancers that can be potentially cured with treatment involving myelosuppressive, multiagent, intensive chemotherapy (IC). However, such treatment is associated ...

    Authors: Lydia Flett, Radwa Abdelatif, Sarah Akhtar Baz, Samantha Brady, Belén Corbacho, Kate Common, Abbie Cowling, Caroline Fairhurst, Ellie Fitzmaurice, Shreyans Gandhi, Andrea Hilton, William Hope, Alex Howard, Joanne Laycock, Patrick Lillie, Gemma Mitchell…
    Citation: Trials 2024 25:427
  12. Current management of mesenteric ischemia is primarily endovascular stent treatment. Typical CMI symptoms are postprandial abdominal pain, food fear, weight loss, and diarrhea. Revascularization is often neces...

    Authors: Alexandra A. Brandtzäg, Jonas P. Eiberg, Lars Lönn, Mikkel Taudorf and Timothy A. Resch
    Citation: Trials 2024 25:426
  13. Social isolation and loneliness (SIL) worsens mortality and other outcomes among older adults as much as smoking. We previously tested the impact of the HOW R U? intervention using peer support from similar-ag...

    Authors: David Zheng, Louise Rose, Bjug Borgundvaag, Shelley L. McLeod, Donald Melady, Rohit Mohindra, Samir Sinha, Virginia Wesson, Lesley Wiesenfeld, Sabrina Kolker, Alex Kiss, Judy A. Lowthian and Jacques S. Lee
    Citation: Trials 2024 25:425
  14. Most patients starting chronic in-center hemodialysis (HD) receive conventional hemodialysis (CHD) with three sessions per week targeting specific biochemical clearance. Observational studies suggest that pati...

    Authors: Mariana Murea, Jochen G. Raimann, Jasmin Divers, Harvey Maute, Cassandra Kovach, Emaad M. Abdel-Rahman, Alaa S. Awad, Jennifer E. Flythe, Samir C. Gautam, Vandana D. Niyyar, Glenda V. Roberts, Nichole M. Jefferson, Islam Shahidul, Ucheoma Nwaozuru, Kristie L. Foley, Erica J. Trembath…
    Citation: Trials 2024 25:424
  15. Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low vitamin D levels at birth and a limited intake during the first month. Ente...

    Authors: Mar Romero-Lopez, Jon E. Tyson, Mamta Naik, Claudia Pedroza, Lindsay F. Holzapfel, Elenir Avritscher, Ricardo Mosquera, Amir Khan and Matthew Rysavy
    Citation: Trials 2024 25:423
  16. Bladder dysfunction, notably urinary retention, emerges as a significant complication for cervical cancer patients following radical hysterectomy, predominantly due to nerve damage, severely impacting their po...

    Authors: Yanli Chen, Ling Li, Yuanxiang Shi, Xin Rong, Yan Wang, Jiaojiao Wu, Xiaolong Liang and Zhimin Wu
    Citation: Trials 2024 25:422
  17. Cocaine craving is a central symptom of cocaine use disorders (CUD). Virtual reality cue-exposure therapy for craving (VRCET) allows more immersive, realistic, and controllable exposure than traditional non-VR...

    Authors: T. Lehoux, Antonio Capobianco, Jérôme Lacoste, Sloane Rollier, Yann Mopsus, Manuela Melgire, Flavien Lecuyer, Miguel Gervilla and Luisa Weiner
    Citation: Trials 2024 25:421
  18. Treatment of displaced distal forearm fractures in children has traditionally been closed reduction and pin fixation, although they might heal and remodel without surgery with no functional impairment. No rand...

    Authors: Katrine Rønn Abildgaard, Peter Buxbom, Ole Rahbek, Martin Gottliebsen, Per Hviid Gundtoft, Bjarke Viberg and Stig Brorson
    Citation: Trials 2024 25:420
  19. Mental health literacy is a promising avenue of intervention for addressing the development of psychopathology, as well as its associated consequences, such as a decrease in academic performance. The current s...

    Authors: Cezar Giosan, Alexandru Pană, Ana Cosmoiu, Ana-Maria Chira, Ana-Maria Toma, Claudiu-Cristian Papasteri, Cătălin Nedelcea and Cătălina Popoviciu
    Citation: Trials 2024 25:419
  20. Hemiplegic shoulder pain (HSP) is a common complication after stroke. It severely affects the recovery of upper limb motor function. Early shoulder pain in hemiplegic patients is mainly neuropathic caused by c...

    Authors: Peng Zheng, Yu Shi, Hang Qu, Meng lin Han, Zhi qiang Wang, Qing Zeng, Manxu Zheng and Tao Fan
    Citation: Trials 2024 25:418
  21. According to the World Health Organization, alcohol is a major global public health problem, leading to a significant increase in illness and death. To treat alcohol use disorders, new therapeutic tools are be...

    Authors: Fanny Nègre, Maud Lemercier-Dugarin, Romain Gomet, Antoine Pelissolo, Eric Malbos, Lucia Romo and El-Hadi Zerdazi
    Citation: Trials 2024 25:417
  22. Randomized controlled trials (RCTs) are rigorous scientific research designs for evaluating intervention effectiveness. However, implementing RCTs in a real-world context is challenging. To develop strategies ...

    Authors: Mélanie Levasseur, Agathe Chaintré-Prieur, Marie-France Dubois, Catherine Maisonneuve, Johanne Filiatrault and Helen-Maria Vassiliadis
    Citation: Trials 2024 25:415
  23. Improving outcomes after surgery is a major public health research priority for patients, clinicians and the NHS. The greatest burden of perioperative complications, mortality and healthcare costs lies amongst...

    Authors: Joyce Yeung, Shaman Jhanji, John Braun, Janet Dunn, Lucy Eggleston, Samuel Frempong, Louise Hiller, Claire Jacques, Monica Jefford, James Mason, Ramani Moonesinghe, Rupert Pearse, Benjamin Shelley and Cecilia Vindrola
    Citation: Trials 2024 25:414
  24. Morbid obesity is a complex chronic condition characterized by a body mass index of 40 kg/m2 or higher. The incidence of the condition is on the rise in developed countries, and bariatric surgery has been propose...

    Authors: Alejandro Gómez-Bruton, Pilar Irún, Angel Matute-Llorente, Gabriel Lozano-Berges, Ana Moradell, Susana Ara-Gimeno, Jorge Subias-Perie, Marta Sánchez-Luengo, Gonzalo Hijos-Mallada, Sandra García-Mateo, Samantha Arechavaleta, María José Palacios Fanlo, Angel Lanas and Jose A. Casajús
    Citation: Trials 2024 25:413
  25. Parents of children with a neurodevelopmental disorder (NDD) experience more stress than parents of typically developing children. In a cocreation process with experts and parents, a low-threshold application ...

    Authors: Kim J. M. Tönis, Constance H. C. Drossaert, Peter M. ten Klooster, Marie Schaer, Thomas Bourgeron, Jan K. Buitelaar, Yair Sadaka, Christine M. Freitag, Keren Mayer Lapidus, Andreas G. Chiocchetti, Wouter G. Staal and Ernst T. Bohlmeijer
    Citation: Trials 2024 25:412
  26. The Movethehip trial investigates the effectiveness of an exercise and patient education intervention for adults with acetabular dysplasia. The intervention involves eight tailored one-to-one sessions with tra...

    Authors: Julie S. Jacobsen, Rhiannon Evans, Kelly Morgan, Kristian Thorborg, Lisa G. Oestergaard and Dorthe Sørensen
    Citation: Trials 2024 25:411
  27. Authors: Fabio Silvio Taccone, Rafael Badenes, Carla Bittencourt Rynkowski, Pierre Bouzat, Anselmo Caricato, Pedro Kurtz, Kirsten Moller, Manuel Quintana Diaz, Mathieu Van Der Jagt, Walter Videtta and Jean-Louis Vincent
    Citation: Trials 2024 25:410

    The original article was published in Trials 2023 24:20

  28. Adverse events suffer from poor reporting within randomised controlled trials, despite them being crucial to the evaluation of a treatment. A recent update to the CONSORT harms checklist aims to improve report...

    Authors: Nikki Totton, Ed Waddingham, Ruth Owen, Steven Julious, Dyfrig Hughes and Jonathan Cook
    Citation: Trials 2024 25:409
  29. There are no approved pharmacotherapies for methamphetamine use disorder. Two preliminary phase 2 randomised controlled trials have found mirtazapine, a tetracyclic antidepressant, to be effective in reducing ...

    Authors: Rebecca McKetin, Tayla J. Degan, Lucy Saunders, Long Nguyen, Gregory Dore, Steven Shoptaw, Michael Farrell, Louisa Degenhardt, Peter J. Kelly, Alyna Turner, Philip J. Clare, Olivia M. Dean, Shalini Arunogiri, Samantha Colledge-Frisby, Juanita Koeijers, David Goodman-Meza…
    Citation: Trials 2024 25:408
  30. Due to the burden of musculoskeletal diseases in the elderly and the multifactorial nature of such conditions, controlling the pain caused by these disorders requires multidisciplinary approach. This approach ...

    Authors: Sogand Habibi, Sedigheh Sadat Tavafian, Reza Maghbouli and Ali Montazeri
    Citation: Trials 2024 25:406
  31. The inter-reviewer reliability of the risk of bias (RoB) assessment lacked agreement in previous studies. It is important to analyse these disagreements to improve the repeatability of RoB assessment. The objecti...

    Authors: Yi Yao, Jing Shen, Jianzhao Luo, Nian Li, Xiaoyang Liao and Yonggang Zhang
    Citation: Trials 2024 25:405
  32. Gout remains a leading cause of inflammatory arthritis worldwide, and the main risk factor for gout is persistent hyperuricemia. The clinical management of gout is mostly drug-based, and other treatment option...

    Authors: Manting Cao, Hazwani Ahmad Yusof, Jianer Chen, Mohd Faizal Jalil, Siti Khairizan Rahim and Mohamad Zulfadhli Abdullah
    Citation: Trials 2024 25:404
  33. Disease recurrence remains one of the biggest concerns in patients after resection of pancreatic ductal adenocarcinoma (PDAC). Despite (neo)adjuvant systemic therapy, most patients experience local and/or dist...

    Authors: L. A. Daamen, I. W. J. M. van Goor, V. P. Groot, P. C. M. Andel, L. A. A. Brosens, O. R. Busch, G. A. Cirkel, N. Haj Mohammad, H. D. Heerkens, I. H. J. T. de Hingh, F. Hoogwater, H. W. M. van Laarhoven, M. Los, G. J. Meijer, V. E. de Meijer, R. Pande…
    Citation: Trials 2024 25:401

    The Correction to this article has been published in Trials 2024 25:456

  34. This trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Singapore, with the aim of measuring the efficacy of male Wolbachia-infected Aedes aegypti deployments in re...

    Authors: Jue Tao Lim, Diyar Mailepessov, Chee-Seng Chong, Chia-Chen Chang, Borame Dickens, Yee Ling Lai, Lu Deng, Caleb Lee, Li Yun Tan, Grace Chain, Soon Hoe Ho, Muhammad Faizal Zulkifli, Jonathan Liew, Kathryn Vasquez, Vernon Lee, Judith Chui Ching Wong…
    Citation: Trials 2024 25:400

    The Study protocol to this article has been published in Trials 2022 23:1023

  35. Children and adolescents growing up in child welfare institutions have been frequently exposed to traumatic events and psychosocial stress and show elevated rates of mental disorders. Yet, there is a lack of e...

    Authors: Elisa Pfeiffer, Loni Dörrie, Jessica Köksal, Fabienne Krech, Rainer Muche, Jacob Segler and Cedric Sachser
    Citation: Trials 2024 25:399
  36. Dupuytren’s contractures (DC) are fibrous cords under the skin of the hand that cause one or more fingers to curl gradually and irreversibly towards the palm. These contractures are usually painless but can ca...

    Authors: Samantha Harrison, Reuben Ogollah, William Hollingworth, Nicola Mills, Alexia Karantana, Jane Blazeby, Alan Montgomery, Aisha Shafayat, Hugh Jarrett and Tim Davis
    Citation: Trials 2024 25:398
  37. Borderline personality disorder (BPD) is considered a disorder of emotion regulation resulting from the expression of a biologically determined emotional vulnerability (that is, heightened sensitivity to emoti...

    Authors: Giuseppe Guerriero, Sophie I. Liljedahl, Hanne K. Carlsen, Marta López Muñoz, Alexander R. Daros, Anthony C. Ruocco and Steinn Steingrimsson
    Citation: Trials 2024 25:397
  38. Fear memory extinction is closely related to insomnia. Repetitive transcranial magnetic stimulation (rTMS) is safe and effective for treating insomnia disorder (ID), and it has been shown to be an efficient me...

    Authors: Jingjing Sun, Bidan Zhang, Wenyue Xu, Panpan Li, Danwei Zhang, Bei Zhao, Zhoubing Wang and Bin Wang
    Citation: Trials 2024 25:396
  39. Research in the neurosciences has highlighted the importance of intersubjective relationships in promoting neuromental development of the child. Children’s learning in early childhood occurs mainly in a dyadic...

    Authors: Cena Loredana, Trainini Alice, Murray Lynne, Cooper Peter, Calza Stefano and Belluardo Mauro
    Citation: Trials 2024 25:395
  40. In Kenya, 65% of sexually active unmarried women use modern contraceptives, a population at increased risk of HIV acquisition compared to other populations. Anchoring HIV prevention services, including pre-exp...

    Authors: Harison K. Lagat, Jillian Pintye, Elizabeth Harrington, Samantha Houck, Zachary Kwena, Meena Lenn, Felix Mogaka, Vincent Momanyi, Melissa Mugambi, Bernard Nyerere, Josephine Odoyo, Victor Omollo, Katrina F. Ortblad, Greshon Rota, Monisha Sharma and Elizabeth A. Bukusi
    Citation: Trials 2024 25:394
  41. Lifestyle-related risk factors can increase complications during pregnancy and negatively impact the health of a mother and her child. Knowledge about these compliances among many pregnant women and women of c...

    Authors: Mareike Krämer, Laura Wohlhüter, Lina Hermeling, Jan Koetsenruijter, Martina Kamradt, Michel Wensing and Manuela Bombana
    Citation: Trials 2024 25:393
  42. Hematopoietic cell transplantation (HCT) is a highly invasive and life-threatening treatment for hematological neoplasms and some types of cancer that can challenge the patient’s meaning structures. Restoring ...

    Authors: Aleksandra Kroemeke, Joanna Dudek, Marta Kijowska, Ray Owen and Małgorzata Sobczyk-Kruszelnicka
    Citation: Trials 2024 25:392
  43. Evidence indicates that trial participants often struggle to understand participant information leaflets (PILs) for clinical trials, including the concept of randomisation. We analysed the language used to des...

    Authors: Frances Shiely, Ellen Murphy, Katie Gilles, Kerry Hood, Lydia O’Sullivan, Nicola Harman, Talia Isaacs and Shaun Treweek
    Citation: Trials 2024 25:391
  44. Authors: Corina Benjet, Ronald C. Kessler, Alan E. Kazdin, Pim Cuijpers, Yesica Albor, Nayib Carrasco Tapias, Carlos C. Contreras-Ibáñez, Ma Socorro Durán González, Sarah M. Gildea, Noé González, José Benjamín Guerrero López, Alex Luedtke, Maria Elena Medina-Mora, Jorge Palacios, Derek Richards, Alicia Salamanca-Sanabria…
    Citation: Trials 2024 25:389

    The original article was published in Trials 2022 23:450

  45. Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment for end-stage liver disease but is limited by a shortage of suitable donor organs. As a r...

    Authors: Syed Hussain Abbas, Carlo D. L. Ceresa, Leanne Hodson, David Nasralla, Christopher J. E. Watson, Hynek Mergental, Constantin Coussios, Fotini Kaloyirou, Kerrie Brusby, Ana Mora, Helen Thomas, Daphne Kounali, Katie Keen, Joerg-Matthias Pollok, Rohit Gaurav, Satheesh Iype…
    Citation: Trials 2024 25:386

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