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  1. Content type: Study protocol

    Hypoparathyroidism is one of the most common complications encountered in thyroidectomy. In addition to parathyroid in-situ preservation, parathyroid autotransplantation (PA) is another important remedial meth...

    Authors: Qiuxia Cui, Deguang Kong, Zhihua Li, Kun Wang, Dan Zhang, Jianing Tang, Xing Liao, Qianqian Yuan, Yan Gong and Gaosong Wu

    Citation: Trials 2019 20:96

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  2. Content type: Study protocol

    Acute heart failure (AHF) is one of the most common diagnoses for elderly patients in the emergency department (ED), with an admission rate above 80% and 1-month mortality around 10%. The European guidelines f...

    Authors: Yonathan Freund, Judith Gorlicki, Marine Cachanado, Sarah Salhi, Vanessa Lemaître, Tabassome Simon and Alexandre Mebazaa

    Citation: Trials 2019 20:95

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  3. Content type: Study protocol

    The highest incidence and prevalence of mental health problems across the lifespan as well as the first onset of most long-term mental health conditions are reported for youths between 14 and 25 years of age. ...

    Authors: Michael Kaess, Sabrina Ritter, Sophia Lustig, Stephanie Bauer, Katja Becker, Heike Eschenbeck, Markus Moessner, Christine Rummel-Kluge, Hans-Joachim Salize, Rainer Thomasius, Franz Resch and Julian Koenig

    Citation: Trials 2019 20:94

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  4. Content type: Update

    General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) is a multicentre, individually randomised controlled trial aiming to compare the use of intermitte...

    Authors: Sharmala Thuraisingam, Patty Chondros, Max Catchpool, Kim Dalziel, Jo-Anne Manski-Nankervis, Jane Speight, Elizabeth Holmes-Truscott, Ralph Audehm, Jason Chiang, Irene Blackberry, David O’Neal, Kamlesh Khunti, James Best and John Furler

    Citation: Trials 2019 20:93

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    The Study protocol to this article has been published in Trials 2017 18:174

  5. Content type: Study protocol

    Atrial fibrillation (AF) is frequent and causes great morbidity in the aging population. While initial events may be symptomatic, many patients have silent AF and are at risk of ischemic embolic complications....

    Authors: Sara Schukraft, Marco Mancinetti, Daniel Hayoz, Yannick Faucherre, Stéphane Cook, Diego Arroyo and Serban Puricel

    Citation: Trials 2019 20:92

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  6. Content type: Study protocol

    The development of efficacious, cost-effective, and widely accessible programs for the prevention of eating disorders (EDs) is crucial in order to reduce the ED-related burden of illness. Programs using disson...

    Authors: Stephanie Bauer, Sally Bilić, Christina Reetz, Fikret Ozer, Katja Becker, Heike Eschenbeck, Michael Kaess, Christine Rummel-Kluge, Hans-Joachim Salize, Silke Diestelkamp and Markus Moessner

    Citation: Trials 2019 20:91

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  7. Content type: Study protocol

    Many cancer patients are interested in complementary and integrative medicine during and after regular cancer treatment. Given the high number of users it is important that physicians and patients engage in a ...

    Authors: Stefanie M. Helmer, Alizé A. Rogge, Felix Fischer, Daniel Pach, Markus Horneber, Stephanie Roll and Claudia M. Witt

    Citation: Trials 2019 20:90

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  8. Content type: Study protocol

    A stroke often results in gait impairments, activity limitations and restricted participation in daily life. Virtual reality (VR) has shown to be beneficial for improving gait ability after stroke. Previous st...

    Authors: Ilona J. M. de Rooij, Ingrid G. L. van de Port, Johanna M. A. Visser-Meily and Jan-Willem G. Meijer

    Citation: Trials 2019 20:89

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  9. Content type: Study protocol

    Older adults with Mild Cognitive Impairment (MCI) are at high risk of progressing to Alzheimer’s disease (AD). Slowing down the effect of dementia by enhancing brain plasticity represents one of the most promi...

    Authors: Fabienne Marlats, Leila Djabelkhir-Jemmi, Eric Azabou, Marouane Boubaya, Sjaak Pouwels and Anne-Sophie Rigaud

    Citation: Trials 2019 20:88

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  10. Content type: Study protocol

    Persecutory delusions are a major psychiatric problem and are associated with a wide range of adverse outcomes. Our theoretical model views these delusions as unfounded threat beliefs which persist due to defe...

    Authors: Daniel Freeman, Rachel Lister, Felicity Waite, Ly-Mee Yu, Mel Slater, Graham Dunn and David Clark

    Citation: Trials 2019 20:87

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  11. Content type: Study protocol

    Despite the known adverse effects of maternal overt hypothyroidism on the neurocognitive development of children, there is uncertainty regarding the impact of gestational thyroid dysfunction or autoimmune thyr...

    Authors: Sima Nazarpour, Fahimeh Ramezani Tehrani, Firoozeh Sajedi, Razieh Bidhendi Yarandi and Fereidoun Azizi

    Citation: Trials 2019 20:86

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  12. Content type: Study protocol

    Pre-eclampsia is a pregnancy disorder, characterised by hypertension and multisystem complications in the mother. The adverse outcomes of pre-eclampsia include severe hypertension, stroke, renal and hepatic in...

    Authors: Lucy C. Chappell, Marcus Green, Neil Marlow, Jane Sandall, Rachael Hunter, Stephen Robson, Ursula Bowler, Virginia Chiocchia, Pollyanna Hardy, Edmund Juszczak, Louise Linsell, Anna Placzek, Peter Brocklehurst and Andrew Shennan

    Citation: Trials 2019 20:85

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  13. Content type: Study protocol

    Even in the current drug-eluting stent era, revascularization for coronary stenosis with fractional flow reserve (FFR) between 0.75 and 0.80, the so-called “gray zone,” is a matter of debate. Previous studies ...

    Authors: Hironori Kitabata, Takashi Kubo, Yasutsugu Shiono, Kunihiro Shimamura, Yasushi Ino, Takashi Tanimoto, Yasushi Hayashi, Kenichi Komukai, Hiromichi Sougawa, Keizo Kimura, Masahiro Gohda, Toshikazu Hashizume, Masahiro Obana, Kazuisa Maeda, Junichi Yamaguchi and Takashi Akasaka

    Citation: Trials 2019 20:84

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  14. Content type: Study protocol

    Several studies have reported that the triangulating stapling method decreases the incidence of anastomotic stricture after esophagectomy. Our previous randomized controlled trial, however, could not confirm t...

    Authors: Toshiaki Tsuji, Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Masahiro Katsuda, Keiji Hayata, Junya Kitadani, Shimpei Maruoka, Toshio Shimokawa and Hiroki Yamaue

    Citation: Trials 2019 20:83

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  15. Content type: Research

    Despite worldwide interest in reducing re-hospitalization, there is limited knowledge regarding characteristics of patients who chose to decline participation in such efforts and why. The aim is to explore rea...

    Authors: Maria Flink, Carina Brandberg and Mirjam Ekstedt

    Citation: Trials 2019 20:82

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  16. Content type: Study protocol

    Tobacco abuse is a frequent issue in general practitioners' (GPs') offices, with doctors playing a key role in promoting smoking cessation to their patients. However, not all smokers are ready and willing to g...

    Authors: Thomas Grischott, Oliver Senn, Thomas Rosemann, Anja Frei, Jacques Cornuz, Eva Martin-Diener and Stefan Neuner-Jehle

    Citation: Trials 2019 20:81

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  17. Content type: Study protocol

    Hearing and vision impairments are highly prevalent in people with dementia and may have a negative impact on quality of life and other dementia-related outcomes. Intervening to optimise sensory impairment and...

    Authors: Jemma Regan, Eric Frison, Fidéline Collin, Piers Dawes, Mark Hann, Ines Himmelsbach, Emma Hooper, David Reeves, Zoe Simkin, Chryssoula Thodi, Fan Yang and Iracema Leroi

    Citation: Trials 2019 20:80

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  18. Content type: Study protocol

    Knee osteoarthritis (KOA) is one of the most common musculoskeletal disorders. Although the available evidence for its efficacy is inconclusive, acupuncture is used as an alternative therapy for KOA. The aim o...

    Authors: Jian-Feng Tu, Jing-Wen Yang, Lu-Lu Lin, Tian-Qi Wang, Yu-Zheng Du, Zhi-Shun Liu, Hui Hu, Jing-Jie Zhao, Xiao-Gang Yu, Chun-Sheng Jia, Jun Wang, Tong Wang, Ya-Quan Hou, Xuan Zou, Yu Wang, Jia-Kai Shao…

    Citation: Trials 2019 20:79

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  19. Content type: Study protocol

    Vitiligo is a chronic skin disorder presenting with depigmentation, the pathogenesis of which is complex but the autoimmune theory is now preferred. Multiple immunologic processes, including stimulation of the...

    Authors: Anna Niezgoda, Andrzej Winnicki, Tomasz Kosmalski, Bogna Kowaliszyn, Jerzy Krysiński and Rafał Czajkowski

    Citation: Trials 2019 20:78

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  20. Content type: Study protocol

    Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated...

    Authors: Ingebjørg Irgens, Jana M. Hoff, Hilde Sørli, Hanne Haugland, Johan K. Stanghelle and Tiina Rekand

    Citation: Trials 2019 20:77

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  21. Content type: Study protocol

    Cardiac rehabilitation (CR) programs addressing risk factor management, educational interventions, and exercise contribute to reduce mortality after myocardial infarction (MI). However, the fulfillment of guid...

    Authors: Manuel Gonzalez, Ingela Sjölin, Maria Bäck, Halldora Ögmundsdottir Michelsen, Tina Tanha, Camilla Sandberg, Alexandru Schiopu and Margret Leosdottir

    Citation: Trials 2019 20:76

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  22. Content type: Study protocol

    Frequent users of emergency medical services for issues that could be more appropriately managed through non-urgent care deplete the limited resources of the health-care system. Community paramedicine is an em...

    Authors: Gina Agarwal, Melissa Pirrie, Brent McLeod, Ricardo Angeles, Walter Tavares, Francine Marzanek and Lehana Thabane

    Citation: Trials 2019 20:75

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  23. Content type: Study protocol

    Only a small fraction of individuals with pathological or problematic gambling seek professional help despite available evidence-based treatments such as cognitive behavioral therapy (CBT). Anonymous Internet-...

    Authors: Lara Bücker, Stefan Westermann, Simone Kühn and Steffen Moritz

    Citation: Trials 2019 20:74

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  24. Content type: Study protocol

    Early and excessive alcohol use is a significant threat to healthy development. Evidence supports the effectiveness of electronic alcohol interventions for young drinkers. However, effects are typically small ...

    Authors: Silke Diestelkamp, Lutz Wartberg, Michael Kaess, Stephanie Bauer, Christine Rummel-Kluge, Katja Becker, Heike Eschenbeck, Hans-Joachim Salize, Markus Moessner, Christiane Baldus, Nicolas Arnaud and Rainer Thomasius

    Citation: Trials 2019 20:73

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  26. Content type: Study protocol

    Postoperative delirium is a common disorder in older adults that is associated with higher morbidity and mortality, prolonged cognitive impairment, development of dementia, higher institutionalization rates, a...

    Authors: Alba Sánchez, Christine Thomas, Friederike Deeken, Sören Wagner, Stefan Klöppel, Felix Kentischer, Christine A. F. von Arnim, Michael Denkinger, Lars O. Conzelmann, Janine Biermann-Stallwitz, Stefanie Joos, Heidrun Sturm, Brigitte Metz, Ramona Auer, Yoanna Skrobik, Gerhard W. Eschweiler…

    Citation: Trials 2019 20:71

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  27. Content type: Study protocol

    Low-dose acetylsalicylic acid (ASA) in patients with chronic subdural hematoma (cSDH) represents a significant neurosurgical challenge. While continuation of ASA during the perioperative phase might increase r...

    Authors: Maria Kamenova, Christian Mueller, Michael Coslovsky, Raphael Guzman, Luigi Mariani and Jehuda Soleman

    Citation: Trials 2019 20:70

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  28. Content type: Study protocol

    Chronic low-back pain (CLBP) is one of the most common reasons for seeking medical care and it imposes a significant burden on individuals and society at large. Systematic reviews evaluating the effectiveness ...

    Authors: Suzana Pustivšek and Nejc Šarabon

    Citation: Trials 2019 20:69

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  30. Content type: Study protocol

    Respiratory distress syndrome (RDS) and feeding intolerance are common conditions in preterm infants and among the major causes of neonatal mortality and morbidity.

    Authors: Francesco Cresi, Elena Maggiora, Silvia Maria Borgione, Elena Spada, Alessandra Coscia, Enrico Bertino, Fabio Meneghin, Luigi Tommaso Corvaglia, Maria Luisa Ventura and Gianluca Lista

    Citation: Trials 2019 20:67

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  31. Content type: Study protocol

    People with allergic rhinitis (AR) often seek help from Chinese medicine due to dissatisfaction with conventional treatments. Lung-spleen qi deficiency syndrome (LSQDS) is the most common type of AR, and the Chin...

    Authors: Qiulan Luo, Shiqing Zhou, Xiaoshan Li, Qubo Chen, Wenmin Lin, Liming Lu, Hua Li, Caifeng Chen, Wenyong Chen and Yunying Li

    Citation: Trials 2019 20:66

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  32. Content type: Study protocol

    Postprandial distress syndrome (PDS) has a considerable impact on quality of life. Our previous pilot trial suggested that acupuncture might be a potential treatment option for PDS. We will conduct this large ...

    Authors: Ya-Quan Hou, Xin Zhang, Jian-Feng Tu, Yang Zheng, Jing-Wen Yang, Mirim Kim, Hui Hu, Li-Qiong Wang, Jing-Jie Zhao, Wei Zhou, Jun Wang, Xuan Zou, Yu Wang, Guang-Xia Shi and Cun-Zhi Liu

    Citation: Trials 2019 20:65

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  33. Content type: Study protocol

    Schools are an ideal setting in which to promote health. However, empirical data on the effectiveness of school-based mental health promotion programs are rare, and research on universal Internet-based prevent...

    Authors: Heike Eschenbeck, Laya Lehner, Hanna Hofmann, Stephanie Bauer, Katja Becker, Silke Diestelkamp, Michael Kaess, Markus Moessner, Christine Rummel-Kluge and Hans-Joachim Salize

    Citation: Trials 2019 20:64

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  34. Content type: Study protocol

    At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange. Although the optimal approach to the initial respiratory...

    Authors: Carl H. Backes, Jennifer L. Notestine, Jane M. Lamp, Jeanne C. Balough, Allison M. Notestine, Crystal M. Alfred, Juli M. Kern, Michael R. Stenger, Brian K. Rivera, Mohannad Moallem, Randy R. Miller, Apurwa Naik, Jennifer N. Cooper, Christopher R. Howard, Stephen E. Welty, Noah H. Hillman…

    Citation: Trials 2019 20:63

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  35. Content type: Study protocol

    Variations in care models contribute to cancer pain being under-recognised and under-treated in half of all patients with cancer. International and national cancer pain management guidelines are achievable wit...

    Authors: Jane L. Phillips, Nicole Heneka, Melanie Lovell, Lawrence Lam, Patricia Davidson, Frances Boyle, Nikki McCaffrey, Sally Fielding and Tim Shaw

    Citation: Trials 2019 20:62

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  36. Content type: Study protocol

    Currently available prophylactic migraine treatment options are limited and are associated with many, often intolerable, side-effects. Various lines of research suggest that abnormalities in energy metabolism ...

    Authors: Elena Gross, Niveditha Putananickal, Anna-Lena Orsini, Simone Schmidt, Deborah R. Vogt, Sven Cichon, Peter Sandor and Dirk Fischer

    Citation: Trials 2019 20:61

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  37. Content type: Study protocol

    Mechanical ventilation (MV) is a life-saving technology that restores or assists breathing. Like any treatment, MV has side effects. In some patients it can cause diaphragmatic atrophy, injury, and dysfunction...

    Authors: Douglas Evans, Deborah Shure, Linda Clark, Gerard J. Criner, Martin Dres, Marcelo Gama de Abreu, Franco Laghi, David McDonagh, Basil Petrof, Teresa Nelson and Thomas Similowski

    Citation: Trials 2019 20:60

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  38. Content type: Study protocol

    Chronic neck pain (CNP) is a common and disabling musculoskeletal disorder in developing and developed countries. Previous studies have shown that tuina and traditional Chinese massage are effective treatments fo...

    Authors: Zhiwei Wu, Lingjun Kong, Qingguang Zhu, Pengfei Song, Min Fang, Wuquan Sun, Hao Zhang, Yanbin Cheng, Shanda Xu, Guangxin Guo, Xin Zhou and Zhizhen Lv

    Citation: Trials 2019 20:59

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  39. Content type: Study protocol

    Celecoxib is frequently prescribed to treat knee osteoarthritis (KOA), but how celecoxib influences the activity of the central nervous system to alleviate chronic pain remains unclear.

    Authors: Chenjian Tang, Xiaohui Dong, Wenhua He, Shirui Cheng, Yang Chen, Yong Huang, Bao Yin, Yu Sheng, Jun Zhou, Xiaoli Wu, Fang Zeng, Zhengjie Li and Fanrong Liang

    Citation: Trials 2019 20:58

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  40. Content type: Study protocol

    Treatment success rates of multidrug-resistant tuberculosis (MDR-TB) remain unsatisfactory, and long-term use of second-line anti-TB drugs is accompanied by the frequent occurrence of adverse events, low treat...

    Authors: Myungsun Lee, Jeongha Mok, Deog Kyeom Kim, Tae Sun Shim, Won-Jung Koh, Doosoo Jeon, Taehoon Lee, Seung Heon Lee, Ju Sang Kim, Jae Seuk Park, Ji Yeon Lee, Song Yee Kim, Jae Ho Lee, Kyung-Wook Jo, Byung Woo Jhun, Young Ae Kang…

    Citation: Trials 2019 20:57

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  41. Content type: Study protocol

    Sciatica is a relatively frequent illness that easily becomes a chronic and relapsing condition. Although numerous systematic reviews have analyzed various therapies for sciatica, the validity of their include...

    Authors: Koh-Woon Kim, Kyungmo Park, Hi-Joon Park, Geon-Ho Jahng, Dae-Jean Jo, Jae-Heung Cho, Eun-Mo Song, Woo-Chul Shin, Ye-Ji Yoon, Soo-Jeon Kim, Seulgi Eun and Mi-Yeon Song

    Citation: Trials 2019 20:56

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  42. Content type: Study protocol

    Inguinal hernia repair is one of the most common surgical operations globally; more than 20 million groin herniae are repaired annually worldwide. Recurrence after an inguinal hernia operation is a considerabl...

    Authors: C. S. Seefeldt, J. S. Meyer, J. Knievel, A. Rieger, R. Geißen, R. Lefering and M. M. Heiss

    Citation: Trials 2019 20:55

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  43. Content type: Update

    Social isolation potentiates the risk of death by cancer in the older cancer patient population. The PREDOMOS study investigates the impact of establishing a Program of Social intervention associated with tech...

    Authors: Anne-Laure Couderc, Emilie Nouguerède, Karine Baumstarck, Sandrine Loubière, Hervé Le Caer, Olivier Guillem, Frédérique Rousseau, Laurent Greillier, Emmanuelle Norguet-Monnereau, Maud Cecile, Rabia Boulahssass, Françoise Le Caer, Sandrine Tournier, Chantal Butaud, Pierre Guillet, Sophie Nahon…

    Citation: Trials 2019 20:54

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    The Study protocol to this article has been published in Trials 2017 18:174

  44. Content type: Study protocol

    Depression is a serious mental health problem and is common in children and adolescents. Online interventions are promising in overcoming the widespread undertreatment of depression and in improving the help-s...

    Authors: Sabrina Baldofski, Elisabeth Kohls, Stephanie Bauer, Katja Becker, Sally Bilic, Heike Eschenbeck, Michael Kaess, Markus Moessner, Hans Joachim Salize, Silke Diestelkamp, Elke Voß and Christine Rummel-Kluge

    Citation: Trials 2019 20:53

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  45. Content type: Research

    The objective of this study was to analyze the impact of two forms of secondary preventive follow-up on the association between education level and levels of blood pressure (BP) and low-density lipoprotein cho...

    Authors: Anna-Lotta Irewall, Joachim Ögren, Lisa Bergström, Katarina Laurell, Lars Söderström and Thomas Mooe

    Citation: Trials 2019 20:52

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  46. Content type: Study protocol

    A fiberoptic bronchoscope (FOB) is commonly used to identify the proper placement of a double-lumen endotracheal tube (DLT) for good lung isolation during thoracic surgery. We hypothesized that the FOB-guided ...

    Authors: Taeha Ryu, Eugene Kim, Jong Hae Kim, Seong Jun Woo, Woon Seok Roh and Sung Hye Byun

    Citation: Trials 2019 20:51

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  47. Content type: Study protocol

    Women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with poor ovarian respond (POR) always have very low clinical pregnancy rates. In previous data, dehydroepiandrosterone ...

    Authors: Wei Wang, Hong Liu, Jing Li, Daimin Wei, Jiangtao Zhang, Jianfeng Wang, Jinlong Ma, Yuhua Shi and Zi-Jiang Chen

    Citation: Trials 2019 20:50

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  48. Content type: Study protocol

    Gabapentin has shown efficacy in the treatment of chronic neuropathic or mixed pain in adults. Although pediatric pain specialists have extensive experience with gabapentin for the treatment of neuropathic pai...

    Authors: Thomas G. de Leeuw, Laura Mangiarini, Rebecca Lundin, Florentia Kaguelidou, Tjitske van der Zanden, Oscar Della Pasqua, Dick Tibboel, Adriana Ceci and Saskia N. de Wildt

    Citation: Trials 2019 20:49

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  49. Content type: Correction

    Following publication of the original article [1], we have been notified that one of the author names was listed incorrectly. Both incorrect and correct author names are presented below. The original publicati...

    Authors: David S. Lawrence, Nabila Youssouf, Síle F. Molloy, Alexandre Alanio, Melanie Alufandika, David R. Boulware, Timothée Boyer-Chammard, Tao Chen, Francoise Dromer, Admire Hlupeni, William Hope, Mina C. Hosseinipour, Cecilia Kanyama, Oliver Lortholary, Angela Loyse, David B. Meya…

    Citation: Trials 2019 20:48

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    The original article was published in Trials 2018 19:649

  50. Content type: Research

    A system of dementia-specific case conferences (WELCOME-IdA) was evaluated using a stepped-wedge design in six nursing homes (NHs) to enable nursing staff to analyse properly the behavioural and psychological ...

    Authors: Daniela Holle, Rene Müller-Widmer, Sven Reuther, Ute Rosier-Segschneider, Rabea Graf, Martina Roes and Margareta Halek

    Citation: Trials 2019 20:45

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