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  1. Chronic health conditions have a big impact on disability, morbidity, and mortality worldwide. Smartphone health applications (apps) can improve the health of patients with chronic conditions and enhance the q...

    Authors: Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar and Claudia M. Witt
    Citation: Trials 2022 23:909
  2. Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and meta-analyses, functional and oncological outcom...

    Authors: Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti…
    Citation: Trials 2022 23:906
  3. Participant recruitment into clinical trials remains challenging. The global increase in the number of social media users has accelerated the use of social media as a modality of recruitment, particularly duri...

    Authors: Arabella Baker, Eleanor J. Mitchell and Kim S. Thomas
    Citation: Trials 2022 23:905
  4. Although screening for coronary artery disease (CAD) using computed tomography coronary angiography in patients with stable chest pain has been reported to be beneficial, patients with chronic kidney disease (...

    Authors: Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka…
    Citation: Trials 2022 23:904
  5. Dental implant placement may require a bone graft for vertical and horizontal alveolar ridge augmentation. Due to its osteoconduction, osteoinductive, and osteogenesis, autogenous bone graft characteristics ar...

    Authors: Carolina Mendonça de Almeida Malzoni, Victor Gonçalves, Juliana Possari and Elcio Marcantonio Junior
    Citation: Trials 2022 23:903
  6. The long-standing view that auditory verbal hallucinations (AVH) or hearing voices is a sign of schizophrenia has been challenged by research demonstrating that they lie on a continuum ranging from normal to p...

    Authors: Marialuisa Cavelti, Janko M. Kaeser, Stefan Lerch, Stephanie Bauer, Markus Moessner, Thomas Berger, Mark Hayward and Michael Kaess
    Citation: Trials 2022 23:902
  7. Pediatric patients have increasing rates of hospital-associated venous thromboembolism (HA-VTE), and while several risk-prediction models have been developed, few are designed to assess all general pediatric p...

    Authors: Shannon C. Walker, Benjamin French, Ryan Moore, Henry J. Domenico, Jonathan P. Wanderer, Sreenivasa Balla, C. Buddy Creech, Daniel W. Byrne and Allison P. Wheeler
    Citation: Trials 2022 23:901
  8. Metabolic surgery induces rapid remission of type 2 diabetes mellitus (T2DM). There is a paucity of high level evidence comparing the efficacy of the laparoscopic Roux-en-Y gastric bypass (RYGB) and the laparo...

    Authors: A. van Rijswijk, N. van Olst, A. S. Meijnikman, Y. I. Z. Acherman, S. C. Bruin, A. W. van de Laar, C. C. van Olden, O. Aydin, H. Borger, U. H. W. Beuers, H. Herrema, J. Verheij, J. A. Apers, F. Bäckhed, V. E. A. Gerdes, M. Nieuwdorp…
    Citation: Trials 2022 23:900
  9. The COVID-19 pandemic has had major impacts in many different spheres, including mental health. Children and adolescents are especially vulnerable because their central nervous system is still in development a...

    Authors: Caio Borba Casella, Pedro Fonseca Zuccolo, Luisa Sugaya, Aline Santana de Souza, Luara Otoch, Fernanda Alarcão, Wagner Gurgel, Daniel Fatori and Guilherme V. Polanczyk
    Citation: Trials 2022 23:899
  10. Tic disorders (TD) is a neuropsychiatric disease with twitch as the main manifestation in childhood. Jiu-Wei-Xi-Feng granules has been marketed in China for treating children with TD. As Long Gu (Os Draconis) in ...

    Authors: Sheng-xuan Guo, Rui-ben Li, Si-yuan Hu, Qiu-han Cai, Cheng-liang Zhong and Rui-min Hao
    Citation: Trials 2022 23:898
  11. Chemoradiotherapy is the standard of care for esophageal cancer as a neoadjuvant treatment before surgery, or as a definitive treatment for unresectable disease. Intensity-modulated radiotherapy (IMRT) has bee...

    Authors: Chawalit Lertbutsayanukul, Sarin Kitpanit, Danita Kannarunimit, Chakkapong Chakkabat, Sornjarod Oonsiri, Kullathorn Thephamongkhol, Putipun Puataweepong, Kanyarat Katanyoo, Jirasak Sukhaboon, Chokaew Tovanabut, Sirikanya Chongsathientham, Pornravee Treeratsapanich, Jirarat Soonthornrak and Anussara Prayongrat
    Citation: Trials 2022 23:897
  12. Systematically screening for child anxiety problems, and offering and delivering a brief, evidence-based intervention for children who are identified as likely to benefit would minimise common barriers that fa...

    Authors: Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence…
    Citation: Trials 2022 23:896
  13. Infection is one of the most common causes of death in patients with hematological malignancies during chemotherapy. Due to its special location, local warmth and humidity, repeated pollution with stool and ur...

    Authors: Yuqin Luo, Yingli Wang, Mei Yang, Ting Luo, Fengjiao Chen, Yamei Leng, Li Zhou, Jinbo Fang, Yuan Li and Chen Chen
    Citation: Trials 2022 23:895
  14. Chronic radiation-associated dysphagia (C-RAD) is considered to be one of the most severe functional impairments in head and neck cancer survivors treated with radiation (RT) or chemoradiation (CRT). Given the...

    Authors: Hanne Massonet, Ann Goeleven, Leen Van den Steen, Alice Vergauwen, Margot Baudelet, Gilles Van Haesendonck, Olivier Vanderveken, Heleen Bollen, Lisette van der Molen, Fréderic Duprez, Peter Tomassen, Sandra Nuyts and Gwen Van Nuffelen
    Citation: Trials 2022 23:893
  15. Couple relationship distress is common and associated with poor physical, psychological, and relational outcomes for both partners. Emotionally Focused Therapy for couples (EFT) is a short-term structured appr...

    Authors: Martiño Rodríguez-Gonzalez, Shayne Anderson, Alfonso Osorio, Marie-France Lafontaine, Paul S. Greenman, María Calatrava, Dania Andrade, Ragan Lybbert, Pilar Martínez-Diaz, Patrick Steffen, Jokin de Irala and Jonathan Sandberg
    Citation: Trials 2022 23:891
  16. Attention deficit/hyperactivity disorder (ADHD) is the most common chronic mental and behavioral disorder among children. Some studies showed the lower levels of vitamin D in patients with ADHD compared with t...

    Authors: Abbas Ali Sangouni, Hamid Mirhosseini and Mahdieh Hosseinzadeh
    Citation: Trials 2022 23:890
  17. Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions ha...

    Authors: Markus Harboe Olsen, Aksel Karl Georg Jensen, Josef Dankiewicz, Markus B. Skrifvars, Matti Reinikainen, Marjaana Tiainen, Manoj Saxena, Anders Aneman, Christian Gluud, Susann Ullén, Niklas Nielsen and Janus Christian Jakobsen
    Citation: Trials 2022 23:889
  18. Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side ...

    Authors: David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans and Alexander F. J. E. Vrancken
    Citation: Trials 2022 23:888
  19. The study will compare the efficacy and safety of nalbuphine hydrochloride injection and morphine hydrochloride injection for perioperative analgesia in tumor ablation and the differences between the two group...

    Authors: Youhua Xue, Zhengli Huang, Bingwei Cheng, Jie Sun, Haidong Zhu, Yuting Tang and Xiaoyan Wang
    Citation: Trials 2022 23:887
  20. Aboriginal Australians are known to suffer high levels of acquired brain injury (stroke and traumatic brain injury) yet experience significant barriers in accessing rehabilitation services. The aim of the Heal...

    Authors: Elizabeth Armstrong, Tapan Rai, Deborah Hersh, Sandra Thompson, Juli Coffin, Natalie Ciccone, Leon Flicker, Dominique Cadilhac, Erin Godecke, Deborah Woods, Colleen Hayward, Graeme J. Hankey, Meaghan McAllister and Judith Katzenellenbogen
    Citation: Trials 2022 23:886
  21. Xanthohumol (XN), a bioactive flavonoid from Humulus lupulus with anti-inflammatory properties, has potential benefits for patients with Crohn’s disease (CD), a type of inflammatory bowel disease. We recently com...

    Authors: Blake O. Langley, Jennifer Joan Ryan, John Phipps, Lita Buttolph, Brenna Bray, Joseph E. Aslan, Thomas O. Metz, Jan F. Stevens and Ryan Bradley
    Citation: Trials 2022 23:885
  22. As a pragmatic randomised timing-of-birth trial, WILL adapted its trial procedures in response to the COVID-19 pandemic. These are reviewed here to inform post-pandemic trial methodology.

    Authors: Laura A. Magee, Sue Tohill, Katie Kirkham, Ruth Evans, Eleni Gkini, Catherine A. Moakes, Clive Stubbs, Jim Thornton and Peter von Dadelszen
    Citation: Trials 2022 23:884
  23. Recruiting patients to randomised controlled trials (RCTs) is often reported to be challenging, and the evidence base for effective interventions that could be used by staff (recruiters) undertaking recruitmen...

    Authors: Nicola Farrar, Daisy Elliott, Catherine Houghton, Marcus Jepson, Nicola Mills, Sangeetha Paramasivan, Lucy Plumb, Julia Wade, Bridget Young, Jenny L. Donovan and Leila Rooshenas
    Citation: Trials 2022 23:883
  24. Enteral nutrition is a major pathway of nutrition for patients requiring critical care. However, it remains unclear whether intermittent or continuous feeding is the better approach, especially after nasogastr...

    Authors: Guang Yang, Aijing Deng, Bojun Zheng, Jian Li, Yi Yu, Honglian Ouyang, Xin Huang and Hong Chen
    Citation: Trials 2022 23:882
  25. To inform the oversight of future clinical trials during a pandemic, we summarise the experiences of the Data Monitoring Committee (DMC) for the Randomised Evaluation of COVID therapy trial (RECOVERY), a large...

    Authors: Peter A. G. Sandercock, Janet Darbyshire, David DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Natalie Staplin, Adilia Warris, Janet Wittes and Jonathan R. Emberson
    Citation: Trials 2022 23:881
  26. Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate pro...

    Authors: L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson and A. R. Lingford-Hughes
    Citation: Trials 2022 23:880
  27. Non-erosive reflux disease (NERD) is characterized by typical gastroesophageal reflux symptoms, such as heartburn and regurgitation but an absence of esophageal mucosal damage during upper gastrointestinal end...

    Authors: Xia Li, Haomeng Wu, Beihua Zhang, Ting Chen, Xiaoshuang Shi, Jinxin Ma, Jiaqi Zhang, Xudong Tang and Fengyun Wang
    Citation: Trials 2022 23:879
  28. Surgical care, which is performed by intensely interacting multidisciplinary teams of surgeons, anesthetists, and nurses, remains associated with significant morbidity and mortality. Intraoperative communicati...

    Authors: Sandra Keller, Franziska Tschan, Norbert K. Semmer, Sven Trelle, Tanja Manser and Guido Beldi
    Citation: Trials 2022 23:878
  29. Menière’s disease is an idiopathic disorder characterized by recurrent episodes of vertigo lasting more than 20 min, unilateral sensorineural hearing loss, and tinnitus. If vertigo attacks occur frequently, th...

    Authors: Casper Grønlund Larsen, Mikael Karlberg, Frank Guldfred, Louise Devantier, Mathias Maagaard, Preben Homøe and Bjarki Ditlev Djurhuus
    Citation: Trials 2022 23:877
  30. This study is in regard to the comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain meta...

    Authors: Xiaofang Zhang, Tianlu Wang, Chen Yu Wang, Peng Zhao, Bo Huang, Lei He and Ying Qiu Song
    Citation: Trials 2022 23:876
  31. Since early 2022, patients with 2019 novel coronavirus (COVID-19) infection have increased rapidly in Shanghai, China. Nevertheless, there is no widely used unified rehabilitation treatment available for disch...

    Authors: Guangxin Guo, Xiruo Xu, Wong Yu Yin, Kunyu Zhang, Jacelyn Pang Min Hui, Janice Hiew Yuen Yee, Bryan Chung Qi Heng, Yuan Qin, Fei Yao and Min Fang
    Citation: Trials 2022 23:875
  32. The value of pulsed electromagnetic field (PEMF) in postoperative pain management, due to the inconsistent findings so far, remains unclear. We extended the evaluation of PEMF on postoperative pain and intrave...

    Authors: Muralitharan Perumal, Aizatul Isla Abdul Latib, Malarvilee Paul Samy, Mohd Rohisham bin Zainal Abidin, Elanngovan Nagandran, Tham Sim Wan, Pamela Francis and Chee Yoong Foo
    Citation: Trials 2022 23:874
  33. Neuromuscular electrical stimulation (NMES) is an established therapy that has been widely used for many decades to improve circulation in the legs. However, studies using NMES devices in an elderly, ambulant,...

    Authors: Binoy Kumaran, Darren Targett and Tim Watson
    Citation: Trials 2022 23:873
  34. Stroke, the incidence of which increases with age, has a negative impact on motor and cognitive performance, quality of life, and the independence of the person and his or her family, leading to a number of di...

    Authors: Silvia Giovannini, Chiara Iacovelli, Fabrizio Brau, Claudia Loreti, Augusto Fusco, Pietro Caliandro, Lorenzo Biscotti, Luca Padua, Roberto Bernabei and Letizia Castelli
    Citation: Trials 2022 23:872
  35. Intracerebral hemorrhage (ICH) is a devastating disease, its mortality and disability rate are high. In China, hypertensive intracerebral hemorrhage (HICH) is responsible for 75% of all the cases of primary IC...

    Authors: Min Jia, Yan Lu, Xiao Liang, Chenguang Tong, Jian Wang, Jun Tang, Jian Yang, Min Wang, Weiwei Jiao, Wanqing Du, Jingjing Wei, Zixiu Zeng, Zhenmin Xu, Qian Chen, Lin Lei, Xing Liao…
    Citation: Trials 2022 23:871
  36. The evidence on what strategies can improve recruitment to clinical trials in maternity care is lacking. As trial recruiters, maternity healthcare professionals (MHCPs) perform behaviours (e.g. talking about t...

    Authors: Vivienne Hanrahan, Louisa Lawrie, Eilidh Duncan, Linda Biesty and Katie Gillies
    Citation: Trials 2022 23:870
  37. The complexities associated with delivering randomised surgical trials, such as clustering effects, by centre or surgeon, and surgical learning, are well known. Despite this, approaches used to manage these co...

    Authors: Elizabeth J. Conroy, Jane M. Blazeby, Girvan Burnside, Jonathan A. Cook and Carrol Gamble
    Citation: Trials 2022 23:869
  38. Early detection of Alzheimer’s disease and related dementias (ADRD) in a primary care setting is challenging due to time constraints and stigma. The implementation of scalable, sustainable, and patient-driven ...

    Authors: Michael J. Kleiman, Abbi D. Plewes, Arthur Owora, Randall W. Grout, Paul Richard Dexter, Nicole R. Fowler, James E. Galvin, Zina Ben Miled and Malaz Boustani
    Citation: Trials 2022 23:868
  39. Despite substantial awareness that certain groups (e.g. ethnic minorities) are under-represented and under-served in trials, limited progress has been made in addressing this. As well as a public service and e...

    Authors: Lydia Morris, Jo Dumville, Shaun Treweek, Nasima Miah, Ffion Curtis and Peter Bower
    Citation: Trials 2022 23:867
  40. Visits to the emergency department (ED) are inflection points in patients’ illness trajectories and are an underutilized setting to engage seriously ill patients in conversations about their goals of care. We ...

    Authors: Thidathit Prachanukool, Susan D. Block, Donna Berry, Rachel S. Lee, Sarah Rossmassler, Mohammad A. Hasdianda, Wei Wang, Rebecca Sudore, Mara A. Schonberg, James A. Tulsky and Kei Ouchi
    Citation: Trials 2022 23:866
  41. In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and re...

    Authors: Julia M. Neuhann, Jannik Stemler, Antonio Carcas, Jesús Frías-Iniesta, Ullrich Bethe, Sarah Heringer, Lea Tischmann, Marouan Zarrouk, Arnd Cüppers, Franz König, Martin Posch and Oliver A. Cornely
    Citation: Trials 2022 23:865
  42. Rifampicin-resistant tuberculosis (RR-TB) remains an important global health problem. Ideally, the complete drug-resistance profile guides individualized treatment for all RR-TB patients, but this is only prac...

    Authors: Annelies Van Rie, Elise De Vos, Emilyn Costa, Lennert Verboven, Felex Ndebele, Tim H. Heupink, Steven Abrams, Boitumelo Fanampe, Anneke Van der Spoel Van Dyk, Salome Charalambous, Gavin Churchyard and Rob Warren
    Citation: Trials 2022 23:864
  43. The way information about potential harms of trial intervention is shared within participant information leaflets (PILs) varies widely and can cause subjective ‘nocebo’ harms. This study aimed to develop princ...

    Authors: Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek and Jeremy Howick
    Citation: Trials 2022 23:863
  44. The COVID-19 pandemic forced many research teams to adjust the way they conduct studies, including moving to remote delivery of some or all of their recruitment and data collection processes. The Montreal Cogn...

    Authors: Caroline Brundle, Anne Heaven and Andrew Clegg
    Citation: Trials 2022 23:862
  45. Bariatric surgery has adverse effects on the muscular-skeletal system with loss of bone mass and muscle mass and an increase in the risk of fracture. Zoledronic acid is widely used in osteoporosis and prevents...

    Authors: Søren Gam, Bibi Gram, Claus Bogh Juhl, Anne Pernille Hermann and Stinus Gadegaard Hansen
    Citation: Trials 2022 23:861
  46. Shift work is considered a risk factor for a number of chronic health conditions including obesity. Weight reduction in obese patients lowers the risk for cardiovascular disease, diabetes, certain cancers, and...

    Authors: Piumika Sooriyaarachchi, Ranil Jayawardena, Toby Pavey and Neil A. King
    Citation: Trials 2022 23:860
  47. The complexity of past trauma and ongoing post-migration stressors challenges the existing mental health treatment for trauma-affected refugees. Therefore, interventions are needed to accommodate these complex...

    Authors: Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj and Jessica Carlsson
    Citation: Trials 2022 23:859
  48. The clinical trial landscape has evolved over the last two decades, shaped by advances in therapeutics and drug development and innovation in trial design and methods. The tracking of such changes became possi...

    Authors: Gillian Gresham, Jill L. Meinert, Arthur G. Gresham, Steven Piantadosi and Curtis L. Meinert
    Citation: Trials 2022 23:858

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