Skip to main content

Articles

Page 2 of 166

  1. Physical activity breaks are widely being implemented in school settings as a solution to increase academic performance and reduce sitting time. However, the underlying physiological mechanisms suggested to im...

    Authors: Emerald G. Heiland, Karin Kjellenberg, Olga Tarassova, Maria Fernström, Gisela Nyberg, Maria M. Ekblom, Björg Helgadottir and Örjan Ekblom

    Citation: Trials 2022 23:22

    Content type: Study protocol

    Published on:

  2. Communication is one of the most important predictors of social reintegration after stroke. Approximately 15–42% of stroke survivors experience post-stroke aphasia. Helping people recover from aphasia is one o...

    Authors: Blanca Fuentes, Lydia de la Fuente-Gómez, Cristian Sempere-Iborra, Celia Delgado-Fernández, Aida Tarifa-Rodríguez, María Alonso de Leciñana, Elena de Celis-Ruiz, Raquel Gutiérrez-Zúñiga, José López-Tàppero, Marta Martín Alonso, Sylvia Pastor-Yborra, Ricardo Rigual, Gerardo Ruiz-Ares, Jorge Rodríguez-Pardo, Javier Virués-Ortega, Alberto M. Borobia…

    Citation: Trials 2022 23:21

    Content type: Study protocol

    Published on:

  3. The coronavirus disease 2019 (COVID-19) pandemic continues to affect the globe. After 18 months of the SARS-CoV-2 emergence, clinicians have clearly defined a subgroup of patients with lasting, disabling sympt...

    Authors: Francisco Mera Cordero, Sara Bonet Monne, Jesús Almeda Ortega, Ana García-Sangenís, Oriol Cunillera Puèrtolas, Sara Contreras-Martos, Gemma Alvarez Muñoz, Ramon Monfà Escolà, Marina Balanzó Joué, Rosa Morros Pedrós and Betlem Salvador-Gonzalez

    Citation: Trials 2022 23:19

    Content type: Study protocol

    Published on:

  4. One of the main effectors on the quality of life of living-kidney donors is postoperative fatigue. Caloric restriction (CR) and short-term fasting (STF) are associated with improved fitness and increased resis...

    Authors: C. A. J. Oudmaijer, R. C. Minnee, R. A. Pol, W. M. C. van den Boogaard, D. S. J. Komninos, J. van de Wetering, M. H. van Heugten, E. J. Hoorn, J. S. F. Sanders, J. H. J. Hoeijmakers, W. P. Vermeij and J. N. M. IJzermans

    Citation: Trials 2022 23:18

    Content type: Study protocol

    Published on:

  5. Currently, the population with myopia climbs steadily, and is developing toward younger age, posing a great concern to the health of adolescents. Myopia in severe cases can cause irreversible consequences such...

    Authors: Yibo Li, Lili Zhu, Raoying Wang, Xingyue Yang, Xinqi Jiang and Tao Lu

    Citation: Trials 2022 23:16

    Content type: Study protocol

    Published on:

  6. The prevailing medical opinion is that medication is the primary (some might argue, only) effective intervention for osteoporosis. It is nevertheless recognized that osteoporosis medications are not universall...

    Authors: Belinda Beck, Clinton Rubin, Amy Harding, Sanjoy Paul and Mark Forwood

    Citation: Trials 2022 23:15

    Content type: Study protocol

    Published on:

  7. Treatment for ovarian cancer includes platinum-based chemotherapy, but many women become resistant to chemotherapy, becoming platinum-resistant. Standard of care for these women is weekly paclitaxel chemothera...

    Authors: Consuelo Nóhpal de la Rosa, Jonathan Krell, Emily Day, Aaron Clarke, Meena Reddi, Lee Webber and Francesca Fiorentino

    Citation: Trials 2022 23:13

    Content type: Update

    Published on:

  8. Men with localized prostate cancer often experience urinary, sexual, bowel, and hormonal symptoms; general distress; pain; fatigue; and sleep disturbance. For men in an intimate relationship, these symptoms di...

    Authors: Lixin Song, Matthew E. Nielsen, Ronald C. Chen, Christine Rini, Thomas C. Keyserling, Eno Idiagbonya, Gail P. Fuller, Laurel Northouse, Mary H. Palmer and Xianming Tan

    Citation: Trials 2022 23:12

    Content type: Study protocol

    Published on:

  9. Insomnia disorder (ID) is characterized by dissatisfaction with the quantity or quality of sleep and is often accompanied by negative emotions such as anxiety and depression. Patients with insomnia become trap...

    Authors: Tongfei Jiang, Qi Zhang, Fang Yuan, Fan Zhang and Jing Guo

    Citation: Trials 2022 23:11

    Content type: Study protocol

    Published on:

  10. Depression is one of the most frequent and severe psychiatric conditions. Many chemical drugs to treat depression are associated with adverse reactions and have shortcomings. Traditional Chinese medicine is of...

    Authors: Zhe Xue, Zhen Huang, Shu-li Cheng, Xi-hong Wang, Xuan Zhou, Qing-yu Ma and Jia-xu Chen

    Citation: Trials 2022 23:10

    Content type: Study protocol

    Published on:

  11. Urinary incontinence is a common complication post radical prostatectomy. Acupuncture is considered an effective treatment for post-prostatectomy incontinence (PPI), but the evidence is still limited. We propo...

    Authors: Yao Zhang, Shanqi Guo, Chaoran Wang, Xiaodi Liu, Yan Liu, Hongcai Shang, Peiying Yang, Liang Wang, Jingbo Zhai, Xiaojiang Li and Yingjie Jia

    Citation: Trials 2022 23:9

    Content type: Study protocol

    Published on:

  12. Lung function is highly age-dependent as it decreases in varying degrees with age, even in healthy people. Decreased lung function results in less elastic lung tissue, reduced chest wall compliance, reduced ar...

    Authors: Wenlong Li, Yapei Song, Qiuping Xiang, Xinlei Wang, Xiaoyun Wei and Tonggang Fan

    Citation: Trials 2022 23:8

    Content type: Study protocol

    Published on:

  13. Excess weight gain in young adulthood is associated with future weight gain and increased risk of chronic disease. Although multimodal, technology-based weight-loss interventions have the potential to promote ...

    Authors: Shadia J. Mansour-Assi, Natalie M. Golaszewski, Victoria Lawhun Costello, David Wing, Hailey Persinger, Aaron Coleman, Leslie Lytle, Britta A. Larsen, Sonia Jain, Nadir Weibel, Cheryl L. Rock, Kevin Patrick, Eric Hekler and Job G. Godino

    Citation: Trials 2022 23:7

    Content type: Study protocol

    Published on:

  14. Knee osteoarthritis (KOA) is a common degenerative disease that causes pain, functional impairment, and reduced quality of life. Resistance training is considered as an effective approach to reduce the risk of...

    Authors: Hao-Nan Wang, Yan Chen, Lin Cheng, Shen-Tao Wang, De-Xin Hu, Li-Na Wang and Guo-Xin Ni

    Citation: Trials 2022 23:6

    Content type: Study protocol

    Published on:

  15. Breastfeeding offers many medical and neurodevelopmental advantages for birthing parents and infants; however, the majority of parents stop breastfeeding before it is recommended. Professional lactation suppor...

    Authors: Lori Uscher-Pines, Jill Demirci, Molly Waymouth, Rebecca Lawrence, Amanda Parks, Ateev Mehrotra, Kristin Ray, Maria DeYoreo and Kandice Kapinos

    Citation: Trials 2022 23:5

    Content type: Study protocol

    Published on:

  16. Cardiogenic shock (CS) is a life-threatening condition characterized by circulatory insufficiency caused by an acute dysfunction of the heart pump. The pathophysiological approach to CS has recently been enric...

    Authors: Armand Mekontso Dessap, François Bagate, Clément Delmas, Tristan Morichau-Beauchant, Bernard Cholley, Alain Cariou, Benoit Lattuca, Mouhamed Moussa, Nicolas Mongardon, Damien Fard, Matthieu Schmidt, Adrien Bouglé, Mathieu Kerneis, Emmanuel Vivier, François Roubille, Matthieu Duprey…

    Citation: Trials 2022 23:4

    Content type: Study protocol

    Published on:

  17. In previous retrospective studies, low serum progesterone level on the embryo transfer day is associated with lower clinical pregnancy and ongoing pregnancy rates. Whether adding progesterone in low serum prog...

    Authors: Lin Haiyan, Yang Gang, Li Yu, Li Lin, Chen Xiaoli and Zhang Qingxue

    Citation: Trials 2022 23:3

    Content type: Study protocol

    Published on:

  18. Maternal undernutrition is critical in the etiology of poor perinatal outcomes and accounts for 20% of small-for-gestational-age (SGA) births. High levels of food insecurity, antenatal undernourishment, and ch...

    Authors: Ameer Muhammad, Zoha Zahid Fazal, Benazir Baloch, Imran Nisar, Fyezah Jehan and Yasir Shafiq

    Citation: Trials 2022 23:2

    Content type: Study protocol

    Published on:

  19. Jiangniaosuan formula (JNSF) is commonly used in China for treating hyperuricemia, but there is little research-based evidence to support its use. This randomized controlled trial aims to assess the efficacy a...

    Authors: Yafang Guo, Hong Lu, Jing Gan, Dongdong Li, Jiandong Gao and Changming Zhang

    Citation: Trials 2022 23:1

    Content type: Study protocol

    Published on:

  20. Intensive care unit-acquired atrophy and weakness are associated with high mortality, a reduction in physical function, and quality of life. Passive mobilization (PM) and neuromuscular electrical stimulation w...

    Authors: Thaís Marina Pires de Campos Biazon, Cleiton Augusto Libardi, Jose Carlos Bonjorno Junior, Flávia Rossi Caruso, Tamara Rodrigues da Silva Destro, Naiara Garcia Molina, Audrey Borghi-Silva and Renata Gonçalves Mendes

    Citation: Trials 2021 22:969

    Content type: Study protocol

    Published on:

  21. Authors: Houria E. L. Ouazzani, Steeve Rouillon, Nicolas Venisse, Lynda Sifer-Rivière, Antoine Dupuis, Guillaume Cambien, Sarah Ayraud-Thevenot, Anne-Sophie Gourgues, Pascale Pierre-Eugène, Fabrice Pierre, Sylvie Rabouan, Virginie Migeot and Marion Albouy-Llaty

    Citation: Trials 2021 22:968

    Content type: Correction

    Published on:

    The original article was published in Trials 2021 22:876

  22. More than half of the adults with visual impairment experience severe symptoms of fatigue, with a negative impact on daily life. Since there is no evidence-based treatment to reduce fatigue in adults with visu...

    Authors: Manon H. J. Veldman, Hilde P. A. van der Aa, Christina Bode, Hans Knoop, Carel T. J. Hulshof, Marc Koopmanschap, Edwin Stavleu, Ger H. M. B. van Rens and Ruth M. A. van Nispen

    Citation: Trials 2021 22:966

    Content type: Study protocol

    Published on:

  23. Compared to conventional thoracotomy, minimally invasive thoracic surgery (MITS) can reduce postoperative pain, reduce tissue trauma and contribute to better recovery. However, it still causes significant acut...

    Authors: Aneurin Moorthy, Aisling Ni Eochagain, Eamon Dempsey and Donal Buggy

    Citation: Trials 2021 22:965

    Content type: Study protocol

    Published on:

  24. One out of three patients with schizophrenia failed to respond adequately to antipsychotics and continue to experience debilitating symptoms such as auditory hallucinations and negative symptoms. The developme...

    Authors: Jerome Brunelin, Marine Mondino, Julie Haesebaert, Jerome Attal, Michel Benoit, Marie Chupin, Sonia Dollfus, Wissam El-Hage, Filipe Galvao, Renaud Jardri, Pierre Michel Llorca, Laurent Magaud, Marion Plaze, Anne Marie Schott-Pethelaz, Marie-Françoise Suaud-Chagny, David Szekely…

    Citation: Trials 2021 22:964

    Content type: Study protocol

    Published on:

  25. Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both maternal and child risk of developing non-communicable diseases such as type 2 diabetes and obesity. Whilst lifestyle interven...

    Authors: Sharleen L. O’Reilly, Christy Burden, Cristina Campoy, Fionnuala M. McAuliffe, Helena Teede, Jesper Andresen, Karen J. Campbell, Aisling A. Geraghty, Cheryce L. Harrison, Rachel Laws, Jane E. Norman, Helle T. Maindal, Karsten Vrangbæk, Ricardo Segurado, Vincent L. Versace and Timothy C. Skinner

    Citation: Trials 2021 22:963

    Content type: Study protocol

    Published on:

  26. Multiple observational studies have associated metformin prescription with reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial (MAT) will test whether metformin reduces the ris...

    Authors: Jonathan Golledge, Clare Arnott, Joseph Moxon, Helen Monaghan, Richard Norman, Dylan Morris, Qiang Li, Greg Jones, Justin Roake, Matt Bown and Bruce Neal

    Citation: Trials 2021 22:962

    Content type: Study protocol

    Published on:

  27. Evidence-based establishment and implementation of best principles, laws and ordinances that regulate clinical research depend on the consultation and involvement of trial participants. Yet, guidance on method...

    Authors: Aita Signorell, Jasmina Saric, Christian Appenzeller-Herzog, Hannah Ewald, Christian Burri, Martin Goetz and Jana Gerold

    Citation: Trials 2021 22:961

    Content type: Review

    Published on:

  28. Childhood adversities, such as poor parental practices, exposure to violence, and risk behaviours strongly impact children’s future mental and behavioural problems. Adversities affect families living in disadv...

    Authors: Diana Tăut, Adriana Băban, Inga Frantz, Ingrid Dănilă, Jamie M. Lachman, Nina Heinrichs, Catherine L. Ward, Frances Gardner, Xiangming Fang, Judy Hutchings, Marija Raleva, Galina Lesco, Hugh Murphy and Heather Foran

    Citation: Trials 2021 22:960

    Content type: Study protocol

    Published on:

  29. The global burden of osteoarthritis (OA) is steadily increasing due to demographic and lifestyle changes. The nervous system can undergo peripheral and central neuroplastic changes (sensitization) in patients ...

    Authors: Nadia Ammitzbøll, Lars Arendt-Nielsen, Davide Bertoli, Christina Brock, Anne Estrup Olesen, Andreas Kappel, Asbjørn Mohr Drewes and Kristian Kjær Petersen

    Citation: Trials 2021 22:958

    Content type: Study protocol

    Published on:

  30. Management of inoperable chronic thromboembolic pulmonary hypertension (CTEPH) remains a clinical challenge. Currently, riociguat, a soluble guanylate-cyclase stimulator is recommended by international guideli...

    Authors: Qin-Hua Zhao, Su-Gang Gong, Jing He, Ping Yuan, Wen-Hui Wu, Ci-Jun Luo, Rong Jiang, Rui Zhang, Hong-Ling Qiu, Hui-Ting Li, Yuan Li, Jin-Ming Liu and Lan Wang

    Citation: Trials 2021 22:957

    Content type: Study protocol

    Published on:

  31. Adolescents and youth living with HIV (AYAHIV) have worse HIV outcomes than other age groups, particularly in sub-Saharan Africa (SSA). AYAHIV in SSA face formidable health system, interpersonal- and individua...

    Authors: Phepo Mogoba, Maia Lesosky, Allison Zerbe, Joana Falcao, Claude Ann Mellins, Christopher Desmond, Carlos Arnaldo, Bill Kapogiannis, Landon Myer and Elaine J. Abrams

    Citation: Trials 2021 22:956

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in Trials 2022 23:48

  32. Influenza can fall into three categories according to severity: mild influenza, severe influenza, and critical influenza. Severe influenza can result in critical illness and sometimes death particularly in pat...

    Authors: Lei Qiu, Xian-wei Wu, Shao-yan Zhang, Ming Yang, Shun-xian Zhang, Ji-you Fu, Cui Li, Zhi-jie Zhang, Pei-yong Zheng and Zhen-hui Lu

    Citation: Trials 2021 22:955

    Content type: Study protocol

    Published on:

  33. Pancreatoduodenectomy is a complex and challenging procedure that requires meticulous tissue dissection and proficient suturing skills. Minimally invasive surgery with the utilization of robotic platforms has ...

    Authors: Jiabin Jin, Yusheng Shi, Mengmin Chen, Jianfeng Qian, Kai Qin, Zhen Wang, Wei Chen, Weiwei Jin, Fengchun Lu, Zheyong Li, Zehua Wu, Li Jian, Bing Han, Xiao Liang, Chuandong Sun, Zheng Wu…

    Citation: Trials 2021 22:954

    Content type: Study protocol

    Published on:

  34. Type 1 diabetes is a main health burden with several related comorbidities. It has been shown that endothelial function, vascular structure, and metabolic parameters are considerably disrupted in patients with...

    Authors: Masoud Khorshidi, Aliakbar Sayyari, Beheshteh Olang, Mohammad Reza Alaei, Sakineh Shab-Bidar, Mitra Khalili, Masoud Salehi and Naheed Aryaeian

    Citation: Trials 2021 22:953

    Content type: Study protocol

    Published on:

  35. In 2020, the COVID-19 pandemic developed into a global crisis, the enormity and urgency of which accelerated research activities in the field. At the same time, manuscripts describing these research projects u...

    Authors: Sabrina Tulka, Christine Baulig and Stephanie Knippschild

    Citation: Trials 2021 22:952

    Content type: Study protocol

    Published on:

  36. Hemodialysis (HD) is a common renal replacement therapy for patients with renal failure. Cardiovascular and cerebrovascular diseases are known to shorten survival periods and worsen the quality of life of HD p...

    Authors: Kojiro Ohba, Yasuyoshi Miyata, Takeaki Shinzato, Satoshi Funakoshi, Kanenori Maeda, Tomohiro Matsuo, Kensuke Mitsunari, Yasushi Mochizuki, Tomoya Nishino and Hideki Sakai

    Citation: Trials 2021 22:950

    Content type: Study protocol

    Published on:

  37. Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evalua...

    Authors: Steven Savvas, Anita M. Y. Goh, Frances Batchelor, Colleen Doyle, Erica Wise, Esther Tan, Anita Panayiotou, Sue Malta, Margaret Winbolt, Phillip Clarke, Jason Burton, Lee-Fay Low, Samantha M. Loi, Anne Fairhall, Meg Polacsek, Jay Stiles…

    Citation: Trials 2021 22:949

    Content type: Study protocol

    Published on:

  38. Despite high morbidity and mortality among people who use drugs (PWUD) in rural America, most research is conducted within urban areas. Our objective was to describe influencing factors, motivations, and barri...

    Authors: Angela T. Hetrick, April M. Young, Miriam R. Elman, Sarann Bielavitz, Rhonda L. Alexander, Morgan Brown, Elizabeth Needham Waddell, P. Todd Korthuis and Kathryn E. Lancaster

    Citation: Trials 2021 22:948

    Content type: Research

    Published on:

  39. Despite the success of gold standard cognitive-behavioral therapy for problem and disordered gambling, the majority of individuals with gambling problems do not seek or receive professional treatment. Thus, th...

    Authors: Brad W. Brazeau, David C. Hodgins, John A. Cunningham, Kylie Bennett and Anthony Bennett

    Citation: Trials 2021 22:947

    Content type: Study protocol

    Published on:

  40. Conventional cardiopulmonary resuscitation (CPR) training for the general public involves the use of a manikin and a training video, which has limitations related to a lack of realism and immersion. To overcom...

    Authors: Dong Keon Lee, Chang Woo Im, You Hwan Jo, Todd Chang, Joo Lee Song, Cindy Luu, Ralph Mackinnon, Suresh Pillai, Chuen Neng Lee, Sanghoon Jheon, Soyeon Ahn and Seung Hyun Won

    Citation: Trials 2021 22:946

    Content type: Study protocol

    Published on:

  41. Percutaneous transluminal angioplasty is the current standard treatment for arteriovenous fistula (AVF) stenosis. The mid- and long-term patency with plain balloon angioplasty (PBA) is however far from satisfa...

    Authors: Suh Chien Pang, Ru Yu Tan, Edward Choke, Jackie Ho, Kiang Hiong Tay, Apoorva Gogna, Farah G. Irani, Kun Da Zhuang, Luke Toh, Shaun Chan, Pradesh Krishnan, Kristen A. Lee, Sum Leong, Richard Lo, Ankur Patel, Bien Soo Tan…

    Citation: Trials 2021 22:945

    Content type: Study protocol

    Published on:

  42. Children predominantly remain sedentary in a traditional classroom. This study aimed to demonstrate the design and baseline characteristics of a three-armed intervention program that targeted enhancements in c...

    Authors: Ming Hui Li, Cindy Hui Ping Sit, Stephen Heung Sang Wong, Yun Kwok Wing, Ching Kong Ng and Raymond Kim Wai Sum

    Citation: Trials 2021 22:944

    Content type: Research

    Published on:

  43. Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the tre...

    Authors: Lili Song, Xin Hu, Lu Ma, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Paula Muñoz-Venturelli, Carlos Abanto, Octavio Marques Pontes-Neto, Arauz Antonio, Mohammad Wasay, Asita de Silva, Nguyen Huy Thang, Jeyaraj Durai Pandian, Kolawole Wasiu Wahab…

    Citation: Trials 2021 22:943

    Content type: Study protocol

    Published on:

  44. The prevalence of sarcopenia increases as renal function decreases, and a considerable number of hemodialysis (HD) patients have sarcopenia. Exercise and nutritional support are established interventions to pr...

    Authors: Mi-yeon Yu, Jae Hyeon Park, Yong Chul Kim, Jae Yoon Park and Ran-hui Cha

    Citation: Trials 2021 22:942

    Content type: Study protocol

    Published on:

  45. Authors: Kenneth Sandin, Ragne G. H. Gjengedal, Kåre Osnes, Marit Hannisdal, Torkil Berge, Jonas S. R. Leversen, Lars G. Røv, Silje Endresen Reme, Suzanne Lagerveld, Roland Blonk, Hans M. Nordahl, Gemma Shields, Adrian Wells and Odin Hjemdal

    Citation: Trials 2021 22:941

    Content type: Correction

    Published on:

    The original article was published in Trials 2021 22:854

  46. Core outcome sets (COS) are standardised sets of outcomes, which represent the minimum outcomes that should be measured and reported in clinical trials. COS can enhance comparability across health trials by re...

    Authors: Chiara Bellucci, Karen Hughes, Elaine Toomey, Paula R. Williamson and Karen Matvienko-Sikar

    Citation: Trials 2021 22:937

    Content type: Research

    Published on:

  47. The distal radius fracture (DRF) is a common fracture, with the majority of these fractures being stable. Of all diagnosed fractures, 17% is a DRF, of which a large part is extra-articular and one-third is non...

    Authors: Emily Boersma, Erik van de Krol, Tjarda Tromp, Maria Nijhuis - van der Sanden and Michael Edwards

    Citation: Trials 2021 22:936

    Content type: Study protocol

    Published on:

Annual Journal Metrics