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  1. Age-related hearing loss (ARHL) signifies the bilateral, symmetrical, sensorineural hearing loss that commonly occurs in elderly individuals. Several studies have suggested a higher risk of dementia among pati...

    Authors: Ying Chen, Lei Guan, Jie Chen, Kun Han, Qiongfei Yu, Jin Zhou, Xue Wang, Yunqian Ma, Xiangyu Ji, Zhonglu Zhao, Qiyue Shen, Anxian Wang, Mengping Wang, Jin Li, Jiali Yu, Yiwen Zhang…
    Citation: Trials 2023 24:767
  2. Frozen shoulder (FS) is a common condition that can cause severe pain and limited range of motion in the shoulder joint. While intra-articular steroid injection has been shown to be an effective treatment for ...

    Authors: Wuwei Song, Xiaoyu Guo, Xiang Wang, Jiacheng Yu, Wenyu Jiang, Chen Wei and Yuhao Zhao
    Citation: Trials 2023 24:765
  3. Many patients during manual therapy after anterior ligament reconstruction will experience severe pain, which has a negative impact on their rehabilitation. However, there is rarely an analgesic method for the...

    Authors: Ziyang Wang, Fei Wang, Yuxiang Li, Yihui Xing, Xiaochen Jiang, Cui Li, Zhiguo Ding and Lu Tang
    Citation: Trials 2023 24:764
  4. Schistosomiasis control relies on praziquantel for preventive chemotherapy. Alternative drugs are needed for the treatment and control of schistosomiasis. Praziquantel is effective against adult schistosome wo...

    Authors: Charles O. Obonyo, Vincent O. Were, Peter Wamae and Erick M. O. Muok
    Citation: Trials 2023 24:763
  5. High-flow nasal oxygen (HFNO) therapy is a leading treatment technique for acute hypoxemic respiratory failure (AHRF), but its treatment failure rate remains high. The awake prone position (APP) has been prove...

    Authors: Xixin Zhou, Xiaoqing Luo, Qin Li, Guihua Chen, Jin Tong and Wang Deng
    Citation: Trials 2023 24:762
  6. Anhedonia and other deficits in reward- and motivation-related processing in psychiatric patients, including patients with major depressive disorder (MDD), represent a high unmet medical need. Neurobiologicall...

    Authors: Luisa Carstens, Margot Popp, Christian Keicher, Rita Hertrampf, David Weigner, Marvin S. Meiering, Gerd Luippold, Sigurd D. Süssmuth, Christian F. Beckmann, Andreas Wunder and Simone Grimm
    Citation: Trials 2023 24:761
  7. Core stability exercise (CSE) is a globally acknowledged intervention for managing chronic low back pain. However, the sustained adherence of patients with chronic low back pain to CSE can be challenging, main...

    Authors: Zheng Fuming, Li Zhicheng, Huang Huanjie, Zhang Xinna, Chen Rong, Peng Jiahui, Yang Liming, Chen Xi and Wang Chuhuai
    Citation: Trials 2023 24:760
  8. Endometriosis is a chronic disease characterized by growth of endometrial tissue outside the uterine cavity which could affect 200 million women (The term “woman” is used for convenience. Individuals gendered ...

    Authors: Géraldine Escriva-Boulley, Charles-André Philip, Sophie Warembourg, Lionel Lenotre, Patrice Flore, Patrice Faure, Thierry Michy, Vincent Letouzey, Carole Arnold, Claire Piluso, Loic Chalmel, Ramzi Kacem, Georges Fabrice Blum, Renaud Detayrac, Candice Trocmé, Isabelle Brigaud…
    Citation: Trials 2023 24:759
  9. Amiodarone and esmolol can help to prevent and treat post-cardiac surgery reperfusion ventricular fibrillation. However, the relative efficacies of these two drugs remain unknown. The aim of the current trial ...

    Authors: Dan Zhu, Yu Li, A-yong Tian and Hong-nan Wang
    Citation: Trials 2023 24:758
  10. Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and l...

    Authors: Marijke de Leeuwerk, Vincent de Groot, Suzanne ten Dam, Hinke Kruizenga, Peter Weijs, Edwin Geleijn, Marike van der Leeden and Marike van der Schaaf
    Citation: Trials 2023 24:757
  11. Providing optimal care for critically ill patients is an extremely important but also highly demanding task, both emotionally and physically. The “ICU Support” team meeting concept aims to support intensive ca...

    Authors: Marie S. Thommes, Martin Klasen, Johannes Bickenbach, Maria Deja, Kristin Engelhard, Roland Francis, Johannes Gramatté, Gunther Hempel, Kerstin Gmeinwieser, Gabriel Reedy, Daniel Röder, Ines Schroeder and Saša Sopka
    Citation: Trials 2023 24:756
  12. Pulsed radiofrequency (PRF) treatment on the dorsal root ganglion (DRG) has been proposed as a good option for the treatment of persistent radicular pain based on its effect of neuromodulation on neuropathic p...

    Authors: Marta Homs, Raimon Milà, Ricard Valdés, David Blay, Rosa Maria Borràs and David Parés
    Citation: Trials 2023 24:755
  13. Window-of-opportunity trials (WOT) are a study design that have been used to investigate drug activity in endometrial cancer (EC). Recruitment to cancer clinical trials by patients from ethnic minority groups ...

    Authors: B. Mandane, A. Amirthanayagam, N. Patel, N. Darko and E. L. Moss
    Citation: Trials 2023 24:754
  14. Awareness with paralysis (AWP) is memory recall during neuromuscular blockade (NMB) and can cause significant psychological harm. Decades of effort and rigorous trials have been conducted to prevent AWP in the...

    Authors: Brian M. Fuller, Brian E. Driver, Michael B. Roberts, Christa A. Schorr, Kathryn Thompson, Brett Faine, Julianne Yeary, Nicholas M. Mohr, Ryan D. Pappal, Robert J. Stephens, Yan Yan, Nicholas J. Johnson and Brian W. Roberts
    Citation: Trials 2023 24:753
  15. Although a benefit of preoperative training prior to anterior cruciate ligament (ACL) reconstruction is likely, there is no consensus on the optimal content (criteria-based programme), supervision (one-on-one ...

    Authors: Rebecca Abel, Daniel Niederer, Christoph Offerhaus, Sven Shafizadeh, Alexander Glowa, Ingo Froböse and Christiane Wilke
    Citation: Trials 2023 24:752
  16. Immersive virtual reality (VR) is an innovative strategy for inpatient rehabilitation programs. Using immersive VR in early mobilization protocols has not yet been investigated in the setting of hospitalized p...

    Authors: Iasmin Borges Fraga, Larissa Gussatschenko Caballero, Pedro Dal Lago, João Lucas Campos de Oliveira, Marina Scherer, Mauren Porto Haeffner and Eneida Rejane Rabelo-Silva
    Citation: Trials 2023 24:751
  17. The negative emotional valence of a stimulus can be altered if paired with a pleasant stimulus, a phenomenon referred to as evaluative conditioning. Disgust, as a central emotion in obsessive-compulsive disord...

    Authors: Faezeh Raeis Al Mohaddesin, Ali Moghimi and Javad Salehi Fadardi
    Citation: Trials 2023 24:750
  18. Left atrial appendage closure (LAAC) procedures prevent cardioembolic stroke in patients with atrial fibrillation who have contraindications to oral anticoagulant medications. However, these procedures carry c...

    Authors: Witold Streb, Anetta Lasek-Bal, Katarzyna Mitręga, Jacek Kowalczyk, Tomasz Podolecki, Wiktoria Kowalska, Anna Olma, Agata Sobczyk and Zbigniew Kalarus
    Citation: Trials 2023 24:749
  19. Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management of acute pain resultin...

    Authors: Ben Shelley, Andreas Goebel, Stephen Grant, Louise Jackson, Hugh Jarrett, Marcus Jepson, Amy Kerr, Nandor Marczin, Rajnikant Mehta, Teresa Melody, Lee Middleton, Babu Naidu, Lajos Szentgyorgyi, Sarah Tearne, Ben Watkins, Matthew Wilson…
    Citation: Trials 2023 24:748
  20. Perinatal women are highly vulnerable to developing mental health issues and particularly susceptible to a recurrence of psychiatric illness. Poor mental health during the perinatal period can have long-term i...

    Authors: Grace Branjerdporn, Kerri Gillespie, Elizabeth Martin, Vivianne Kissane, Alex De Young, Tatjana Ewais, Kathleen Goldsmith, Susan Wilson, Sam Adhikary, Greg McGahan, Constanze Schulz and Michael Beckmann
    Citation: Trials 2023 24:747
  21. Myopia is one of the most common eye diseases causing visual impairment and blindness, and the high prevalence in adolescents remains a major public health concern. Based on clinical studies using optical defo...

    Authors: Li Shen, Wennan He, Weiming Yang, Weili Yan and Chenhao Yang
    Citation: Trials 2023 24:746
  22. Authors: Martin Law, Dominique-Laurent Couturier, Babak Choodari-Oskooei, Phillip Crout, Carrol Gamble, Peter Jacko, Philip Pallmann, Mark Pilling, David S. Robertson, Michael Robling, Matthew R. Sydes, Sofía S. Villar, James Wason, Graham Wheeler, S. Faye Williamson, Christina Yap…
    Citation: Trials 2023 24:744

    The original article was published in Trials 2023 24:640

  23. Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects cartilage and bone. Psychological stress can both trigger disease exacerbation and result from disease activity. As standard pha...

    Authors: Lennart Seizer, Ellis Huber, Miriam Schirmer, Sven Hilbert, Eva-Maria Wiest and Christian Schubert
    Citation: Trials 2023 24:743
  24. Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are chronic autoimmune lifelong diseases with fluctuating activity over time. The treatment includes medical therapy and surgery, howev...

    Authors: Ken Lund, Torben Knudsen, Jens Kjeldsen, Rasmus Gaardskær Nielsen, Carsten Bogh Juhl and Bente Mertz Nørgård
    Citation: Trials 2023 24:742
  25. Both acute normovolumic hemodilution (ANH) and autologous platelet-rich plasma (aPRP) have been demonstrated blood-protective effects in cardiac aortic surgery; however, the efficacies of the two methods have ...

    Authors: Dan Zhu, Yu Li, A-yong Tian and Hong-nan Wang
    Citation: Trials 2023 24:741
  26. Preventing dropout (attrition) from clinical trials is vital for improving study validity. Dropout is particularly important in justice-involved populations as they can be very challenging to engage and recrui...

    Authors: Natalie Doring, Ye In (Jane) Hwang, Emaediong Akpanekpo, Mathew Gullotta, Bianca Ton, Lee Knight, Crosbi Knight, Peter Schofield and Tony Gerard Butler
    Citation: Trials 2023 24:740
  27. With recent growth in the conduct of pragmatic clinical trials, the reliance on frontline staff to contribute to trial-related activities has grown as well. Active partnerships with staff members are often cri...

    Authors: Lisa A. Juckett, Kimberly P. Bernard and Kali S. Thomas
    Citation: Trials 2023 24:739
  28. The hallmark symptom of heart failure (HF) is severe exercise intolerance. Fortunately, accumulated evidence suggests that exercise programs improve physical performance, enhance autonomy in daily activities a...

    Authors: Vanessa Christina Costa da Silva, Fernando Zanela da Silva Arêas, Antônio Luiz Ribeiro Boechat Lopes, Fernando Fonseca de Almeida e Val, Allyson Guimarães da Costa, Joana Colares Correa dos Santos, João Marcos Bemfica Barbosa Ferreira and Guilherme Peixoto Tinoco Arêas
    Citation: Trials 2023 24:738
  29. Extremely preterm infants have a high mortality and morbidity. Here, we present a statistical analysis plan for secondary Bayesian analyses of the pragmatic, sufficiently powered multinational, trial—SafeBoosC...

    Authors: Markus Harboe Olsen, Mathias Lühr Hansen, Theis Lange, Christian Gluud, Lehana Thabane, Gorm Greisen and Janus Christian Jakobsen
    Citation: Trials 2023 24:737
  30. Electroencephalography (EEG)-based brain-computer interfaces (BCIs) allow to modulate the sensorimotor rhythms and are emerging technologies for promoting post-stroke motor function recovery. The Promotoer stu...

    Authors: Marta Cipriani, Floriana Pichiorri, Emma Colamarino, Jlenia Toppi, Federica Tamburella, Matteo Lorusso, Alessandra Bigioni, Giovanni Morone, Francesco Tomaiuolo, Filippo Santoro, Daniele Cordella, Marco Molinari, Febo Cincotti, Donatella Mattia and Maria Puopolo
    Citation: Trials 2023 24:736
  31. Dysphagia can lead to serious complications such as aspiration and aspiration pneumonia, timely and effective rehabilitation training can improve the swallowing function of patients. However, the conventional ...

    Authors: Bohan Zhang, Cai Guo, Vivian Hui, Ka Po Wong, Yue Liu, Zihan Liu, Yanan Xu, Qian Xiao, Shu-Cheng Chen and Jing Qin
    Citation: Trials 2023 24:735
  32. Emergence agitation or emergence delirium is a common complication of unknown etiology in pediatric anesthesia. Pediatric anesthesia emergence delirium (PAED) has been reported most commonly in younger childre...

    Authors: Yasuyuki Suzuki, Kiyoyuki W. Miyasaka, Kuniyoshi Hayashi, Osamu Takahashi and Yasuko Nagasaka
    Citation: Trials 2023 24:734
  33. The Large-scale Assessment of the Key health-promoting Activities of two New mass drug administration regimens with Azithromycin (LAKANA) trial in Mali aims to evaluate the efficacy and safety of azithromycin ...

    Authors: Juho Luoma, Laura Adubra, Dagmar Alber, Per Ashorn, Ulla Ashorn, Elaine Cloutman-Green, Fatoumata Diallo, Camilla Ducker, Riku Elovainio, Yue-Mei Fan, Lily Gates, Gwydion Gruffudd, Tiia Haapaniemi, Fadima Haidara, Lotta Hallamaa, Rikhard Ihamuotila…
    Citation: Trials 2023 24:733
  34. Disrupted sleep is believed to contribute to short- and long-term neurodevelopmental problems in very preterm infants (VPIs). This study presents a protocol for an evaluator-blinded, randomized crossover trial...

    Authors: Xiaoli Tang, Sha Sha, Nanping Shen, Zhiyu Zhu, Yanmin Qin, Junyi Shen and Fei Bei
    Citation: Trials 2023 24:732
  35. Upper limb lymphedema (ULLy) is an external (and/or internal) manifestation of lymphatic system insufficiency and deranged lymph transport for more than 3 months and frequently affects people as a consequence ...

    Authors: Federico Arippa, Andrea Scribante, Barbara Rocca and Marco Monticone
    Citation: Trials 2023 24:731
  36. Peritoneal dialysis (PD)-related infections, such as peritonitis, exit site, and tunnel infections, substantially impair the sustainability of PD. Accordingly, PD-related infection is the top-priority research...

    Authors: Josephine S. F. Chow, Neil Boudville, Yeoungjee Cho, Suetonia Palmer, Elaine M. Pascoe, Carmel M. Hawley, Donna M. Reidlinger, Laura E. Hickey, Ruth Stastny, Andrea Valks, Liza Vergara, Ramya Movva, Charani Kiriwandeniya, Hayley Candler, Gabor Mihala, Bernadette Buisman…
    Citation: Trials 2023 24:730
  37. The rising prevalence of knee osteoarthritis is placing a considerable strain on the global healthcare system. To address this issue, telemedicine-supported multicomponent exercise therapy has emerged as a pro...

    Authors: Yuan Feng, Yan Wu, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang, Jielei Huang, Yiwei Jiang, Chengqi He and Siyi Zhu
    Citation: Trials 2023 24:729
  38. Type 2 diabetes (T2D), a major risk factor for cardiovascular disease and other adverse health conditions, is on the rise in Singapore. TRIPOD is a randomized controlled trial aimed to determine whether comple...

    Authors: Joann Bairavi, Daphne Su-Lyn Gardner, Ester Yeoh, Kwang Wei Tham, Mihir Gandhi, Ngiap Chuan Tan, Phong Ching Lee, Robyn Su May Lim, Thofique Adamjee, Yin Bun Cheung, Yong Mong Bee and Eric Andrew Finkelstein
    Citation: Trials 2023 24:728
  39. The VenUS 6 parallel-group randomised controlled trial (RCT) will compare the clinical and cost-effectiveness of compression wraps, two-layer compression bandage and evidence-based compression therapy, compris...

    Authors: Maartje Kletter, Jane Griffiths, Catherine Arundel and Jo Dumville
    Citation: Trials 2023 24:727
  40. Authors: D. Molina-Morant, M. L. Fernández, P. Bosch-Nicolau, E. Sulleiro, M. Bangher, F. Salvador, A. Sanchez-Montalva, A. L. P. Ribeiro, A. M. B. de Paula, S. Eloi, R. Correa-Oliveira, J. C. Villar, S. Sosa-Estani and I. Molina
    Citation: Trials 2023 24:726

    The original article was published in Trials 2020 21:328

  41. Early blood transfusion improves survival in patients with life-threatening bleeding, but the optimal transfusion strategy in the pre-hospital setting has yet to be established. Although there is some evidence...

    Authors: Jason E. Smith, Ed B. G. Barnard, Charlie Brown-O’Sullivan, Rebecca Cardigan, Jane Davies, Annie Hawton, Emma Laing, Joanne Lucas, Richard Lyon, Gavin D. Perkins, Laura Smith, Simon J. Stanworth, Anne Weaver, Tom Woolley and Laura Green
    Citation: Trials 2023 24:725
  42. Preoperative anxiety management is gaining particular attention in paediatric anaesthesia. Pharmacological and non-pharmacological resorts can be implemented to address this special issue. Despite the various ...

    Authors: Meng-Qiu Zhang, Ming-Zhe Xu, Yi He, Yong-Wei Su, Jun Ma and Yun-Xia Zuo
    Citation: Trials 2023 24:724
  43. Australia persistently has one of the highest rates of colorectal cancer (CRC) in the world. Australia’s National Bowel Cancer Screening Program (NBCSP) sends a biennial Faecal Immunochemical Test (FIT)—the ‘N...

    Authors: Jennifer G. McIntosh, Jon D. Emery, Anna Wood, Patty Chondros, Belinda C. Goodwin, Judy Trevena, Carlene Wilson, Shanton Chang, Jane Hocking, Tina Campbell, Finlay Macrae, Kristi Milley, Jie-Bin Lew, Claire Nightingale, Ian Dixon, Makala Castelli…
    Citation: Trials 2023 24:723
  44. Migraine is a complex, chronic, and debilitating multifactorial disorder characterized by recurrent episodes of headache and related symptoms. It typically begins in early ages and is more prevalent in women t...

    Authors: Mahdi Vajdi, Fariborz Khorvash, Mohammad Hossein Rouhani, Abed Ghavami, Cain C. T. Clark and Gholamreza Askari
    Citation: Trials 2023 24:722
  45. Cervical facet joint disease is a common source of neck pain and its prevalence increases with aging. Conservative multimodal management options (e.g., strengthening of neck muscles, non-steroidal anti-inflamm...

    Authors: Abeer Alomari, Guilherme Ferreira-Dos-Santos, Mandeep Singh, Taylor Burnham, Xingshan Cao, Zachary McCormick, David Flamer, Pranab Kumar, Yasmine Hoydonckx, James S. Khan, Paul S. Tumber, Danielle Alvares and Anuj Bhatia
    Citation: Trials 2023 24:721
  46. In the severe forms of COVID-19 and many other infectious diseases, the patients develop a cytokine storm syndrome (CSS) where pro-inflammatory cytokines such as IL-6 and TNF-α play a key role in the developme...

    Authors: Maryam Hafizi, Somayeh Kalanaky, Saideh Fakharzadeh, Pegah Karimi, Atefeh Fakharian, Somayeh Lookzadeh, Esmaeil Mortaz, Maryam Sadat Mirenayat, Jalal Heshmatnia, Mehrdad Bakhshayesh Karam, Homa Zamani, Alireza Nadji, Mihan Pourabdollah Toutkaboni, Saeed Oraee-Yazdani, Mohammad Esmaeil Akbari, Hamidreza Jamaati…
    Citation: Trials 2023 24:720
  47. The physiologic and anthropometric characteristics changes associated with obesity may result in the alternation of pharmacologic management. Remimazolam tosylate is a new type of ultra-short-acting benzodiaze...

    Authors: Wenwen Ni, Xiuwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu, Yuan Han, Ji’e Jia and Wenxian Li
    Citation: Trials 2023 24:719
  48. Blinding drugs through simulation techniques is an important means to control the subjective bias of investigators and subjects. However, clinical trials face significant challenges in the placebo production o...

    Authors: Qingna Li, Mengli Xiao, Xingfang Liu, Yang Zhao, Haoling Zhang, Yundong Yin, Panbo Qiu, Fang Lu and Rui Gao
    Citation: Trials 2023 24:716

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