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  1. Mood-stabilizing medications are a cornerstone of treatment for people with bipolar disorder, though approximately half of these individuals are poorly adherent with their medication, leading to negative and e...

    Authors: Jennifer B. Levin, Farren Briggs, Carol Blixen, Mark Bauer, Douglas Einstadter, Jeffrey M. Albert, Celeste Weise, Nicole Woods, Edna Fuentes-Casiano, Kristin A. Cassidy, Julie Rentsch, Kaylee Sarna and Martha Sajatovic
    Citation: Trials 2022 23:634
  2. The number of exercise trials examining cardiometabolic outcomes in spinal cord injury (SCI) is low, and prescribed exercise is often inconvenient for individuals with SCI to perform within their community. In...

    Authors: Jacob Adams, Byron Lai, James Rimmer, Danielle Powell, Ceren Yarar-Fisher, Robert A. Oster and Gordon Fisher
    Citation: Trials 2022 23:633
  3. Various washout policies are widely used in adults living with long-term catheters (LTC). There is currently insufficient evidence on the benefits and potential harms of prophylactic LTC washout policies in th...

    Authors: Mohamed Abdel-fattah, Diana Johnson, Lynda Constable, Ruth Thomas, Seonaidh Cotton, Sheela Tripathee, David Cooper, Sue Boran, Konstantinos Dimitropoulos, Suzanne Evans, Paraskeve Granitsiotis, Hashim Hashim, Mary Kilonzo, James Larcombe, Paul Little, Sara MacLennan…
    Citation: Trials 2022 23:630
  4. Women with stress urinary incontinence (SUI) experience urine leakage with physical activity. Currently, the interventional treatments for SUI are surgical, or endoscopic bulking injection(s). However, these p...

    Authors: L. Clark, B. Fitzgerald, S. Noble, S. MacNeill, S. Paramasivan, N. Cotterill, H. Hashim, S. Jha, P. Toozs-Hobson, T. Greenwell, N. Thiruchelvam, W. Agur, A. White, V. Garner, M. Cobos-Arrivabene, C. Clement…
    Citation: Trials 2022 23:628
  5. Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and where nearly all deaths occur in children. Adding to this high burden is the co-existence of inte...

    Authors: Muhammed O. Afolabi, Doudou Sow, Jean Louis A. Ndiaye and Brian Greenwood
    Citation: Trials 2022 23:627
  6. Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease, characterised by oligodendrocyte death and demyelination. Oligodendrocyte progenitor cells can differentiate into new replacement oligo...

    Authors: Kalina Makowiecki, Natasha Stevens, Carlie L. Cullen, Amin Zarghami, Phuong Tram Nguyen, Lewis Johnson, Jennifer Rodger, Mark R. Hinder, Michael Barnett, Kaylene M. Young and Bruce V. Taylor
    Citation: Trials 2022 23:626
  7. The World Health Organization recommends tuberculosis (TB) preventive treatment (TPT) for all people living with HIV (PLH) and household contacts (HHC) of index TB patients. Tests for TB infection (TBI) or to ...

    Authors: Anete Trajman, Menonli Adjobimey, Mayara Lisboa Bastos, Chantal Valiquette, Olivia Oxlade, Federica Fregonese, Dissou Affolabi, Marcelo Cordeiro-Santos, Renato T. Stein, Andrea Benedetti and Dick Menzies
    Citation: Trials 2022 23:624
  8. Guanfacine is a α2A adrenergic receptor agonist approved for treating attention deficit hyperactivity disorder (ADHD). It is thought to act via postsynaptic receptors in the prefrontal cortex, modulating execu...

    Authors: Karen Hoang, Hilary Watt, Mara Golemme, Richard J. Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard and Paresh A. Malhotra
    Citation: Trials 2022 23:623
  9. Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ae...

    Authors: Sondre Serigstad, Christian Ritz, Daniel Faurholt-Jepsen, Dagfinn Markussen, Marit H. Ebbesen, Øyvind Kommedal, Rune O. Bjørneklett, Lars Heggelund, Tristan W. Clark, Cornelis H. van Werkhoven, Siri T. Knoop, Elling Ulvestad and Harleen M. S. Grewal
    Citation: Trials 2022 23:622
  10. Latinas are at increased risk for many lifestyle-related chronic diseases and are one of the least physically active populations in the US Innovative strategies are needed to help Latinas achieve the health be...

    Authors: Andrea S. Mendoza-Vasconez, Tanya Benitez, Shira Dunsiger, Kim M. Gans, Sheri J. Hartman, Sarah E. Linke, Britta A. Larsen, Dorothy Pekmezi and Bess H. Marcus
    Citation: Trials 2022 23:621
  11. Vaccination is one of the most effective strategies for prevention and eradication of immunopreventable diseases, but community acceptance of vaccination can be influenced by different factors, such as pain an...

    Authors: Elaine Aparecida da Cunha Lima, Luana Vieira Toledo, Marisa Dibbern Lopes Correia, Daniela de Almeida Pereira, Renata Oliveira Caetano, Thaís Bitencourt Faria and Luciene Muniz Braga
    Citation: Trials 2022 23:620
  12. The clinical inability to correctly identify late fetal growth restriction (FGR) within a group of fetuses who are identified as small for gestational age (SGA) is an everyday problem for all obstetrician-gyne...

    Authors: M. Smies, S. E. Damhuis, R. G. Duijnhoven, A. G. Leemhuis, S. J. Gordijn and W. Ganzevoort
    Citation: Trials 2022 23:619
  13. Childhood obesity rates more than double during primary school in England. Acquiring competent cooking skills is a key part of children’s education that can lead to improved knowledge of a healthy lifestyle an...

    Authors: Karen L. Vaughan, Janet E. Cade, Marion M. Hetherington, Jennie E. Cockroft, Mirjam M. Heinen, Holly Rippin and Charlotte E. L. Evans
    Citation: Trials 2022 23:618
  14. One relevant strategy to prevent the onset and progression of type 2 diabetes mellitus (T2DM) focuses on increasing physical activity. The use of activity trackers by patients could enable objective measuremen...

    Authors: M. Mähs, J. S. Pithan, I. Bergmann, L. Gabrys, J. Graf, A. Hölzemann, K. Van Laerhoven, S. Otto-Hagemann, M. L. Popescu, L. Schwermann, B. Wenz, I. Pahmeier and A. Teti
    Citation: Trials 2022 23:617
  15. More than half of patients undergoing paraesophageal hernia repair (PEHR) will have radiographic hernia recurrence at 5 years after surgery. Gastropexy is a relatively low-risk intervention that may decrease r...

    Authors: K. E. Blake, S. J. Zolin, C. Tu, K. F. Baier, L. R. Beffa, D. Alaedeen, D. M. Krpata, A. S. Prabhu, M. J. Rosen and C. C. Petro
    Citation: Trials 2022 23:616
  16. Major depression is one of the main mental illnesses in old age, with acute exacerbated episodes requiring treatment in geriatric psychiatry. A meta-analysis showed that aerobic exercise in moderate intensity ...

    Authors: Laura Elani Schulte, Tim Fleiner, Rieke Trumpf, Daria Wirtz, Thiemo Schnorr, Wiebren Zijlstra and Peter Haussermann
    Citation: Trials 2022 23:615
  17. Decentralised clinical trials (DCTs) are clinical trials where all or most trial activities occur in or near participants’ homes instead of hospitals or research sites. While more convenient for participants, ...

    Authors: Joanne Coyle, Amy Rogers, Rachel Copland, Giorgia De Paoli, Thomas M. MacDonald and Isla S. Mackenzie
    Citation: Trials 2022 23:614
  18. Persistent post-concussion symptoms (PCS) are associated with prolonged disability, reduced health-related quality of life and reduced workability. At present, no strong evidence for treatments for people with...

    Authors: Erhard Trillingsgaard Næss-Schmidt, Mille Møller Thastum, Henriette Holm Stabel, Lene Odgaard, Asger Roer Pedersen, Charlotte Ulrikka Rask, Noah D. Silverberg, Andreas Schröder and Jørgen Feldbæk Nielsen
    Citation: Trials 2022 23:613
  19. There are around 250 million adolescents in India. Adolescents are vulnerable to common mental disorders with depression and self-harm accounting for a major share of the burden of death and disability in this...

    Authors: Sandhya Kanaka Yatirajula, Sudha Kallakuri, Srilatha Paslawar, Ankita Mukherjee, Amritendu Bhattacharya, Susmita Chatterjee, Rajesh Sagar, Ashok Kumar, Heidi Lempp, Usha Raman, Renu Singh, Beverley Essue, Laurent Billot, David Peiris, Robyn Norton, Graham Thornicroft…
    Citation: Trials 2022 23:612
  20. Premature birth is the leading cause of neonatal death and can cause major morbidity. Maximising the amount of maternal breastmilk given to very premature infants is important to improve outcomes, but this can...

    Authors: Ilana Levene, Jennifer L. Bell, Christina Cole, Kayleigh Stanbury, Frances O’Brien, Mary Fewtrell and Maria A. Quigley
    Citation: Trials 2022 23:611
  21. Many patients with metastatic breast cancer experience cancer- and treatment-related side effects that impair activities of daily living and negatively affect the quality of life. There is a need for intervent...

    Authors: Anouk E. Hiensch, Evelyn M. Monninkhof, Martina E. Schmidt, Eva M. Zopf, Kate A. Bolam, Neil K. Aaronson, Jon Belloso, Wilhelm Bloch, Dorothea Clauss, Johanna Depenbusch, Milena Lachowicz, Mireia Pelaez, Helene Rundqvist, Elzbieta Senkus, Martijn M. Stuiver, Mark Trevaskis…
    Citation: Trials 2022 23:610
  22. Hypertension is the biggest contributor to the global cardiovascular burden with evidence for ethnic differences in treatment response and outcomes. Under-representation of ethnic minorities in clinical resear...

    Authors: Stefanie Lip, Georgia Dempster, Sahil Jain, Katriona Brooksbank, Nazim Ghouri, Linsay McCallum and Sandosh Padmanabhan
    Citation: Trials 2022 23:609
  23. Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo. While BPPV is best treated with canalicular repositioning manoeuvres, they are not routinely performed in primary care (PC).

    Authors: Jenniffer Elizabeth Pérez Patiño, José Lluís Ballvé Moreno, Yolanda Rando Matos, Jesús Almeda Ortega, Oriol Cunillera Puértolas, Ricard Carrillo Muñoz, Iván Villar Balboa, Xavier González Compta, Olga Lucía Arias Agudelo, Sebastiá Calero Muñoz, Vanessa Monforte Rodríguez, Anna Navarro Cortes and Eva Peguero Rodríguez
    Citation: Trials 2022 23:608
  24. Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity enhances health. Moreo...

    Authors: M. B. Syrjälä, L. Bennet, P. C. Dempsey, E. Fharm, M. Hellgren, S. Jansson, S. Nilsson, M. Nordendahl, O. Rolandsson, K. Rådholm, A. Ugarph-Morawski, P. Wändell and P. Wennberg
    Citation: Trials 2022 23:607
  25. Carotid endarterectomy is currently recommended for patients with recently symptomatic carotid stenosis ≥50%, based on randomised trials conducted 30 years ago. Several factors such as carotid plaque ulceratio...

    Authors: Suk Fun Cheng, Twan J. van Velzen, John Gregson, Toby Richards, Hans Rolf Jäger, Robert Simister, M. Eline Kooi, Gert J. de Borst, Francesca B. Pizzini, Paul J. Nederkoorn, Martin M. Brown and Leo H. Bonati
    Citation: Trials 2022 23:606
  26. The global incidence of dry eye disease (DED) is very high. DED seriously affects the quality of life of patients; however, the current curative effect of medicine for moderate to severe DED is poor. This rand...

    Authors: Xue Zhang, Bo Zhang, Siyang Peng, Guoliang Zhang, Jumei Ma and Wenzeng Zhu
    Citation: Trials 2022 23:605
  27. Knee osteoarthritis (KOA) is a high-priority problem among the aging population. While exercise has been shown to be beneficial in management of the disease, scalable and low-cost interventions to improve exer...

    Authors: William Leach, Caleigh Doherty, Marianna Olave, Bryant R. England, Katherine Wysham, Gail Kerr, Mercedes Quinones, Alexis Ogdie, Dan White, Tuhina Neogi, Carla R. Scanzello and Joshua F. Baker
    Citation: Trials 2022 23:604
  28. Some probiotics appear to improve athletic performance, endurance, and recovery after intense exercise. Other formulations may provide performance-related benefits via immune and gastrointestinal functions in ...

    Authors: Caitlin E. McDermott, Heather K. Vincent, Anne E. Mathews, Brunella Gonzalez Cautela, Mariana Sandoval, Annie Tremblay and Bobbi Langkamp-Henken
    Citation: Trials 2022 23:603
  29. Older adults with chronic pain, opioid use, and opioid use disorder (OUD) present complex management decisions in primary care. Clinical tools are needed to improve care delivery. This study protocol describes...

    Authors: Ainur Kagarmanova, Heather Sparkman, Neda Laiteerapong, Katherine Thompson, Linda Rosul, Danielle Lazar, Erin Staab, Wen Wan, Amanda Kass and Mim Ari
    Citation: Trials 2022 23:602
  30. To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT)...

    Authors: Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel and Sally Hopewell
    Citation: Trials 2022 23:601
  31. To compare the effects of two biologic disease-modifying antirheumatic drug (bDMARD) administration strategies on the maintenance effect and safety of patients with rheumatoid arthritis (RA) in remission, to a...

    Authors: Shangwen Lei, Zijia Li, Xiaoli Zhang and Shuhong Zhou
    Citation: Trials 2022 23:600
  32. Evidence for effective pain management and opioid minimization of intravenous ketamine in elective surgery has been extrapolated to acutely injured patients, despite limited supporting evidence in this populat...

    Authors: Thaddeus J. Puzio, James Klugh, Michael W. Wandling, Charles Green, Julius Balogh, Samuel J. Prater, Christopher T. Stephens, Paulina B. Sergot, Charles E. Wade, Lillian S. Kao and John A. Harvin
    Citation: Trials 2022 23:599
  33. Hypotension and blood pressure (BP) variability during endovascular therapy (EVT) for acute ischemic stroke (AIS) due to an anterior large vessel occlusion (LVO) is associated with worse outcomes. However, the...

    Authors: Benjamin Maïer, Benjamin Gory, Russell Chabanne, Benoît Tavernier, Baptiste Balanca, Gérard Audibert, Laurie-Anne Thion, Morgan Le Guen, Thomas Geeraerts, Lionel Calviere, Vincent Degos, Bertrand Lapergue, Sebastien Richard, Azeddine Djarallah, Ornellia Mophawe, Perrine Boursin…
    Citation: Trials 2022 23:598
  34. In the aftermath of a myocardial infarction with non-obstructive coronary arteries (MINOCA) or Takotsubo syndrome (TS), patients commonly express high levels of stress and anxiety. Current treatment alternativ...

    Authors: Erik M. G. Olsson, Fredrika Norlund, Elisabet Rondung, Sophia M. Humphries, Claes Held, Patrik Lyngå, Jonas Spaak, Örjan Sundin, Runa Sundelin, Philip Leissner, Lena Kövamees and Per Tornvall
    Citation: Trials 2022 23:597
  35. Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary ...

    Authors: M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales…
    Citation: Trials 2022 23:596
  36. Surviving breast cancer does not necessarily mean complete recovery to a premorbid state of health. Among the multiple psychological and somatic symptoms that reduce the quality of life of breast cancer surviv...

    Authors: Anne Lukas, Maurice Theunissen, Dianne de Korte-de Boer, Sander van Kuijk, Lotte Van Noyen, Walter Magerl, Werner Mess, Wolfgang Buhre and Madelon Peters
    Citation: Trials 2022 23:595
  37. Authors: Dong-Ju Choi, Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Seok Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-Ju Kim, Soon-Jun Hong, Seok Yeon Kim and Jae-Joong Kim
    Citation: Trials 2022 23:594

    The original article was published in Trials 2018 19:103

  38. Trauma-focused cognitive-behavioural treatments have been proven to be effective for reducing symptoms in female survivors of intimate partner violence (IPV), although they still present some difficulties (e.g...

    Authors: M. Crespo, A. Miguel-Alvaro, C. Hornillos, S. Sánchez-Ferrer and A. A. Antón
    Citation: Trials 2022 23:593
  39. Generalized anxiety disorder (GAD) is a chronic mental health condition that results in a significant individual and societal burden. While cognitive behavioral therapy (CBT) is well established as an efficaci...

    Authors: Vesna Trenoska Basile, Toby Newton-John and Bethany M. Wootton
    Citation: Trials 2022 23:592
  40. There is a lack of consensus related to the collection of standardized data for individuals with vitiligo enrolled in clinical trials and registries as well as those seen in clinical practice which causes diff...

    Authors: Nanja van Geel, Iltefat H. Hamzavi, Amit G. Pandya, Albert Wolkerstorfer, Julien Seneschal, Amit Garg, Phyllis Spuls, Caroline B. Terwee, Sue Mallett, Reinhart Speeckaert, Jean Marie Meurant, Viktoria Eleftheriadou and Khaled Ezzedine
    Citation: Trials 2022 23:591
  41. Childhood and adolescent overweight and obesity are among the most serious health challenges today. Structured weight reduction programs can be helpful to reduce severe health consequences but evidence is part...

    Authors: Katrin Ziser, Florian Junne, Anne Herschbach, Peter Martus, Johann Jacoby, Felicitas Stuber, Zahra Rahmani Azad, Isabelle Mack, Alisa Weiland, Inga Krauß, Constanze Greule, Gorden Sudeck, Lydia Kastner, Guido Zurstiege, Andreas Hoell, Wolfgang Bethge…
    Citation: Trials 2022 23:590
  42. Borderline personality disorder (BPD) is a severe mental disorder characterized by an unstable sense of self, intense and rapidly changing affect, as well as impulsive and self-destructive behaviors. Interpers...

    Authors: Charlotte Rosenbach, Nina Heinrichs, Robert Kumsta, Silvia Schneider and Babette Renneberg
    Citation: Trials 2022 23:589
  43. Maternal substance use disorder (SUD) represents a risk condition for quality of parenting and child development. The current literature highlights the need to identify interventions that effectively enhance t...

    Authors: Alessio Porreca, Alessandra Simonelli, Pietro De Carli, Lavinia Barone, Bianca Filippi, Paola Rigo, Marinus H. van IJzendoorn and Marian J. Bakermans-Kranenburg
    Citation: Trials 2022 23:588
  44. Ischemic brain injury is a major hurdle that limits the survival of resuscitated out-of-hospital cardiac arrest (OHCA).

    Authors: Jin-Ho Choi, Byeong Jo Chun, Seok Ran Yeom, Sung Phil Chung, Young Hwan Lee, Yun-Hee Kim, Ji Sung Lee, Jin Hwan Lee, Hwan Goo Lee, Jing Yu Jin, Chun San An and Byoung Joo Gwag
    Citation: Trials 2022 23:587
  45. Inadequate postoperative pain management increases the risk of adverse events after the surgery and aggressive perioperative pain prevention has both short-term and long-term benefits. S(+)-ketamine is an N-me...

    Authors: Hong Wang, Chongyang Duan, Jianmin Zhang, Shuangquan Qu, Ying Sun, Lizhi Zhou, Lujia Yang, Chen Lan, Weidong Mi and Pingyan Chen
    Citation: Trials 2022 23:586
  46. Autism is a neurodevelopmental disability affecting over 1% of UK children. The period following a child’s autism diagnosis can present real challenges in adaptation for families. Twenty to 50% of caregivers s...

    Authors: Kathy Leadbitter, Richard Smallman, Kirsty James, Gemma Shields, Ceri Ellis, Sophie Langhorne, Louisa Harrison, Latha Hackett, Alison Dunkerley, Leo Kroll, Linda Davies, Richard Emsley, Penny Bee and Jonathan Green
    Citation: Trials 2022 23:585
  47. Robotic radical prostatectomy (RARP) is a first-line curative treatment option for localized prostate cancer. Postoperative erectile dysfunction and urinary incontinence are common associated adverse side effe...

    Authors: Eoin Dinneen, Jack Grierson, Ricardo Almeida-Magana, Rosie Clow, Aiman Haider, Clare Allen, Daniel Heffernan-Ho, Alex Freeman, Tim Briggs, Senthil Nathan, Susan Mallett, Chris Brew-Graves, Nicola Muirhead, Norman R. Williams, Elena Pizzo, Raj Persad…
    Citation: Trials 2022 23:584
  48. The 2020 pandemic of SARS-CoV-2 causing COVID-19 disease is an unprecedented global emergency. COVID-19 appears to be a disease with an early phase where the virus replicates, coinciding with the first present...

    Authors: Tania Smith, Carlos Hoyo-Vadillo, Akosua Agyeman Adom, Liliana Favari-Perozzi, Silke Gastine, Hakim-Moulay Dehbi, Beatriz Villegas-Lara, Eduardo Mateos, Yessica Sara Pérez González, Maria D. Navarro-Gualito, Alejandra S. Cruz-Carbajal, Miguel A. Cortes-Vazquez, Carolina Bekker-Méndez, Charmina Aguirre-Alvarado, Gisela Aguirre-Gil, Lucero Delgado-Pastelin…
    Citation: Trials 2022 23:583
  49. Obesity increases the risk of type 2 diabetes, heart disease, stroke, mobility problems and some cancers, and its prevalence is rising. Men engage less than women in existing weight loss interventions. Game of...

    Authors: Lisa Macaulay, Catriona O’Dolan, Alison Avenell, Paula Carroll, Seonaidh Cotton, Stephan Dombrowski, Andrew Elders, Beatriz Goulao, Cindy Gray, Fiona M. Harris, Kate Hunt, Frank Kee, Graeme MacLennan, Matthew David McDonald, Michelle McKinley, Rebecca Skinner…
    Citation: Trials 2022 23:582

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