Skip to main content

Articles

Page 1 of 211

  1. Fear memory extinction is closely related to insomnia. Repetitive transcranial magnetic stimulation (rTMS) is safe and effective for treating insomnia disorder (ID), and it has been shown to be an efficient me...

    Authors: Jingjing Sun, Bidan Zhang, Wenyue Xu, Panpan Li, Danwei Zhang, Bei Zhao, Zhoubing Wang and Bin Wang
    Citation: Trials 2024 25:396
  2. Research in the neurosciences has highlighted the importance of intersubjective relationships in promoting neuromental development of the child. Children’s learning in early childhood occurs mainly in a dyadic...

    Authors: Cena Loredana, Trainini Alice, Murray Lynne, Cooper Peter, Calza Stefano and Belluardo Mauro
    Citation: Trials 2024 25:395
  3. In Kenya, 65% of sexually active unmarried women use modern contraceptives, a population at increased risk of HIV acquisition compared to other populations. Anchoring HIV prevention services, including pre-exp...

    Authors: Harison K. Lagat, Jillian Pintye, Elizabeth Harrington, Samantha Houck, Zachary Kwena, Meena Lenn, Felix Mogaka, Vincent Momanyi, Melissa Mugambi, Bernard Nyerere, Josephine Odoyo, Victor Omollo, Katrina F. Ortblad, Greshon Rota, Monisha Sharma and Elizabeth A. Bukusi
    Citation: Trials 2024 25:394
  4. Lifestyle-related risk factors can increase complications during pregnancy and negatively impact the health of a mother and her child. Knowledge about these compliances among many pregnant women and women of c...

    Authors: Mareike Krämer, Laura Wohlhüter, Lina Hermeling, Jan Koetsenruijter, Martina Kamradt, Michel Wensing and Manuela Bombana
    Citation: Trials 2024 25:393
  5. Hematopoietic cell transplantation (HCT) is a highly invasive and life-threatening treatment for hematological neoplasms and some types of cancer that can challenge the patient’s meaning structures. Restoring ...

    Authors: Aleksandra Kroemeke, Joanna Dudek, Marta Kijowska, Ray Owen and Małgorzata Sobczyk-Kruszelnicka
    Citation: Trials 2024 25:392
  6. Evidence indicates that trial participants often struggle to understand participant information leaflets (PILs) for clinical trials, including the concept of randomisation. We analysed the language used to des...

    Authors: Frances Shiely, Ellen Murphy, Katie Gilles, Kerry Hood, Lydia O’Sullivan, Nicola Harman, Talia Isaacs and Shaun Treweek
    Citation: Trials 2024 25:391
  7. Authors: Corina Benjet, Ronald C. Kessler, Alan E. Kazdin, Pim Cuijpers, Yesica Albor, Nayib Carrasco Tapias, Carlos C. Contreras-Ibáñez, Ma Socorro Durán González, Sarah M. Gildea, Noé González, José Benjamín Guerrero López, Alex Luedtke, Maria Elena Medina-Mora, Jorge Palacios, Derek Richards, Alicia Salamanca-Sanabria…
    Citation: Trials 2024 25:389

    The original article was published in Trials 2022 23:450

  8. Complete surgical removal of pancreatic ductal adenocarcinoma (PDAC) is central to all curative treatment approaches for this aggressive disease, yet this is only possible in patients technically amenable to r...

    Authors: Lin Li, Jessica Kasza, Ariadna Recasens, Liane Ioannou, Elysia Greenhill, Neil Merrett, David Cavallucci, Samantha Ellis, Helen Madgwick, Hyun Soo Ko, Lorraine Chantrill, Benjamin Loveday, Mehrdad Nikfarjam, Daniel Croagh, Jessica Yang, Andrew Dwyer…
    Citation: Trials 2024 25:388
  9. Untreated hepatitis C virus (HCV) infection can result in cirrhosis and hepatocellular cancer. Direct-acting antiviral (DAA) therapies are highly effective and have few side effects compared to older interfero...

    Authors: Parveen Fathima, Mark Jones, Reena D’Souza, James Totterdell, Nada Andric, Penelope Abbott, Richard Norman, Kirsten Howard, Wendy Cheng, Alisa Pedrana, Joseph S. Doyle, Jane Davies and Thomas Snelling
    Citation: Trials 2024 25:387
  10. Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment for end-stage liver disease but is limited by a shortage of suitable donor organs. As a r...

    Authors: Syed Hussain Abbas, Carlo D. L. Ceresa, Leanne Hodson, David Nasralla, Christopher J. E. Watson, Hynek Mergental, Constantin Coussios, Fotini Kaloyirou, Kerrie Brusby, Ana Mora, Helen Thomas, Daphne Kounali, Katie Keen, Joerg-Matthias Pollok, Rohit Gaurav, Satheesh Iype…
    Citation: Trials 2024 25:386
  11. A significant proportion of the global population has been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at some point since the onset of the pandemic. Although most individuals wh...

    Authors: Thomas Radtke, Lisa Künzi, Julia Kopp, Manuela Rasi, Julia Braun, Kyra D. Zens, Babette Winter, Alexia Anagnostopoulos, Milo A. Puhan and Jan S. Fehr
    Citation: Trials 2024 25:385
  12. In recent years, alternative monitoring approaches, such as risk-based and remote monitoring techniques, have been recommended instead of traditional on-site monitoring to achieve more efficient monitoring. Re...

    Authors: Osamu Yamada, Shih-Wei Chiu, Toru Nakazawa, Satoru Tsuda, Mitsuhide Yoshida, Toshifumi Asano, Taiki Kokubun, Kazuki Hashimoto, Munenori Takata, Suzuka Ikeda, Yosuke Kawabe, Yuko Tamura and Takuhiro Yamaguchi
    Citation: Trials 2024 25:384
  13. The TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation) trial assesses the clinical and cost-effectiveness of two biopsy procedures in terms of detection of clinically signi...

    Authors: Ioana R. Marian, Alexander Ooms, Jane Holmes, Matthew J. Parkes, Alastair D. Lamb and Richard J. Bryant
    Citation: Trials 2024 25:383
  14. Patients from socioeconomically disadvantaged backgrounds are underserved in randomised controlled trials, yet they experience a much greater burden of disease compared with patients from socioeconomically adv...

    Authors: Mariana Popa, Bridget Young, Nikki Rousseau, Mary G. Cherry, Isobel Jenkins, Jane Cloke, Andrew Pettitt, Michael D. Jenkinson, Saiqa Ahmed, Allan R. Pemberton and Frances C. Sherratt
    Citation: Trials 2024 25:382
  15. Prolonged exposure (PE) therapy is widely recognized as an effective treatment for post-traumatic stress disorder (PTSD) and is often considered one of the primary options for addressing this condition. Nevert...

    Authors: Maria Bragesjö, Brooke Fina, Ekaterina Ivanova, Volen Z Ivanov and Christian Rück
    Citation: Trials 2024 25:381
  16. Maintaining venous access is of great clinical importance. Running a slow continuous infusion to keep the vein open (KVO) is often used in peripheral intravenous catheters (PIVCs). Previous studies have compar...

    Authors: Rongmei Li, Mian Zhou, Lulu Sun, Lili Sha, Biyun Xu, Taishun Li, Tingting Tao and Ling Yuan
    Citation: Trials 2024 25:380
  17. Critically ill patients are exposed to several physical and emotional stressors, needing analgesic and sedative drugs to tolerate invasive procedures and the harsh intensive care unit (ICU) environment. Howeve...

    Authors: Giovanni Mistraletti, Anna Solinas, Silvia Del Negro, Carlotta Moreschi, Stefano Terzoni, Paolo Ferrara, Katerina Negri, Davide Calabretta, Paolo Formenti, Angelo Formenti and Michele Umbrello
    Citation: Trials 2024 25:379
  18. There is no known effective pharmacological therapy for long COVID, which is characterized by wide-ranging, multisystemic, fluctuating, or relapsing symptoms in a large proportion of survivors of acute COVID. ...

    Authors: Shani S. Thankachen, Niveditha Devasenapathy, Abhinav Bassi, Arpita Ghosh, Sumaiya Arfin, Balaji Gummidi, Aneesh Basheer, Ashfak Bangi, Dibakar Sahu, Ashish Bhalla, Merlin Blesson, Manish Jain and Vivekanand Jha
    Citation: Trials 2024 25:378
  19. Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurosurgical emergency with a high mortality rate. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CVS) are delayed products of early br...

    Authors: Fa Lin, Runting Li, Yu Chen, Jun Yang, Ke Wang, Yitong Jia, Heze Han, Qiang Hao, Guangzhi Shi, Shuo Wang, Yuanli Zhao and Xiaolin Chen
    Citation: Trials 2024 25:377
  20. Intensive care medicine continues to improve, with advances in technology and care provision leading to improved patient survival. However, this has not been matched by similar advances in ICU bedspace design....

    Authors: Oystein Tronstad, Barbara Zangerl, Sue Patterson, Dylan Flaws, Stephanie Yerkovich, Irene Szollosi, Nicole White, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Benjamin D. Weger, Frédéric Gachon, David Brain, Jayshree Lavana, Carol Hodgson and John F. Fraser
    Citation: Trials 2024 25:376
  21. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a predominant chronic liver condition globally and is strongly associated with obesity, diabetes mellitus, and dyslipidemia. Essential phosph...

    Authors: Norbert Stefan, Marek Hartleb, Branko Popovic and Rafael Varona
    Citation: Trials 2024 25:374
  22. Surgical handover is associated with a significant risk of care failures. Existing research displays methodological deficiencies and little consensus on the outcomes that should be used to evaluate interventio...

    Authors: Jessica M. Ryan, Declan Devane, Anastasija Simiceva, Walter Eppich, Dara O. Kavanagh, Christine Cullen, Aisling M. Hogan and Deborah A. McNamara
    Citation: Trials 2024 25:373
  23. Retaining participants in randomised controlled trials (RCTs) is challenging and trial teams are often required to use strategies to ensure retention or improve it. Other than monetary incentives, there is no ...

    Authors: Ellen Murphy, Katie Gillies and Frances Shiely
    Citation: Trials 2024 25:372
  24. Insomnia is a highly prevalent disorder associated with numerous adverse health outcomes. Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment by clinical guidelines but is...

    Authors: F. Benz, L. Grolig, S. Hannibal, C. Buntrock, P. Cuijpers, K. Domschke, D. D. Ebert, J. Ell, M. Janneck, C. Jenkner, A. F. Johann, A. Josef, M. Kaufmann, A. Koß, T. Mallwitz, H. Mergan…
    Citation: Trials 2024 25:371
  25. Endovascular therapy has become established as a first-line therapy in most arterial regions. However, open vascular surgery (endarterectomy) remains the treatment of choice for common femoral artery (CFA) les...

    Authors: Aljoscha Rastan, Tanja Böhme and Thomas Zeller
    Citation: Trials 2024 25:370
  26. Nearly two-thirds of family caregivers of persons living with Alzheimer’s disease or related dementias (AD/ADRD) provide complex care, including medical care. Family caregivers typically receive little to no t...

    Authors: Kylie Meyer, Kyungmi Lee, Sutthinee Thorngthip, Patricia Burant, Megan Lippe, Daria Neidre, Carole White, Rocio Norman, Byeong Yeob Choi, Crystal M. Glover, Janice Bell and Kenneth Hepburn
    Citation: Trials 2024 25:369
  27. Early identification of patients with chronic kidney disease (CKD) and advancing kidney insufficiency, followed by specialist care, can decelerate the progression of the disease. However, awareness of the impo...

    Authors: D. Stelzer, H. Binder, M. Glattacker, E. Graf, M. Hahn, M. Hollenbeck, K. Kaier, B. Kowall, N. Kuklik, G. Metzner, N. Mueller, L. Seiler, S. Stolpe and C. Blume
    Citation: Trials 2024 25:368
  28. Obese patients undergoing laparoscopic sleeve gastrectomy (LSG) are particularly at risk of opioid-related side effects. To reduce patient exposure to opioids, multimodal analgesia, which involves the use of d...

    Authors: Piotr Mieszczanski, Grzegorz Gorniewski, Marek Janiak and Janusz Trzebicki
    Citation: Trials 2024 25:367
  29. Chemotherapy with lomustine is widely considered as standard treatment option for progressive glioblastoma. The value of adding radiotherapy to second-line chemotherapy is not known.

    Authors: Matthias Preusser, Tomáš Kazda, Emilie Le Rhun, Felix Sahm, Marion Smits, Jens Gempt, Johan AF Koekkoek, Angelo F Monti, Marcell Csanadi, János György Pitter, Helen Bulbek, Beatrice Fournier, Caroline Quoilin, Thierry Gorlia, Michael Weller and Giuseppe Minniti
    Citation: Trials 2024 25:366
  30. Arterial hypertension (aHT) is a major cause for premature morbidity and mortality. Control rates remain poor, especially in low- and middle-income countries. Task-shifting to lay village health workers (VHWs)...

    Authors: Felix Gerber, Ravi Gupta, Thabo Ishmael Lejone, Thesar Tahirsylaj, Tristan Lee, Giuliana Sanchez-Samaniego, Maurus Kohler, Maria-Inés Haldemann, Fabian Raeber, Mamakhala Chitja, Malebona Mathulise, Thuso Kabi, Mosoetsi Mokaeane, Malehloa Maphenchane, Manthabiseng Molulela, Makhebe Khomolishoele…
    Citation: Trials 2024 25:365
  31. Women with polycystic ovary syndrome (PCOS) are usually selected to undergo an ovulation induction regimen or a programmed regimen for endometrial preparation in the frozen-thawed embryo transfer (FET) during ...

    Authors: Yanqiu Xie, Min Deng, Weifen Deng, Qi Fan and Yuhua Shi
    Citation: Trials 2024 25:364
  32. Patient participation in treatment decision making is a pillar of recovery-oriented care and is associated with improvements in empowerment and well-being. Although demand for increased involvement in treatmen...

    Authors: Emily B. H. Treichler, Lauren E. McBride, Elissa Gomez, Joanna Jain, Sydney Seaton, Kasey E. Yu, David Oakes, Dimitri Perivoliotis, Vanessa Girard, Samantha Reznik, Michelle P. Salyers, Michael L. Thomas, William D. Spaulding, Eric L. Granholm, Borsika A. Rabin and Gregory A. Light
    Citation: Trials 2024 25:363
  33. Flash visual evoked potentials (FVEPs) are a reliable method for protecting visual function during spine surgery in prone position. However, the popularization and application of FVEPs remain limited due to th...

    Authors: Jiajia Ma, Jing Wang, Yun Li, Yuxuan Fu, Yang Li, Hui Qiao and Ruquan Han
    Citation: Trials 2024 25:362
  34. Although hematopoietic stem cell transplantation provides the chances of survival for aplastic anemia patients, it is also related to many treatment-related physical and psychological side effects that severel...

    Authors: Menghua Ye, Ting Liu, Xiaopei Mao, Xiaoxue Tan, Jin Wang and Min Xu
    Citation: Trials 2024 25:361
  35. There is general agreement that sexuality is a central aspect of human development; it is key in sexual health and reproductive education during adolescence. However, in spite of the existing interventions on ...

    Authors: Loreto Leiva, Betzabé Torres-Cortés, Andrés Antivilo-Bruna and Gloria Zavala-Villalón
    Citation: Trials 2024 25:360
  36. Providing supported self-management for people with asthma can reduce the burden on patients, health services and wider society. Implementation, however, remains poor in routine clinical practice. IMPlementing...

    Authors: J. Sheringham, L. Steed, K. McClatchey, B. Delaney, A. Barat, V. Hammersley, V. Marsh, N. J. Fulop, S. J. C. Taylor and H. Pinnock
    Citation: Trials 2024 25:359
  37. This multicenter, double-blinded, randomized controlled trial (RCT) aims to assess the impact of an artificial intelligence (AI)-based model on the efficacy of intracranial aneurysm detection in CT angiography...

    Authors: Zhao Shi, Bin Hu, Mengjie Lu, Zijian Chen, Manting Zhang, Yizhou Yu, Changsheng Zhou, Jian Zhong, Bingqian Wu, Xueming Zhang, Yongyue Wei and Long Jiang Zhang
    Citation: Trials 2024 25:358
  38. Recent meta-analyses and randomized studies have shown that among patients with acute ischemic stroke undergoing endovascular thrombectomy, general anesthesia with mechanical ventilation is associated with bet...

    Authors: Manuel Taboada, Ana Estany-Gestal, Jorge Fernández, Laura Barreiro, Kora Williams, Manuel Rodríguez-Yáñez, Pablo Otero, Alberto Naveira, Valentín Caruezo, Sonia Veiras, Eva San Luis, Laura Dos Santos, María Diaz-Vieito, Susana Arias-Rivas, María Santamaría-Cadavid, Emilio Rodríguez-Castro…
    Citation: Trials 2024 25:357
  39. Patients diagnosed with pancreatic, biliary tract, and liver cancer often suffer from a progressive loss of muscle mass. Given the considerable functional impairments in these patients, high musculoskeletal we...

    Authors: Poorna Anandavadivelan, Daniele Cardinale, Rune Blomhoff, Berit Sunde, Kristoffer Lassen, Dyre Kleive, Christian Sturesson, Stefan Gilg, Truls Raastad and Sara Mijwel
    Citation: Trials 2024 25:356
  40. About 17–80% stroke survivors experience the deficit of upper limb function, which strongly influences their independence and quality of life. Robot-assisted training and functional electrical stimulation are ...

    Authors: Xu Yang, Wang Fengyi, Chen Yi, Qiu Lin, Lin Yang, Li Xize, Liu Shaxin and Yang Yonghong
    Citation: Trials 2024 25:355
  41. Cancer is a medical condition where some cells of the body reproduce uncontrollably and metastasize to other parts of the body. The burden of the disease is significantly high both at the global and national l...

    Authors: Fatima Abdul Rashid, Wajiha Anwar, Praveen Kumar Kandakurti and Animesh Hazari
    Citation: Trials 2024 25:354
  42. The SAVVY project aims to improve the analyses of adverse events (AEs) in clinical trials through the use of survival techniques appropriately dealing with varying follow-up times and competing events (CEs). T...

    Authors: Kaspar Rufibach, Jan Beyersmann, Tim Friede, Claudia Schmoor and Regina Stegherr
    Citation: Trials 2024 25:353
  43. Knee osteoarthritis (KOA) is a chronic musculoskeletal disorder characterized by pain and functional impairment. Blood flow restriction (BFR) with low-load resistance training (LLRT) demonstrates a similar imp...

    Authors: Qiao-Mei Hong, Hao-Nan Wang, Xi-Hui Liu, Wen-Qi Zhou and Xiao-Bing Luo
    Citation: Trials 2024 25:352
  44. Patients with chronic obstructive pulmonary disease (COPD) often suffer from a combination of mild cognitive impairment (MCI) and a significant reduction in their quality of life. In the exercise programme of ...

    Authors: Feiyun Song, Kexin Ding, Mingyun Sun and Rui Xia
    Citation: Trials 2024 25:351
  45. Authors: Taylan Gurgenci, Janet Hardy, Georgie Huggett, Karyn Foster, Anita Pelecanos, Ristan Greer, Jennifer Philip, Alison Haywood, Ruwani Mendis, Patsy Yates and Phillip Good
    Citation: Trials 2024 25:350

    The original article was published in Trials 2024 25:293

  46. Paediatric convulsive status epilepticus is the most common neurological emergency presenting to emergency departments. Risks of resultant neurological morbidity and mortality increase with seizure duration. I...

    Authors: Rob Forsyth, Maria Allen, Emma Bedson, Alice Downes, Chris Gough, Stuart Hartshorn, Kelly Lawton, Mark D. Lyttle, Shrouk Messahel, Niall Mullen, Joseph Raper, Anna Rosala-Harris, Leigh Taggart, Jason Urron, Emily Walton and Carrol Gamble
    Citation: Trials 2024 25:349
  47. Embryo implantation remains a critical barrier in assisted reproductive technologies. One of the main causes of unsuccessful embryo implantation is window of implantation (WOI) displacement, particularly in pa...

    Authors: Yao Lu, Xinyi Mao, Yaqiong He, Yuan Wang and Yun Sun
    Citation: Trials 2024 25:348
  48. Educational and self-care measures are important for women after gynecological pelvic cancer treatment. Pelvic floor muscle training exercises (PFMT) are a conservative treatment for pelvic floor (PF) dysfunct...

    Authors: Tatiana de Bem Fretta, Gabriela Dassie Dacanal, Pauliana Carolina de Souza Mendes, Mirella Dias and Cristine Homsi Jorge
    Citation: Trials 2024 25:347

Annual Journal Metrics

  • 2022 Citation Impact
    2.5 - 2-year Impact Factor
    2.5 - 5-year Impact Factor
    0.827 - SNIP (Source Normalized Impact per Paper)
    0.814 - SJR (SCImago Journal Rank)

    2023 Speed
    33 days submission to first editorial decision for all manuscripts (Median)
    129 days submission to accept (Median)

    2023 Usage 
    6,282,238 downloads
    5,569 Altmetric mentions