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  1. Sepsis is the leading cause of intensive care unit (ICU) admission and ICU death. In recognition of the burden of sepsis, the Surviving Sepsis Campaign (SSC) and the Institute for Healthcare Improvement develo...

    Authors: Hannah E. Frank, Laura Evans, Gary Phillips, RPhillip Dellinger, Jessyca Goldstein, Lori Harmon, David Portelli, Nima Sarani, Christa Schorr, Kathleen M. Terry, Sean R. Townsend and Mitchell M. Levy
    Citation: Trials 2023 24:620
  2. Radiation-associated dysphagia is defined as impaired swallowing efficiency/safety following (chemo)radiotherapy in head and neck cancer patients. In a dysphagia framework, impaired coughing may lead to lung a...

    Authors: Sofiana Mootassim-Billah, Gwen Van Nuffelen, Jean Schoentgen, Marc De Bodt and Dirk Van Gestel
    Citation: Trials 2023 24:619
  3. Authors: Angela T. Hetrick, April M. Young, Miriam R. Elman, Sarann Bielavitz, Rhonda L. Alexander, Morgan Brown, Elizabeth Needham Waddell, P. Todd Korthuis and Kathryn E. Lancaster
    Citation: Trials 2023 24:618

    The original article was published in Trials 2021 22:948

  4. In contrast to evidence for interventions supporting victim/survivors of domestic violence and abuse (DVA), the effectiveness of perpetrator programmes for reduction of abuse is uncertain. This study aims to e...

    Authors: Karen Morgan, Mei-See Man, Rachael Bloomer, Madeleine Cochrane, Melissa Cole, Sandi Dheensa, Nathan Eisenstadt, Gene Feder, Daisy M. Gaunt, Rwth Leach, Rebecca Kandiyali, Sian Noble, Tim J. Peters, Beverly A. Shirkey and Helen Cramer
    Citation: Trials 2023 24:617
  5. Neck pain is the fourth worldwide leading cause of disability and represents 22% of musculoskeletal disorders. Conservative intervention has been strongly recommended to treat chronic neck pain and Telerehabil...

    Authors: Juliene Corrêa Barbosa, Josielli Comachio, Amelia Pasqual Marques, Bruno Tirotti Saragiotto and Mauricio Oliveira Magalhaes
    Citation: Trials 2023 24:616
  6. Many people experience withdrawal symptoms when they attempt to stop antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing need for medication, contributing to long-term use (> 1...

    Authors: Katharine A. Wallis, Maria Donald, Mark Horowitz, Joanna Moncrieff, Robert S. Ware, Joshua Byrnes, Karen Thrift, MaryAnne Cleetus, Idin Panahi, Nicholas Zwar, Mark Morgan, Chris Freeman and Ian Scott
    Citation: Trials 2023 24:615
  7. Authors: M. Masiá, S. Padilla, G. Estañ, J. Portu, A. Silva, A. Rivero, A. González-Cordón, L. García-Fraile, O. Martínez, E. Bernal, C. Galera, V. Boix Martínez, J. Macias, M. Montero, D. García-Rosado, M. J. Vivancos-Gallego…
    Citation: Trials 2023 24:614

    The original article was published in Trials 2021 22:851

  8. Two characteristics of commonly used outcomes in medical research are zero inflation and non-negative integers; examples include the number of hospital admissions or emergency department visits, where the majo...

    Authors: Kyung Hyun Lee, Claudia Pedroza, Elenir B. C. Avritscher, Ricardo A. Mosquera and Jon E. Tyson
    Citation: Trials 2023 24:613
  9. Respiratory distress syndrome is the main cause of mortality and morbidity in preterm infants. “Less invasive surfactant administration” (LISA), which describes intratracheal surfactant administration to spont...

    Authors: Wolfgang Göpel, Tanja K. Rausch, Barbara Mitschdörfer, Silke Mader, Egbert Herting, Inke R. König and Guido Stichtenoth
    Citation: Trials 2023 24:612
  10. Effectiveness of actions to reduce sugar-sweetened beverage (SB) consumption in children still needs to be improved. Furthermore, the growing concern about sustainable food systems encourages to develop sustai...

    Authors: Katia Castetbon, Wassila Assakali, Isabelle Thiébaut and Lucille Desbouys
    Citation: Trials 2023 24:611
  11. Parkinson’s disease (PD) is a neurodegenerative disorder with debilitating motor and non-motor symptoms which affect participation in meaningful occupations. Occupation-based interventions can improve particip...

    Authors: Mahsa Meimandi, Akram Azad, Jafar Haj Ghani, Fatemeh HojabriFard, Philip von Rosen, Naeeme Haji Alizadeh and Ghorban Taghizadeh
    Citation: Trials 2023 24:610
  12. People with substance use disorders are vulnerable to acquiring HIV. Testing is fundamental to diagnosis, treatment, and prevention; however, in the past decade, there has been a decline in the number of subst...

    Authors: Jemima A. Frimpong, Carrigan L. Parish, Daniel J. Feaster, Lauren K. Gooden, Mindy C. Nelson, Tim Matheson, Karolynn Siegel, Louise Haynes, Benjamin P. Linas, Sabrina A. Assoumou, Susan Tross, Tiffany Kyle, Terri K. Liguori, Oliene Toussaint, Debra Annane and Lisa R. Metsch
    Citation: Trials 2023 24:609
  13. Malignant gastric outlet obstruction (GOO) is a debilitating condition that frequently occurs in patients with malignancies of the distal stomach and (peri)ampullary region. The standard palliative treatment f...

    Authors: Janine B. Kastelijn, Yorick L. van de Pavert, Marc G. Besselink, Paul Fockens, Rogier P. Voermans, Roy L. J. van Wanrooij, Thomas R. de Wijkerslooth, Wouter L. Curvers, Ignace H. J. T. de Hingh, Marco J. Bruno, Bas Groot Koerkamp, Gijs A. Patijn, Alexander C. Poen, Jeanin E. van Hooft, Akin Inderson, J. Sven D. Mieog…
    Citation: Trials 2023 24:608
  14. Postoperative delirium (POD) is a common complication, and it has a high incidence in neurosurgery patients. Awake craniotomy (AC) has been widely performed in patients with glioma in eloquent and motor areas....

    Authors: Muhan Li, Minying Liu, Qianyu Cui, Min Zeng, Shu Li, Liyong Zhang and Yuming Peng
    Citation: Trials 2023 24:607
  15. Limited access to specialized palliative care exposes persons with late-stage Alzheimer’s disease and related dementias (ADRD) to burdensome treatment and unnecessary hospitalization and their caregivers to av...

    Authors: M. Toles, C. Kistler, F. C. Lin, M. Lynch, K. Wessell, S. L. Mitchell and L. C. Hanson
    Citation: Trials 2023 24:606
  16. During the cochlear implantation procedure, the receiver/stimulator (R/S) part of the implant is fixated to prevent postoperative device migration, which could have an adverse effect on the position of the ele...

    Authors: Laura M. Markodimitraki, Timen C. ten Harkel, Edwin Bennink, Inge Stegeman and Hans G. X. M. Thomeer
    Citation: Trials 2023 24:605
  17. Spinal cord stimulation (SCS) is one of the neuromodulation therapies for chronic neuropathic pain. The conventional paresthesia-based SCS involves the application of tonic stimulation that induces a sense of ...

    Authors: Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa and Ryuta Saito
    Citation: Trials 2023 24:604
  18. Haemoglobin SC (HbSC) is a common form of sickle cell disease (SCD), especially among individuals of West African ancestry. Persons with HbSC disease suffer from the same clinical complications and reduced qua...

    Authors: Luke R. Smart, Catherine I. Segbefia, Teresa S. Latham, Susan E. Stuber, Kwesi N. Amissah-Arthur, Klenam Dzefi-Tettey, Adam C. Lane, Yvonne A. Dei-Adomakoh and Russell E. Ware
    Citation: Trials 2023 24:603
  19. Due to the growing gap between the demand and supply of therapeutic services for people suffering from depression, with this study, we are investigating the effectiveness and factors of influence of new approa...

    Authors: Leona Kind, Katharina Luttenberger, Vivien Leßmann, Lisa Dorscht, Christiane Mühle, Christian P. Müller, Eva-Maria Siegmann, Sophia Schneider and Johannes Kornhuber
    Citation: Trials 2023 24:602
  20. No consensus currently exists regarding the optimal protocol for repetitive transcranial magnetic stimulation (rTMS) treatment of upper-extremity motor dysfunction after stroke. Studies have shown that combine...

    Authors: Yuan Huang, Ruizhu Lin, Hongyu Li, Yujuan Xu, Fubao Tian, Liangchen Ma, Xiaoli Liu, Shuming Ma, Xiaolong Li, Zheying Lai, Chuanping Bai, Weichun He, Qi Ma, Jingkai Wang and Ning Zhu
    Citation: Trials 2023 24:601
  21. Severe acute pancreatitis complicated by acute respiratory distress is a common cause of intensive care unit (ICU) admission. These patients are at risk of a decline in physical activity due to bed rest. Neuro...

    Authors: Feng Zhou, Dingrong Fan, Yan Feng, Cuijuan Zhou, Xiaodong Chen, Xiaoyun Ran and Botao Tan
    Citation: Trials 2023 24:600
  22. The 2022 ASA guidelines recommend the video laryngoscope, video stylet, and flexible videoscope as airway management tools. This study aims to compare the efficacy of three airway devices in intubating patient...

    Authors: Tao Zhang, Kai-Yuan Zhao, Ping Zhang and Ren-Hu Li
    Citation: Trials 2023 24:599
  23. Authors: Caroline Cake, Emma Ogburn, Heather Pinches, Garry Coleman, David Seymour, Fran Woodard, Sinduja Manohar, Marjia Monsur, Martin Landray, Gaynor Dalton, Andrew D. Morris, Patrick F. Chinnery, F. D. Richard Hobbs and Christopher Butler
    Citation: Trials 2023 24:598

    The original article was published in Trials 2022 23:62

  24. Since the onset of the COVID-19 pandemic, the worldwide prevalence of maternal depression has risen sharply; it is now estimated that one quarter of mothers experience clinically significant depression symptom...

    Authors: Lara Penner-Goeke, Madeline Belows, Amanda Kristjanson, Brendan F. Andrade, Emily E. Cameron, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Nicole Letourneau, Natalie Mota, Kristin Reynolds, Maureen Zalewski, Ashley Pharazyn and Leslie E. Roos
    Citation: Trials 2023 24:597
  25. The lumbar plexus originates from multiple segments of the spinal cord. Both single-level lumbar plexus block (LPB) and transmuscular quadratus lumborum block (TQLB) are commonly used to provide analgesia for ...

    Authors: Xiaofeng Wang, Hui Zhang, Yongzhu Chen, Zhenwei Xie, Moxi Chen, Yonglin Chen and Junfeng Zhang
    Citation: Trials 2023 24:596
  26. Community-acquired pneumonia (CAP) is a significant public health concern and a leading cause of hospitalization and inpatient antimicrobial use in the USA. However, determining the etiologic pathogen is chall...

    Authors: Abhishek Deshpande, Ramara Walker, Rebecca Schulte, Andrea M. Pallotta, Larisa G. Tereshchenko, Bo Hu, Sameer S. Kadri, Michael Klompas and Michael B. Rothberg
    Citation: Trials 2023 24:595
  27. Pulmonary segmentectomy, when combined with hilar and mediastinal lymphadenectomy, is currently considered the gold standard treatment for early-stage lung tumors (NSCLC) smaller than 2 cm in diameter. The pre...

    Authors: Francesco Zaraca, Andreas Kirschbaum, Marco Damiano Pipitone and Luca Bertolaccini
    Citation: Trials 2023 24:594
  28. Cardiovascular events, driven by endothelial dysfunction, are a recognised complication of COVID-19. SARS-CoV-2 infections remain a persistent concern globally, and an understanding of the mechanisms causing e...

    Authors: Asad Shabbir, Ismita Chhetri, Rayomand S. Khambata, Tipparat Parakaw, Clement Lau, Muhammad A. B. N. Aubdool, Gianmichele Massimo, Nicki Dyson, Vikas Kapil, Thomas Godec, Vanessa Apea, Jan Flint, Chloe Orkin, Krishnaraj S. Rathod and Amrita Ahluwalia
    Citation: Trials 2023 24:593
  29. Stress is highly prevalent in patients with ischemic heart disease (IHD) and is associated with lower health-related quality of life and impaired cardiovascular outcome. The importance of stress management is ...

    Authors: Julia Lortz, Tienush Rassaf, Christoph Jansen, Ramtin Knuschke, Adam Schweda, Lenka Schnaubert, Christos Rammos, Juliane Köberlein-Neu, Eva-Maria Skoda, Martin Teufel and Alexander Bäuerle
    Citation: Trials 2023 24:592
  30. About 50% of older patients with acute myeloid leukemia (AML) fail to attain complete remission (CR) following cytarabine plus anthracycline-based induction therapy. Salvage chemotherapy regimens are based on ...

    Authors: Sonia Jaramillo, Lucian Le Cornet, Markus Kratzmann, Johannes Krisam, Martin Görner, Mathias Hänel, Christoph Röllig, Maxi Wass, Sebastian Scholl, Mark Ringhoffer, Alexander Reichart, Björn Steffen, Sabine Kayser, Jan-Henrik Mikesch, Kerstin Schaefer-Eckart, Jörg Schubert…
    Citation: Trials 2023 24:591
  31. The CRADLE Vital Signs Alert intervention (an accurate easy-to-use device that measures blood pressure and pulse with inbuilt traffic-light early warning system, and focused training package) was associated wi...

    Authors: Alexandra E. Ridout, Francis L. Moses, Simren Herm-Singh, Cristina Fernandez Turienzo, Paul T. Seed, Venetia Goodhart, Nicola Vousden, Betty Sam, Mariama Momoh, Daniel Kamara, Katy Kuhrt, Sorie Samura, Candace Beoku-Betts, Alice Hurrell, Kate Bramham, Sartie Kenneh…
    Citation: Trials 2023 24:590
  32. Polycystic ovary syndrome (PCOS) is the most prevalent, chronic endocrine-metabolic disorder of adolescents and young women (AYAs), affecting 5–10% of AYAs worldwide. There is no approved pharmacological thera...

    Authors: Cristina Garcia-Beltran, Rita Malpique, Marianne S. Andersen, Firdevs Bas, Judit Bassols, Feyza Darendeliler, Marta Díaz, Barbara Dieris, Flaminia Fanelli, Elke Fröhlich-Reiterer, Alessandra Gambineri, Dorte Glintborg, Abel López-Bermejo, Christopher Mann, Silvia Marin, Barbara Obermayer-Pietsch…
    Citation: Trials 2023 24:589
  33. The National Institute for Health and Care Excellence (NICE) recommends that cognitive behaviour therapy (CBT) is offered to all patients with a psychosis diagnosis. However, only a minority of psychosis patie...

    Authors: Mark Hayward, Katherine Berry, Stephen Bremner, Kate Cavanagh, Guy Dodgson, David Fowler, Heather Gage, Kathryn Greenwood, Cassie Hazell, Anna-Marie Bibby-Jones, Sam Robertson, Morro Touray, Natalie Dailey and Clara Strauss
    Citation: Trials 2023 24:588
  34. Influenza (flu) vaccination rates in UK care home staff are extremely low. Less than 40% of staff in care homes are vaccinated for influenza (flu), presenting risks to the health of frail residents and potenti...

    Authors: Linda Birt, Thando Katangwe-Chigamba, Sion Scott, David J Wright, Adam P. Wagner, Erika Sims, Veronica Bion, Carys Seeley, Faisal Alsaif, Allan Clarke, Alys Griffiths, Liz Jones, Alison Bryant and Amrish Patel
    Citation: Trials 2023 24:587
  35. The conventional treatments for non-acute subdural hematoma (SDH) are facing the challenge of high hematoma recurrence and progression. A novel treatment of middle meningeal artery (MMA) embolization showed th...

    Authors: Qiao Zuo, Wei Ni, Pengfei Yang, Yuxiang Gu, Ying Yu, Heng Yang, Charles B. L. M. Majoie, Mayank Goyal, Jianmin Liu and Ying Mao
    Citation: Trials 2023 24:586
  36. Applying technology through the use of the Internet and mobile phones can help provide education and trained peer support for patients with diabetes after coronary artery bypass (CABG). We are conducting a ran...

    Authors: Yangwu Song, Yifeng Nan and Wei Feng
    Citation: Trials 2023 24:585
  37. Approximately one in ten women have high blood pressure during pregnancy. Hypertension is associated with adverse maternal and perinatal outcomes, and as treatment improves maternal outcomes, antihypertensive ...

    Authors: Danielle Ashworth, Cheryl Battersby, Debra Bick, Marcus Green, Pollyanna Hardy, Lisa Leighton, Laura A. Magee, Alisha Maher, Richard J. McManus, Catherine Moakes, R. Katie Morris, Catherine Nelson-Piercy, Jenie Sparkes, Oliver Rivero-Arias, Andrew Webb, Hannah Wilson…
    Citation: Trials 2023 24:584
  38. A substantial proportion of patients with bipolar disorder experience daily subsyndromal mood swings, and the term “mood instability” reflecting the variability in mood seems associated with poor prognostic fa...

    Authors: Maria Faurholt-Jepsen, Natacha Blauenfeldt Kyster, Malene Schwarz Dyreholt, Ellen Margrethe Christensen, Pernille Bondo-Kozuch, Anna Skovgaard Lerche, Birte Smidt, Ulla Knorr, Kim Brøndmark, Anne-Marie Bangsgaard Cardoso, Anja Mathiesen, Rene Sjælland, Henrik Nørbak-Emig, Lotte Linnemann Sponsor, Darius Mardosas, Ida Palmblad Sarauw-Nielsen…
    Citation: Trials 2023 24:583
  39. Tuberculosis (TB) remains a major cause of morbidity and mortality in the world, despite being a preventable and curable disease. The World Health Organization (WHO) End-TB Strategy, aligned with the Sustainab...

    Authors: Desalegne Amare, Fentie Ambaw and Kefyalew Addis Alene
    Citation: Trials 2023 24:582
  40. Prompt recognition of delirium is the first key step in its proper management. A previous study has demonstrated that nurses’ delirium screening using the usual paper version assessment tool has no effect on c...

    Authors: Jiamin Wang, Sen Niu and Ying Wu
    Citation: Trials 2023 24:581
  41. Spinal cord stimulation (SCS) is a surgical technique used in patients with chronic intractable pain, and its effectiveness and safety have been validated by multiple studies. However, to maintain an optimal a...

    Authors: Yuanchen Cheng, Duo Xie, Yan Han, Siying Guo, Zhenxing Sun, Linkai Jing, Weitao Man, Dongkang Liu, Kaiyuan Yang, Dan Lei, Zhe Meng, Huifang Zhang, Guoqin Wang, Weiwei Wu, Guihuai Wang and Yang Lu
    Citation: Trials 2023 24:580
  42. The last few decades have seen increasing interest in the use of cannabis for post-traumatic stress disorder (PTSD). Recent attempts to evaluate the clinical efficacy of cannabis for PTSD were inconclusive and...

    Authors: Zach Walsh, Ian Mitchell, Kim Crosby, Michelle St. Pierre, Drew DeClerck, Kaye Ong and Philippe Lucas
    Citation: Trials 2023 24:578
  43. Multidisciplinary team meetings (MDMs), also known as tumor conferences, are a cornerstone of cancer treatments. However, barriers such as incomplete patient information or logistical challenges can postpone t...

    Authors: Sharlyn S. T. Ng, Robert Oehring, Nikitha Ramasetti, Roland Roller, Philippe Thomas, Yuxuan Chen, Simon Moosburner, Axel Winter, Max-Magnus Maurer, Timo A. Auer, Can Kamali, Johann Pratschke, Christian Benzing and Felix Krenzien
    Citation: Trials 2023 24:577
  44. Pancreatic cancer is a devastating disease with less than 5% 5-year survival. Inoperable patients often present with pain. Randomized controlled trial have shown that endoscopic ultrasound-guided celiac plexus...

    Authors: Eslam Esmail, Sarto C Paquin and Anand V Sahai
    Citation: Trials 2023 24:576
  45. Rectal cancer is a common cancer worldwide. Surgery for rectal cancer with low anterior resection often includes the formation of a temporary protective loop ileostomy. The temporary ostomy is later reversed i...

    Authors: Karolina Eklöv, Sven Bringman, Jenny Löfgren, Jonas Nygren and Åsa H. Everhov
    Citation: Trials 2023 24:575
  46. Low back pain (LBP) is a multifactorial disorder associated with a high range of physical and psychological burden on the society. Patient-led goal-setting approach has shown potential effects for improving ch...

    Authors: Sahar Soheili, Amir Letafatkar and Mahdi Hosseinzadeh
    Citation: Trials 2023 24:573
  47. International guidelines of groin hernia treatment strongly recommend to fixate the mesh in large M3 medial defects during TAPP/TEP procedures. The main purpose of fixation is to decrease the recurrence rate w...

    Authors: Mateusz Zamkowski and Maciej Śmietański
    Citation: Trials 2023 24:572
  48. Pre-hospital pain management has traditionally been performed with intravenous (IV) morphine, but oligoanalgesia remain a recognized problem. Pain reduction is essential for patient satisfaction and is regarde...

    Authors: Randi Simensen, Lars Olav Fjose, Marius Rehn, Jostein Hagemo, Kjetil Thorsen and Fridtjof Heyerdahl
    Citation: Trials 2023 24:571

Annual Journal Metrics

  • 2022 Citation Impact
    2.5 - 2-year Impact Factor
    2.5 - 5-year Impact Factor
    0.827 - SNIP (Source Normalized Impact per Paper)
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    41 days submission to first editorial decision for all manuscripts (Median)
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