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  1. Cerebrospinal fluid (CSF) leakage is a frequent and challenging complication in neurosurgery, especially in the posterior fossa, with a prevalence of 8%. It is associated with substantial morbidity and increas...

    Authors: Andrew P. Carlson, Emma M. H. Slot, Tristan P. C. van Doormaal, E. H. J. Voormolen, J. W. Dankbaar, P. Depauw, B. Brouwers, M. R. Germans, E. Baert, J. Vandersteene, C. F. Freyschlag, J. Freyschlag, C. Thomé, F. Zenga, F. Penner, A. Abdulazim…
    Citation: Trials 2022 23:581
  2. Improving the functional outcome following total knee arthroplasty (TKA) by using different alignment techniques remains controversial. The surgical techniques and technologies used so far to obtain these alig...

    Authors: Simon W. Young, Nina Zeng, Mei Lin Tay, David Fulker, Christina Esposito, Matthew Carter, Ali Bayan, Bill Farrington, Rupert Van Rooyen and Matthew Walker
    Citation: Trials 2022 23:580
  3. Inferior scapular notching is a complication unique to reverse shoulder arthroplasty. The most efficient technique to avoid inferior scapular notching has been reported to be lateralization of the glenoid offs...

    Authors: Marie Louise Jensen, Bo S. Olsen, Marc R. K. Nyring, Müjgan Yilmaz, Michael M. Petersen, Gunnar Flivik and Jeppe V. Rasmussen
    Citation: Trials 2022 23:579
  4. Long-lasting insecticidal nets (LLINs) have contributed to the reduction of malaria in sub-Saharan Africa, including Tanzania. However, they rely on daily user behaviour and high coverage which is difficult to...

    Authors: Olukayode G. Odufuwa, Sarah Jane Moore, Zawadi Mageni Mboma, Emmanuel Mbuba, Joseph Barnabas Muganga, Jason Moore, Rose Philipo, Mohammed Ally Rashid, Rune Bosselmann, Ole Skovmand and John Bradley
    Citation: Trials 2022 23:578
  5. Systematic reviews suggest that preschool environmental/organizational changes may be effective in increasing physical activity (PA) levels of preschool children, but evidence is scarce regarding feasible, eff...

    Authors: C. Chen, V. H. Ahlqvist, P. Henriksson, J. H. Migueles, F. Christiansen, M. R. Galanti and D. Berglind
    Citation: Trials 2022 23:577
  6. Delirium is a highly prevalent and morbid syndrome in mechanically ventilated intensive care unit (ICU) patients. Music is a promising non-pharmacological intervention with beneficial effects on anxiety and st...

    Authors: Sarah Seyffert, Salwa Moiz, Matthew Coghlan, Patil Balozian, Jason Nasser, Emilio Abi Rached, Yasser Jamil, Kiran Naqvi, Lori Rawlings, Anthony J. Perkins, Sujuan Gao, J. Downs Hunter III, Sikandar Khan, Annie Heiderscheit, Linda L. Chlan and Babar Khan
    Citation: Trials 2022 23:576
  7. In the last decades, autologous fat grafting has been used to treat adherent dermal scars. The observed regenerative and scar-reducing properties have been mainly ascribed to the tissue-derived stromal vascula...

    Authors: Linda Vriend, Joris A. van Dongen, Anouk Pijpe, Marianne K. Nieuwenhuis, Sandra J. M. Jongen, Martin C. Harmsen, Paul P. M. van Zuijlen and Berend van der Lei
    Citation: Trials 2022 23:575
  8. Migraine is a highly prevalent neurological disorder. It is the third most prevalent disorder and the seventh highest cause of disability worldwide. Acupuncture may be a viable prophylactic treatment option fo...

    Authors: Jiao Chen, Siyuan Zhou, Mingsheng Sun, Yanan Wang, Xiaoqin Chen, Taipin Guo, Lu Liu, Jing Luo, Xixiu Ni, Xuguang Yang, Dehua Li, Shan Gao, Zhenxi He, Dingjun Cai and Ling Zhao
    Citation: Trials 2022 23:574
  9. Burns are a global public health problem and cause approximately 180,000 deaths annually, mainly in low- and middle-income countries. Topical antibiotics and occlusive dressing are standard treatments for burn...

    Authors: Silvana Cristina de Araújo Pereira Venceslau, Júlia Lacet Silva Ferreira, Renata Maria Freire Barros, Ronny Marcos de Morais, Heleodório Honorato dos Santos, Valéria Mayaly Alves de Oliveira and Palloma Rodrigues de Andrade
    Citation: Trials 2022 23:573
  10. The incidence of Gram-negative bacteraemia is rising globally and remains a major cause of morbidity and mortality. The majority of patients with Gram-negative bacteraemia initially receive intravenous (IV) an...

    Authors: I. Russel Lee, Steven Y. C. Tong, Joshua S. Davis, David L. Paterson, Sharifah F. Syed-Omar, Kwong Ran Peck, Doo Ryeon Chung, Graham S. Cooke, Eshele Anak Libau, Siti-Nabilah B. A. Rahman, Mihir P. Gandhi, Luming Shi, Shuwei Zheng, Jenna Chaung, Seow Yen Tan, Shirin Kalimuddin…
    Citation: Trials 2022 23:572
  11. Each year in the UK, approximately 35,000 women develop gestational diabetes mellitus (GDM). The condition increases the risk of obstetric and neonatal complications for mother and child, including preeclampsi...

    Authors: Holly Lovell, Alice Mitchell, Caroline Ovadia, Noelia Pitrelli, Annette Briley, Claire Singh, Hanns-Ulrich Marschall, Kennedy Cruickshank, Helen Murphy, Paul Seed and Catherine Williamson
    Citation: Trials 2022 23:571
  12. High-flow nasal cannula oxygen therapy (HFNC) is recommended by some scholars as an optimized respiratory support method for blunt chest trauma (BCT) patients. The basis of this recommendation is limited, howe...

    Authors: Qingcheng Zhu, Bingxia Wang, Yujie Li, Bingyu Ling, Jun Xu, Kui Jin, Ming Sun, Jianjun Zhu, Joseph Walline, Yunyun Wang, Peng Cao, Xiaojuan Guo and Dingyu Tan
    Citation: Trials 2022 23:570
  13. Dual antiplatelet therapy (DAPT) is recommended in secondary prevention after coronary artery bypass grafting (CABG), but it is inevitably associated with the risk of bleeding, of which gastrointestinal bleedi...

    Authors: Yunpeng Zhu, Xiaojin Wang, Yi Yang, Lei Liu, Qiang Zhao and Lifen Yu
    Citation: Trials 2022 23:569
  14. Fatigue is the most frequent and burdensome symptom of patients with diffuse glioma. It is closely linked to decreased health-related quality of life and symptoms such as depression and sleep disturbances. Cur...

    Authors: Jantine Geertruida Röttgering, Linda Douw, Philip C. de Witt Hamer, Mathilde C. M. Kouwenhoven, Tom Würdinger, Peter M. van de Ven, Louise Sharpe, Hans Knoop and Martin Klein
    Citation: Trials 2022 23:568
  15. An incision for total hip arthroplasty (THA) via the direct anterior approach (DAA) is generally made outside of the space between the sartorius and tensor fasciae latae muscles to prevent lateral femoral cuta...

    Authors: Hiroki Tanabe, Tomonori Baba, Yu Ozaki, Naotake Yanagisawa, Sammy Banno, Taiji Watari, Yasuhiro Homma, Masashi Nagao, Kazuo Kaneko and Muneaki Ishijima
    Citation: Trials 2022 23:567
  16. Combining robotic therapy (RT) with task-oriented therapy is an emerging strategy to facilitate motor relearning in stroke rehabilitation. This study protocol will compare novel rehabilitation regimens that us...

    Authors: Yi-chen Lee, Yi-chun Li, Keh-chung Lin, Grace Yao, Ya-ju Chang, Ya-yun Lee, Chien-ting Liu, Wan-ling Hsu, Yi-hsuan Wu, Ho-ta Chu, Ting-xuan Liu, Yi-ping Yeh and Chieh Chang
    Citation: Trials 2022 23:566
  17. Paediatric fractures are highly prevalent and are most often treated with plaster. The removal of plaster is often an anxious experience for children. Virtual reality (VR) has proven to effectively distract ch...

    Authors: Lisa van der Water, Max A. Poppelaars, Iris Koenraadt-van Oost, Pieter Boele van Hensbroek and Christiaan J. A. van Bergen
    Citation: Trials 2022 23:565
  18. Anovulation is one of the main causes of female infertility. This study will evaluate the effectiveness and safety of Bushen Culuan Decoction for anovulatory infertility caused by six diseases, including anovu...

    Authors: Kun Ma, Yun Shi, Junqin He, Xiuxiang Teng, Rongyu Wang, Guohua Wang, Yanan Yu, Yanxia Chen, Linjuan Gong, Yuan Yuan, Huixian Zhang, Bochao Yuan and Chenhui Zhang
    Citation: Trials 2022 23:563
  19. Breast cancer is the leading cancer in women in France both in incidence and mortality. Organized breast cancer screening (OBCS) has been implemented nationwide since 2004, but the participation rate remains l...

    Authors: Elodie Guillaume, Quentin Rollet, Ludivine Launay, Séverine Beuriot, Olivier Dejardin, Annick Notari, Elodie Crevel, Ahmed Benhammouda, Laurent Verzaux, Marie-Christine Quertier and Guy Launoy
    Citation: Trials 2022 23:562
  20. To improve interprofessional collaboration between registered nurses (RNs) and general practitioners (GPs) for nursing home residents (NHRs), the interprof ACT intervention package was developed. This complex int...

    Authors: Linda Steyer, Christian Kortkamp, Christiane Müller, Britta Tetzlaff, Nina Fleischmann, Clarissa E. Weber, Martin Scherer, Anja Kühn, Anne-Marei Jarchow, Frederike Lüth, Sascha Köpke, Tim Friede, Hans-Helmut König, Eva Hummers, Indre Maurer and Katrin Balzer
    Citation: Trials 2022 23:561
  21. The generalizability of randomized controlled trials (RCTs) with a low response can be limited by systematic differences between participants and nonparticipants. This participation bias, however, is rarely in...

    Authors: Jonas Czwikla, Alexandra Herzberg, Sonja Kapp, Stephan Kloep, Heinz Rothgang, Ina Nitschke, Cornelius Haffner and Falk Hoffmann
    Citation: Trials 2022 23:560
  22. Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans that affects skin, soft tissues, and bones, causing long-term morbidity, stigma, and disability. The recommended treatment for BU...

    Authors: Roch Christian Johnson, Emma Sáez-López, Esaï Sèdjro Anagonou, Godwin Gérard Kpoton, Adjimon Gilbert Ayelo, Ronald Sètondji Gnimavo, Franck Zinsou Mignanwande, Jean-Gabin Houezo, Ghislain Emmanuel Sopoh, Juliet Addo, Lindsay Orford, Georgios Vlasakakis, Nandita Biswas, Felix Calderon, Oscar Della Pasqua, Anna Gine-March…
    Citation: Trials 2022 23:559
  23. Minimally invasive dentistry is a highly convenient and efficient method of managing caries in pediatric patients. Silver diamine fluoride (SDF) is commonly used to arrest active caries lesions. However, the a...

    Authors: Nour Ammar, Magda M. El-Tekeya, Sara Essa, Marwa M. Essawy, Samar N. El Achy and Dalia M. Talaat
    Citation: Trials 2022 23:558
  24. Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular malformations presenting as clusters of cysts filled with lymph fluid or blood. Even small well-limited lesions can be responsib...

    Authors: A. Marchand, A. Caille, V. Gissot, B. Giraudeau, C. Lengelle, H. Bourgoin, B. Largeau, S. Leducq and A. Maruani
    Citation: Trials 2022 23:557
  25. Cervical cancer is the fourth most common malignancy in women, which is threatening female reproductive tract health. Chemotherapy can be used for neoadjuvant therapy of locally advanced cervical cancer and po...

    Authors: Ze Yang He, Hai Ying Li, Jiao Yan, Si Jin Li, Dao Cheng Li and Zhong Zhe Liang
    Citation: Trials 2022 23:556
  26. Both massage and topically administered NSAIDs are safe and effective treatments for knee osteoarthritis (KOA); however, different massage technique sects in China caused assessment difficulties for the treatm...

    Authors: Wang Wen-yue, Xu Ying-peng, Ding Quan-mao, Xie Li-min, Wang De-zhi, Bai Yang, Wang Li-su, Li Yu-bin, Niu Zhi-jun, Ma Yan-xu, Chen Wu-zhong, Bai Li-qun, Liu Yang and Jin Li-kun
    Citation: Trials 2022 23:555
  27. Social competence training interventions, especially child-focused ones, have proven to be effective in the treatment of children with conduct disorder. Therapy homework assignments implemented between the the...

    Authors: Anja Görtz-Dorten, Marlin Frank, Anja Fessel, Leonie Hofmann and Manfred Döpfner
    Citation: Trials 2022 23:554
  28. The global increase in total hip or knee arthroplasty has led to concern about the provision of postoperative rehabilitation. Telerehabilitation may be a strategy to meet the patients’ requirements for rehabil...

    Authors: Qingling Wang, Sharyn Hunter, Regina Lai-Tong Lee, Xiaofeng Wang and Sally Wai-Chi Chan
    Citation: Trials 2022 23:553
  29. Irritable bowel syndrome (IBS) is a common functional bowel disorder that has a considerable impact on patient quality of life and substantial societal and health care resource costs. Current treatments are of...

    Authors: Sarah L. Alderson, Alexandra Wright-Hughes, Alexander C. Ford, Amanda Farrin, Suzanne Hartley, Catherine Fernandez, Christopher Taylor, Pei Loo Ow, Emma Teasdale, Daniel Howdon, Elspeth Guthrie, Robbie Foy, Matthew J. Ridd, Felicity L. Bishop, Delia Muir, Matthew Chaddock…
    Citation: Trials 2022 23:552
  30. Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world. There is strong evidence that dyslipidemia and other cardio-metabolic disorders are highly prevalent in patients...

    Authors: Hamid Vahedi, Masoumeh Atefi, Mohammad Hassan Entezari and Akbar Hassanzadeh
    Citation: Trials 2022 23:551
  31. Authors: Salum Mshamu, Arnold Mmbando, Judith Meta, John Bradley, Thomas Chevalier Bøjstrup, Nicholas P. J. Day, Mavuto Mukaka, Fredros Okumu, Ally Olotu, Christopher Pell, Jacqueline Deen, Jakob Knudsen, Steven W. Lindsay and Lorenz von Seidlein
    Citation: Trials 2022 23:550

    The original article was published in Trials 2022 23:519

  32. Authors: Paolo Mendogni, Alessandra Mazzucco, Alessandro Palleschi, Lorenzo Rosso, Ilaria Righi, Rosaria Carrinola, Francesco Damarco, Emilia Privitera, Jacopo Fumagalli, Gianluca Bonitta, Mario Nosotti and Davide Tosi
    Citation: Trials 2022 23:549

    The original article was published in Trials 2021 22:163

  33. Cancer pain is one of the most frequent and relevant symptoms in cancer patients and impacts on patient’s quality of life. International and local standards recommend as an initial strategy the use of an analg...

    Authors: Ofelia Leiva, Joel Castellano, Luz M. Letelier, Luis Rojas, Paola Viviani, Antonio Gonzalez and Pedro Perez-Cruz
    Citation: Trials 2022 23:548
  34. Authors: Joanna M. Nemis-White, Laura M. Hamilton, Sarah Shaw, James H. MacKillop, Ratika Parkash, Shurjeel H. Choudhri, Antonio Ciaccia, Feng Xie, Lehana Thabane and Jafna L. Cox
    Citation: Trials 2022 23:547

    The original article was published in Trials 2021 22:531

  35. Authors: Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R. Berry, Mark Fitzgerald, Thomas Hills, Kathy Brickell, David Cosgrave, Alex Semprini, Susan Morpeth, Scott Berry, Peter Doran, Paul Young, Richard Beasley and Alistair Nichol
    Citation: Trials 2022 23:546

    The original article was published in Trials 2022 23:534

  36. Anorexia nervosa (AN) is a severe psychiatric disease that often takes a chronic course due to insufficient treatment options. Emerging evidence on the gut-brain axis offers the opportunity to find innovative ...

    Authors: Lara Keller, Astrid Dempfle, Brigitte Dahmen, Samira Schreiber, Roger A. H. Adan, Nadia Andrea Andreani, Unna N. Danner, Albrecht Eisert, Sergueï Fetissov, Florian Ph. S. Fischmeister, Andreas Karwautz, Kerstin Konrad, Karlijn L. Kooij, Stefanie Trinh, Benny van der Vijgh, Annemarie A. van Elburg…
    Citation: Trials 2022 23:545
  37. Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy (CFT) is a promising new...

    Authors: Mariana Romano de Lira, Ney Armando de Mello Meziat-Filho, Gabriela Zuelli Martins Silva and Thaís Cristina Chaves
    Citation: Trials 2022 23:544
  38. Atherosclerotic cardiovascular disease (ASCVD) remains a major source of mortality in China. Convincing evidence has demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is correlated...

    Authors: Xu-Lin Hong, Yi Luan, Hong-Ying Liu and Wen-Bin Zhang
    Citation: Trials 2022 23:543
  39. Substance use is highly prevalent among children and adolescents in Chile, and it is known how it impacts their health and social adjustment. The call for effective prevention of substance use among children a...

    Authors: Jorge Gaete, Constanza Inzunza, Saray Ramírez, Daniela Valenzuela, Cristian Rojas and Ricardo Araya
    Citation: Trials 2022 23:542
  40. Authors: Per Andrén, Lorena Fernández de la Cruz, Kayoko Isomura, Fabian Lenhard, Charlotte L. Hall, E. Bethan Davies, Tara Murphy, Chris Hollis, Filipa Sampaio, Inna Feldman, Matteo Bottai, Eva Serlachius, Erik Andersson and David Mataix-Cols
    Citation: Trials 2022 23:541

    The original article was published in Trials 2021 22:669

  41. Motor aphasia after stroke is a common and intractable complication of stroke. Acupuncture and language training may be an alternative and effective approach. However, the efficacy of acupuncture and language ...

    Authors: Shizhe Deng, Bomo Sang, Boxuan Li, Hai Lu, Lili Zhang, Guang Tian, Ting Hao, Yufeng Zhang, Lei Shi, Kaihang Sun, Te Ba, Feng Li, Ying Kong, Mengni Qin, Jianli Zhang, Xiaofeng Zhao…
    Citation: Trials 2022 23:540
  42. Cardiovascular disease in individuals with mental health conditions such as bipolar disorder is highly prevalent and often poorly managed. Individuals with bipolar disorder face significant medication adherenc...

    Authors: Jennifer B. Levin, David J. Moore, Colin Depp, Jessica L. Montoya, Farren Briggs, Mahboob Rahman, Kurt C. Stange, Douglas Einstadter, Celeste Weise, Carla Conroy, Joy Yala, Ethan Radatz and Martha Sajatovic
    Citation: Trials 2022 23:539
  43. Impairments in upper limb motor function and cognitive ability are major health problems experienced by stroke patients, necessitating the development of novel and effective treatment options in stroke care. T...

    Authors: Yana Wang, Mingzhu Ye, Yujie Tong, Li Xiong, Xuejiao Wu, Chao Geng, Wen Zhang, Ziqi Dai, Wei Tian and Jifeng Rong
    Citation: Trials 2022 23:538
  44. Randomised trials support improved decision-making through the data they collect. One important piece of data is the primary outcome — so called because it is what the investigators decide is the most importan...

    Authors: Shaun Treweek, Viviane Miyakoda, Dylan Burke and Frances Shiely
    Citation: Trials 2022 23:537
  45. Hemorrhoidectomy is associated with intense postoperative pain that requires multimodal analgesia. It includes nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and local anesthetics to reach adequ...

    Authors: Ekaterina Kazachenko, Tatiana Garmanova, Alexander Derinov, Daniil Markaryan, Hanjoo Lee, Sabrina Magbulova and Petr Tsarkov
    Citation: Trials 2022 23:536
  46. Blinding is an established approach in clinical trials which aims to minimise the risk of performance and detection bias. There is little empirical evidence to guide UK clinical trials units (CTUs) about the p...

    Authors: Mais Iflaifel, Christopher Partlett, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery and Kirsty Sprange
    Citation: Trials 2022 23:535
  47. Coronavirus disease 2019 (COVID-19) has exposed the disproportionate effects of pandemics on frontline workers and the ethical imperative to provide effective prophylaxis. We present a model for a pragmatic ra...

    Authors: Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R. Berry, Mark Fitzgerald, Thomas Hills, Kathy Brickell, David Cosgrave, Alex Semprini, Susan Morpeth, Scott Berry, Peter Doran, Paul Young, Richard Beasley and Alistair Nichol
    Citation: Trials 2022 23:534

    The Correction to this article has been published in Trials 2022 23:546

  48. Family members of critically ill patients face considerable uncertainty and distress during their close others’ intensive care unit (ICU) stay. About 20–60% of family members experience adverse mental health o...

    Authors: Rahel Naef, Miodrag Filipovic, Marie-Madlen Jeitziner, Stefanie von Felten, Judith Safford, Marco Riguzzi and Michael Rufer
    Citation: Trials 2022 23:533
  49. More than a third of the 65,000 people living with kidney failure in the UK attend a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion...

    Authors: Fergus J. Caskey, Sunita Procter, Stephanie J. MacNeill, Julia Wade, Jodi Taylor, Leila Rooshenas, Yumeng Liu, Ammar Annaw, Karen Alloway, Andrew Davenport, Albert Power, Ken Farrington, Sandip Mitra, David C. Wheeler, Kristian Law, Helen Lewis-White…
    Citation: Trials 2022 23:532

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