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  1. Low back pain (LBP) is a significant public health problem, is very prevalent, and is often characterized by the persistence of symptoms. Transcutaneous electrical nerve stimulation (TENS) may benefit people w...

    Authors: Richard E. Liebano, Kathleen A. Sluka, Joshua Roy, Meghan Savinelli, Dana L. Dailey and Sean P. Riley
    Citation: Trials 2024 25:242
  2. Randomised controlled trials (RCTs) aim to estimate the causal effect of one or more interventions relative to a control. One type of outcome that can be of interest in an RCT is an ordinal outcome, which is u...

    Authors: Chris J. Selman, Katherine J. Lee, Kristin N. Ferguson, Clare L. Whitehead, Brett J. Manley and Robert K. Mahar
    Citation: Trials 2024 25:241
  3. Accumulated evidence suggests that exercise training exerts beneficial effects on people with congenital heart conditions. These findings are predominantly derived from small, single-centre exercise trials con...

    Authors: Gina Wood, Anna Scheer, Jelena Saundankar, Derek Tran, Rachael Cordina and Andrew Maiorana
    Citation: Trials 2024 25:239
  4. Functional constipation (FC) in children is a common gastrointestinal disorder with a worldwide-pooled prevalence of 9.5%. Complaints include infrequent bowel movements, painful defecation due to hard and/or l...

    Authors: Carrie A. M. Wegh, Margriet H. C. Schoterman, Elaine E. Vaughan, Sofie C. C. van der Zalm, Hauke Smidt, Clara Belzer and Marc A. Benninga
    Citation: Trials 2024 25:238
  5. Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85–95% within the first 10 min. Over the last 10 years, recommendations regarding the ideal level of the initial fr...

    Authors: Georg M. Schmölzer, Elizabeth V. Asztalos, Marc Beltempo, Hector Boix, Eugene Dempsey, Walid El-Naggar, Neil N. Finer, Jo-Anna Hudson, Amit Mukerji, Brenda H. Y. Law, Maryna Yaskina, Prakesh S. Shah, Ayman Sheta, Amuchou Soraisham, William Tarnow-Mordi and Max Vento
    Citation: Trials 2024 25:237
  6. During hospitalisation, older patients spend most of their time passive in bed, which increases the risk of functional decline and negative adverse outcomes. Our aim is to examine the impact of robot-assisted ...

    Authors: Ann Sophia Bertelsen, Tahir Masud, Charlotte Suetta, Lisbeth Rosenbek Minet, Stig Andersen, Jørgen T. Lauridsen and Jesper Ryg
    Citation: Trials 2024 25:235
  7. Indigenous youth in Northwestern Ontario who need mental health supports experience longer waits than non-Indigenous youth within the region and when compared to youth in urban areas. Limited access and extend...

    Authors: Aislin R. Mushquash, Teagan Neufeld, Ishaq Malik, Elaine Toombs, Janine V. Olthuis, Fred Schmidt, Crystal Dunning, Kristine Stasiuk, Tina Bobinski, Arto Ohinmaa, Amanda Newton and Sherry H. Stewart
    Citation: Trials 2024 25:234
  8. The treatment of persistent fatigue after COVID-19 infection is complex. On the one hand, it involves maintaining a sufficient level of physical and mental activity to counteract possible degenerative processe...

    Authors: Jonas Tesarz, Hannah Lange, Marietta Kirchner, Axel Görlach, Wolfgang Eich and Hans-Christoph Friederich
    Citation: Trials 2024 25:232
  9. Breast cancer is the most prevalent cancer among women globally, and surgical procedures continue to be the primary treatment. However, over 50% of patients experience preoperative anxiety due to the unknown a...

    Authors: Xiao Xiao, Yi-Ding Zuo, Shu-Yu Kuang, Chun-Yuan Liu, Kun-Shao, Heng Wang, Si-Yu Yan, Feng Yu, Yan Xu, Li Zhou and Chun-Ling Jiang
    Citation: Trials 2024 25:231
  10. Cancer-related fatigue (CRF) is still undertreated in most patients, as evidence for pharmacological treatments is limited and conflicting. Also, the efficacy of the pharmacological agents relative to each oth...

    Authors: Mojtaba Miladinia, Mina Jahangiri, Sharon Jackson White, Hossein Karimpourian, Alessandro Inno, Sally Wai-Chi Chan, Reza Ganji, Mahmood Maniati, Kourosh Zarea, Marziyeh Ghalamkari, Ali Farahat and Cecilia Fagerström
    Citation: Trials 2024 25:230
  11. To date, colchicine and prednisolone are two effective therapies for the treatment of acute gout but have never been compared directly in a randomized clinical trial. In addition, in previous trials of treatin...

    Authors: Adrian Richter, Julia Truthmann, Eva Hummers, Julia Freyer Martins Pereira, Ildikó Gágyor, Franziska Schuster, Amelie Witte, Susanne Böhm, Alexandra Greser, Petra Kamin, Sylvia Stracke, Marcus Dörr, Robin Bülow, Stefan Engeli, Jean François Chenot and Till Ittermann
    Citation: Trials 2024 25:229
  12. Two million people in the UK are living with or beyond cancer and a third of them report poor quality of life (QoL) due to problems such as fatigue, fear of cancer recurrence, and concerns about returning to w...

    Authors: Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance…
    Citation: Trials 2024 25:228
  13. The lack of safe, effective, and simple short-course regimens (SCRs) for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment has significantly impeded TB control efforts in China.

    Authors: Jingtao Gao, Mengqiu Gao, Jian Du, Yu Pang, Gary Mao, Nacer Lounis, Nyasha Bakare, Yanxin Jiang, Ying Zhan, Yuhong Liu and Liang Li
    Citation: Trials 2024 25:227
  14. Burn-related injuries are a major global health issue, causing 180,000 deaths per year. Early debridement of necrotic tissue in association with a split-thickness skin graft is usually administered for some of...

    Authors: Shayan Farzanbakhsh, Mohammad Amin Shahrbaf, Hoda Madani, Mostafa Dahmardei, Bahareh Sadri and Massoud Vosough
    Citation: Trials 2024 25:226
  15. Adolescence is a critical stage for the development of self-care. Many adolescents use mobile apps to monitor and improve their health. Health information technology plays a significant role in the field of se...

    Authors: Razieh Rezaee, Mohtasham Ghaffari, Reza Rabiei, Amir Kavousi and Sakineh Rakhshanderou
    Citation: Trials 2024 25:225
  16. Explainer animations are a means to communicate aspects of clinical trials to participants in a more engaging and accessible way. Delivered well these have the potential to enhance recruitment and retention. T...

    Authors: Vicki S. Barber, Clare Calvert, Duncan Appelbe, Kirsty Sprange, Claire Nollett, Samantha Tanner and Duncan B. Richards
    Citation: Trials 2024 25:224
  17. The prevalence of sacroiliac joint pain (SIJP) is estimated to be 10–30% in patients with chronic low back pain. Numerous conservative and surgical treatment modalities for SIJP have been described with limite...

    Authors: Tarik Alp Sargut, Dimitri Tkatschenko, Anton Früh, Jochen Tüttenberg, Alexander Heckert, Steffen Fleck, Anja Kuckuck and Simon Heinrich Bayerl
    Citation: Trials 2024 25:223
  18. Employment is a vital source for experiencing well-being and lowering the risk of long-term social marginalisation and poverty. For persons with alcohol and drug addiction, it may also improve sobriety. Howeve...

    Authors: Ulrika Bejerholm, Anders Håkansson, Marcus Knutagård and Helene Hillborg
    Citation: Trials 2024 25:222
  19. Approximately 85% of women experience an obstetric tear at delivery and up to 25% subsequently experience wound dehiscence and/or infection. Previous publications suggest that intravenous antibiotics administr...

    Authors: Kathrine Perslev, Niels Klarskov, Thomas Bergholt and Hanna Jangö
    Citation: Trials 2024 25:221
  20. Trapeziometacarpal (TMC) osteoarthritis (OA) is a common cause of pain and weakness during thumb pinch leading to disability. There is no consensus about the best surgical treatment in unresponsive cases. The ...

    Authors: Serafín Lirola-Palmero, Guillem Salva-Coll, Aina María Yáñez-Juan and Eduardo Sánchez-Iriso
    Citation: Trials 2024 25:220
  21. Acute microcirculatory perfusion disturbances and organ edema are important factors leading to organ dysfunction during cardiac surgery with cardiopulmonary bypass (CPB). Priming of the CPB system with crystal...

    Authors: Anne M. Beukers, Carolien S. E. Bulte, Ruben J. Bosch, Susanne Eberl, Charissa E. van den Brom, Stephan A. Loer and Alexander B. A. Vonk
    Citation: Trials 2024 25:219
  22. The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducin...

    Authors: Eva Visser, Lianne Heuthorst, Shri Pathmakanthan, Willem A. Bemelman, Geert R. D’Haens, Kelly Handley, Apostolos Fakis, Thomas D. Pinkney, Christianne J. Buskens and Marcel G. W. Dijkgraaf
    Citation: Trials 2024 25:218
  23. Depression ranks as the foremost mental health concern among childbearing women. Within low- and middle-income countries (LMICs), between 20 and 25% of women encounter depression during pregnancy or soon after...

    Authors: Peter Fonagy, Rabih El Chammay, Carol Ngunu, Manasi Kumar, Lena Verdeli, Elizabeth Allison, Ghida Anani, Pasco Fearon, Fouad Fouad, Zoe Hoare, Lucina Koyio, Henrietta Moore, Andrew Nyandigisi, Stephen Pilling, Hannah Sender, Jolene Skordis…
    Citation: Trials 2024 25:217
  24. The effectiveness of immunisation with pneumococcal conjugate vaccine (PCV) has been demonstrated in many countries. However, the global impact of PCV is limited by its cost, which has prevented its introducti...

    Authors: Grant A. Mackenzie, Isaac Osei, Rasheed Salaudeen, Paul V. Licciardi, Brian Greenwood, Kim Mulholland and Cattram Nguyen
    Citation: Trials 2024 25:216
  25. Populations around the world are rapidly ageing and more people are living with multiple long-term conditions. There is an urgent need for evidence about high quality, cost-effective, and integrated systems of...

    Authors: Jennifer McAnuff, Tim Rapley, Leigh Rooney and Phillip Whitehead
    Citation: Trials 2024 25:215
  26. Endovascular repair of aortic aneurysmal disease is established due to perceived advantages in patient survival, reduced postoperative complications, and shorter hospital lengths of stay. High spatial and cont...

    Authors: James Budge, Tom Carrell, Medeah Yaqub, Hatem Wafa, Matt Waltham, Izabela Pilecka, Joanna Kelly, Caroline Murphy, Stephen Palmer, Yanzhong Wang and Rachel E Clough
    Citation: Trials 2024 25:214
  27. Chronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause of graft loss in the long-term. However, the treatment for caAMR remai...

    Authors: Lillian Streichart, Marie Felldin, Jana Ekberg, Lars Mjörnstedt, Per Lindnér, Annette Lennerling, Verena Bröcker, Johan Mölne, Jan Holgersson, Kristien Daenen, Lars Wennberg, Tomas Lorant and Seema Baid-Agrawal
    Citation: Trials 2024 25:213
  28. Significant disparities continue to exist in the HIV care continuum, whereby Hispanic and Black people living with HIV (PLWH) are less likely to achieve viral suppression compared to their White counterparts. ...

    Authors: Eileen V. Pitpitan, Keith J. Horvath, Jeannette Aldous, Jamila K. Stockman, Thomas L. Patterson, Megan Liang, Constantino Barrozo, Veronica Moore, Katherine Penninga and Laramie R. Smith
    Citation: Trials 2024 25:212
  29. Dysphagia, with its negative impact on life expectancy and quality of life, is a major side effect of head and neck squamous cell carcinoma (HNSCC). In a typical Head and Neck Cancer Center, more than half of ...

    Authors: Julian Kuenzel, Stephan Duerr, Sarah Vester, Florian Zeman, Gunnar Huppertz, Michael Koller, Gerda Pfleger, Annika Woertgen, Hazem Salloum, Monika Klinkhammer-Schalke, Tobias Pukrop and Peter Kummer
    Citation: Trials 2024 25:211
  30. A therapeutic effect of sacral neuromodulation (SNM) on fecal incontinence (FI) and quality of life has been proven in adults. SNM is, however, rarely used in pediatric cases. The aim of the study is to invest...

    Authors: Manuel Besendörfer, Annemarie Kirchgatter, Roman Carbon, Christel Weiss, Hanna Müller, Klaus E. Matzel and Sonja Diez
    Citation: Trials 2024 25:210
  31. Despite a number of recommended strategies, effective treatment of migraine remains elusive. Given the role of oxidative stress in the pathogenesis of migraine, selenium, as an antioxidant nutrient, may have a...

    Authors: Arghavan Balali, Omid Sadeghi, Javad Anjom-Shoae, Mohammad Hossein Rouhani, Fariborz Khorvash and Gholamreza Askari
    Citation: Trials 2024 25:209
  32. Authors: Catharina F. van der Boor, Dalili Taban, Wietse A. Tol, Josephine Akellot, Melissa Neuman, Helen A. Weiss, Giulia Greco, Anna Vassall, Carl May, Abhijit Nadkarni, Eugene Kinyanda, Bayard Roberts and Daniela C. Fuhr
    Citation: Trials 2024 25:208

    The original article was published in Trials 2024 25:148

  33. Diabetes distress (DD) affects at least 36% of T2DM patients and is often associated with insufficient support and care. This study examines an intervention that targets DD through enhanced cross-sectoral coll...

    Authors: Steffan Holst Hansen, Troels Mygind Jensen, Gitte Stentebjerg Petersen, Francois Pouwer, Anders Larrabee Sonderlund and Jens Søndergaard
    Citation: Trials 2024 25:207

    The Correction to this article has been published in Trials 2024 25:233

  34. There is little evidence on how to support ultra-poor people with disabilities to adopt sustainable livelihoods. The Disability-Inclusive Graduation (DIG) programme targets ultra-poor people with disabilities ...

    Authors: Elijah Kipchumba, Calum Davey, Sarah Marks, Anthony Mugeere, Shanquan Chen, Lena Morgon Banks, Kazi Eliza Islam, Tom Shakespeare, Hannah Kuper and Munshi Sulaiman
    Citation: Trials 2024 25:206
  35. With one in five individuals aged 65 or older living with type 2 diabetes worldwide, it is crucial to acknowledge and address the challenges faced by this population. In this context, our study aims to evaluat...

    Authors: Frederico Ludwig da Costa, Lucas Strassburger Matzenbacher, Vicenzo Gheno, Maria Antônia Bertuzzo Brum, Laura Gomes Boabaid de Barros, Isabela Semmelmann Maia, Luiza Machado Blank, Lucas Friedrich Fontoura, Janine Alessi and Gabriela Heiden Telo
    Citation: Trials 2024 25:205
  36. Interventional clinical studies conducted in the regulated drug research environment are designed using International Council for Harmonisation (ICH) regulatory guidance documents: ICH E6 (R2) Good Clinical Pr...

    Authors: Madhavi Gidh-Jain, Tom Parke, Franz König, Cecile Spiertz and Peter Mesenbrink
    Citation: Trials 2024 25:204
  37. Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat ...

    Authors: Franz Schaefer, Giovanni Montini, Hee Gyung Kang, Johan Vande Walle, Joshua Zaritsky, Michiel F. Schreuder, Mieczyslaw Litwin, Andrea Scalise, Helen Scott, James Potts, Pablo Iveli, Stefanie Breitenstein and Bradley A. Warady
    Citation: Trials 2024 25:203
  38. Chronic diseases, such as chronic obstructive pulmonary disease (COPD), asthma, type 2 diabetes, and heart failure, often coexist and contribute to a significant burden on individuals and health systems. The A...

    Authors: Christian J. Wiedermann, Pasqualina Marino, Angelika Mahlknecht, Verena Barbieri, Giuliano Piccoliori, Adolf Engl and Annerika H. M. Gidding-Slok
    Citation: Trials 2024 25:202
  39. Invasive mechanical ventilation contributes to bronchopulmonary dysplasia (BPD), the most common complication of prematurity and the leading respiratory cause of childhood morbidity. Non-invasive ventilation (...

    Authors: David N. Matlock, Sarah J. Ratcliffe, Sherry E. Courtney, Haresh Kirpalani, Kimberly Firestone, Howard Stein, Kevin Dysart, Karen Warren, Mitchell R. Goldstein, Kelli C. Lund, Aruna Natarajan, Ejigayehu Demissie and Elizabeth E. Foglia
    Citation: Trials 2024 25:201
  40. The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range. Additionally, enhanced gamma oscillations may serve...

    Authors: Hong-yu Zhang, Ting-ting Hou, Zhao-hui Jin, Tian Zhang, Yi-heng Wang, Zi-hao Cheng, Yong-hong Liu, Jin-ping Fang, Hong-jiao Yan, Yi Zhen, Xia An, Jia Du, Ke-ke Chen, Zhen-zhen Li, Qing Li, Qi-ping Wen…
    Citation: Trials 2024 25:200
  41. There exist many different methods of allocating participants to treatment groups during a randomised controlled trial. Although there is research that explores trial characteristics that are associated with t...

    Authors: Cydney L. Bruce, Mais Iflaifel, Alan Montgomery, Reuben Ogollah, Kirsty Sprange and Christopher Partlett
    Citation: Trials 2024 25:199
  42. Infants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine practice includes immediate clamping of the umbilical cord and endotrac...

    Authors: Emily J. J. Horn-Oudshoorn, Marijn J. Vermeulen, Ronny Knol, Rebekka Bout-Rebel, Arjan B. te Pas, Stuart B. Hooper, Suzan C. M. Cochius-den Otter, Rene M. H. Wijnen, Kelly J. Crossley, Neysan Rafat, Thomas Schaible, Willem P. de Boode, Anne Debeer, Berndt Urlesberger, Calum T. Roberts, Florian Kipfmueller…
    Citation: Trials 2024 25:198
  43. Acute viral bronchiolitis is the most common reason for hospitalization of infants in the USA. Infants hospitalized for bronchiolitis are at high risk for recurrent respiratory symptoms and wheeze in the subse...

    Authors: Kelly Cowan, Erin O. Semmens, Jeannette Y. Lee, Ethan S. Walker, Paul G. Smith, Linda Fu, Rosalyn Singleton, Sara McClure Cox, Jennifer Faiella, Laurie Chassereau, Lora Lawrence, Jun Ying, Jaime Baldner, Maryam Garza, Robert Annett, Sheva K. Chervinskiy…
    Citation: Trials 2024 25:197
  44. The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individu...

    Authors: Ping-ping Zhang, You-xin Wang, Fang-jing Shen, Yun-fei Xing, Jia-ying Gu, Xue-ying Li, Han Jin, Shi-feng Jin, Miao Xu, Hai-jun Wang, Hui Wang and Li Li
    Citation: Trials 2024 25:196
  45. Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition in young and active adults. Exercise therapy is an essential part of rehabilitation in people with PFPS (PwPFPS). Telerehabilitation is...

    Authors: Negar Amirabadi, Masumeh Hessam, Saeideh Monjezi, Farshad Molhemi, Mohammad Mehravar and Pardis Hosseinpour
    Citation: Trials 2024 25:195
  46. Pulmonary rehabilitation (PR) is a programme of exercise and education and the most effective treatment for the symptoms and disability associated with chronic obstructive pulmonary disease. However, the benef...

    Authors: Gill Gilworth, Katherine Harris, Toby L. Morgan, Salma Ayis, Julia Fox-Rushby, Emma Godfrey, Nicholas S. Hopkinson, Simon Lewin, Ka Keat Lim, Arietta Spinou, Stephanie J. C. Taylor and Patrick White
    Citation: Trials 2024 25:194
  47. Without surgical repair, flexor tendon injuries do not heal and patients’ ability to bend fingers and grip objects is impaired. However, flexor tendon repair surgery also requires optimal rehabilitation. There...

    Authors: Emma Bamford, Hannah Berntsson, Suzanne Beale, Lauren Desoysa, Joseph Dias, Sienna Hamer-Kiwacz, Daniel Hind, Nick Johnson, Amanda Loban, Kaye Molloy, Emma Morvan, Ines Rombach, Anna Selby, Praveen Thokala, Chris Turtle, Stephen Walters…
    Citation: Trials 2024 25:193

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