Skip to main content

Articles

Page 1 of 176

  1. Impairments in upper limb motor function and cognitive ability are major health problems experienced by stroke patients, necessitating the development of novel and effective treatment options in stroke care. T...

    Authors: Yana Wang, Mingzhu Ye, Yujie Tong, Li Xiong, Xuejiao Wu, Chao Geng, Wen Zhang, Ziqi Dai, Wei Tian and Jifeng Rong
    Citation: Trials 2022 23:538
  2. Randomised trials support improved decision-making through the data they collect. One important piece of data is the primary outcome — so called because it is what the investigators decide is the most importan...

    Authors: Shaun Treweek, Viviane Miyakoda, Dylan Burke and Frances Shiely
    Citation: Trials 2022 23:537
  3. Hemorrhoidectomy is associated with intense postoperative pain that requires multimodal analgesia. It includes nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and local anesthetics to reach adequ...

    Authors: Ekaterina Kazachenko, Tatiana Garmanova, Alexander Derinov, Daniil Markaryan, Hanjoo Lee, Sabrina Magbulova and Petr Tsarkov
    Citation: Trials 2022 23:536
  4. Blinding is an established approach in clinical trials which aims to minimise the risk of performance and detection bias. There is little empirical evidence to guide UK clinical trials units (CTUs) about the p...

    Authors: Mais Iflaifel, Christopher Partlett, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery and Kirsty Sprange
    Citation: Trials 2022 23:535
  5. Coronavirus disease 2019 (COVID-19) has exposed the disproportionate effects of pandemics on frontline workers and the ethical imperative to provide effective prophylaxis. We present a model for a pragmatic ra...

    Authors: Pepa Bruce Metadata, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R. Berry, Mark Fitzgerald, Thomas Hills, Kathy Brickell, David Cosgrave, Alex Semprini, Susan Morpeth, Scott Berry, Peter Doran, Paul Young, Richard Beasley and Alistair Nichol
    Citation: Trials 2022 23:534
  6. Family members of critically ill patients face considerable uncertainty and distress during their close others’ intensive care unit (ICU) stay. About 20–60% of family members experience adverse mental health o...

    Authors: Rahel Naef, Miodrag Filipovic, Marie-Madlen Jeitziner, Stefanie von Felten, Judith Safford, Marco Riguzzi and Michael Rufer
    Citation: Trials 2022 23:533
  7. More than a third of the 65,000 people living with kidney failure in the UK attend a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion...

    Authors: Fergus J. Caskey, Sunita Procter, Stephanie J. MacNeill, Julia Wade, Jodi Taylor, Leila Rooshenas, Yumeng Liu, Ammar Annaw, Karen Alloway, Andrew Davenport, Albert Power, Ken Farrington, Sandip Mitra, David C. Wheeler, Kristian Law, Helen Lewis-White…
    Citation: Trials 2022 23:532
  8. Pneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35–40% in infants hospitalized with severe pneumonia. Bacterial pathogens and Pneumocystis jirovecii ...

    Authors: Pablo Rojo, Cinta Moraleda, Alfredo Tagarro, Sara Domínguez-Rodríguez, Lola Madrid Castillo, Luis Manuel Prieto Tato, Aranzazu Sancho López, Lilit Manukyan, Olivier Marcy, Valeriane Leroy, Alessandra Nardone, David Burger, Quique Bassat, Matthew Bates, Raoul Moh, Pui-Ying Iroh Tam…
    Citation: Trials 2022 23:531
  9. Malignant pleural effusions (MPEs) are common. MPE causes significant breathlessness and impairs quality of life. Indwelling pleural catheters (IPC) allow ambulatory drainage and reduce hospital days and re-in...

    Authors: Deirdre B. Fitzgerald, Calvin Sidhu, Charley Budgeon, Ai Ling Tan, Catherine A. Read, Benjamin C. H. Kwan, Nicola Ann Smith, Edward T. Fysh, Sanjeevan Muruganandan, Tajalli Saghaie, Ranjan Shrestha, Arash Badiei, Phan Nguyen, Andrew Burke, John Goddard, Morgan Windsor…
    Citation: Trials 2022 23:530
  10. Inequality in health can have profound effects on a child’s opportunities later in life. To prevent these downstream effects in families at increased risk of adversity, programs are needed to provide support a...

    Authors: Maiken Pontoppidan, Mette Thorsager, Mette Friis-Hansen, Arietta Slade and Lois S. Sadler
    Citation: Trials 2022 23:529
  11. Valvular heart diseases are frequent and increasing in prevalence. Minimally invasive heart valve surgery embedded in an interdisciplinary enhanced recovery after surgery (ERAS) program may have potential bene...

    Authors: Susanne G. R. Klotz, Gesche Ketels, Christian A. Behrendt, Hans-Helmut König, Sebastian Kohlmann, Bernd Löwe, Johannes Petersen, Sina Stock, Eik Vettorazzi, Antonia Zapf, Inke Zastrow, Christian Zöllner, Hermann Reichenspurner and Evaldas Girdauskas
    Citation: Trials 2022 23:528
  12. The 2019 novel coronavirus disease (COVID-19) pandemic has highlighted the importance of health research and fostered clinical research as never before. A huge number of clinical trials for potential COVID-19 ...

    Authors: Maria Puopolo, Cristina Morciano, Maria Buoncervello, Chiara De Nuccio, Rosa Luisa Potenza, Elena Toschi and Lucia Palmisano
    Citation: Trials 2022 23:527
  13. The one anastomosis gastric bypass (OAGB) is being performed by an increasing number of bariatric centers over the world. However, the optimal length of the biliopancreatic (BP) limb remains a topic of discuss...

    Authors: Nienke Slagter, Loek J. M. de Heide, Ewoud H. Jutte, Mirjam A. Kaijser, Stefan L. Damen, André P. van Beek and Marloes Emous
    Citation: Trials 2022 23:526
  14. Infertility is a common problem globally and impaired semen quality is responsible for up to 40% of all cases. Almost all infertile couples are treated with either insemination or assisted reproductive techniq...

    Authors: Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Jørgen Holm Petersen, Niels Jørgensen, Anders Juul and Martin Blomberg Jensen
    Citation: Trials 2022 23:525
  15. Cannabis is the most-frequently used illicit drug in Europe. Over the last few years in Spain, treatment demand has increased, yet most cannabis users do not seek treatment despite the related problems. A web-...

    Authors: J. I. Mestre-Pintó, F. Fonseca, M. P. Schaub, C. Baumgartner, M. Alias-Ferri and M. Torrens
    Citation: Trials 2022 23:524
  16. Various priming techniques to enhance neuroplasticity have been examined in stroke rehabilitation research. Most priming techniques are costly and approved only for research. Here, we describe a priming techni...

    Authors: Mary Ellen Stoykov, Olivia M. Biller, Alexandra Wax, Erin King, Jacob M. Schauer, Louis F. Fogg and Daniel M. Corcos
    Citation: Trials 2022 23:523
  17. Treatment of acute myocardial infarction has been the subject of studies over the past years. However, the initial months after myocardial infarction are crucial from the perspective of the patient’s prognosis...

    Authors: Bartosz Krzowski, Michał Peller, Maria Boszko, Paulina Hoffman, Natalia Żurawska, Karolina Jaruga, Kamila Skoczylas, Gabriela Osak, Łukasz Kołtowski, Marcin Grabowski, Grzegorz Opolski and Paweł Balsam
    Citation: Trials 2022 23:522
  18. Many community college students experience poor sexual and relationship health outcomes. Young adults consume a plethora of media content, much of which depicts unhealthy sexual and romantic relationships, and...

    Authors: Tracy M. Scull, Christina V. Dodson, Reina Evans-Paulson, Liz C. Reeder, Jacob Geller, Kathryn N. Stump and Janis B. Kupersmidt
    Citation: Trials 2022 23:521
  19. Major depressive disorder (MDD) is a leading cause of disease morbidity. Combined treatment with antidepressant medication (ADM) plus psychotherapy yields a much higher MDD remission rate than ADM only. But 77...

    Authors: Robert M. Bossarte, Ronald C. Kessler, Andrew A. Nierenberg, Ambarish Chattopadhyay, Pim Cuijpers, Angel Enrique, Phyllis M. Foxworth, Sarah M. Gildea, Bea Herbeck Belnap, Marc W. Haut, Kari B. Law, William D. Lewis, Howard Liu, Alexander R. Luedtke, Wilfred R. Pigeon, Larry A. Rhodes…
    Citation: Trials 2022 23:520
  20. Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited air...

    Authors: Salum Mshamu, Arnold Mmbando, Judith Meta, John Bradley, Thomas Chavalier Bøjstrup, Nicholas P. J. Day, Mavuto Mukaka, Fredros Okumu, Ally Olotu, Christopher Pell, Jacqueline Deen, Jakob Knudsen, Steven W. Lindsay and Lorenz von Seidlein
    Citation: Trials 2022 23:519
  21. There is a pressing need for scalable healthcare solutions and a shift in the rehabilitation paradigm from hospitals to homes to tackle the increase in stroke incidence while reducing the practical and economi...

    Authors: Anna Mura, Martina Maier, Belén Rubio Ballester, Javier De la Torre Costa, Judit López-Luque, Axelle Gelineau, Stephane Mandigout, Per Hamid Ghatan, Raffaele Fiorillo, Fabrizio Antenucci, Ton Coolen, Iñigo Chivite, Antonio Callen, Hugo Landais, Olga Irina Gómez, Cristina Melero…
    Citation: Trials 2022 23:518
  22. Hyperuricemia increases the risk of gout and cardiovascular complications, and how to manage asymptomatic hyperuricemia is controversial. Randomized controlled trials and comparative studies are needed to guid...

    Authors: Jingyao Yan, Yingyan Zhou, Qiaowen Yang, Jiaqi Wu and Xiaohong He
    Citation: Trials 2022 23:517
  23. Multimodal analgesia that provides optimal pain treatment with minimal side effects is important for optimal recovery after open cardiac surgery. Regional anaesthesia can be used to block noxious nerve signals...

    Authors: Mark Larsson, Ulrik Sartipy, Anders Franco-Cereceda, Anders Öwall and Jan Jakobsson
    Citation: Trials 2022 23:516
  24. Existing therapeutic interventions to treat diabetes are well known, yet the majority of people with diabetes do not consistently achieve blood glucose targets (even individual therapy targets) for optimal hea...

    Authors: Ryan Charles Kelly, Peter Phiri, Hermione Price, Amar Ali, Irene Stratton, Kayleigh Austin, Alice Neave and Katharine Barnard-Kelly
    Citation: Trials 2022 23:515
  25. Young men who have sex with men (YMSM) are disproportionately impacted by the HIV epidemic in the USA, and a large number of new infections among YMSM occur in the context of main or primary partnerships. At t...

    Authors: Michael E. Newcomb, Elissa L. Sarno, Emily Bettin, Adam Conway, James Carey, Christopher Garcia, Ricky Hill, Kyle Jozsa, Gregory Swann, Elizabeth L. Addington, Jody D. Ciolino, Kathryn Macapagal, Judith T. Moskowitz, Brian Mustanski and Sarah W. Whitton
    Citation: Trials 2022 23:514
  26. Risks to mother and fetus following Ebola virus infection are very high. Evaluation of safety and immunogenicity of non-replicating Ebola vaccine candidates is a priority for use in pregnant women. This is the...

    Authors: Etienne Karita, Julien Nyombayire, Rosine Ingabire, Amelia Mazzei, Tyronza Sharkey, Jeannine Mukamuyango, Susan Allen, Amanda Tichacek, Rachel Parker, Frances Priddy, Felix Sayinzoga, Sabin Nsanzimana, Cynthia Robinson, Michael Katwere, Dickson Anumendem, Maarten Leyssen…
    Citation: Trials 2022 23:513
  27. Strong evidence suggests that maternal-infant skin-to-skin contact (SSC) is effective in reducing behavioural responses to pain. Given the multi-sensory benefits of SSC, it is highly likely that SSC provided d...

    Authors: Marsha Campbell-Yeo, Britney Benoit, Aaron Newman, Celeste Johnston, Tim Bardouille, Bonnie Stevens and Arlene Jiang
    Citation: Trials 2022 23:512
  28. Sending a social norms feedback letter to general practitioners who are high prescribers of antibiotics has been shown to reduce antibiotic prescribing. The 2017-9 Quality Premium for primary care in England s...

    Authors: Natalie Gold, Anna Sallis, Ayoub Saei, Rohan Arambepola, Robin Watson, Sarah Bowen, Matija Franklin and Tim Chadborn
    Citation: Trials 2022 23:511
  29. Endometrial fibrosis caused by intrauterine adhesion (IUA) can lead to hypomenorrhea, amenorrhea, and even infertility and abortion. The postoperative recurrence rate of severe IUA remains high, giving rise to...

    Authors: Wen-Juan Pang, Qing Zhang, Hai-Xia Ding, Ning-Xia Sun and Wen Li
    Citation: Trials 2022 23:510
  30. Understanding patient and health practitioner perspectives on clinical trials can inform opportunities to enhance trial conduct and design, and therefore patient experience. Patients with haematological cancer...

    Authors: Frances C. Sherratt, Peter Fisher, Amy Mathieson, Mary G. Cherry, Andrew R. Pettitt and Bridget Young
    Citation: Trials 2022 23:509
  31. The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in cardiac surgery and orthopedics confirmed this finding. The ai...

    Authors: M. Balik, J. Kosina, P. Husek, J. Pacovsky, M. Brodak and F. Cecka
    Citation: Trials 2022 23:508
  32. Sarcomas are a heterogeneous group of rare malignant tumors of mesenchymal origin in the musculoskeletal system. The main treatment is surgery often supplemented with pre-or postoperative radiotherapy.

    Authors: Müjgan Yilmaz, Andrea Thorn, Michala Skovlund Sørensen, Claus Lindkær Jensen and Michael Mørk Petersen
    Citation: Trials 2022 23:507
  33. Many cancer patients experience high symptom burden. Healthcare in the USA is reactive, not proactive, and doctor-patient communication is often suboptimal. As a result, symptomatic patients may suffer between...

    Authors: Michael J. Hassett, Sandra Wong, Raymond U. Osarogiagbon, Jessica Bian, Don S. Dizon, Hannah Hazard Jenkins, Hajime Uno, Christine Cronin and Deborah Schrag
    Citation: Trials 2022 23:506
  34. Globally, household air pollution (HAP) is a leading environmental cause of morbidity and mortality. Our trial aims to assess the impact of liquefied petroleum gas (LPG) for cooking to reduce household air pol...

    Authors: Camille Raynes-Greenow, Sk Masum Billah, Sajia Islam, S. M. Rokonuzzaman, Fahmida Tofail, Elizabeth K. Kirkwood, Ashraful Alam, Ryan Chartier, Tarana E. Ferdous, Shams El Arifeen, Michael J. Dibley, Nusrat Homaira, Alison Hayes, Jonathan Thornburg and Patrick Kelly
    Citation: Trials 2022 23:505
  35. Mobile health (mHealth) is increasingly advocated for diabetes management. It is unclear if mobile applications are effective in improving glycaemic control, clinical outcomes, quality of life and overall pati...

    Authors: Noor Suleiman, Meis Alkasem, Zaina Al Amer, Obada Salameh, Noora Al-Thani, Mohammad Khair Hamad, Khaled Baagar, Ibrahem Abdalhakam, Manal Othman, Ragae Dughmosh, Dabia Al-Mohanadi, Ali Al Sanousi, Mohammed Bashir, Odette Chagoury, Shahrad Taheri and Abdul-Badi Abou-Samra
    Citation: Trials 2022 23:504
  36. Delivering acute hospital care to patients at home might reduce costs and improve patient experience. Mayo Clinic’s Advanced Care at Home (ACH) program is a novel virtual hybrid model of “Hospital at Home.” Th...

    Authors: Xiaoxi Yao, Margaret Paulson, Michael J. Maniaci, Ajani N. Dunn, Chad R. Nelson, Emma M. Behnken, Melissa S. Hart, Lindsey R. Sangaralingham, Shealeigh A. Inselman, Michelle A. Lampman, Shannon M. Dunlay, Sean C. Dowdy and Elizabeth B. Habermann
    Citation: Trials 2022 23:503
  37. Staphylococcus aureus is a frequent colonizer of the human skin and mucous membranes but can also cause a variety of serious infections. Antimicrobial resistance is an increasing worldwide challenge and is mainl...

    Authors: Mona Katrine Alberthe Holm, Heidi Karin Meiniche, Michael Pedersen, Helle Brander Eriksen, Henrik Westh, Barbara J. Holzknecht and Mette Damkjær Bartels
    Citation: Trials 2022 23:502
  38. Treatment fidelity is inconsistently reported in aphasia research, contributing to uncertainty about the effectiveness of types of aphasia therapy following stroke. We outline the processes and outcomes of tre...

    Authors: Erin Godecke, Emily Brogan, Natalie Ciccone, Miranda L. Rose, Elizabeth Armstrong, Anne Whitworth, Fiona Ellery, Audrey Holland, Sandy Middleton, Tapan Rai, Graeme J. Hankey, Dominique Cadilhac and Julie Bernhardt
    Citation: Trials 2022 23:501
  39. Anorexia nervosa (AN) is a serious and disabling mental disorder with a high disease burden. In a proportion of cases, intensive hospital-based treatments, i.e. inpatient or day patient treatment, are required...

    Authors: Madeleine Irish, Bethan Dalton, Laura Potts, Catherine McCombie, James Shearer, Katie Au, Nikola Kern, Sam Clark-Stone, Frances Connan, A. Louise Johnston, Stanimira Lazarova, Shiona Macdonald, Ciarán Newell, Tayeem Pathan, Jackie Wales, Rebecca Cashmore…
    Citation: Trials 2022 23:500
  40. Hypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis possibly leading to chronic kidney disease (CKD) and bone complications in adults. Orphan ...

    Authors: Aurélia Bertholet-Thomas, Aurélie Portefaix, Sacha Flammier, Carole Dhelens, Fabien Subtil, Laurence Dubourg, Valérie Laudy, Myrtille Le Bouar, Inesse Boussaha, Marietou Ndiaye, Arnaud Molin, Sandrine Lemoine and Justine Bacchetta
    Citation: Trials 2022 23:499
  41. Over 2021, COVID-19 vaccination programs worldwide focused on raising population immunity through the primary COVID-19 vaccine series. In Singapore, two mRNA vaccines (BNT162b2 and mRNA-1273) and the inactivat...

    Authors: Xuan Ying Poh, I. Russel Lee, Clarissa Lim, Jefanie Teo, Suma Rao, Po Ying Chia, Sean W. X. Ong, Tau Hong Lee, Ray J. H. Lin, Lisa F. P. Ng, Ee Chee Ren, Raymond T. P. Lin, Lin-Fa Wang, Laurent Renia, David Chien Lye and Barnaby E. Young
    Citation: Trials 2022 23:498
  42. The efficacy of pericardium 6 (P6) acupoint stimulation to reduce the incidence of postoperative nausea and vomiting (PONV) has been proven in several randomised controlled clinical trials. However, little is ...

    Authors: Benedict Weber, Selena Knoth, Peter Kranke and Leopold Eberhart
    Citation: Trials 2022 23:497
  43. Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also as...

    Authors: Solmaz Surano, Helena Grip, Fredrik Öhberg, Marcus Karlsson, Erik Faergemann, Maria Bjurman, Hugo Davidsson, Torbjörn Ledin, Ellen Lindell, Jan Mathé, Fredrik Tjernström, Tatjana Tomanovic, Gabriel Granåsen and Jonatan Salzer
    Citation: Trials 2022 23:496
  44. Women in Africa face disproportionate risk of human immunodeficiency virus (HIV) acquisition, accounting for more than half of new infections in Africa and similarly face a disproportionate burden of sexually ...

    Authors: Jenell Stewart, Elizabeth Bukusi, Fredericka A. Sesay, Kevin Oware, Deborah Donnell, Olusegun O. Soge, Connie Celum, Josephine Odoyo, Zachary A. Kwena, Caitlin W. Scoville, Lauren R. Violette, Susan Morrison, Jane Simoni, R. Scott McClelland, Ruanne Barnabas, Monica Gandhi…
    Citation: Trials 2022 23:495
  45. Biological disease-modifying anti-rheumatic drugs (bDMARDs) are effective in the treatment of rheumatoid arthritis (RA) but are expensive and increase the risk of infection. Therefore, in patients with a stabl...

    Authors: Marianne A. Messelink, Matthijs S. van der Leeuw, Alfons A. den Broeder, Janneke Tekstra, Marlies C. van der Goes, Marloes W. Heijstek, Floris Lafeber and Paco M. J. Welsing
    Citation: Trials 2022 23:494
  46. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat sciatica, despite insufficient evidence from placebo-controlled trials. NSAIDs may cause serious side effects; hence, there is a strong ne...

    Authors: Lars Grøvle, Eivind Hasvik, Rene Holst and Anne Julsrud Haugen
    Citation: Trials 2022 23:493
  47. There is an ongoing discussion about the advantages and disadvantages of different surgical positions (semi-sitting and lateral position) for vestibular schwannoma surgery. Each position has its advantages, di...

    Authors: Xiaolong Wu, Xu Wang, Gang Song, Mingchu Li, Chengbei Hou, Ge Chen, Hongchuan Guo, Xinru Xiao, Jie Tang, Qingtang Lin, Yuhai Bao and Jiantao Liang
    Citation: Trials 2022 23:492
  48. Endoscopic submucosal dissection (ESD) is widely used as an effective treatment of early gastric and esophageal tumors, as it is minimally invasive, safe, and convenient. Epigastric pain is a common complicati...

    Authors: Xin Luo, Li-Xin An, Pei-Shan Chen, Xin-Lu Chang and Yang Li
    Citation: Trials 2022 23:491
  49. The high prevalence of dysphagia among Alzheimer’s disease (AD) patients has become a public health and economic concern. Therefore, effective and accessible dysphagia treatments are needed. As a fundamental r...

    Authors: Chenxin Wu, Kun Zhang, Junrong Ye, Xingxiao Huang, Hang Yang, Lexin Yuan, Haoyun Wang, Ting Wang, Xiaomei Zhong, Jianxiong Guo, Lin Yu and Aixiang Xiao
    Citation: Trials 2022 23:490
  50. Authors: Isabel Mank, Raissa Sorgho, Fanta Zerbo, Moubassira Kagoné, Boubacar Coulibaly, John Oguso, Michael Mbata, Sammy Khagayi, Erick M. O. Muok, Ali Sié and Ina Danquah
    Citation: Trials 2022 23:489

    The original article was published in Trials 2022 23:449

Annual Journal Metrics