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  1. Perioperative malnutrition is common in patients undergoing gastrointestinal-oncology surgery and is associated with longer hospital stays, increased postoperative complications, poorer quality of life, and lo...

    Authors: A’ishah Zafirah Abdul A’zim, Zalina Abu Zaid, Barakatun Nisak Mohd Yusof, Mohd Faisal Jabar and Aainaa Syarfa Mohd Shahar
    Citation: Trials 2022 23:961
  2. Dental implant therapy requires the preservation of peri-implant tissue in the cosmetic zone. Various surgical procedures have been presented, including ridge preservation, flapless method, and quick provision...

    Authors: Mehrnoush MeshkatAlsadat, Ali Hassani, Tahereh Bitaraf and Salar Chaychi Salmasi
    Citation: Trials 2022 23:960
  3. Metabolic syndrome (MetS) is a group of risk factors that increase the risk of death and a variety of chronic diseases. Recent studies have indicated that the imbalance of gut microbiota might contribute to de...

    Authors: Seyed Mohammad Mousavi, Hanieh-Sadat Ejtahed, Hanieh Malmir, Seyed Davar Siadat, Shirin Hasani-Ranjbar, Bagher Larijani and Ahmad Esmaillzadeh
    Citation: Trials 2022 23:959
  4. Randomised controlled trials of non-pharmacological interventions in children’s therapy are rare. This is, in part, due to the challenges of the acceptability of common trial designs to therapists and service ...

    Authors: Samantha Armitage, Tim Rapley, Lindsay Pennington, Jennifer McAnuff, Elaine McColl, Catherine Duff, Rob Brooks and Niina Kolehmainen
    Citation: Trials 2022 23:958
  5. Randomised trials play a vital role in underpinning evidence-based care. However, trials involving adults with impaired capacity to consent raise a number of ethical and methodological challenges, leading to t...

    Authors: Victoria Shepherd, Fiona Wood, Katie Gillies, Adam Martin, Abby O’Connell and Kerenza Hood
    Citation: Trials 2022 23:957
  6. Enhanced Recovery After Surgery (ERAS) represents the standard of care in colorectal surgery. Among ERAS items, early removal of urinary catheter (UC) is considered a key issue, though adherence to this specif...

    Authors: Corrado Pedrazzani, Isacco Montroni, Cristian Conti, Giulia Turri, Caterina Foppa, Michele Carvello, Giovanni Taffurelli, Giampaolo Ugolini and Antonino Spinelli
    Citation: Trials 2022 23:956
  7. Knee osteoarthritis (KOA) is the most common form of arthritis, causing disability and impaired quality of life especially in the elderly. Sri Lankan traditional medicine (STM) is widely used to treat OA, but ...

    Authors: Himalee De Silva, Pathirage Kamal Perera, Saroj Jayasinghe and Shreenika De Silva Weliange
    Citation: Trials 2022 23:955
  8. Surgical site infection (SSI), as one of the most common hospital-acquired infection, is usually associated with increased morbidity, mortality, and health care burden. SSI is a significant perioperative compl...

    Authors: Liang He, Meng Li, Jia-xin Zhang, Wei-hua Tong, Yan Chen and Quan Wang
    Citation: Trials 2022 23:954
  9. A resurgence of research into phase II trial design in the mid-2000s led to the use of futility designs in a wide variety of disease areas. Phase II futility studies differ from efficacy studies in that their ...

    Authors: Jonathan Beall, Christy Cassarly and Renee Martin
    Citation: Trials 2022 23:953
  10. Patients resuscitated from out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality risk and often develop post-cardiac arrest syndrome (PCAS) involving systemic inflammation. The severity of ...

    Authors: Laust Emil Roelsgaard Obling, Rasmus Paulin Beske, Sebastian Wiberg, Fredrik Folke, Jacob Eifer Moeller, Jesper Kjaergaard and Christian Hassager
    Citation: Trials 2022 23:952
  11. Tai Chi (TC), as one of mild to moderate exercise therapies specifically recommended by clinical practice guideline from the American College of Physician, is a viable option for chronic non-specific low back ...

    Authors: Ruihan Wan, Jian Shi, Kun Hu, Yafei Wang, Xue Jiang, Wangwang Yan, Mali Cao and Yuling Wang
    Citation: Trials 2022 23:951
  12. Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on po...

    Authors: Xiaoyuan Liu, Xingyue Zhang, Yifang Fan, Shu Li and Yuming Peng
    Citation: Trials 2022 23:950
  13. The core intrinsic connectivity networks (core-ICNs), encompassing the default-mode network (DMN), salience network (SN) and central executive network (CEN), have been shown to be dysfunctional in individuals ...

    Authors: Tyson M. Perez, Paul Glue, Divya B. Adhia, Muhammad S. Navid, Jiaxu Zeng, Peter Dillingham, Mark Smith, Imran K. Niazi, Calvin K. Young and Dirk De Ridder
    Citation: Trials 2022 23:949
  14. Colorectal cancer (CRC) is the third most common cancer worldwide, with a median age of 72–75 years at diagnosis. Curative treatment usually involves surgery; if left untreated, symptoms may require emergency ...

    Authors: Maria Normann, Niklas Ekerstad, Eva Angenete and Mattias Prytz
    Citation: Trials 2022 23:948
  15. There is a marked increase in unscheduled care visits in school-aged children with asthma after returning to school in September. This is potentially associated with children not taking their asthma preventer ...

    Authors: Rami A. Alyami, Rebecca Simpson, Phillip Oliver and Steven A. Julious
    Citation: Trials 2022 23:947
  16. Intraoperative hypotension is common in patients having non-cardiac surgery and is associated with serious complications and death. However, optimal intraoperative blood pressures for individual patients remai...

    Authors: Alina Bergholz, Agnes S. Meidert, Moritz Flick, Linda Krause, Eik Vettorazzi, Antonia Zapf, Frank M. Brunkhorst, Patrick Meybohm, Kai Zacharowski, Alexander Zarbock, Daniel I. Sessler, Karim Kouz and Bernd Saugel
    Citation: Trials 2022 23:946
  17. A Core Outcome Set (COS) is a standardised list of outcomes that should be reported as a minimum in all clinical trials. In epilepsy, the choice of outcomes varies widely among existing studies, particularly i...

    Authors: James W. Mitchell, Adam Noble, Gus Baker, Rachel Batchelor, Francesco Brigo, Jakob Christensen, Jacqueline French, Antonio Gil-Nagel, Alla Guekht, Nathalie Jette, Reetta Kälviäinen, John Paul Leach, Melissa Maguire, Terence O’Brien, Felix Rosenow, Philippe Ryvlin…
    Citation: Trials 2022 23:943
  18. In the context of COVID-19, NHS Child and Adolescent Mental Health Services (CAMHS) and other children’s mental health services have faced major challenges in providing psychological treatments that (i) work w...

    Authors: Lucy Taylor, Sophie Giles, Sophie Howitt, Zoe Ryan, Emma Brooks, Lucy Radley, Abigail Thomson, Emily Whitaker, Fauzia Knight, Claire Hill, Mara Violato, Polly Waite, Vanessa Raymont, Ly-Mee Yu, Victoria Harris, Nicola Williams…
    Citation: Trials 2022 23:942
  19. Due to some unique physical, social and psychological features in the adolescent population, adolescents can be a time of heightened caries activity and periodontal disease. Oral health-related behaviors can b...

    Authors: Pei Liu, May Chun Mei Wong, Gillian Hiu Man Lee, Cynthia Kar Yung Yiu and Edward Chin Man Lo
    Citation: Trials 2022 23:941
  20. Chronic neck and shoulder region pain affects many people around the world. This study aims to compare the effectiveness of three 8-week meditation training programmes (each using a different meditation techni...

    Authors: Aranjan Lionel Karunanayake, Emma Solomon-Moore and Nikki Coghill
    Citation: Trials 2022 23:940
  21. Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity. Anti-CD20 B cell depletion wit...

    Authors: Mieke van Schaik, Eline J. Arends, Darius Soonawala, Ellen van Ommen, Karina de Leeuw, Maarten Limper, Pieter van Paassen, Tom W. J. Huizinga, René E. M. Toes, Cees van Kooten, Joris I. Rotmans, Ton J. Rabelink and Y. K. Onno Teng
    Citation: Trials 2022 23:939
  22. Authors: Lea Wetzel, Madeleine Pourbaix, Alisa Riegler, Anna-Maria Pfeifer, Iris Reinhard, Sabine Hofmann, Sabine Vollstädt-Klein, Falk Kiefer, Wolfgang Sommer, Jan Malte Bumb, Patrick Bach and Anne Koopmann
    Citation: Trials 2022 23:938

    The original article was published in Trials 2022 23:693

  23. The Workwell trial is a multi-centre randomised controlled trial with the aims of evaluating the effectiveness and cost-effectiveness of job retention vocational rehabilitation for employed people with inflamm...

    Authors: Alison Hammond, Kathryn A. Radford, Angela Ching, Yeliz Prior, Rachel O’Brien, Sarah Woodbridge, June Culley, Jennifer Parker and Paula Holland
    Citation: Trials 2022 23:937
  24. Evidence suggests that children from low-income families begin the preschool stage with less academic and non-academic skills development compared to higher-income families. There are several successful experi...

    Authors: Cristian A. Rojas-Barahona, Jorge Gaete, Mauricio Véliz, Ramón D. Castillo, Saray Ramírez and Ricardo Araya
    Citation: Trials 2022 23:936
  25. Anxiety and depression are increasingly prevalent in adolescents, often causing daily distress and negative long-term outcomes. Despite the significant and growing burden, less than 25% of those with probable ...

    Authors: Stephen Lisk, Ben Carter, Kirsty James, Paul Stallard, Jessica Deighton, Jynna Yarrum, Peter Fonagy, Crispin Day, Sarah Byford, James Shearer, Timothy Weaver, Irene Sclare, Claire Evans, Maria Farrelly, Pin-Cheng Ho and June Brown
    Citation: Trials 2022 23:935
  26. Due to the physical dose distribution characteristic of “Bragg peak” and the biological effect as a kind of high linear energy transfer ray, heavy ion therapy has advantages over conventional photon therapy in...

    Authors: Wei Hu, Ping Li, Zhengshan Hong, Xiaomao Guo, Yulei Pei, Zhenshan Zhang and Qing Zhang
    Citation: Trials 2022 23:934
  27. Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) ...

    Authors: Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan…
    Citation: Trials 2022 23:933
  28. COVID-19 poses a global health challenge with more than 325 million cumulative cases and above 5 million cumulative deaths reported till January 17, 2022, by the World Health Organization. Several potential tr...

    Authors: Shaukat Ali, Elisha Shalim, Farah Farhan, Fatima Anjum, Ayesha Ali, Syed Muneeb Uddin, Faisal Shahab, Mustafa Haider, Iqra Ahmed, Mir Rashid Ali, Sadaf Khan, Sadia Rao, Kabeer Guriro, Saud Elahi, Muhammad Ali, Tehreem Mushtaq…
    Citation: Trials 2022 23:932
  29. External randomised pilot trials aim to assess whether a future definitive randomised controlled trial (RCT) is feasible. Pre-specified progression criteria help guide the interpretation of pilot trial finding...

    Authors: Katie Mellor, James Harwood, Jennie Hejdenberg, Ben Morgan, Susan J. Dutton and Sally Hopewell
    Citation: Trials 2022 23:931
  30. The importance of insulin resistance is gaining increasing attention as it plays an important role in carcinogenesis in hepatocellular carcinoma (HCC). Although exercise is the most important intervention for ...

    Authors: Seung Mi Yeo, Joo Hyun Oh, Hee Ju Yu, Dong Hyun Sinn and Ji Hye Hwang
    Citation: Trials 2022 23:930
  31. Total hip arthroplasty (THA) is very effective in alleviating pain, but functional deficits persist up to a year following surgery. Regardless of standard physiotherapy programs, significant additional muscula...

    Authors: Pika Krištof Mirt, Vojko Strojnik, Gregor Kavčič and Rihard Trebše
    Citation: Trials 2022 23:929
  32. Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV...

    Authors: Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou…
    Citation: Trials 2022 23:928
  33. The coronavirus disease 2019 (COVID-19) pandemic resulted in severe interruptions to clinical research worldwide. This global public health crisis required investigators and researchers to rapidly develop and ...

    Authors: Jie Deng, John N. Lukens, Joy C. Cohn, Erin McMenamin, Barbara Murphy, Bryan A. Spinelli, Niya Murphy, Alicia K. Steinmetz, Megan A. Landriau and Alexander Lin
    Citation: Trials 2022 23:927
  34. Chronic subdural hematoma (cSDH) is one of the most common neurosurgical disorders and the incidence is rising. The routine treatment is neurosurgical hematoma evacuation, which is associated with recurrence r...

    Authors: Mattias Drake, Teresa Ullberg, Henrietta Nittby, Niklas Marklund and Johan Wassélius
    Citation: Trials 2022 23:926
  35. No conclusive evidence recommends a prior treatment for insertional Achilles tendinopathy (IAT). It is theorized that both percutaneous radiofrequency coblation and extracorporeal shockwave therapy (ESWT) reli...

    Authors: Yu-Jie Song, Wen-Kai Xuan and Ying-Hui Hua
    Citation: Trials 2022 23:925
  36. The HemiSPAIRE trial is being conducted to determine whether a modified muscle sparing technique (SPAIRE-“Save Piriformis and Internus, Repairing Externus”) in hip hemiarthroplasty brings clinical benefits com...

    Authors: Susan Ball, Amy McAndrew, Alex Aylward, Emma Cockcroft, Elizabeth Gordon, Alison Kerridge, Sarah Morgan-Trimmer, Roy Powell, Anna Price, Shelley Rhodes, Andrew J. Timperley, Jayden van Horik, Robert Wickins and John Charity
    Citation: Trials 2022 23:924
  37. Considering the confinement recommended by the World Health Organization due to the pandemic caused by COVID-19, many community physical exercise programmes for older adults have had their activities cancelled...

    Authors: Ana Claudia Silva Farche, Gabriela Cassemiliano, Paulo Giusti Rossi, Bianca Ferdin Carnavale, Stefany Lee, Laura Bonome Message, Vinícius Ramon da Silva Santos, Juliana Hotta Ansai, Eduardo Ferriolli, Natália Duarte Pereira, Guillermo Rúben Oviedo, Myriam Guerra-Balic, Maria Giné-Garriga, Marina Araújo Lopes and Anielle Cristhine de Medeiros Takahashi
    Citation: Trials 2022 23:923
  38. Stellate ganglion block has been reported to expand cerebral vessels and alleviate vasospasm after aneurysmal subarachnoid hemorrhage. However, the causal relationship between early stellate ganglion block and...

    Authors: Longnian Jing, Youxuan Wu, Fa Liang, Minyu Jian, Yang Bai, Yunzhen Wang, Haiyang Liu, Anxin Wang, Xiaolin Chen and Ruquan Han
    Citation: Trials 2022 23:922
  39. Advances in autologous hematopoietic stem cell transplantation (HSCT) and supportive care have led to marked improvements in survival for patients with multiple myeloma. Despite these improvements, patients wi...

    Authors: Kyuwan Lee, Nitya Nathwani, Justin Shamunee, Lanie Lindenfeld, F. Lennie Wong, Amrita Krishnan and Saro Armenian
    Citation: Trials 2022 23:921
  40. Although many efforts have been made to decrease the incidence of anastomotic leak (AL), it remains one of the most serious complications of rectal cancer surgery. Many previous studies have reported an associ...

    Authors: Soo Young Lee, Sohyun Kim, Gyung Mo Son, Hye Jin Kim, Soo Yeun Park, Jun Seok Park, Chang Hyun Kim, Gi Won Ha, Kyung-Ha Lee, Jin Soo Kim, Ki Beom Bae, Sung Uk Bae and Sung Il Kang
    Citation: Trials 2022 23:920
  41. Failure to consider relevant cultural, ethnic and diversity parameters (and the intersection between these parameters) during trial protocol development and trial conduct may negatively impact recruitment, int...

    Authors: Nandi Louise Siegfried, Sally Hopewell, Lesley-Ann Erasmus-Claassen and Bronwyn Myers
    Citation: Trials 2022 23:918
  42. Infectious complications are the main causes of morbidity after pancreaticoduodenectomy (PD). Early enteral nutrition (EN) is a reasonable form of nutritional support that aims to mitigate the occurrence and s...

    Authors: Yoshinori Takeda, Yoshihiro Mise, Yoji Kishi, Hiroyuki Sugo, Yusuke Kyoden, Kiyoshi Hasegawa, Yu Takahashi and Akio Saiura
    Citation: Trials 2022 23:917
  43. Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of blindness in individuals over 50 years of age, with no available effective treatment. The oral dual endothelin receptor antagonist, ...

    Authors: Christophe Chiquet, Catherine Vignal, Philippe Gohier, Emmanuel Heron, Gilles Thuret, Marie Bénédicte Rougier, Audrey Lehmann, Laurent Flet, Jean-Louis Quesada, Mathieu Roustit, Dan Milea and Jean-Louis Pepin
    Citation: Trials 2022 23:916
  44. Disease recurrence is the main cause of mortality after resection of pancreatic ductal adenocarcinoma (PDAC). In 20–30% of resected patients, isolated local PDAC recurrence occurs. Retrospective studies have s...

    Authors: I. W. J. M. van Goor, L. A. Daamen, M. G. Besselink, A. M. E. Bruynzeel, O. R. Busch, G. A. Cirkel, B. Groot Koerkamp, N. Haj Mohammed, H. D. Heerkens, H. W. M. van Laarhoven, G. J. Meijer, J. Nuyttens, H. C. van Santvoort, G. van Tienhoven, H. M. Verkooijen, J. W. Wilmink…
    Citation: Trials 2022 23:913
  45. Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hos...

    Authors: Matthew D. Smith, Emma Tenison, Marcus J. Drake, Yoav Ben-Shlomo and Emily J. Henderson
    Citation: Trials 2022 23:912
  46. Coronavirus disease 2019 (COVID-19) vaccines demonstrate excellent effectiveness against infection, severe disease, and death. However, pediatric COVID-19 vaccination rates lag among individuals from rural and...

    Authors: Russell J. McCulloh, Paul M. Darden, Jessica Snowden, Songthip Ounpraseuth, Jeannette Lee, Martina Clarke, Sophia R. Newcomer, Linda Fu, DeAnn Hubberd, Jaime Baldner, Maryam Garza and Ellen Kerns
    Citation: Trials 2022 23:911
  47. Implantable collamer lens implantation (ICL) is a form of ‘foldable’ posterior chamber phakic intraocular lens refractive surgery that generally does not impair cornea and natural accommodation. The potential ...

    Authors: Kangjun Li, Zheng Wang and Ming X. Wang
    Citation: Trials 2022 23:910

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