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  1. Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics. Although some studies have observed the efficacy of music...

    Authors: Masatsugu Kishida, Yosuke Yamada, Emi Inayama, Mineaki Kitamura, Tomoya Nishino, Keiko Ota, Ayumi Shintani and Tatsuyoshi Ikenoue

    Citation: Trials 2019 20:631

    Content type: Study protocol

    Published on:

  2. Randomized controlled trials are considered the gold standard in assessing treatment regimens, and since abstracts may be the only part of a paper that a physician reads, accurate reporting of data in abstract...

    Authors: Rohan Kumar Ochani, Asim Shaikh and Naser Yamani

    Citation: Trials 2019 20:630

    Content type: Letter

    Published on:

    The Research to this article has been published in Trials 2018 19:591

  3. An important prerequisite for optimal healthcare is a secure, safe and comfortable environment. There is little research on how the physical design of birthing rooms affects labour, birth, childbirth experienc...

    Authors: Marie Berg, Lisa Goldkuhl, Christina Nilsson, Helle Wijk, Hanna Gyllensten, Göran Lindahl, Kerstin Uvnäs Moberg and Cecily Begley

    Citation: Trials 2019 20:629

    Content type: Study protocol

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  4. An error occurred during the publication of the original article [1] which led to the text being incorrectly converted into Portuguese.

    Authors: Catarina Magalhães Porto, Tatiana de Paula Santana da Silva and Everton Botelho Sougey

    Citation: Trials 2019 20:628

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:583

  5. In Denmark, exercise therapy in combination with work modification is the first-choice treatment for persons with shoulder complaints and high occupational shoulder exposures. To obtain this treatment they mus...

    Authors: Jeanette Trøstrup, Lone Ramer Mikkelsen, Poul Frost, Annett Dalbøge, Mette Terp Høybye, Sven Dalgas Casper, Lene Bastrup Jørgensen, Thomas Martin Klebe and Susanne Wulff Svendsen

    Citation: Trials 2019 20:627

    Content type: Study protocol

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  6. Gait disorders in individuals with Parkinson’s disease (PD) may be associated with alterations in the motor control system and aggravated by psychoemotional and cognitive issues. Therapeutic strategies aimed a...

    Authors: Isaíra Almeida Pereira da Silva Nascimento, Lorenna Marques de Melo Santiago, Aline Alves de Souza, Camila de Lima Pegado, Tatiana Souza Ribeiro and Ana Raquel Rodrigues Lindquist

    Citation: Trials 2019 20:626

    Content type: Study protocol

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  7. Fatigue is one of the primary symptoms in lung cancer, with a prevalence of 88.0% in survivors of cancer, and an even higher prevalence post resection surgery. Effective fatigue control after lung cancer surge...

    Authors: Zhaoqin Wang, Shanshan Li, Luyi Wu, Qin Qi, Huirong Liu, Xiaoming Jin, Jianhui Tian, Ming Zhang, Xiaopeng Ma, Deli Sun, Shifen Xu and Huangan Wu

    Citation: Trials 2019 20:625

    Content type: Study protocol

    Published on:

  8. Recruitment and retention of participants are both critical for the success of trials, yet both remain significant problems. The use of incentives to target participants and trial staff has been proposed as on...

    Authors: Beth Parkinson, Rachel Meacock, Matt Sutton, Eleonora Fichera, Nicola Mills, Gillian W. Shorter, Shaun Treweek, Nicola L Harman, Rebecca C. H. Brown, Katie Gillies and Peter Bower

    Citation: Trials 2019 20:624

    Content type: Review

    Published on:

  9. This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient dep...

    Authors: J. Schiller, T. Kellner, J. Briest, K. Hoepner, A. Woyciechowski, A. Ostermann, C. Korallus, C. Sturm, T. Weiberlenn, L. Jiang, C. Egen, F. Beissner, M. Stiesch, M. Karst, C. Gutenbrunner and M. G. Fink

    Citation: Trials 2019 20:623

    Content type: Study protocol

    Published on:

  10. Use of minimally invasive surgical techniques for lung resection surgery (LRS), such as video-assisted thoracoscopy (VATS), has increased in recent years. However, there is little information about the best an...

    Authors: Francisco De la Gala, Patricia Piñeiro, Almudena Reyes, Carlos Simón, Elena Vara, Lisa Rancan, Luis Javier Huerta, Guillermo Gonzalez, Carmen Benito, Marta Muñoz, Pilar Grande, Sergio D. Paredes, Pablo Tomas Aznar, Alvaro Perez, David Martinez, Fernando Higuero…

    Citation: Trials 2019 20:622

    Content type: Study protocol

    Published on:

  11. Participant recruitment for clinical trials is a significant challenge for the scientific research community. Federal funding agencies have made continuation of funding of clinical trials contingent on meeting...

    Authors: Barbara A. Myers, Yegan Pillay, W. Guyton Hornsby Jr, Jay Shubrook, Chandan Saha, Kieren J. Mather, Karen Fitzpatrick and Mary de Groot

    Citation: Trials 2019 20:621

    Content type: Research

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  12. Postoperative pulmonary complications (PPCs) are the most common perioperative complications following surgical site infection (SSI). They prolong the hospital stay and increase health care costs. A lung-prote...

    Authors: Xue-Fei Li, Dan Jiang, Yu-Lian Jiang, Hong Yu, Jia-Li Jiang, Lei-Lei He, Xiao-Yun Yang and Hai Yu

    Citation: Trials 2019 20:619

    Content type: Study protocol

    Published on:

  13. Many randomised controlled trials (RCT) fail to meet their recruitment goals. Study personnel play a key role in recruitment. The aim of this study was to identify successful strategies that study personnel co...

    Authors: Eva Isaksson, Per Wester, Ann Charlotte Laska, Per Näsman and Erik Lundström

    Citation: Trials 2019 20:618

    Content type: Research

    Published on:

  14. Following publication of the original article [1], we have been notified that Figure 1 was published with the track changes. In this Correction the incorrect and correct Fig. 1 are shown.

    Authors: Felicity L. Brown, Frederik Steen, Karine Taha, May Aoun, Richard A. Bryant, Mark J. D. Jordans, Aiysha Malik, Mark van Ommeren, Adnan Abualhaija, Ibrahim Said Aqel, Maha Ghatasheh, Rand Habashneh, Marit Sijbrandij, Rabih El Chammay, Sarah Watts and Aemal Akhtar

    Citation: Trials 2019 20:617

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:545

  15. Investigator-initiated clinical studies (IITs) are crucial to generate reliable evidence that answers questions of day-to-day clinical practice. Many challenges make IITs a complex endeavour, for example, IITs...

    Authors: A. Magnin, V. Cabral Iversen, G. Calvo, B. Čečetková, O. Dale, R. Demlova, Gy. Blasko, F. Keane, G. L. Kovacs, C. Levy-Marchal, E. C. Monteiro, L. Palmisano, D. Pella, A. Portolés Pérez, O. Rascol, C. Schmid…

    Citation: Trials 2019 20:616

    Content type: Research

    Published on:

  16. The amount of mandibular protrusion is a key factor in optimizing the efficacy of mandibular advancement device (MAD) therapy in an individual patient diagnosed with obstructive sleep apnea. This process is ca...

    Authors: Marijke Dieltjens, Marc J. Braem, Sara Op de Beeck, Anneclaire V. M. T. Vroegop, Elahe Kazemeini, Eli Van de Perck, Jolien Beyers, Chloé Kastoer, Kristien Wouters, Marc Willemen, Johan A. Verbraecken and Olivier M. Vanderveken

    Citation: Trials 2019 20:615

    Content type: Study protocol

    Published on:

  17. Cognitive and mood disorders negatively impact daily life in patients with multiple sclerosis (MS). Pharmacological treatments did not demonstrate any effect on cognition compared with cognitive rehabilitation...

    Authors: Caroline Harand, France Daniel, Audrey Mondou, Damien Chevanne, Christian Creveuil and Gilles Defer

    Citation: Trials 2019 20:614

    Content type: Study protocol

    Published on:

  18. Poor recruitment to, and retention in, clinical trials is a source of research waste that could be reduced by more informed choices about participation. Barriers to effective recruitment and retention can be w...

    Authors: Katie Gillies, Iain Chalmers, Paul Glasziou, Diana Elbourne, Jim Elliott and Shaun Treweek

    Citation: Trials 2019 20:613

    Content type: Commentary

    Published on:

  19. Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dress...

    Authors: Alexandra Poinas, Pierre Perrot, Judith Lorant, Olivier Nerrière, Jean-Michel Nguyen, Soraya Saiagh, Cécile Frenard, Audrey Leduc, Olivier Malard, Florent Espitalier, Franck Duteille, Anne Chiffoleau, Florence Vrignaud, Amir Khammari and Brigitte Dréno

    Citation: Trials 2019 20:612

    Content type: Study protocol

    Published on:

  20. Following publication of the original article [1], we have been notified that one of an error in the Conclusions section of the Abstract.

    Authors: Stephen J. Walters, Richard M. Jacques, Inês Bonacho dos Anjos Henriques-Cadby, Jane Candlish, Nikki Totton and Mica Teo Shu Xian

    Citation: Trials 2019 20:611

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:566

  21. Following publication of the original article [1], we have been notified that the final specification of randomisation implemented in the study is slightly different to that stated in the protocol and needs to...

    Authors: Sam Eldabe, Ashish Gulve, Simon Thomson, Ganesan Baranidharan, Rui Duarte, Susan Jowett, Harbinder Sandhu, Raymond Chadwick, Morag Brookes, Anisah Tariq, Jenny Earle, Jill Bell, Anu Kansal, Shelley Rhodes and Rod S. Taylor

    Citation: Trials 2019 20:610

    Content type: Correction

    Published on:

    The original article was published in Trials 2018 19:633

  22. Palliative antalgic treatments represent an issue for clinical management and a challenge for scientific research. Radiotherapy (RT) plays a central role. Techniques such as stereotactic body radiotherapy (SBR...

    Authors: Francesco Cellini, Stefania Manfrida, Francesco Deodato, Savino Cilla, Ernesto Maranzano, Stefano Pergolizzi, Fabio Arcidiacono, Rossella Di Franco, Francesco Pastore, Matteo Muto, Valentina Borzillo, Costanza Maria Donati, Giambattista Siepe, Salvatore Parisi, Antonia Salatino, Antonino D’Agostino…

    Citation: Trials 2019 20:609

    Content type: Study protocol

    Published on:

  23. Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic acid (Li/VPA) and lithium plus carbamazepine (Li/CBZ) are used in clinical practice but were not pre...

    Authors: Giovani Missio, Doris Hupfeld Moreno, Frederico Navas Demetrio, Marcio Gerhardt Soeiro-de-Souza, Fernando dos Santos Fernandes, Vivian Boschesi Barros and Ricardo Alberto Moreno

    Citation: Trials 2019 20:608

    Content type: Research

    Published on:

  24. Models of collaborative care and consultation liaison propose organizational changes to improve the quality of care for people with common mental disorders, such as anxiety and depression. Some literature sugg...

    Authors: Nadja Kehler Curth, Ursula Brinck-Claussen, Kirstine Bro Jørgensen, Susanne Rosendal, Carsten Hjorthøj, Merete Nordentoft and Lene Falgaard Eplov

    Citation: Trials 2019 20:607

    Content type: Study protocol

    Published on:

  25. Following publication of the original article [1], we have been notified that one of the authors’ names is spelled incorrectly. In this Correction the incorrect and correct author name are shown.

    Authors: Devin S. McCaskell, Alexander J. Molloy, Laura Childerhose, F. Aileen Costigan, Julie C. Reid, Magda McCaughan, France Clarke, Deborah J. Cook, Jill C. Rudkowski, Christopher Farley, Tim Karachi, Bram Rochwerg, Anastasia Newman, Alison Fox-Robichaud, Margaret S. Herridge, Vincent Lo…

    Citation: Trials 2019 20:606

    Content type: Correction

    Published on:

    The original article was published in Trials 2019 20:532

  26. Recent estimates suggest an 11% prevalence of current late-life depression (LLD) and a lifetime prevalence of 16–20%. LLD leads to cognitive disturbance as well as a nearly two to three times increased risk of...

    Authors: Stephen Benjamin Peckham, Emily Ionson, Marouane Nassim, Kevin Ojha, Lena Palaniyappan, Joe Gati, Jean Thebérge, Andrea Lazosky, Mark Speechley, Imants Barušs, Soham Rej and Akshya Vasudev

    Citation: Trials 2019 20:605

    Content type: Study protocol

    Published on:

  27. Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia and fatigue. Exposure to high altitude can also...

    Authors: O. Fisher, R. A. Benson, S. Wayte, P. K. Kimani, C. Hutchinson and C. H. E. Imray

    Citation: Trials 2019 20:604

    Content type: Study protocol

    Published on:

  28. Routine application of chlorhexidine oral rinse is recommended to reduce risk of ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Recent reappraisal of the evidence from two meta-anal...

    Authors: Craig M. Dale, Louise Rose, Sarah Carbone, Orla M. Smith, Lisa Burry, Eddy Fan, Andre Carlos Kajdacsy-Balla Amaral, Victoria A. McCredie, Ruxandra Pinto, Carlos R. Quiñonez, Susan Sutherland, Damon C. Scales and Brian H. Cuthbertson

    Citation: Trials 2019 20:603

    Content type: Study protocol

    Published on:

  29. Following publication of the original article [1], we have been notified of a few mistakes:

    Authors: William Sones, Steven A. Julious, Joanne C. Rothwell, Craig Robert Ramsay, Lisa V. Hampson, Richard Emsley, Stephen J. Walters, Catherine Hewitt, Martin Bland, Dean A. Fergusson, Jesse A. Berlin, Doug Altman, Luke David Vale and Jonathan Alistair Cook

    Citation: Trials 2019 20:602

    Content type: Correction

    Published on:

    The original article was published in Trials 2018 19:542

  30. Fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease, and calcimimetic therapy reduces plasma concentrations of FGF23. It remains un...

    Authors: Katharina Dörr, Michael Kammer, Roman Reindl-Schwaighofer, Matthias Lorenz, Christian Loewe, Rodrig Marculescu, Reinhold Erben and Rainer Oberbauer

    Citation: Trials 2019 20:601

    Content type: Study protocol

    Published on:

  31. There is a growing debate on the relationship between health-related quality of life (HRQoL) and patient survival which has been going on for the last few decades. The greatest wish of clinicians is to extend ...

    Authors: Lei Wang, Liang Wang, Xuefei Song, Chang Cui, Chunyue Ma, Bing Guo and Xingjun Qin

    Citation: Trials 2019 20:600

    Content type: Study protocol

    Published on:

  32. With the substantially growing trend of the aging populations in China and the rest of the world, the number of total hip and total knee arthroplasty (THA and TKA) cases are increasing dramatically. It is impo...

    Authors: Jingyi Li, Haibei Zhu and Ren Liao

    Citation: Trials 2019 20:599

    Content type: Study protocol

    Published on:

  33. The Mesothelioma and Radical Surgery Trial (MARS 2) aims to evaluate a surgical procedure by comparing chemotherapy and surgery against chemotherapy alone. The pilot study for MARS 2 evaluated the viability of...

    Authors: Clare Warnock, Karen Lord, Bethany Taylor and Angela Tod

    Citation: Trials 2019 20:598

    Content type: Research

    Published on:

  34. Currently there are campaigns to raise the awareness of the need to practice physical exercise with several objectives, mainly as a preventive measure. The Pilates method is a form of therapeutic exercise for ...

    Authors: Allysiê Priscilla de Souza Cavina, Eduardo Pizzo Junior, Aryane Flauzino Machado, Taíse Mendes Biral, Carlos Marcelo Pastre and Franciele Marques Vanderlei

    Citation: Trials 2019 20:597

    Content type: Study protocol

    Published on:

  35. Disorders of consciousness (DOC) after traumatic brain injury (TBI) raise the mortality of patients, restrict the rehabilitation of patients with TBI, and increase the physical and economic burden that TBI imp...

    Authors: Shilin Li, Xiangli Dong, Weiming Sun, Na Zhao, Guohua Yu and Lang Shuai

    Citation: Trials 2019 20:596

    Content type: Study protocol

    Published on:

  36. Following publication of the original article [1], we have been notified of a few mistakes in the “Sample size calculations” section, second paragraph.

    Authors: Rachel B. van Oostveen, Alberto Romero-Palacios, Richard Whitlock, Shun Fu Lee, Stuart Connolly, Alex Carignan, C. David Mazer, Mark Loeb and Dominik Mertz

    Citation: Trials 2019 20:595

    Content type: Correction

    Published on:

    The original article was published in Trials 2018 19:688

  37. Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to suppor...

    Authors: Andrea J. Loizeau, Erika M. C. D’Agata, Michele L. Shaffer, Laura C. Hanson, Ruth A. Anderson, Timothy Tsai, Daniel A. Habtemariam, Elaine H. Bergman, Ruth P. Carroll, Simon M. Cohen, Erin M. E. Scott, Erin Stevens, Jeremy D. Whyman, Elizabeth H. Bennert and Susan L. Mitchell

    Citation: Trials 2019 20:594

    Content type: Study protocol

    Published on:

  38. One of the top three research priorities for the UK clinical trial community is to address the gap in evidence-based approaches to improving participant retention in randomised trials. Despite this, there is l...

    Authors: Dan Brunsdon, Linda Biesty, Peter Brocklehurst, Valerie Brueton, Declan Devane, Jim Elliott, Sandra Galvin, Carrol Gamble, Heidi Gardner, Patricia Healy, Kerenza Hood, Joan Jordan, Doris Lanz, Beccy Maeso, Amanda Roberts, Imogen Skene…

    Citation: Trials 2019 20:593

    Content type: Methodology

    Published on:

  39. Patients with haematological malignancies often develop thrombocytopenia as a consequence of either their disease or its treatment. Platelet transfusions are commonly given to raise a low platelet count and re...

    Authors: Lise J. Estcourt, Zoe McQuilten, Gillian Powter, Claire Dyer, Eleanor Curnow, Erica M. Wood and Simon J. Stanworth

    Citation: Trials 2019 20:592

    Content type: Study protocol

    Published on:

  40. Older people are frequent emergency department (ED) users who present with complex issues that are linked to poorer health outcomes following the index visit, often have increased ED length of stay, and tend t...

    Authors: Marica Cassarino, Katie Robinson, Íde O’Shaughnessy, Eimear Smalle, Stephen White, Collette Devlin, Rosie Quinn, Dominic Trépel, Fiona Boland, Marie E. Ward, Rosa McNamara, Margaret O’Connor, Gerard McCarthy, Damien Ryan and Rose Galvin

    Citation: Trials 2019 20:591

    Content type: Study protocol

    Published on:

  41. Recent experimental research has suggested that spinal manipulative therapy (SMT) may reduce pain through modulation of the ascending pain signals and/or the central pain-regulating mechanisms. People with per...

    Authors: Anders Galaasen Bakken, Iben Axén, Andreas Eklund and Søren O’Neill

    Citation: Trials 2019 20:590

    Content type: Study protocol

    Published on:

  42. Actinic keratoses (AK) are common skin lesions that can progress to invasive squamous cell carcinoma of the skin. A variety of lesion- or field-targeted treatment options exist and their efficacy has been demo...

    Authors: Markus V. Heppt, Theresa Steeb, Lutz Schmitz, Claus Garbe, Lars E. French, Ulrike Leiter and Carola Berking

    Citation: Trials 2019 20:589

    Content type: Study protocol

    Published on:

  43. Neuropathic pain is a common pain condition that has a major negative impact on health-related quality of life. However, despite decades of research, it remains difficult to treat neuropathic pain. Lacosamide ...

    Authors: Malin E. Carmland, Melissa Kreutzfeldt, Jakob V. Holbech, Niels T. Andersen, Troels S. Jensen, Flemming W. Bach, Søren H. Sindrup and Nanna B. Finnerup

    Citation: Trials 2019 20:588

    Content type: Study protocol

    Published on:

  44. In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followe...

    Authors: K. E. A. Burns, Leena Rizvi, Deborah J. Cook, Andrew J. E. Seely, Bram Rochwerg, Francois Lamontagne, John W. Devlin, Peter Dodek, Michael Mayette, Maged Tanios, Audrey Gouskos, Phyllis Kay, Susan Mitchell, Kenneth C. Kiedrowski and Nicholas S. Hill

    Citation: Trials 2019 20:587

    Content type: Study protocol

    Published on:

  45. Patellofemoral pain (PFP) often affects young women, and the etiology is multifactorial and poorly understood. Conservative intervention has been focused on risk factors or aggravating factors and is composed ...

    Authors: Natália Camin Silva, Matheus de Castro Silva, Morisa Garcia Guimarães, Manoela Beatriz de Oliveira Nascimento and Lilian Ramiro Felicio

    Citation: Trials 2019 20:586

    Content type: Study protocol

    Published on:

  46. Nutritional support is essential in the care of critically ill children since malnutrition in this population is associated with increased morbidity and mortality. Injury in patients admitted to pediatric inte...

    Authors: Reyes Fernández, Javier Urbano, Ángel Carrillo, Ana Vivanco, María José Solana, Corsino Rey and Jesús López-Herce

    Citation: Trials 2019 20:585

    Content type: Study protocol

    Published on:

  47. Depression is a major cause of chronic disability throughout the world and an important cardiovascular risk factor, increasing the relative risk of coronary artery disease as well as rates of cardiovascular mo...

    Authors: Catarina Magalhães Porto, Tatiana de Paula Santana da Silva and Everton Botelho Sougey

    Citation: Trials 2019 20:583

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in Trials 2019 20:628

  48. Intraoperative hypotension is associated with increased morbidity and mortality. Current treatment is mostly reactive. The Hypotension Prediction Index (HPI) algorithm is able to predict hypotension minutes be...

    Authors: M. Wijnberge, J. Schenk, L. E. Terwindt, M. P. Mulder, M. W. Hollmann, A. P. Vlaar, D. P. Veelo and B. F. Geerts

    Citation: Trials 2019 20:582

    Content type: Study protocol

    Published on:

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