Skip to main content

Articles

Page 4 of 191

  1. A common challenge for randomised controlled trials (RCTs) is recruiting enough participants to be adequately powered to answer the research question. Recruitment has been set as a priority research area in tr...

    Authors: Keith R. Moffat, Wen Shi, Paul Cannon and Frank Sullivan
    Citation: Trials 2023 24:90
  2. A cancer diagnosis is a known precipitant of psychological distress, with fear of recurrence being a well-documented distressing consequence of cancer. Cancer recurrence often results in an additional psycholo...

    Authors: Sinead Lynch, Damien Lowry, Clodagh Finnerty, Yvonne O’Meara and Donal Brennan
    Citation: Trials 2023 24:89
  3. Multisite practical clinical trials evaluate treatments in real-world practice. A multisite randomized Veterans Health Administration (VHA) cooperative study (CSP#555) published in 2011 compared the first long...

    Authors: Robert Rosenheck, Sonia T. Anand, Stephen G. Kurtz, Cynthia Hau, Diane Smedberg, James F. Pontzer, Ryan E. Ferguson and Cynthia R. Davis
    Citation: Trials 2023 24:85
  4. Urinary continence care for residents of nursing homes who are unable to communicate their toileting needs usually involves care aides manually checking continence products (pads) to determine the level of uri...

    Authors: Muyibat Omotunde, Fredrik Agholme, Arne Böhling, Nicole Huige, Hardy Schweigel, Daniela Hayder-Beichel, Robert Reidy and Adrian Wagg
    Citation: Trials 2023 24:80
  5. Peripheral neuropathy is a common dose-limiting side effect of paclitaxel. To date, there is no effective strategy to prevent paclitaxel-induced peripheral neuropathy. A recent small phase II study demonstrate...

    Authors: Praful Pandey, Akash Kumar, Deepam Pushpam, Sachin Khurana, Prabhat Singh Malik, Ajay Gogia, Elavarasi Arunmozhimaran, Mamta Bhushan Singh, Dinu Santha Chandran and Atul Batra
    Citation: Trials 2023 24:79
  6. Lateral compression type1 (LC-1) fragility fractures are a common, painful injury in older adults resulting in reduced mobility. The incidence of these fractures is increasing with the growing older adult popu...

    Authors: Elizabeth Cook, Joanne Laycock, Mehool Acharya, Michael Ross Backhouse, Belen Corbacho, Laura Doherty, Daren Forward, Catherine Hewitt, Catherine Hilton, Peter Hull, Jamila Kassam, Camila Maturana, Catriona Mcdaid, Jenny Roche, Dhanupriya Sivapathasuntharam, David Torgerson…
    Citation: Trials 2023 24:78
  7. Young people are vulnerable to experiencing problematic levels of loneliness which can lead to poor mental health outcomes. Loneliness is a malleable treatment target and preliminary evidence has shown that it...

    Authors: Michelle H. Lim, Lily Thurston, Robert Eres, Thomas L. Rodebaugh, Mario Alvarez-Jimenez, David L. Penn, Vassilis Kostakos and John F. M. Gleeson
    Citation: Trials 2023 24:77
  8. Incisional hernia is a frequent complication following loop ileostomy reversal. Incisional hernias are associated with morbidity, loss of health-related quality of life and costs and warrant the investigation ...

    Authors: Sven Müller, Dirk Weyhe, Florian Herrle, Philipp Horvath, Robert Bachmann, Viktor von Ehrlich-Treuenstätt, Patrick Heger, Nadir Nasir, Christina Klose, Alexander Ritz, Anja Sander, Erich Grohmann, Colette Dörr-Harim and André L. Mihaljevic
    Citation: Trials 2023 24:76
  9. Individuals living with long COVID experience multiple, interacting and fluctuating symptoms which can have a dramatic impact on daily living. The aim of the Long Covid Personalised Self-managemenT support Eva...

    Authors: Claire Potter, Fiona Leggat, Rachel Lowe, Philip Pallmann, Muhammad Riaz, Christy Barlow, Adrian Edwards, Aloysius Niroshan Siriwardena, Nick Sevdalis, Bernadette Sewell, Jackie McRae, Jessica Fish, Maria Ines de Sousa de Abreu, Fiona Jones and Monica Busse
    Citation: Trials 2023 24:75
  10. Follow-up programs for gynecological cancer patients are currently under revision. There is limited evidence that traditional follow-up and clinical examinations improve survival in an early-stage gynecologica...

    Authors: Stinne Holm Bergholdt, Dorte Gilsaa Hansen, Anna Thit Johnsen, Bo Snedker Boman and Pernille Tine Jensen
    Citation: Trials 2023 24:74
  11. Obstructive sleep apnea (OSA) is quite common among the adult population, according to recent epidemiological studies. The most frequently suggested alternate treatment for mild to moderate OSA is oral applian...

    Authors: Vikram Belkhode, Surekha Godbole, Sharayu Nimonkar, Sweta Pisulkar and Pranali Nimonkar
    Citation: Trials 2023 24:73
  12. The high incidence of intraoperative glucose dysregulations in liver transplantation (LT) is related to the lack of highly orchestrated control of intraoperative blood glucose. Glucose monitoring based on a si...

    Authors: Yi Duan, Zuo-Zhi Li, Pan Liu, Lei Cui, Zhifeng Gao and Huan Zhang
    Citation: Trials 2023 24:72
  13. Existing guidelines recommend statisticians remain blinded to treatment allocation prior to the final analysis and that any interim analyses should be conducted by a separate team from the one undertaking the ...

    Authors: Mais Iflaifel, Kirsty Sprange, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven A. Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery and Christopher Partlett
    Citation: Trials 2023 24:71
  14. Prophylactic dressings are increasingly used to prevent pressure injuries in hospitalised patients. However, evidence regarding the effectiveness of these dressings is still emerging. This trial aims to determ...

    Authors: R. M. Walker, W. Chaboyer, M. Cooke, J. A. Whitty, L. Thalib, I. Lockwood, S. Latimer, J. Campbell, R. Probert and B. M. Gillespie
    Citation: Trials 2023 24:70
  15. Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease creating an immense burden on social health care systems. Pulmonary rehabilitation (PR) has proven to be effective in patien...

    Authors: Yuting Jing, Yuying Ma, Hongxing Zhang, Zhenhu Wu, Yongwen Li, Haoxuan Li, Minling Huang, Lin Lin and Yinji Xu
    Citation: Trials 2023 24:69
  16. Diarrhoeal disease remains a significant cause of morbidity and mortality among the under-fives in many low- and middle-income countries. Changes to food safety practices and feeding methods around the weaning...

    Authors: Evans A. Asamane, Laura Quinn, Samuel I. Watson, Richard J. Lilford, Karla Hemming, Cheick Sidibe, Ryan T. Rego, Sami Bensassi, Youssouf Diarra, Samba Diop, Om Prasad Gautam, Mohammad Sirajul Islam, Louise Jackson, Kate Jolly, Kassoum Kayentao, Ousmane Koita…
    Citation: Trials 2023 24:68
  17. The double-lumen tube (DLT) is an essential equipment for thoracic anesthesia and the precise position of DLT placement is particularly important for anesthesia and surgery. However, the incidence of DLT malpo...

    Authors: Xi Zhang, Dong-Xu Wang, Qin Zhang, Qi-Bin Shen, Fei Tong, Yong-He Hu, Zhen-Duo Zhang, Fei-Fan Liu, Ya-Wen Tang, Juan-Li Chen, He Liu, Feng Zhou and Si-Ping Hu
    Citation: Trials 2023 24:67
  18. For children and young people with eye and vision conditions, research is essential to advancing evidence-based recommendations in diagnosis, prevention, treatments and cures. Patient ‘experience’ reflects a k...

    Authors: Jacqueline Miller, Katherine Curtis-Tyler, Michelle Maden, Annegret Dahlmann-Noor and Jane Chudleigh
    Citation: Trials 2023 24:66
  19. Foot and ankle involvement is common in rheumatic and musculoskeletal diseases (RMDs). High-quality evidence is lacking to determine the effectiveness of treatments for these disorders. Heterogeneity in the ou...

    Authors: Lara S. Chapman, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Toby O. Smith, John B. Arnold, Dorcas Beaton, Philip G. Conaghan, Yvonne M. Golightly, Marian T. Hannan, Catherine Hofstetter, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Peter Tugwell, Philip Helliwell…
    Citation: Trials 2023 24:65
  20. Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are di...

    Authors: Cornelis Jan van Dam, Monique van Velzen, Cornelis Kramers, Arnt Schellekens, Erik Olofsen, Marieke Niesters and Albert Dahan
    Citation: Trials 2023 24:64
  21. Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patien...

    Authors: Sarah E. Rowan, Jason Haukoos, Kevin F. Kamis, Emily Hopkins, Stephanie Gravitz, Carolynn Lyle, Alia A. Al-Tayyib, Edward M. Gardner, James W. Galbraith, Yu-Hsiang Hsieh, Michael S. Lyons, Richard E. Rothman, Douglas A. E. White, Jake R. Morgan, Benjamin P. Linas, Allison L. Sabel…
    Citation: Trials 2023 24:63
  22. This trial aims to assess whether dexmedetomidine can reduce the incidence of postoperative cognitive dysfunction in elderly orthopaedic patients and explore the specific mechanism.

    Authors: Weihong Zhao, Huanhuan Zhang and Jianli Li
    Citation: Trials 2023 24:62
  23. Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited con...

    Authors: Enya Daynes, Molly Baldwin, Neil J. Greening, Thomas Yates, Nicolette C. Bishop, George Mills, Matthew Roberts, Malik Hamrouni, Tatiana Plekhanova, Ioannis Vogiatzis, Carlos Echevarria, Rashmita Nathu, Hamish J. C. McAuley, Lorna Latimer, Jennifer Glennie, Francesca Chambers…
    Citation: Trials 2023 24:61

    The Correction to this article has been published in Trials 2023 24:98

  24. Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predominantly medium-sized arteries, particularly the coronary arteries. A number of recent studies conducted in different Eur...

    Authors: Despina Eleftheriou, Yolanda Collaco Moraes, Cara Purvis, Molly Pursell, Marta Merida Morillas, Robin Kahn, Maria Mossberg, Filip Kucera, Robert Tulloh, Joseph F. Standing, Veronica Swallow, Rachael McCormack, Jethro Herberg, Michael Levin, Mandy Wan, Nigel Klein…
    Citation: Trials 2023 24:60
  25. Severe mental illness (SMI) presents a major challenge worldwide, affecting approximately 5–8% of the world’s population. It causes significant distress to affected people, families and wider communities, gene...

    Authors: Victoria Jane Bird, Sana Zehra Sajun, Renata Peppl, Sara Evans-Lacko, Stefan Priebe, Swaran Singh, Lakshmi Venkatraman, Padmavati Ramachandran, Aneeta Pasha, Ashar Malik and Onaiza Qureshi
    Citation: Trials 2023 24:59
  26. Trials evaluating drug discontinuation (drug discontinuation trials, DDTs) show a broad methodological spectrum. There are several specific methodological aspects in drug discontinuation trials (e.g., determin...

    Authors: Nina Grede, Katrin Kuss, Ina Staudt, Norbert Donner-Banzhoff and Annika Viniol
    Citation: Trials 2023 24:58
  27. Dysarthria after stroke is when speech intelligibility is impaired, and this occurs in half of all stroke survivors. Dysarthria often leads to social isolation, poor psychological well-being and can prevent re...

    Authors: C. Mitchell, A. Bowen, P. Conroy, B. M. Whelan, S. J. Wallace, A. Dancer, K. Woodward-Nutt and J. J. Kirkham
    Citation: Trials 2023 24:57
  28. A “mismatch” sequence of less prenatal weight gain and more postnatal weight gain may lead to ectopic lipid accumulation, and trigger the development of early adrenarche/pubarche and the activation of the gona...

    Authors: Judit Bassols, Francis de Zegher, Marta Diaz, Gemma Carreras-Badosa, Cristina Garcia-Beltran, Elsa Puerto-Carranza, Cora Oliver-Vila, Paula Casano, Céline Alicia Franco, Rita Malpique, Abel López-Bermejo and Lourdes Ibáñez
    Citation: Trials 2023 24:56
  29. Authors: I. W. J. M. van Goor, L. A. Daamen, M. G. Besselink, A. M. E. Bruynzeel, O. R. Busch, G. A. Cirkel, B. Groot Koerkamp, N. Haj Mohammed, H. D. Heerkens, H. W. M. van Laarhoven, G. J. Meijer, J. Nuyttens, H. C. van Santvoort, G. van Tienhoven, H. M. Verkooijen, J. W. Wilmink…
    Citation: Trials 2023 24:55

    The original article was published in Trials 2022 23:913

  30. Children < 5 years old in contact with TB cases are at high risk for developing severe and fatal forms of TB. Contact investigation, BCG vaccination, and isoniazid preventive therapy (IPT) are the most effecti...

    Authors: L. Otero, N. Zetola, M. Campos, J. Zunt, A. Bayer, M. Curisinche, T. Ochoa, M. Reyes, V. Vega, P. Van der Stuyft and TR. Sterling
    Citation: Trials 2023 24:54
  31. External randomised pilot trials aim to determine whether a future definitive randomised controlled trial (RCT) should be conducted, and if so, how. However, not every pilot trial that suggests that a definiti...

    Authors: Katie Mellor, Susan J. Dutton and Sally Hopewell
    Citation: Trials 2023 24:53
  32. We unfortunately need to make an update to our published study protocol that describes a significant change in the design of the study. The Committee on Health Research Ethics of the Capital Region Denmark rec...

    Authors: U. N. Jeppesen, A. S. Due, L. Mariegaard, A. Pinkham, M. Vos, W. Veling, M. Nordentoft and L. B. Glenthøj
    Citation: Trials 2023 24:52

    The Study protocol to this article has been published in Trials 2022 23:658

  33. Design and implementation of multi-country clinical trials for multidrug-resistant tuberculosis (MDR-TB) are complex for several reasons, including trial duration, varying levels of experience and infrastructu...

    Authors: Leena N. Patel, Meera Gurumurthy, Gay Bronson, Karen Sanders and I. D. Rusen
    Citation: Trials 2023 24:51
  34. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common adverse effects of antineoplastic agents, ranging in prevalence from 19% to over 85%. Clinically, CIPN is a predominantly sensory neu...

    Authors: Christele Le Gouill-Jaijarat, Yann Péréon, Maxime Leroy, Olivier Lépine, Aymeric Loloum, Claire Peluchon, Christelle Volteau, Anne-Sophie Martineau, Simon Korner, Caroline Perrault, Asmahane Benmaziane, Paul Girot, Caroline Petorin, Clément Perret, Catherine Ligeza-Poisson, Didier Mayeur…
    Citation: Trials 2023 24:50
  35. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the standard of care after coronary stenting, including coronary stenting involving bioresorbable scaffolds (BRSs). Current clinical guide...

    Authors: Yizhe Wu, Jiasheng Yin, Chenguang Li, Wei Zhang, Li Shen, Lei Ge, Juying Qian and Junbo Ge
    Citation: Trials 2023 24:49
  36. Cognitive difficulties experienced by people with multiple sclerosis (MS) impact on quality of life and daily functioning, from childcare and work to social and self-care activities. The Cognitive Occupation-B...

    Authors: Christopher P. Dwyer, Alberto Alvarez-Iglesias, Robert Joyce, Timothy J. Counihan, Dympna Casey and Sinéad M. Hynes
    Citation: Trials 2023 24:48

    The Study protocol to this article has been published in Trials 2020 21:269

  37. von Willebrand Factor (vWF) is a key protein mediating platelet adhesion on the surface of damaged endothelia. To the best of our knowledge, no trial exists that investigated the effect of platelet transfusion...

    Authors: Goetz Herrmann, Andrea Blum, Daniel Bolliger, Rita Achermann, Anna Estermann, Caroline Eva Gebhard, Anne Henn, Jan Huber, Jasprit Singh, Atanas Todorov, Tatjana Zehnder, Núria Zellweger, Andreas Buser, Dimitrios A. Tsakiris, Alexa Hollinger and Martin Siegemund
    Citation: Trials 2023 24:47
  38. Imaging repositories are commonly attached to ongoing clinical trials, but capturing, transmitting, and storing images can be complicated and labor-intensive. Typical methods include outdated technologies such...

    Authors: Adrienne N. Dula, Truman J. Milling Jr., S. Claiborne Johnston, Jayson Aydelotte, Gary W. Peil, Alec Robinson, Kaiz Asif, Stephen Pan, Sohan Parekh and Steven Warach
    Citation: Trials 2023 24:46
  39. Osteoarthritis is a chronic pathology that involves multidisciplinary management. Self-management for patients is an essential element, present in all international guidelines. During the time of the spa thera...

    Authors: A. Goldstein, C. Lanhers, C. Gay, K. Dubourg, L. Grange, C. F. Roques, B. Pereira and E. Coudeyre
    Citation: Trials 2023 24:45
  40. Chronic stress is detrimental to health, and children and young people have had to cope with significantly more stress since the start of the COVID-19 pandemic. In particular, stress at school and in relation ...

    Authors: Christin Scheiner, Andrea Daunke, Alexandra Seidel, Sabrina Mittermeier, Marcel Romanos, Michael Kölch and Arne Buerger
    Citation: Trials 2023 24:44
  41. Major depression represents a pressing challenge for health care. In England, Increasing Access to Psychological Therapies (IAPT) services provide evidence-based psychological therapies in a stepped-care appro...

    Authors: Thorsten Barnhofer, Barnaby D. Dunn, Clara Strauss, Florian Ruths, Barbara Barrett, Mary Ryan, Asha Ladwa, Frances Stafford, Roberta Fichera, Hannah Baber, Ailis McGuinness, Isabella Metcalfe, Delilah Harding, Sarah Walker, Poushali Ganguli, Shelley Rhodes…
    Citation: Trials 2023 24:43
  42. Current guidelines emphasize cancer patients should increase their physical activity levels, encouraging physical exercise practice as a complementary therapy to mitigate adverse effects during treatment. Tele...

    Authors: João S. Henkin, Cíntia E. Botton, Mariana S. Simon, Guilherme G. Rocha, Caroline B. Silveira, Ricardo S. Gehrke, Gabriella B. Freitas, Gabriel S. Trajano, Ronei S. Pinto and Stephanie S. Pinto
    Citation: Trials 2023 24:42
  43. This multicentre study explores the effects of pre-operative exercise on physical fitness, post-operative complications, recovery, and health-related quality of life in older individuals with low pre-operative...

    Authors: Mikael Andersson, Monika Egenvall, Johanna Danielsson, Anders Thorell, Christian Sturesson, Mattias Soop, Malin Nygren-Bonnier and Elisabeth Rydwik
    Citation: Trials 2023 24:41
  44. Nearly one in seven women worldwide suffers from chronic pelvic pain syndrome (CPPS) each year. Often, CPPS necessitates a combination of treatments. Studies have shown the good therapeutic effects of repetiti...

    Authors: Mengyang Wang, Rui Xia, Jiao Shi, Chunhua Yang, Yongqing Zhang, Zhengxian Xu, Cancan Yu, Ziyi Wu, Min Wang, Shangjie Chen and Hongdang Qu
    Citation: Trials 2023 24:40
  45. The COVID-19 pandemic remains ongoing, with a significant number of survivors who have experienced moderate to severe clinical conditions and who have suffered losses of great magnitude, especially in function...

    Authors: Rodrigo Sudatti Delevatti, Angelica Danielevicz, Maria Eduarda Sirydakis, Paulo Urubatan Gama de Melo, Cíntia de la Rocha Freitas, Cassiano Ricardo Rech, Luiz Guilherme Antonacci Guglielmo, Guilherme Fleury Fina Speretta, Fernanda Hansen, Fernanda Rodrigues Fonseca, Ana Carolina Starke, Ricardo Dantas de Lucas, José Tavares de Melo Junior, Rosemeri Maurici and Aline Mendes Gerage
    Citation: Trials 2023 24:39
  46. Blood loss and red blood cell (RBC) transfusion in liver surgery are areas of concern for surgeons, anesthesiologists, and patients alike. While various methods are employed to reduce surgical blood loss, the ...

    Authors: Guillaume Martel, Tori Lenet, Christopher Wherrett, François-Martin Carrier, Leah Monette, Aklile Workneh, Karine Brousseau, Monique Ruel, Michaël Chassé, Yves Collin, Franck Vandenbroucke-Menu, Élodie Hamel-Perreault, Michel-Antoine Perreault, Jeieung Park, Shirley Lim, Véronique Maltais…
    Citation: Trials 2023 24:38
  47. A randomized clinical trial assessing plasma rich in growth factors (PRGF) versus hyaluronic acid for knee osteoarthritis was published in 2012 (sponsor trial ID BTI-01-EC/07/ART). Evidence of misreporting was...

    Authors: Luis Carlos Saiz, Juan Erviti, Leire Leache and Marta Gutiérrez-Valencia
    Citation: Trials 2023 24:37
  48. Tobacco use is the leading cause of many preventable diseases, resulting in premature death or disease. Given that the majority of adult who smoke want to stop, this health burden could be significantly reduce...

    Authors: Chengguo Xing, John Malaty, Melissa Bou Malham, Anna Maria Abi Nehme, Breanne Freeman, Zhiguang Huo, Roberto Firpi-Morrel and Ramzi G. Salloum
    Citation: Trials 2023 24:36

Annual Journal Metrics