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  1. Overweight and obesity have reached an epidemic level which impacts individual health and creates a financial burden worldwide. Evidence has shown that electroacupuncture is effective for weight loss when comb...

    Authors: Ching Yee Chung, Angela Wei Hong Yang, Alexander Foe, Mingdi Li and George Binh Lenon
    Citation: Trials 2022 23:818
  2. Increasing life expectancy is associated with a growing number of people living in nursing homes, while the availability of outpatient medical care, especially from family doctors, is stagnating in this sector...

    Authors: David Brücken, Jenny Unterkofler, Sophie Pauge, Jonas Bienzeisler, Christian Hübel, Sebastian Zechbauer, Rolf Rossaint, Wolfgang Greiner, Birthe Aufenberg, Rainer Röhrig, Leo Cornelius Bollheimer and Jörg Christian Brokmann
    Citation: Trials 2022 23:814
  3. Prophylactic abdominal drainage is current standard practice after distal pancreatectomy (DP), with the aim to divert pancreatic fluid in case of a postoperative pancreatic fistula (POPF) aimed to prevent furt...

    Authors: F. L. Vissers, A. Balduzzi, E. A. van Bodegraven, J. van Hilst, S. Festen, M. Abu Hilal, H. J. Asbun, J. S. D. Mieog, B. Groot Koerkamp, O. R. Busch, F. Daams, M. Luyer, M. De Pastena, G. Malleo, G. Marchegiani, J. Klaase…
    Citation: Trials 2022 23:809
  4. Many elderly individuals who experience sleep disturbances would consider complementary and alternative medicine as an alternative therapeutic option in light of the limitations of traditional treatments. Mind...

    Authors: Sunny Ho-Wan Chan, Siu-Man Ng, Chong-Ho Yu, Ching-Man Chan, Shu-Mei Wang and Wai-Chi Chan
    Citation: Trials 2022 23:808
  5. Despite high acceptance rates in the field, the implementation of the 2019 published German evidence and consensus-based S3 guideline is unsatisfactory. This study aims to assess the superiority of an adaptive...

    Authors: Carolin Lorenz, Gabriele Gaigl, Duygu Güler, Theresa Halms, Naiiri Khorikian-Ghazari, Astrid Röh, Marco Schneider, Elias Wagner, Thomas Schneider-Axmann, Angelika Kapfhammer, Marisa Flick, Charline Pielenz, Eva Salveridou-Hof, Peter Falkai, Wolfgang Gaebel, Alkomiet Hasan…
    Citation: Trials 2022 23:807
  6. Obstructive sleep apnea (OSA) and insomnia are commonly co-occurring conditions that amplify morbidity and complicates the management of affected patients. Unfortunately, previous research provides limited gui...

    Authors: E. Devon Eldridge-Smith, Rachel Manber, Sheila Tsai, Clete Kushida, Bryan Simmons, Rachel Johnson, Roxane Horberg, Ann Depew, Aysha Abraibesh, Norah Simpson, Matthew Strand, Colin A. Espie and Jack D. Edinger
    Citation: Trials 2022 23:806
  7. Applications of mobile technologies (mHealth) have the potential to reduce health inequalities, give patients more control over their health, and improve health care’s cost-effectiveness. The widespread use of...

    Authors: Sara Kazemi, Fatemeh Zarei, Alireza Heidarnia and Fatemeh Alhani
    Citation: Trials 2022 23:805
  8. Abdominal pain is frequent in patients consulting in emergency departments. The aim of this study is to determine the diagnosis efficacy of point-of-care ultrasound (POCUS) in patients consulting in the ED for...

    Authors: François Brau, Stéphanie Martin, Quentin Le Bastard, Patricia Ricaud, Arnaud Legrand, Emmanuel Montassier and Philippe Le Conte
    Citation: Trials 2022 23:804
  9. The Netherlands Armed Forces have been successfully using deep-frozen (− 80 °C) thrombocyte concentrate (DTC) for the treatment of (massive) bleeding trauma patients in austere environments since 2001. However...

    Authors: Tim W. H. Rijnhout, Femke Noorman, Robert A. van der Horst, Edward C. T. H. Tan, Victor V. A. Viersen, Oscar J. F. van Waes, Leo M. G. van de Watering, B. L. S. Borger van der Burg, Jaap J. Zwaginga, Michael H. J. Verhofstad and Rigo Hoencamp
    Citation: Trials 2022 23:803
  10. The quality of children’s early home learning environment has an influence on their cognitive development, preliteracy skills, and subsequent educational outcomes. Early intervention programs that promote posi...

    Authors: Linda Forssman and Janna M. Gottwald
    Citation: Trials 2022 23:802
  11. This study aims to evaluate the feasibility and effectiveness of the RinasciMENTE program, an Internet-based self-help intervention based on cognitive behavioral therapy (CBT) principles and techniques in supp...

    Authors: Vanessa Bertuzzi, Michelle Semonella, Gerhard Andersson, Gian Mauro Manzoni, Gianluca Castelnuovo, Enrico Molinari and Giada Pietrabissa
    Citation: Trials 2022 23:801
  12. Oxygen-desaturation episodes, blood pressure drops, and involuntary body movement are common problems that occur in propofol-based sedation in the procedure of painless gastrointestinal (GI) endoscopy. As a wi...

    Authors: Xiu-Ru Qi, Jing-Yi Sun, Li-Xin An, Ke Zhang and Fu-Shan Xue
    Citation: Trials 2022 23:800
  13. Hemodynamic stabilization is a core component in the resuscitation of septic shock. However, the optimal target blood pressure remains debatable. Previous randomized controlled trials suggested that uniformly ...

    Authors: Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Kyosuke Takahashi, Hiroki Nagasawa, Yuichi Araki, Mitsuaki Kojima, Toshiki Sera, Masayuki Yagi, Ryo Yamamoto, Jiro Takahashi, Masaki Nakane, Chikashi Takeda, Chihiro Narita, Satoshi Kazuma…
    Citation: Trials 2022 23:799
  14. Fluid overload is associated with worse outcome in critically ill patients requiring continuous renal replacement therapy (CRRT). Net ultrafiltration (UFNET) allows precise control of the fluid removal but is fre...

    Authors: Laurent Bitker, Pierre Pradat, Claire Dupuis, Kada Klouche, Julien Illinger, Bertrand Souweine and Jean-Christophe Richard
    Citation: Trials 2022 23:798
  15. Depression and anxiety are common among pregnant women. Internet-delivered psychological therapies such as cognitive behavioral therapy (iCBT) have been developed to increase accessibility and address common h...

    Authors: Chen-Chi Duan, Jia-Le Yu, Jing Tao, Chen Zhang, Dan Zhang, Xiu Zeng, Wan-Ting Zeng, Hua-Lin Xu, Jian-Yin Qiu, Cindy-Lee Dennis, Li Jin, He-Feng Huang and Yan-Ting Wu
    Citation: Trials 2022 23:797
  16. Preterm birth, especially at less than 30 weeks’ gestation, is significantly associated with respiratory, neurodevelopmental and growth abnormalities. The AZTEC study has recruited 799 infants born at < 30 wee...

    Authors: Sarah J. Kotecha, Christopher W. Course, Kathryn E. Jones, W. John Watkins, Janet Berrington, David Gillespie and Sailesh Kotecha
    Citation: Trials 2022 23:796
  17. Pregnancies affected by gestational diabetes mellitus (GDM) are associated with an increased risk of adverse maternal and foetal outcomes. Current treatments for GDM involve initial medical nutritional therapy...

    Authors: F. Dunne, C. Newman, D. Devane, A. Smyth, A. Alvarez-Iglesias, P. Gillespie, M. Browne and M. O’Donnell
    Citation: Trials 2022 23:795
  18. Authors: Jenniffer Elizabeth Pérez Patiño, José Lluís Ballvé Moreno, Yolanda Rando Matos, Jesús Almeda Ortega, Oriol Cunillera Puértolas, Ricard Carrillo Muñoz, Iván Villar Balboa, Xavier González Compta, Olga Lucía Arias Agudelo, Sebastiá Calero Muñoz, Vanessa Monforte Rodríguez, Anna Navarro Cortes and Eva Peguero Rodríguez
    Citation: Trials 2022 23:793

    The original article was published in Trials 2022 23:608

  19. Minimally invasive thoracic surgery (MITS) has been shown to reduce postoperative pain and contribute to better postoperative quality of life as compared to open thoracic surgery (Bendixen et al., Lancet Oncol...

    Authors: Aisling Ni Eochagain, Aneurin Moorthy, Áine O’Gara and Donal J. Buggy
    Citation: Trials 2022 23:792
  20. Due to the increasing use of online health information, symptom checkers have been developed to provide an individualized assessment of health complaints and provide potential diagnoses and an urgency estimati...

    Authors: Hendrik Napierala, Marvin Kopka, Maria B. Altendorf, Myrto Bolanaki, Konrad Schmidt, Sophie K. Piper, Christoph Heintze, Martin Möckel, Felix Balzer, Anna Slagman and Malte L. Schmieding
    Citation: Trials 2022 23:791
  21. Despite the fast establishment of new therapeutic agents in the management of COVID-19 and large-scale vaccination campaigns since the beginning of the SARS-CoV-2 pandemic in early 2020, severe disease courses...

    Authors: Maria Boesing, Kristin Abig, Michael Brändle, Martin Brutsche, Emanuel Burri, Björn C. Frye, Stéphanie Giezendanner, Jan C. Grutters, Philippe Haas, Justian Heisler, Fabienne Jaun, Anne B. Leuppi-Taegtmeyer, Giorgia Lüthi-Corridori, Joachim Müller-Quernheim, Reto Nüesch, Wolfgang Pohl…
    Citation: Trials 2022 23:790
  22. Mitochondrial disease is a heterogenous group of rare, complex neurometabolic disorders. Despite their individual rarity, collectively mitochondrial diseases represent the most common cause of inherited metabo...

    Authors: Alaa Abouhajar, Lisa Alcock, Theophile Bigirumurame, Penny Bradley, Laura Brown, Ian Campbell, Silvia Del Din, Julie Faitg, Gavin Falkous, Gráinne S. Gorman, Rachel Lakey, Robert McFarland, Jane Newman, Lynn Rochester, Vicky Ryan, Hesther Smith…
    Citation: Trials 2022 23:789

    The Correction to this article has been published in Trials 2022 23:852

  23. It remains controversial whether critical illness-related hyperglycemia should be treated or not, since randomized controlled trials (RCTs) have shown context-dependent outcome effects. Whereas pioneer RCTs fo...

    Authors: Jan Gunst, Liese Mebis, Pieter J. Wouters, Greet Hermans, Jasperina Dubois, Alexander Wilmer, Eric Hoste, Dominique Benoit and Greet Van den Berghe
    Citation: Trials 2022 23:788
  24. Failure of eruption of the maxillary permanent incisor teeth usually presents in the mixed dentition between the ages of 7 and 9 years. Missing and unerupted maxillary incisors can be regarded as unattractive ...

    Authors: Jadbinder Seehra, Andrew T. DiBiase, Shruti Patel, Rachel Stephens, Simon J. Littlewood, Richard J. Spencer, Tom Frawley, Philip E. Benson, Anthony J. Ireland, Farnaz Parvizi, Nikki Atack, Giles Kidner, Gabriella Wojewodka, Christopher Ward, Spyridon N. Papageorgiou, Jonathon T. Newton…
    Citation: Trials 2022 23:787
  25. Among rural Chinese patients with non-communicable diseases (NCDs), low socioeconomic status increases the risk of developing NCDs and associated financial burdens in paying for medicines and treatments. Despi...

    Authors: Zhengting He, Xin Cao, Duan Zhao, Zemin Tang, Jiayu Zhao, Mariel Beasley, Angela Renne, Lei Liu, Shengjie Zhu, Yuexia Gao and Lijing L. Yan
    Citation: Trials 2022 23:785
  26. Corticosteroids are one of the few drugs that have shown a reduction in mortality in coronavirus disease 2019 (COVID-19). In the RECOVERY trial, the use of dexamethasone reduced 28-day mortality compared to st...

    Authors: Anabel Franco-Moreno, María Soledad Acedo-Gutiérrez, Nicolás Labrador-San Martín, Clara Hernández-Blanco, Celia Rodríguez-Olleros, Fátima Ibáñez-Estéllez, Ana Suárez-Simón, Mateo Balado-Rico, Ana Rocío Romero-Paternina, David Alonso-Menchén, Belén Escolano-Fernández, Esther Piniella-Ruiz, Ester Alonso-Monge, Helena Notario-Leo, Carlos Bibiano-Guillén, Gabriela Peña-Lillo…
    Citation: Trials 2022 23:784
  27. Academic-sponsored trials for rare diseases face many challenges; the present paper identifies hurdles in the set-up of six multinational clinical trials for drug repurposing, as use cases.

    Authors: Marta del Álamo, Christoph Bührer, Dirk Fisher, Matthias Griese, Paul Lingor, Giovanni Palladini, Nicolas Sireau, Virginie Hivert, Luca Sangiorgi, Florence Guillot, Juliane Halftermeyer, Lenka Soucková, Kristýna Nosková and Regina Demlová
    Citation: Trials 2022 23:783
  28. At present, vaccines form the only mode of prophylaxis against COVID-19. The time needed to achieve mass global vaccination and the emergence of new variants warrants continued research into other COVID-19 pre...

    Authors: Z. M. Jessop, J. Gibson, J. Y. Lim, T. H. Jovic, E. Combellack, T. D. Dobbs, K. Carter, S. Hiles, S. Islam, B. Healy, I. Humphreys, R. Eccles, H. A. Hutchings and I. S. Whitaker
    Citation: Trials 2022 23:782
  29. Peripherally inserted central catheters (PICCs) are now widely used in modern medicine, and associated complications have also increased. Central line-associated bloodstream infection (CLABSI) is the most seri...

    Authors: Yohan Kwon, Eung Tae Kim, Soo Buem Cho, Jae Hwan Lee and Dong Jae Shim
    Citation: Trials 2022 23:781
  30. Kidney transplant recipients are at an increased risk of severe COVID-19-associated hospitalisation and death. Vaccination has been a key public health strategy to reduce disease severity and infectivity, but ...

    Authors: Matthew Tunbridge, Griffith B. Perkins, Julian Singer, Tania Salehi, Tracey Ying, Branka Grubor-Bauk, Simon Barry, Beatrice Sim, Pravin Hissaria, Steven J. Chadban and P. Toby Coates
    Citation: Trials 2022 23:780
  31. In Sub-Saharan Africa (SSA), febrile illnesses remain a major public health problem in children. However, the persistence of hrp2 antigen and the low sensitivity of pLDH RDT negatively affect antimalarials and an...

    Authors: Francois Kiemde, Adelaide Compaore, Fla Koueta, Athanase M. Some, Berenger Kabore, Daniel Valia, Toussaint Rouamba, Fadima Yaya Bocoum, Seydou Sawadogo, Macaire Nana, Diane Y. Some, Nadine A. Kone, Valentin Pagbeleguem, Inoussa Sangare, Antonia W. Bere, Massa dit Achille Bonko…
    Citation: Trials 2022 23:779
  32. The management of cognitive impairment is an important goal in the treatment of multiple sclerosis (MS). While cognitive rehabilitation has been proven to be effective in improving cognitive performance in MS,...

    Authors: Delphine Van Laethem, Frederik Van de Steen, Daphne Kos, Maarten Naeyaert, Peter Van Schuerbeek, Miguel D’Haeseleer, Marie B. D’Hooghe, Jeroen Van Schependom and Guy Nagels
    Citation: Trials 2022 23:778
  33. In Australia, tobacco smoking rates have declined but inequalities remain with significantly higher smoking prevalence among low-socioeconomic populations. Clinical trial data suggest vaporized nicotine produc...

    Authors: Bridget C Howard, Hayden McRobbie, Dennis Petrie, Daniel Barker, Colin Mendelsohn, Jack Anderson, Ron Borland, Felix Naughton, Piotr Tutka, Nick Zwar, Veronica C Boland, Alexandra Aiken, Anthony Shakeshaft, Coral Gartner, Robyn L Richmond, Wayne Hall…
    Citation: Trials 2022 23:777
  34. Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to eva...

    Authors: Eun Kyoung Kim, Hong-Mi Choi, Eui-Young Choi, Hye Sun Lee, Goeun Park, Dong Woo Han, Sang-Eun Lee, Chan Seok Park, Ji-won Hwang, Jae Hyuk Choi, Mi-Na Kim, Hyung-Kwan Kim, Dae-Hee Kim, Sung-Hee Shin, Il Suk Sohn, Mi-Seung Shin…
    Citation: Trials 2022 23:776
  35. New strategies to increase measles and rubella vaccine coverage, particularly in low- and middle-income countries, are needed if elimination goals are to be achieved. With this regard, measles and rubella vacc...

    Authors: Ikechukwu Adigweme, Edem Akpalu, Mohammed Yisa, Simon Donkor, Lamin B. Jarju, Baba Danso, Anthony Mendy, David Jeffries, Abdoulie Njie, Andrew Bruce, Michael Royals, James L. Goodson, Mark R. Prausnitz, Devin McAllister, Paul A. Rota, Sebastien Henry…
    Citation: Trials 2022 23:775
  36. COVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological features. These include diffuse alveolar damage with extensive pulmonary...

    Authors: John Robert Sheehan, Padraig Calpin, Maeve Kernan, Claire Kelly, Siobhan Casey, Darragh Murphy, Alberto Alvarez-Iglesias, Camilla Giacomini, Catriona Cody, Gerard Curley, Shane McGeary, Ciara Hanley, Bairbre McNicholas, Frank van Haren, John G. Laffey and David Cosgrave
    Citation: Trials 2022 23:774
  37. Many patients suffering from schizophrenia spectrum disorders continue having distressing auditory hallucinations in spite of treatment with antipsychotic medication. The aim of this trial is to examine the ef...

    Authors: L. C. Smith, L. Mariegaard, D. L. Vernal, A. G. Christensen, N. Albert, N. Thomas, C. Hjorthøj, L. B. Glenthøj and M. Nordentoft
    Citation: Trials 2022 23:773
  38. Approximately 1 in 10 patients with a surgically treated open fracture will develop a surgical site infection. The Aqueous-PREP trial will investigate the effect of 10% povidone-iodine versus 4% chlorhexidine ...

    Authors: Nathan N. O’Hara, Diane Heels-Ansdell, Sofia Bzovsky, Shannon Dodds, Lehana Thabane, Mohit Bhandari, Gordon Guyatt, P. J. Devereaux, Gerard P. Slobogean and Sheila Sprague
    Citation: Trials 2022 23:772
  39. The ultimate goal of anterior cruciate ligament reconstructions (ACLR) is to fulfil the return-to-play (RTP) criteria. Quadriceps muscle strength is one of the key determinants for a patient’s successful retur...

    Authors: Michael Tim-Yun Ong, Gene Chi-Wai Man, Lawrence Chun-Man Lau, Xin He, Jihong Qiu, Qianwen Wang, Matthew Chun-Sing Chow, Ben Chi-Yin Choi, Mingqian Yu and Patrick Shu-Hang Yung
    Citation: Trials 2022 23:771
  40. According to recent legislation, facilitated advance care planning (ACP) for nursing home (NH) residents is covered by German sickness funds. However, the effects of ACP on patient-relevant outcomes have not b...

    Authors: Kornelia Götze, Claudia Bausewein, Berend Feddersen, Angela Fuchs, Amra Hot, Eva Hummers, Andrea Icks, Änne Kirchner, Evelyn Kleinert, Stephanie Klosterhalfen, Henrike Kolbe, Sonja Laag, Henriette Langner, Susanne Lezius, Gabriele Meyer, Joseph Montalbo…
    Citation: Trials 2022 23:770
  41. Arterial stiffness and calcification propensity are associated with high cardiovascular risk and increased mortality in chronic kidney disease (CKD). Both magnesium and phosphate are recognized as modulators o...

    Authors: Emma A. Vermeulen, Coby Eelderink, Tiny Hoekstra, Adriana J. van Ballegooijen, Pieter Raijmakers, Joline W. Beulens, Martin H. de Borst and Marc G. Vervloet
    Citation: Trials 2022 23:769
  42. There is an unmet need for treatments for knee osteoarthritis (OA). Effusion-synovitis is a common inflammatory phenotype of knee OA and predicts knee pain and structural degradation. Anti-inflammatory therapi...

    Authors: Guoqi Cai, Graeme Jones, Flavia M. Cicuttini, Anita E. Wluka, Yuanyuan Wang, Catherine Hill, Helen Keen, Benny Antony, Xia Wang, Barbara de Graaff, Michael Thompson, Tania Winzenberg, Kathy Buttigieg and Dawn Aitken
    Citation: Trials 2022 23:768
  43. Acute postoperative pain is a common complication of inguinal hernia repair. Pain management using local application of anesthetic agents over the skin surrounding the surgical incision may reduce the requirem...

    Authors: Hong-min Ahn, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Bon-Wook Koo and Pyung-Bok Lee
    Citation: Trials 2022 23:767
  44. Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-...

    Authors: Cindy K. Barha, Ryan S. Falck, John R. Best, Lindsay S. Nagamatsu, Ging-Yuek Robin Hsiung, A. William Sheel, Chun Liang Hsu, Arthur F. Kramer, Michelle W. Voss, Kirk I. Erickson, Jennifer C. Davis, J. Kevin Shoemaker, Lara Boyd, Rachel A. Crockett, Lisanne ten Brinke, Louis Bherer…
    Citation: Trials 2022 23:766
  45. Cognitions and perceptions of workers with chronic health problems, such as catastrophizing thoughts and fear-avoidance beliefs, can negatively influence work participation. The Progressive Goal Attainment Pro...

    Authors: Mariska de Wit, Hendrika P. Zijlstra, Carel T. J. Hulshof, Sylvia J. van der Burg-Vermeulen and Angela G. E. M. de Boer
    Citation: Trials 2022 23:765
  46. Single-sided deafness (SSD) has functional, psychological, and social consequences. Interventions for adults with SSD include hearing aids and auditory implants. Benefits and harms (outcome domains) of these i...

    Authors: Roulla Katiri, Deborah A. Hall, Derek J. Hoare, Kathryn Fackrell, Adele Horobin, Nicholas Hogan, Nóra Buggy, Paul H. Van de Heyning, Jill B. Firszt, Iain A. Bruce and Pádraig T. Kitterick
    Citation: Trials 2022 23:764
  47. Anaemia in pregnancy is highly prevalent in African countries. High-dose oral iron is the current recommended treatment for pregnancy-related iron deficiency anaemia (IDA) in Nigeria and other African countrie...

    Authors: Bosede B. Afolabi, Ochuwa A. Babah, Opeyemi R. Akinajo, Victoria O. Adaramoye, Titilope A. Adeyemo, Mobolanle Balogun, Aduragbemi Banke-Thomas, Rachel A. Quao, Gbenga Olorunfemi, Ajibola I. Abioye, Hadiza S. Galadanci and Nadia A. Sam-Agudu
    Citation: Trials 2022 23:763
  48. The HEALing (Helping to End Addiction Long-termSM) Communities Study (HCS) is a multi-site parallel group cluster randomized wait-list comparison trial designed to evaluate the effect of the Communities That Heal...

    Authors: Xiaoyu Tang, Timothy Heeren, Philip M. Westgate, Daniel J. Feaster, Soledad A. Fernandez, Nathan Vandergrift and Debbie M. Cheng
    Citation: Trials 2022 23:762

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