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  1. Clinical trials comprise multiple processes at various stages of the trial lifecycle. These processes often involve complex behaviours such as recruiting vulnerable patient populations and clinicians having to...

    Authors: Louisa Lawrie, Eilidh M. Duncan, Jan O. Jansen, Marion K. Campbell, Dan Brunsdon, Zoë Skea, Taylor Coffey, Claire Cochran and Katie Gillies
    Citation: Trials 2022 23:398
  2. Home noninvasive positive pressure ventilation (NIPPV) has become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including ap...

    Authors: Weipeng Jiang and Yuanlin Song
    Citation: Trials 2022 23:393
  3. Central venous access devices (CVADs) can have high rates of failure due to dressing-related complications. CVADs placed in the internal jugular vein are at particular risk of dressing failure-related complica...

    Authors: India Pearse, Amanda Corley, Emily N. Larsen, Claire M. Rickard, Robert S. Ware, Jill Campbell, Fiona Coyer, Evan Alexandrou, Catherine O’Brien and Nicole Marsh
    Citation: Trials 2022 23:390
  4. Rupture of the anterior cruciate ligament (ACL) is a common injury, primarily affecting young, active individuals. Despite surgical intervention being the more common treatment for patients suffering ACL ruptu...

    Authors: Jamie R. Stokes, David J. Beard, Loretta Davies, Beverly A. Shirkey, Andrew Price and Jonathan A. Cook
    Citation: Trials 2022 23:389
  5. Haemorrhage is the most common cause of preventable death after injury. REBOA is a novel technique whereby a percutaneously inserted balloon is deployed in the aorta, providing a relatively quick means of temp...

    Authors: Jan O. Jansen, Claire Cochran, Dwayne Boyers, Katie Gillies, Robbie Lendrum, Sam Sadek, Fiona Lecky, Graeme MacLennan and Marion K. Campbell
    Citation: Trials 2022 23:384
  6. Overall, 55% of the German population suffers from primary episodic headaches according to recent studies. Inadequate management of headache disorders is a significant medical problem. The prevalence of medica...

    Authors: Hans-Christoph Diener, Stephen Donoghue, Charly Gaul, Dagny Holle-Lee, Karl-Heinz Jöckel, Alec Mian, Bernadette Schröder and Tobias Kühl
    Citation: Trials 2022 23:382
  7. Repeated or chronic stress is considered a major source of disease, in terms of both somatic and mental illnesses. The prevention of stress-related disease by interventions for relaxation has thus increased so...

    Authors: Miriam Kampa, Johannes Finke, Tobias Stalder, Leandra Bucher, Holger Klapperich, Fabian Mertl, Christian Zimmer, Christian Geiger, Marc Hassenzahl and Tim Klucken
    Citation: Trials 2022 23:380
  8. Atopic dermatitis (AD) is a chronic relapsing skin disease that has long-term physical and mental health impacts on children with this condition. Current treatments mainly include anti-inflammatory, antibacter...

    Authors: Ya-qin Li, Tao-tao Shen, Qing-ying Wang, Meng-xi Ma, Feng-yan Tian, Yuan-yao She, Yi-cheng Tao, Jing-jing Wang, Hui-yan Chi, Na Lang and Jian-xun Ren
    Citation: Trials 2022 23:379
  9. To our knowledge, there are few trials studying the effect of high-flow nasal cannula (HFNC) during deep sedation. Our hypothesis is that high-flow nasal cannula (HFNC) will prevent hypoxemia and desaturation ...

    Authors: Marloes C. Homberg, Esther A. Bouman, Dominik Linz, Sander M. J. van Kuijk, Bert A. Joosten and Wolfgang F. Buhre
    Citation: Trials 2022 23:378
  10. Alzheimer’s disease and related dementias (AD/ADRD) are a public health challenge for Vietnam because of its rapidly aging population. However, very few community-based programs exist to support people living ...

    Authors: Duyen Tran, Huong Nguyen, Thang Pham, Anh T. Nguyen, Hung T. Nguyen, Ngoc B. Nguyen, Bien H. Nguyen, Danielle Harvey, Laura Gitlin and Ladson Hinton
    Citation: Trials 2022 23:377
  11. Postoperative residual curarization (PORC) may be a potential risk factor of postoperative pulmonary complications (PPCs), and both of them will lead to adverse consequences on surgical patient recovery. The t...

    Authors: Yu-guan Zhang, Ying Chen, Yue-Lun Zhang and Jie Yi
    Citation: Trials 2022 23:376
  12. A hip fracture is a serious event for older adults, given that approximately 50% do not regain their habitual level of physical function, and the mortality rate is high, as is the number of readmissions. The g...

    Authors: Jonas Ammundsen Ipsen, Lars T. Pedersen, Bjarke Viberg, Birgitte Nørgaard, Charlotte Suetta and Inge H. Bruun
    Citation: Trials 2022 23:375
  13. There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the results generated. Despite significant efforts made, limited res...

    Authors: Samuel Driver, Shan Gray, Welile Sikhondze, Ken Awuonda, Helena Wilcox, Alexis Segrt, Lara Pandya, Johanna Roth, Michael Makanga and Trudie Lang
    Citation: Trials 2022 23:374
  14. Approximately 5% of adults have an episode of acute bronchitis each year, accounting for more than 10 million medical visits yearly. The primary goal of treatment is reduction of symptoms. Currently, available...

    Authors: Guilan Cheng, Bin She, Bing Mao and Hongli Jiang
    Citation: Trials 2022 23:373
  15. Platform trial designs are used increasingly in cancer clinical research and are considered an efficient model for evaluating multiple compounds within a single disease or disease subtype. However, these trial...

    Authors: Claire Snowdon, Sarah Kernaghan, Laura Moretti, Nicholas C. Turner, Alistair Ring, Katie Wilkinson, Sue Martin, Stephanie Foster, Lucy S. Kilburn and Judith M. Bliss
    Citation: Trials 2022 23:372
  16. People with mild cognitive impairment (MCI) are at increased risk of converting to dementia. Cognitive training can improve the cognitive abilities of people with MCI. Computerised cognitive training (CCT) off...

    Authors: Stephanie Book, Michael Jank, Anna Pendergrass and Elmar Graessel
    Citation: Trials 2022 23:371
  17. Tranexamic acid reduces head injury deaths in patients with CT scan evidence of intracranial bleeding after mild traumatic brain injury (TBI). However, the cost-effectiveness of tranexamic acid for people with...

    Authors: Jack Williams, Katharine Ker, Ian Roberts, Haleema Shakur-Still and Alec Miners
    Citation: Trials 2022 23:370
  18. The prevalence of hypertension is increasing worldwide. Hypertension self-management usually involves the application and consideration of oral, written, or quantitative information. Hypertensive patients in C...

    Authors: Wei Gan, Qinghua Zhang, Dan Yang, Jinyu Yin, Yujie Wang, Li Song, Ting Chen and Huan Qi
    Citation: Trials 2022 23:369
  19. EGCG is proven to be of good effect to relieve periodontal inflammation, but it has not been applied as a local delivery medicine in patients with periodontitis widely. The aim of this clinical trial was to ev...

    Authors: Jiajun Zeng, Yanfeng Wang, Qiao Yuan and Qingxian Luan
    Citation: Trials 2022 23:368
  20. Despite the recent findings presenting the benefits of measurement-based care (MBC) compared to treatment as usual (TAU), MBC is still not the standard of care used in clinical settings. The aim of the present...

    Authors: Jingjing Zhou, Xiao Wang, Jian Yang, Xuequan Zhu, Le Xiao, Lei Feng and Gang Wang
    Citation: Trials 2022 23:367
  21. Nigeria’s healthcare system capacity to stem the increasing trend in hypertension is limited in coverage, scope and manpower. Use of trained community-based care providers demonstrated to be an effective compl...

    Authors: IkeOluwapo O. Ajayi, Oyediran E. Oyewole, Okechukwu S. Ogah, Joshua O. Akinyemi, Mobolaji M. Salawu, Eniola A. Bamgboye, Taiwo Obembe, Morenikeji Olawuwo and Mahmoud Umar Sani
    Citation: Trials 2022 23:366
  22. Myasthenia gravis (MG) is an acquired autoimmune disease with high heterogeneity. The disease is chronic, relapsing repeatedly and progressive with acute exacerbation occasionally. Although the treatment of MG...

    Authors: Senhui Weng, Jinghao Li, Benshu Chen, Long He, Zhuotai Zhong, Linwen Huang, Shijing Zhang, Fengbin Liu and Qilong Jiang
    Citation: Trials 2022 23:365
  23. Gastroscopy procedures are frequently performed under general sedation to minimize discomfort. Patients who refuse a sedative injection may experience more discomfort and adverse reactions such as pain and nau...

    Authors: Binyu Yu, Philippa Jemma Hazlewood, Xuan Yin, Shanshan Li, Hongyu Yue, Kun Xu, Shifen Xu and Yiqun Mi
    Citation: Trials 2022 23:364
  24. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and understudied consequence of taxane chemotherapy for breast cancer treatment. CIPN symptoms include numbness combined with tingling sensations, ...

    Authors: Patricia Teran-Wodzinski, Douglas Haladay, Tuan Vu, Ming Ji, Jillian Coury, Alana Adams, Lauren Schwab and Constance Visovsky
    Citation: Trials 2022 23:363
  25. Since the beginning of the COVID-19 pandemic, there has been very little guidance in Ireland and abroad, around the conduct of research, and randomised controlled trials (RCTs) in particular. This has led to i...

    Authors: Sinead Pembroke, Shauna Rogerson and Imelda Coyne
    Citation: Trials 2022 23:362
  26. The CLARITY trial (Controlled evaLuation of Angiotensin Receptor Blockers for COVID-19 respIraTorY disease) is a two-arm, multi-centre, randomised controlled trial being run in India and Australia that investi...

    Authors: J. M. McGree, C. Hockham, S. Kotwal, A. Wilcox, A. Bassi, C. Pollock, L. M. Burrell, T. Snelling, V. Jha, M. Jardine and M. Jones
    Citation: Trials 2022 23:361

    The Study protocol to this article has been published in Trials 2021 22:573

  27. The trial YOURTREAT aims to compare the pragmatic, short-term psychotherapy Narrative Exposure Therapy for Children (KIDNET) with treatment as usual (TAU) for the treatment of young refugees in Germany. This u...

    Authors: Jasmin Wittmann, Melissa Groß, Claudia Catani, Telja Schmidt, Sina Neldner, Sarah Wilker, Theodor May, Verena Ertl, Rita Rosner, Areej Zindler, Michael Odenwald and Frank Neuner
    Citation: Trials 2022 23:360

    The Study protocol to this article has been published in Trials 2020 21:185

  28. Aniseikonia represents a potential barrier to neuroplasticity which may limit visual outcomes in children with anisometropic amblyopia. Full correction of refractive error is the first step in standard amblyop...

    Authors: Jayshree South, Tina Gao, Melinda Calderwood, Jason Turuwhenua, Paul Roberts, Arier Lee, Andrew Collins and Joanna Black
    Citation: Trials 2022 23:358
  29. Clinical trial managers play a vital role in the design and conduct of clinical trials in the UK. There is a current recruitment and retention crisis for this specialist role due to a complex set of factors, m...

    Authors: E. J. Mitchell, K. Goodman, N. Wakefield, C. Cochran, S. Cockayne, S. Connolly, R. Desai, S. Hartley, S. A. Lawton, K. Oatey, S. Rhodes, J. S. Savage, J. Taylor and N. F. J. Youssouf
    Citation: Trials 2022 23:357
  30. Acute exacerbations have a significant impact on patients with COPD by accelerating the decline in lung function leading to decreased health-related quality of life and survival time. In telehealth, health car...

    Authors: Pernille Heyckendorff Secher, Stine Hangaard, Thomas Kronborg, Lisa Korsbakke Emtekær Hæsum, Flemming Witt Udsen, Ole Hejlesen and Clara Bender
    Citation: Trials 2022 23:356
  31. Subthreshold exercise, defined as aerobic exercise below the level that causes symptoms, has been utilized as a treatment for youth with persistent postconcussive symptoms (PPCS), but there is currently little...

    Authors: Sara P. D. Chrisman, Beth J. Bollinger, Jason A. Mendoza, Tonya M. Palermo, Chuan Zhou, M. Alison Brooks and Frederick P. Rivara
    Citation: Trials 2022 23:355
  32. Early identification of HCV is a critical health priority, especially now that treatment options are available to limit further transmission and provide cure before long-term sequelae develop. Emergency depart...

    Authors: Jason S. Haukoos, Sarah E. Rowan, James W. Galbraith, Richard E. Rothman, Yu-Hsiang Hsieh, Emily Hopkins, Rachel A. Houk, Matthew F. Toerper, Kevin F. Kamis, Jake R. Morgan, Benjamin P. Linas, Alia A. Al-Tayyib, Edward M. Gardner, Michael S. Lyons, Allison L. Sabel, Douglas A. E. White…
    Citation: Trials 2022 23:354
  33. Severe postoperative pain remains a major problem that is seen in 20 to 40% of patients. The Analgesia/Nociception Index (ANI) is a 0–100 index reflecting the relative parasympathetic activity allowing for int...

    Authors: Adrien Michalot, Jean-Étienne Bazin, Philippe Richebé, Bernard Allaouchiche and Emmanuel Boselli
    Citation: Trials 2022 23:353
  34. Renal colic is the pain experienced by a patient when a renal calculus (kidney stone) causes partial or complete obstruction of part of the renal outflow tract. The standard analgesic regimes for renal colic a...

    Authors: Graham Johnson, Andrew Tabner, Apostolos Fakis, Rachelle Sherman, Victoria Chester, Elizabeth Bedford, Richard Jackson, Hari Ratan and Suzanne Mason
    Citation: Trials 2022 23:352
  35. IMPlementing IMProved Asthma self-management as RouTine (IMP2ART) is a programme of work developing and evaluating a strategy for implementing supported asthma self-management in UK primary care. The strategy enc...

    Authors: Kirstie McClatchey, Viv Marsh, Liz Steed, Steve Holmes, Stephanie J. C. Taylor, Sharon Wiener-Ogilvie, Julia Neal, Rhian Last, Ann Saxon and Hilary Pinnock
    Citation: Trials 2022 23:350
  36. Measles vaccination coverage in Guinea-Bissau is low; fewer than 80% of children are currently measles vaccinated before 12 months of age. The low coverage hampers control of measles. Furthermore, accumulating...

    Authors: Ane B. Fisker, Justiniano S. D. Martins, Andreas M. Jensen, Cesario Martins, Peter Aaby and Sanne M. Thysen
    Citation: Trials 2022 23:349
  37. INTELLiVENT–Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of ventilation for use in critically ill patients. Evidence for benefit of INTELLiVENT–ASV in comparison to ventilation that...

    Authors: Michela Botta, Anissa M. Tsonas, Jante S. Sinnige, Ashley J. R. De Bie, Alexander J. G. H. Bindels, Lorenzo Ball, Denise Battaglini, Iole Brunetti, Laura A. Buiteman–Kruizinga, Pim L. J. van der Heiden, Evert de Jonge, Francesco Mojoli, Chiara Robba, Abraham Schoe, Frederique Paulus, Paolo Pelosi…
    Citation: Trials 2022 23:348
  38. Prevalence of posttraumatic stress disorder (PTSD) in refugees is reportedly higher in comparison to the general population. Refugee children specifically are often coping with trauma and loss and are at risk ...

    Authors: Merel E. Velu, Irene Martens, Mona Shahab, Carlijn de Roos, Ruud A. Jongedijk, Michaela Schok and T. Mooren
    Citation: Trials 2022 23:347
  39. Colorectal adenomas (CRAs) are precancerous lesions of the large intestine presenting as colorectal polyps. At present, the conventional treatment methods for CRA mainly include high-frequency electrocoagulati...

    Authors: Hao Wu, Yuzhen Huang, Lu Yang, Kunhan Su, Shuo Tian, Xin Chen, Siyu Li and Wanli Liu
    Citation: Trials 2022 23:345
  40. Ankylosing spondylitis (AS) is a common chronic inflammatory spondyloarthropathy. It is considered in traditional Chinese medicine (TCM) that the pathogenesis of AS is mainly due to Yang deficiency of kidney g...

    Authors: Yang Liu, Pei Wang, Yan Yan Sun, Jing Qu and Min Li
    Citation: Trials 2022 23:344
  41. Methamphetamine use could jeopardize the current efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBI) are effective in reducing methamphetamine use. However, ...

    Authors: Le Minh Giang, Nguyen Thu Trang, Nguyen Bich Diep, Dao Thi Dieu Thuy, Dinh Thanh Thuy, Han Dinh Hoe, Hoang Thi Hai Van, Thai Thanh Truc, Hoa H. Nguyen, Nguyen Ly Lai, Pham Thi Dan Linh, Vu Thi Tuong Vi, Cathy J. Reback, Arleen Leibowitz, Li Li, Chunqing Lin…
    Citation: Trials 2022 23:342
  42. Opioid use is escalating in North America and comes with a multitude of health consequences, including HIV and hepatitis C virus (HCV) outbreaks among persons who inject drugs (PWID). HIV pre-exposure prophyla...

    Authors: Valérie Martel-Laferrière, Daniel J. Feaster, Lisa R. Metsch, Bruce R. Shackman, Christine Loignon, Bohdan Nosyk, Hansel Tookes, Czarina N. Behrends, Nelson Arruda, Oluleye Adigun, Marie-Eve Goyer, Michael A. Kolber, Jean-Francois Mary, Allan E. Rodriguez, Iveth G. Yanez, Yue Pan…
    Citation: Trials 2022 23:341
  43. Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect ...

    Authors: David Cederberg, Bradley M. Harrington, Adriaan Johannes Vlok and Peter Siesjö
    Citation: Trials 2022 23:340
  44. Current treatment options for the management of depressive episodes in bipolar disorder are often sub-optimal, with some treatments either noted to be only partially effective or to require long durations of t...

    Authors: Cerena Miravalles, Ruán Kane, Eimear McMahon, Colm McDonald, Dara M. Cannon and Brian Hallahan
    Citation: Trials 2022 23:339
  45. Lumbar disc herniation (LDH) is a common chronic musculoskeletal disorder that seriously affects quality of life. The percutaneous endoscopic lumbar diskectomy (PELD) technique was developed to address spinal ...

    Authors: Huihao Wang, Weian Yuan, Zhongxiang Yu, Xiang Wang, Xinxin Zhao, Zhen Deng, Guangyue Yang, Weinan Chen, Zhibi Shen and Hongsheng Zhan
    Citation: Trials 2022 23:338

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