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  1. Evidence-based parenting programmes have strong evidence in preventing and mitigating violence, but in-person programmes are challenging to deliver at scale. ParentApp is an open-source, offline-first app-base...

    Authors: Lauren Baerecke, Abigail Ornellas, Joyce Wamoyi, Mwita Wambura, Jonathan Klapwijk, Angelique N. Chetty, Ashlin Simpson, Roselinde Janowski, Kristen de Graaf, David Stern, Lily Clements, Esmee te Winkel, Laetitia Christine, Gervas Mbosoli, Kija Nyalali, Onduru Gervas Onduru…
    Citation: Trials 2024 25:119
  2. Out-of-hospital cardiac arrest (OHCA) is a significant public health issue worldwide and is associated with low survival rates and poor neurological outcomes. The generation of optimal coronary perfusion press...

    Authors: Hee Eun Kim, Sheng-En Chu, You Hwan Jo, Wen-Chu Chiang, Dong-Hyun Jang, Chin-Hao Chang, So Hee Oh, Hsuan-An Chen, Seung Min Park, Jen-Tang Sun and Dong Keon Lee
    Citation: Trials 2024 25:118
  3. Pragmatic trials evaluating complex health interventions often compare them to usual care. This comparator should resemble care as provided in everyday practice. However, usual care can differ for the same con...

    Authors: Katrina M. Turner, Alyson Huntley, Tom Yardley, Sarah Dawson and Shoba Dawson
    Citation: Trials 2024 25:117
  4. Non-suicidal self-injury (NSSI) is a growing healthcare problem. Individuals with NSSI have an increased risk of suicidality. Due to stigma, they may self-injure in secret, which means they might not seek help...

    Authors: Evelyn Guerrero, Kate Andreasson, Lene Larsen, Niels Buus, Jette Louise Skovgaard Larsen, Jesper Krogh, Rasmus Thastum, Lone Lindberg, Katrine Lindblad, Annette Erlangsen and Merete Nordentoft
    Citation: Trials 2024 25:116
  5. The high incidence combined with the high lethality and bad prognosis of lung cancer highlight the need for psycho-oncological care for both patients and their relatives. While psychological interventions for ...

    Authors: Julia Dusel, Karin Meng, Hanna Arnold, Antonia Rabe and Elisabeth Jentschke
    Citation: Trials 2024 25:115
  6. Economic incentives can improve clinical outcomes among in-care people living with HIV (PLHIV), but evidence is limited for their effectiveness among out-of-care PLHIV or those at risk of disengagement. We pro...

    Authors: Jillian L. Kadota, Laura J. Packel, Matilda Mlowe, Nzovu Ulenga, Natalino Mwenda, Prosper F. Njau, William H. Dow, Jingshen Wang, Amon Sabasaba and Sandra I. McCoy
    Citation: Trials 2024 25:114
  7. Statisticians are fundamental in ensuring clinical research, including clinical trials, are conducted with quality, transparency, reproducibility and integrity. Good Clinical Practice (GCP) is an international...

    Authors: Deborah D. Stocken, Helen Mossop, Emma Armstrong, Steff Lewis, Susan J. Dutton, Claire Peckitt, Carrol Gamble and Julia Brown
    Citation: Trials 2024 25:113
  8. Depression continues to be an ongoing threat to adolescent well-being with Black adolescents being particularly vulnerable to greater burdens of depression as well as lower mental health service utilization. B...

    Authors: Michael A. Lindsey, Laura Mufson, Carolina Vélez-Grau, Tracy Grogan, Damali M. Wilson, Aaron O. Reliford, Meredith Gunlicks-Stoessel and James Jaccard
    Citation: Trials 2024 25:112

    The Correction to this article has been published in Trials 2024 25:253

  9. Authors: Russell J. McCulloh, Paul M. Darden, Jessica Snowden, Songthip Ounpraseuth, Jeannette Lee, Martina Clarke, Sophia R. Newcomer, Linda Fu, DeAnn Hubberd, Jaime Baldner, Maryam Garza and Ellen Kerns
    Citation: Trials 2024 25:111

    The original article was published in Trials 2022 23:911

  10. Preterm and term small for gestational age (SGA) babies are at high risk of experiencing malnutrition and impaired neurodevelopment. Standalone interventions have modest and sometimes inconsistent effects on g...

    Authors: Ranadip Chowdhury, Rukman Manapurath, Ingvild Fossgard Sandøy, Ravi Prakash Upadhyay, Neeta Dhabhai, Saijuddin Shaikh, Harish Chellani, Tarun Shankar Choudhary, Abhinav Jain, Jose Martines, Nita Bhandari, Tor A. Strand and Sunita Taneja
    Citation: Trials 2024 25:110
  11. Improving retention within randomised controlled trials is important. The effectiveness of different strategies can be assessed using a Study Within A Trial (SWAT). Previous research has shown personalised tex...

    Authors: Esther Herbert, Diana Papaioannou, Amanda Loban, Nikki Totton, Marie Hyslop, Robert Bolt and Christopher Deery
    Citation: Trials 2024 25:108
  12. Multicenter trials in orthopedic trauma are costly, yet crucial to advance the science behind clinical care. The number of sites is a key cost determinant. Each site has a fixed overhead cost, so more sites co...

    Authors: Lauren Allen, Robert V. O’Toole, Michael J. Bosse, William T. Obremskey, Kristin R. Archer, Lisa K. Cannada, Jaimie Shores, Lisa M. Reider, Katherine P. Frey, Anthony R. Carlini, Elena D. Staguhn and Renan C. Castillo
    Citation: Trials 2024 25:107
  13. Robotic spinal surgery may result in better pedicle screw placement accuracy, and reduction in radiation exposure and length of stay, compared to freehand surgery. The purpose of this randomized controlled tri...

    Authors: Nicolas Aurouer, Patrick Guerin, Arnaud Cogniet, Nicolas Gangnet, Morad Pedram, Pierre-Thierry Piechaud and Paolo Mangione
    Citation: Trials 2024 25:106
  14. Many research funders have invested billions of US dollars in building research capacity in sub-Saharan Africa (SSA). Despite these colossal investments, many well-intentioned and designed clinical research pr...

    Authors: Yauba Saidu, Sangwe Clovis Nchinjoh, Amani Adidja, Andreas Frambo Besong, Palmer Masumbe Netongo, Paul Ndom and Marya Liebermann
    Citation: Trials 2024 25:105
  15. Neuroimaging studies suggest an association between apathy after deep brain stimulation (DBS) and stimulation of the ventral part of the subthalamic nucleus (STN) due to the associative fibers connected to the...

    Authors: T. J. C. Zoon, G. van Rooijen, M. F. Contarino, S. van der Gaag, R. Zutt, J. T. van Asseldonk, P. van den Munckhof, P. R. Schuurman, D. A. J. P. Denys and R. M. A. de Bie
    Citation: Trials 2024 25:104
  16. Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The cur...

    Authors: Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin…
    Citation: Trials 2024 25:103
  17. Among older people undiagnosed and untreated vision impairment and blindness are common. The leading causes are uncorrected refractive errors and cataracts. Vision problems are associated with a lower quality ...

    Authors: Vera Rooth, Hilde van der Aa, Robert P. L. Wisse, Otto R. Maarsingh, Marc Koopmanschap, Jan E. E. Keunen, Hester Vermeulen, Caroline C. W. Klaver, Gabriëlle Janssen, Ger H. M. B. van Rens and Ruth M. A. van Nispen
    Citation: Trials 2024 25:102
  18. Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compound...

    Authors: Emily B. Hill, Minghua Tang, Julie M. Long, Jennifer F. Kemp, Jamie L. Westcott, Audrey E. Hendricks, Nichole A. Reisdorph, Wayne W. Campbell and Nancy F. Krebs
    Citation: Trials 2024 25:101
  19. Type 2 diabetes mellitus (T2DM) is a common metabolic disease that requires long-term management and treatment. Digital intervention, as an emerging medical model, has been widely used in the treatment of T2DM...

    Authors: Shao Zhong, Jingyi Jiang, Hongying Liu and Ying Pan
    Citation: Trials 2024 25:100
  20. Most cardiac arrest survivors are classified with mild to moderate cognitive impairment; roughly, 50% experience long-term neurocognitive impairment. Postarrest challenges complicate participation in society a...

    Authors: Jan Christensen, Bo Gregers Winkel, Lilli Kirkeskov, Fredrik Folke, Matilde Winther-Jensen, Christine Eckhardt-Bentsen, Jesper Kjærgaard, Christian Hassager and Mette Kirstine Wagner
    Citation: Trials 2024 25:99
  21. Digital interventions offer many possibilities for improving health, as remote interventions can enhance reach and access to underserved groups of society. However, research evaluating digital health intervent...

    Authors: Rebecca A. Krukowski, Kathryn M. Ross, Max J. Western, Rosie Cooper, Heide Busse, Cynthia Forbes, Emmanuel Kuntsche, Anila Allmeta, Anabelle Macedo Silva, Yetunde O. John-Akinola and Laura M. König
    Citation: Trials 2024 25:98
  22. Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on th...

    Authors: Ming-Hui Lai, Xiao-Ming Yu, Yan Lu, Hong-Lin Wang, Wang Fu, Huan-Xia Zhou, Yuan-Li Li, Jun Hu, Jiayi Xia, Zekai Hu, Chun-Lei Shan, Feng Wang and Cong Wang
    Citation: Trials 2024 25:97
  23. Despite the critical importance of clinical trials to provide evidence about the effects of intervention for children and youth, a paucity of published high-quality pediatric clinical trials persists. Sub-opti...

    Authors: Ami Baba, Maureen Smith, Beth K. Potter, An-Wen Chan, David Moher and Martin Offringa
    Citation: Trials 2024 25:96
  24. Healthcare systems data (HSD) has the potential to optimise the efficiency of randomised controlled trials (RCTs), by decreasing trial-specific data demands. Therefore, the use of HSD in trials is expected to ...

    Authors: Alice-Maria Toader, Carrol L. Gamble, Susanna Dodd and Paula R. Williamson
    Citation: Trials 2024 25:95
  25. Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, iss...

    Authors: Alice-Maria Toader, Marion K. Campbell, Jennifer K. Quint, Michael Robling, Matthew R Sydes, Joanna Thorn, Alexandra Wright-Hughes, Ly-Mee Yu, Tom. E. F. Abbott, Simon Bond, Fergus J. Caskey, Madeleine Clout, Michelle Collinson, Bethan Copsey, Gwyneth Davies, Timothy Driscoll…
    Citation: Trials 2024 25:94
  26. The menstrual cycle and its impact on training and performance are of growing interest. However, evidence is lacking whether periodized exercise based on the menstrual cycle is beneficial. The primary purpose ...

    Authors: Linda Ekenros, Philip von Rosen, Jessica Norrbom, Hans-Christer Holmberg, Carl Johan Sundberg, Cecilia Fridén and Angelica Lindén Hirschberg
    Citation: Trials 2024 25:93
  27. Procedural sedation is essential for optimizing upper gastrointestinal endoscopy, particularly in high-risk patients with multiple underlying diseases. Respiratory and circulatory complications present signifi...

    Authors: Zhi Li, Daming Yuan, Yu Yu, Jie Xu, Weili Yang, Li Chen and Nanbo Luo
    Citation: Trials 2024 25:92
  28. Antimicrobial resistance (AMR) is a rising threat in low-resource settings, largely driven by transmission in the community, outside health facilities. Inappropriate antibiotic use is one of the main modifiabl...

    Authors:
    Citation: Trials 2024 25:91
  29. Retinitis pigmentosa (RP) is an inherited disease characterized by a progressive loss of rod photoreceptors of the eye, leading to irreversible blindness. To date, to our knowledge, no clinical prospective stu...

    Authors: Wei Zhou, Ziyang Huang, Kai Xu, Yamin Li, Xiaoyu Li, Jiaxian Li, Yu Jin, Torkel Snellingen and Lina Liang
    Citation: Trials 2024 25:89
  30. Respiratory viral illness (RVI)—e.g., influenza, COVID-19—is a serious threat in long-term care (LTC) facilities. Standard infection control measures are suboptimal in LTC facilities because of residents’ cogn...

    Authors: Hayden P. Nix, Samantha Meeker, Caroline E. King, Melissa Andrew, Ian R. C. Davis, Prosper S. Koto, Meaghan Sim, Jennifer Murdoch, Glenn Patriquin, Chris Theriault, Stephanie Reidy, Michael Rockwood, Tara Sampalli, Samuel D. Searle and Kenneth Rockwood
    Citation: Trials 2024 25:88
  31. Despite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years of age in sub-Saharan Africa. Cerebral malaria (CM), defined as Plasmodi...

    Authors: Nginache Nampota-Nkomba, Osward M. Nyirenda, Jane Mallewa, Yamikani Chimalizeni, Nettie Dzabala, Michael P. Fay, Mathangi Gopalakrishnan, Matthew B. Laurens, Nicole F. O’Brien, Louis H. Miller, Susan K. Pierce, Brittany A. Riggle and Douglas G. Postels
    Citation: Trials 2024 25:87
  32. Lower respiratory tract infections (LRTIs) are among the most frequent infections and a significant contributor to inappropriate antibiotic prescription. Currently, no single diagnostic tool can reliably ident...

    Authors: Cécile Bessat, Roland Bingisser, Markus Schwendinger, Tim Bulaty, Yvan Fournier, Vincent Della Santa, Magali Pfeil, Dominique Schwab, Jörg D. Leuppi, Nicolas Geigy, Stephan Steuer, Friedemann Roos, Michael Christ, Adriana Sirova, Tanguy Espejo, Henk Riedel…
    Citation: Trials 2024 25:86
  33. A high concentration of inspired supplemental oxygen may possibly cause hypercapnia and acidosis and increase mortality in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Ev...

    Authors: Arne Sylvester Rønde Jensen, Jan Brink Valentin, Mathilde Gundgaard Mulvad, Victor Hagenau, Søren Helbo Skaarup, Søren Paaske Johnsen, Ulla Væggemose and Martin Faurholdt Gude
    Citation: Trials 2024 25:85
  34. Dermatitis is a skin condition caused by multiple causes, including radiotherapy treatment. Pharmacological treatments can become chronic and are not exempt from side effects. The latest recommendations of the...

    Authors: Celia Jimenez-Garcia, Luis Angel Perula-de Torres, Enrique Villegas-Becerril, Juan Jose Muñoz-Gavilan, Maria Espinosa-Calvo, Gertrudis Montes-Redondo and Esperanza Romero-Rodriguez
    Citation: Trials 2024 25:84
  35. For the potential benefits of trials to reach all that they should, trials must be designed to ensure that those taking part reflect the population who will receive the intervention. However, adults with impai...

    Authors: Victoria Shepherd, Katherine Joyce, Amanda Lewis, Samantha Flynn, Madeleine Clout, Brittany Nocivelli, Jeremy Segrott and Shaun Treweek
    Citation: Trials 2024 25:83
  36. Cognitive impairments are prevalent across mood disorders and psychosis spectrum disorders, but there is a lack of real-life-like cognitive training programmes. Fully immersive virtual reality has the potentia...

    Authors: Andreas E. Jespersen, Anders Lumbye, Maj Vinberg, Louise Glenthøj, Merete Nordentoft, Eva E. Wæhrens, Gitte M. Knudsen, Guido Makransky and Kamilla W. Miskowiak
    Citation: Trials 2024 25:82
  37. Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmenta...

    Authors: Corinna Engel, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Ana Vilan, Mari Falck, Isabella Mauro, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht…
    Citation: Trials 2024 25:81

    The Correction to this article has been published in Trials 2024 25:192

  38. In an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, pro...

    Authors: Elmir Omerovic, Mark Petrie, Björn Redfors, Stephen Fremes, Gavin Murphy, Guillaume Marquis-Gravel, Alexandra Lansky, Eric Velazquez, Divaka Perera, Christopher Reid, Julian Smith, Peter van der Meer, Eric Lipsic, Peter Juni, John McMurray, Johann Bauersachs…
    Citation: Trials 2024 25:80
  39. In early 2021, the Department of Health and Social Care in the UK called for research on the safety and immunogenicity of concomitant administration of COVID-19 and influenza vaccines. Co-administration of the...

    Authors: Rosie Harris, Russell Thirard, Sarah Baos, Rajeka Lazarus, Rachel Todd, Jana Kirwan, Katherine Joyce, David Hutton, Maddie Clout, Heike Cappel-Porter, Lucy Culliford and Chris A. Rogers
    Citation: Trials 2024 25:79
  40. Unplanned hospital presentations may occur post-stroke due to inadequate preparation for transitioning from hospital to home. The Recovery-focused Community support to Avoid readmissions and improve Participation...

    Authors: Monique F. Kilkenny, Muideen T. Olaiya, Janette Cameron, Natasha A. Lannin, Nadine E. Andrew, Amanda G. Thrift, Maree Hackett, Ian Kneebone, Avril Drummond, Vincent Thijs, Olivia Brancatisano, Joosup Kim, Megan Reyneke, Shaun Hancock, Liam Allan, Fiona Ellery…
    Citation: Trials 2024 25:78
  41. Severe acute respiratory syndrome coronavirus 2 will coexist with humans for a long time, and it is therefore important to develop effective treatments for coronavirus disease 2019 (COVID-19). Recent studies h...

    Authors: Xinlun Tian, Yan Xu, Luo Wang, Chongya Dong, Xiaoyan Yan, Junping Fan, Huaiya Xie, Hong Zhang, Jinglan Wang, Yongjian Liu, Yaqi Wang, Siqi Pan, Aohua Wu, Xueqi Liu, Chen Yao and Mengzhao Wang
    Citation: Trials 2024 25:77
  42. Physical activity levels are low in people with Parkinson’s disease (PD) and have proved difficult to increase with exercise programs alone. Intervention approaches that address both the capacity to engage in ...

    Authors: Sandra G. Brauer, Robyn M. Lamont and John D. O’Sullivan
    Citation: Trials 2024 25:76
  43. The onset of disability in bathing is particularly important for older adults as it can be rapidly followed by disability in other daily activities; this may represent a judicious time point for intervention i...

    Authors: Phillip J. Whitehead, Stuart Belshaw, Samantha Brady, Elizabeth Coleman, Alexandra Dean, Laura Doherty, Caroline Fairhurst, Sandra Francis-Farrell, Miriam Golding-Day, Joanne Gray, Maisie Martland, Jennifer McAnuff, Andrew McCarthy, Peter McMeekin, Natasha Mitchell, Melanie Narayanasamy…
    Citation: Trials 2024 25:75
  44. Postoperative pulmonary complications (PPCs) extend the length of stay of patients and increase the perioperative mortality rate after video-assisted thoracoscopic (VATS) pulmonary surgery. Thoracic paraverteb...

    Authors: Jiayu Zhu, Biyu Wei, Lili Wu, He Li, Yi Zhang, Jinfeng Lu, Shaofei Su, Chunhua Xi, Wei Liu and Guyan Wang
    Citation: Trials 2024 25:74
  45. Maternal oxygen supplementation is usually used as an intrauterine resuscitation technique to prevent fetal hypoxia and acidemia during delivery. However, there has been a great deal of controversy regarding t...

    Authors: Yun-Hui Li, Gui-Yu Lei, Jun Guo, Meng Yi, Yu-Jing Fu and Gu-Yan Wang
    Citation: Trials 2024 25:73
  46. Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that delivers oxygen pressures in proportion to electrical signals of the diaphragm. The proportional assistance can be adjusted ...

    Authors: Grace Poole, Christopher Harris, Sandeep Shetty, Theodore Dassios, Allan Jenkinson and Anne Greenough
    Citation: Trials 2024 25:72

    The Correction to this article has been published in Trials 2024 25:109

  47. In mental health care, the number of patients with diverse cultural backgrounds is growing. Nevertheless, evaluated training programs for transcultural competence are missing. Barriers for engaging in transcul...

    Authors: Selina Studer, Maria Kleinstäuber, Ulrike von Lersner and Cornelia Weise
    Citation: Trials 2024 25:71
  48. Uterine leiomyomas are common for reproductive-aged women and affect women’s quality of life due to heavy menstrual bleeding or dysmenorrhea. Leiomyomas grow according to estradiol exposure and decrease after ...

    Authors: Naoki Kawahara, Ryuji Kawaguchi, Konosuke Yamamoto, Kyohei Nishikawa, Motoki Matsuoka, Tomoka Maehana, Yosuke Fukui, Shoichiro Yamanaka, Sumire Sugimoto, Kana Iwai, Yuki Yamada, Hiroyuki Kurakami, Takumi Hirata, Ryuzo Takashima, Shota Suzuki, Kiyoshi Asada…
    Citation: Trials 2024 25:68

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