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  1. The COVID-19 pandemic has imposed an enormous burden on health care systems around the world. In the past, the administration of convalescent plasma of patients having recovered from SARS and severe influenza ...

    Authors: Timothy Devos, Tatjana Geukens, Alexander Schauwvlieghe, Kevin K. Ariën, Cyril Barbezange, Myriam Cleeren, Veerle Compernolle, Nicolas Dauby, Daniël Desmecht, David Grimaldi, Bart N. Lambrecht, Anne Luyten, Piet Maes, Michel Moutschen, Marta Romano, Lucie Seyler…

    Citation: Trials 2020 21:981

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in Trials 2020 21:1024

  2. Since December 2019, the outbreak of coronavirus pneumonia was observed in China and quickly propagate in all of the world. Nowadays, many trials are underway on this disease in which the efficacy of various t...

    Authors: Maryam Azimi and Fatemeh Sadat Hasheminasab

    Citation: Trials 2020 21:978

    Content type: Study protocol

    Published on:

  3. Despite high-quality cardiopulmonary resuscitation (CPR), early defibrillation, and antiarrhythmic medications, some patients remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac a...

    Authors: Ian R. Drennan, Paul Dorian, Shelley McLeod, Ruxandra Pinto, Damon C. Scales, Linda Turner, Michael Feldman, P. Richard Verbeek, Laurie J. Morrison and Sheldon Cheskes

    Citation: Trials 2020 21:977

    Content type: Study protocol

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  4. Opioid overdose deaths involving synthetic opioids, particularly illicitly manufactured fentanyl, remain a substantial public health concern in North America. Responses to overdose events (e.g., administration...

    Authors: Brendan P. Jacka, Jacqueline E. Goldman, Jesse L. Yedinak, Edward Bernstein, Scott E. Hadland, Jane A. Buxton, Susan G. Sherman, Katie B. Biello and Brandon D. L. Marshall

    Citation: Trials 2020 21:976

    Content type: Study protocol

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  5. College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by ...

    Authors: Ann-Marie Küchler, Dana Schultchen, Olga Pollatos, Morten Moshagen, David D. Ebert and Harald Baumeister

    Citation: Trials 2020 21:975

    Content type: Study protocol

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  6. The management of acute febrile illnesses places a heavy burden on clinical services in many low- and middle-income countries (LMICs). Bacterial and viral aetiologies of acute fevers are often clinically indis...

    Authors: Olawale Salami, Philip Horgan, Catrin E. Moore, Abhishek Giri, Asadu Sserwanga, Ashish Pathak, Buddha Basnyat, Francois Kiemde, Frank Smithuis, Freddy Kitutu, Gajanan Phutke, Halidou Tinto, Heidi Hopkins, James Kapisi, Myo Maung Maung Swe, Neelam Taneja…

    Citation: Trials 2020 21:974

    Content type: Study protocol

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  7. The indication for antibiotic prophylaxis in burn patients remains highly controversial, with no consensus having been reached. The objective of antibiotic prophylaxis is to reduce the risk of postoperative lo...

    Authors: François Dépret, Boris Farny, Mathieu Jeanne, Kada Klouche, Thomas Leclerc, Karine Nouette-Gaulain, Olivier Pantet, Francis Rémerand, Antoine Roquilly, Anne-Françoise Rousseau, Simon Sztajnic, Sandrine Wiramus, Eric Vicaut and Matthieu Legrand

    Citation: Trials 2020 21:973

    Content type: Study protocol

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  8. There is considerable evidence for the efficacy of moderate-intensity continuous exercise benefitting clinically relevant outcomes in persons with multiple sclerosis (MS). However, persons with MS who have wal...

    Authors: Elizabeth A. Hubbard, Robert W. Motl and David J. Elmer

    Citation: Trials 2020 21:972

    Content type: Study protocol

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  9. Three large trials of fluoxetine for stroke recovery (FOCUS (fluoxetine or control under supervision), AFFINITY (the Assessment oF FluoxetINe In sTroke recovery) and EFFECTS (Efficacy oF Fluoxetine—a randomisE...

    Authors: Gillian Elizabeth Mead, Catriona Graham, Laurent Billot, Per Näsman, Erik Lundström, Steff Lewis, Graeme J. Hankey, Maree L. Hackett, John Forbes and Martin Dennis

    Citation: Trials 2020 21:971

    Content type: Update

    Published on:

    The Update to this article has been published in Trials 2017 18:627

  10. Cesarean section is an important surgical procedure, when normal vaginal delivery imposes a risk to mother and/or baby. The World Health Organization states the ideal rate for Cesarean section to be between 10...

    Authors: Mahboubeh Shirzad, Elham Shakibazadeh, Abbas Rahimi Foroushani, Mehrandokht Abedini, Hamid Poursharifi and Sohrab Babaei

    Citation: Trials 2020 21:970

    Content type: Study protocol

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  11. The inflammatory response after aneurysmal subarachnoid haemorrhage (aSAH) has been associated with early brain injury, delayed cerebral ischaemia, poor functional outcome, and case fatality. In experimental S...

    Authors: Inez Koopman, Gabriel J. E. Rinkel and Mervyn D. I. Vergouwen

    Citation: Trials 2020 21:969

    Content type: Study protocol

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  12. Patients with diabetes are - compared to people without diabetes - at increased risk of worse outcomes from COVID-19 related pneumonia during hospitalization. We aim to investigate whether telemetric continuou...

    Authors: Carina Kirstine Klarskov, Birgitte Lindegaard, Ulrik Pedersen-Bjergaard and Peter Lommer Kristensen

    Citation: Trials 2020 21:968

    Content type: Letter

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ana Paula Junqueira-Kipnis, Laura Raniere Borges dos Anjos, Lília Cristina de Souza Barbosa, Adeliane Castro da Costa, Kellen Christina Malheiros Borges, Amanda da Rocha Oliveira Cardoso, Kaio Mota Ribeiro, Sarah Brena Aparecida Rosa, Carine de Castro Souza, Rogério Coutinho das Neves, Guylherme Saraiva, Sueli Meira da Silva, Erika Aparecida Silveira, Marcelo Fouad Rabahi, Marcus Barreto Conte and André Kipnis

    Citation: Trials 2020 21:967

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:881

  14. The optimal timing to administer a P2Y12 inhibitor in patients presenting with a non-ST elevation acute coronary syndrome remains a topic of debate. Pretreatment with ticagrelor before coronary anatomy is know...

    Authors: Giuseppe Tarantini, Marco Mojoli, Ferdinando Varbella, Roberto Caporale, Stefano Rigattieri, Giuseppe Andò, Plinio Cirillo, Simona Pierini, Andrea Santarelli, Paolo Sganzerla, Nicoletta De Cesare, Ugo Limbruno, Alessandro Lupi, Roberto Ricci, Carlo Cernetti, Luca Favero…

    Citation: Trials 2020 21:966

    Content type: Study protocol

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  15. To assess the efficacy of ivermectin in addition to standard treatment compared to standard treatment alone in reducing hospitalizations in the COVID-19 patient population.

    Authors: Julio Vallejos, Rodrigo Zoni, Maria Bangher, Silvina Villamandos, Angelina Bobadilla, Fabian Plano, Claudia Campias, Evangelina Chaparro Campias, Fernando Achinelli, Hector A. Guglielmone, Jorge Ojeda, Fernanda Medina, Diego Farizano Salazar, Gerardo Andino, Natalia E. Ruiz Diaz, Pablo Kawerin…

    Citation: Trials 2020 21:965

    Content type: Letter

    Published on:

  16. Spine metastasis is a common occurrence in cancer patients and results in pain, neurologic deficits, decline in performance status, disability, inferior quality of life (QOL), and reduction in ability to recei...

    Authors: Rupesh Kotecha, Brian J. Schiro, Justin Sporrer, Muni Rubens, Haley R. Appel, Kathleen S. Calienes, Belinda Boulanger, Marietsy V. Pujol, Deborah T. Suarez, Ashley Pena, Alex Kudryashev and Minesh P. Mehta

    Citation: Trials 2020 21:964

    Content type: Study protocol

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  17. Antiretroviral therapy (ART) for HIV, taken daily, is an effective strategy to clinically suppress the virus, providing the dual benefit of improved survival and vastly decreasing the risk of transmission. How...

    Authors: Laura Packel, Prosper Njau, Carolyn Fahey, Angela Ramadhani, William H. Dow, Nicholas P. Jewell and Sandra McCoy

    Citation: Trials 2020 21:963

    Content type: Study protocol

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  18. In common with many countries, Ireland has seen an increasing trend in the number of clinical trials conducted over the past few years. Yet, as elsewhere, trialists in Ireland face several problems and barrier...

    Authors: Lauren Leddy, Prasanth Sukumar, Lydia O’Sullivan, Fionnuala Keane, Declan Devane and Peter Doran

    Citation: Trials 2020 21:962

    Content type: Research

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  19. Citation: Trials 2020 21:961

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:877

  20. Pre-eclampsia is a pregnancy complication characterised by high blood pressure and multi-organ dysfunction in the mother. It is a leading contributor to maternal and perinatal mortality, with 99% of these deat...

    Authors: Alice Beardmore-Gray, Nicola Vousden, Umesh Charantimath, Geetanjali Katageri, Mrutyunjaya Bellad, Kunda Kapembwa, Sebastian Chinkoyo, Bellington Vwalika, Matthew Clark, Rachael Hunter, Paul Seed, Shivaprasad Goudar, Lucy C. Chappell and Andrew Shennan

    Citation: Trials 2020 21:960

    Content type: Study protocol

    Published on:

  21. Individuals who have been diagnosed with melanoma have more than a 9-fold increased risk of developing another melanoma. Ultraviolet radiation (UVR) exposure following a melanoma diagnosis can be modified to r...

    Authors: Rachel I. Vogel, Rebekah H. Nagler, Rehana L. Ahmed, Katherine Brown, Xianghua Luo, Brian C. Martinson and DeAnn Lazovich

    Citation: Trials 2020 21:959

    Content type: Study protocol

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  22. Observational studies have suggested that a high respiratory exchange ratio (RER) is associated with the occurrence of postoperative complications. The study’s primary objective is to demonstrate that the inci...

    Authors: Stéphane Bar, Pierre Boivin, Younes El Amine, Richard Descamps, Mouhamed Moussa, Osama Abou Arab, Marc-Olivier Fischer, Hervé Dupont, Emmanuel Lorne and Pierre-Grégoire Guinot

    Citation: Trials 2020 21:958

    Content type: Study protocol

    Published on:

  23. Epileptic encephalopathy with electrical status epilepticus in sleep (ESES) is an epilepsy syndrome occurring almost exclusively in children, usually at an age between 4 and 12 years. It is characterised by ab...

    Authors: Bart van den Munckhof, Alexis Arzimanoglou, Emilio Perucca, Heleen C. van Teeseling, Frans S. S. Leijten, Kees P. J. Braun and Floor E. Jansen

    Citation: Trials 2020 21:957

    Content type: Study protocol

    Published on:

  24. Influenza is an important public health problem, but data on the impact of influenza among homeless shelter residents are limited. The primary aim of this study is to evaluate whether on-site testing and antiv...

    Authors: Kira L. Newman, Julia H. Rogers, Denise McCulloch, Naomi Wilcox, Janet A. Englund, Michael Boeckh, Timothy M. Uyeki, Michael L. Jackson, Lea Starita, James P. Hughes and Helen Y. Chu

    Citation: Trials 2020 21:956

    Content type: Study protocol

    Published on:

  25. Enteral nutrition is part of the treatment of critically ill patients. Administration of enteral nutrition may be associated with signs of intolerance, such as high gastric residual volumes, diarrhea, and vomi...

    Authors: Ondrej Hrdy, Kamil Vrbica, Eva Strazevska, Petr Suk, Lenka Souckova, Radka Stepanova, Igor Sas and Roman Gal

    Citation: Trials 2020 21:955

    Content type: Study protocol

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  26. Cardiopulmonary bypass (CPB) is an important cause of significant systemic inflammatory response syndrome (SIRS) in the surgical treatment of acute type A aortic dissection (ATAAD). In patients with arch vesse...

    Authors: Jing Yang, Dong Ji, Yue-Qian Zhu, Yun Ren, Xun Zhang, Hong-Yu Dai, Xu Sun, Yi Zhou, Zhi-Yuan Chen, Qing-Guo Li and Hao Yao

    Citation: Trials 2020 21:954

    Content type: Study protocol

    Published on:

  27. Intralipid is a necessary fatty acid carrier that has been safely used as an energy supplier in the clinic. It has played an important role in rescuing the cardiac arrest caused by local anesthetic toxicity. I...

    Authors: Yuan Yuan, Hui Xiong, Yan Zhang, Hong Yu and Rong-Hua Zhou

    Citation: Trials 2020 21:953

    Content type: Study protocol

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  28. Little is known about why parents agree to take part in randomized controlled trials for adolescent mental health. This study aimed to investigate parents’ perspectives on participating in a trial for psycholo...

    Authors: Sally O’Keeffe, Katharina Weitkamp, Danny Isaacs, Mary Target, Virginia Eatough and Nick Midgley

    Citation: Trials 2020 21:952

    Content type: Research

    Published on:

  29. Diabetic kidney disease (DKD) is one of the most important microvascular complications of diabetes, and its prevalence has increased dramatically in the past few decades. DKD is responsible for considerable mo...

    Authors: Rui Wu, Fan Wei, Lianlian Qu, Litao Bai, Jun Li, Fei Li, Weitian Yan, Qiuhong Wang and Junping Wei

    Citation: Trials 2020 21:951

    Content type: Study protocol

    Published on:

  30. Otitis media with effusion is the major cause of acquired hearing problems in children. Some of the affected children need surgery with ventilation tubes in the tympanic membrane to reduce ear complaints and t...

    Authors: Bjarne Austad, Ann Helen Nilsen, Anne-Sofie Helvik, Grethe Albrektsen, Ståle Nordgård and Wenche Moe Thorstensen

    Citation: Trials 2020 21:950

    Content type: Study protocol

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  31. Cough is a common reason for patients to visit general practices. So-called post-infectious cough is defined as lasting 3 to 8 weeks after an upper respiratory tract infection. It can be disabling in daily act...

    Authors: Christoph Merlo, Stefan Essig, D. Oana Brancati-Badarau, Jörg Daniel Leuppi, Benjamin Speich, Tobias E. Erlanger, Lars G. Hemkens and Andreas Zeller

    Citation: Trials 2020 21:949

    Content type: Study protocol

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  32. Since decades, fever and infections have been the most important complications of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the treatment of hematologic malignancies. Neutrop...

    Authors: Charlotte E. M. de Mooij, Lenneke F. J. van Groningen, Anton F. J. de Haan, Bart J. Biemond, Martijn Bakker, Walter J. F. M. van der Velden and Nicole M. A. Blijlevens

    Citation: Trials 2020 21:948

    Content type: Study protocol

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  33. Human milk is recommended for all very low birth weight infants. Breastmilk is highly variable in nutrient content, failing to meet the nutritional demands of this group. Fortification of human milk is recomme...

    Authors: Joanna Seliga-Siwecka, Anna Chmielewska and Katarzyna Jasińska

    Citation: Trials 2020 21:946

    Content type: Study protocol

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  34. Severe perineal trauma sustained during childbirth is a serious complication since it can lead to both short- and long-term consequences for women. Some of the methods used to prevent perineal injuries have be...

    Authors: M. Edqvist, H. G. Dahlen, C. Häggsgård, H. Tern, K. Ängeby, G. Tegerstedt, P. Teleman, G. Ajne and C. Rubertsson

    Citation: Trials 2020 21:945

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in Trials 2020 21:993

  35. Although evidence had demonstrated the effectiveness of smartphone apps in diabetes care, the majority of apps had been developed for type 2 diabetes mellitus (T2DM) patients and targeted at populations outsid...

    Authors: Fansu Huang, Xinyin Wu, Yuting Xie, Fang Liu, Juan Li, Xia Li and Zhiguang Zhou

    Citation: Trials 2020 21:944

    Content type: Study protocol

    Published on:

  36. To evaluate a therapeutic role for omega-3 fatty acid supplementation in the treatment of olfactory dysfunction associated with COVID-19 infection

    Authors: David Lerner, Katherine Garvey, Annie Arrighi-Allisan, Andrey Filimonov, Peter Filip, Katherine Liu, Sen Ninan, Madeleine Schaberg, Patrick Colley, Anthony Del Signore, Satish Govindaraj and Alfred Marc Iloreta

    Citation: Trials 2020 21:942

    Content type: Letter

    Published on:

  37. 1. To compare the effectiveness of four different surveillance strategies in detecting COVID-19 within the homeless shelter population.

    Authors: Timothy O’Shea, Lawrence Mbuagbaw, Vaibhav Mokashi, David Bulir, Jodi Gilchrist, Nicole Smieja, Sylvia Chong, Sarah Marttala, Valentina Vera, Anna Cvetkovic and Marek Smieja

    Citation: Trials 2020 21:941

    Content type: Letter

    Published on:

  38. To assess the effect of prone positioning therapy on intubation rate in awake patients with COVID-19 and acute respiratory failure.

    Authors: Miguel Á. Ibarra-Estrada, Miguel Marín-Rosales, Roxana García-Salcido, Sara A. Aguirre-Díaz, Alexandra Vargas-Obieta, Quetzalcóatl Chávez-Peña, José A. López-Pulgarín, Julio C. Mijangos-Méndez and Guadalupe Aguirre-Avalos

    Citation: Trials 2020 21:940

    Content type: Letter

    Published on:

  39. Pharmacological therapies of proven efficacy in coronavirus disease 2019 (COVID-19) are still lacking. We have identified IFNβ-1a as the most promising drug to be repurposed for COVID-19. The rationale relies ...

    Authors: Emanuele Bosi, Carlo Bosi, Patrizia Rovere Querini, Nicasio Mancini, Giliola Calori, Annalisa Ruggeri, Cecilia Canzonieri, Luciano Callegaro, Massimo Clementi, Francesco De Cobelli, Massimo Filippi and Marco Bregni

    Citation: Trials 2020 21:939

    Content type: Study protocol

    Published on:

  40. Developing low-cost, socio-culturally appropriate, and scalable interventions for youth depression and anxiety symptoms in low-income regions such as countries in sub-Saharan Africa is a global mental health p...

    Authors: Tom L. Osborn, Katherine E. Venturo-Conerly, Akash R. Wasil, Micaela Rodriguez, Elizabeth Roe, Rediet Alemu, Susana Arango G., Jenny Gan, Christine Wasanga, Jessica L. Schleider and John R. Weisz

    Citation: Trials 2020 21:938

    Content type: Study protocol

    Published on:

  41. Gambling and tobacco smoking are highly comorbid among North American adults. However, there is a paucity of treatment options that are integrated (i.e. targeting both gambling and tobacco smoking simultaneous...

    Authors: Elena Bilevicius, Alanna Single, Chris Baumgartner, Van Bui, Tyler Kempe, Michael P. Schaub, Sherry H. Stewart, James MacKillop, David C. Hodgins, Jeffrey D. Wardell, Roisin O’Connor, Jennifer Read, Heather Hadjistavropoulos, Christopher Sundstrom and Matthew T. Keough

    Citation: Trials 2020 21:937

    Content type: Study protocol

    Published on:

  42. Neurogenic bladder (NB) can affect people after stroke episodes. NB features changes in the normal voiding pattern at the bladder filling and emptying phases. Overactive NB is characterized by urgency symptoms...

    Authors: Thais Alves Candido, Bruna Miranda Ribeiro, Cristiane Rodrigues Cardoso de Araújo, Rogério de Melo Costa Pinto, Ana Paula Magalhães Resende and Vanessa Santos Pereira-Baldon

    Citation: Trials 2020 21:936

    Content type: Study protocol

    Published on:

  43. The GETAFIX trial will test the hypothesis that favipiravir is a more effective treatment for COVID-19 infection in patients who have early stage disease, compared to current standard of care. This study will ...

    Authors: Catherine R. Hanna, Kevin G. Blyth, Glenn Burley, Samantha Carmichael, Carol Evans, Samantha Hinsley, Ibrahim Khadra, Saye Khoo, Liz-Anne Lewsley, Robert R. Jones, Raman Sharma, Andrea Taladriz-Sender, Emma C. Thomson and Janet T. Scott

    Citation: Trials 2020 21:935

    Content type: Letter

    Published on:

  44. Zilucoplan (complement C5 inhibitor) has profound effects on inhibiting acute lung injury post COVID-19, and can promote lung repair mechanisms that lead to improvement in lung oxygenation parameters. The purp...

    Authors: Jozefien Declercq, Cedric Bosteels, Karel Van Damme, Elisabeth De Leeuw, Bastiaan Maes, Ans Vandecauter, Stefanie Vermeersch, Anja Delporte, Bénédicte Demeyere, Marnik Vuylsteke, Marianna Lalla, Trevor Smart, Laurent Detalle, René Bouw, Johannes Streffer, Thibo Degeeter…

    Citation: Trials 2020 21:934

    Content type: Letter

    Published on:

  45. Men who have sex with men (MSM) are an important HIV key population in China. However, HIV testing rates among MSM remain suboptimal. Digital crowdsourced media interventions may be a useful tool to reach this...

    Authors: Ci Ren, Joseph D. Tucker, Weiming Tang, Xiaorun Tao, Meizhen Liao, Guoyong Wang, Kedi Jiao, Zece Xu, Zhe Zhao, Yu Yan, Yuxi Lin, Chuanxi Li, Lin Wang, Yijun Li, Dianmin Kang and Wei Ma

    Citation: Trials 2020 21:931

    Content type: Study protocol

    Published on:

  46. Primary Objective: To determine the feasibility of delivering a protocolised, remote, online, Eye Movement Desensitisation and Reprocessing (EMDR) intervention, within 12-weeks of hospital discharge, for adult su...

    Authors: Andrew Bates, Sophie Rushbrook, Elan Shapiro, Michael Grocott and Rebecca Cusack

    Citation: Trials 2020 21:929

    Content type: Letter

    Published on:

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Christina M. Eckhardt, Matthew J. Cummings, Kartik N. Rajagopalan, Sarah Borden, Zachary C. Bitan, Allison Wolf, Alex Kantor, Thomas Briese, Benjamin J. Meyer, Samuel D. Jacobson, Dawn Scotto, Nischay Mishra, Neena M. Philip, Brie A. Stotler, Joseph Schwartz, Beth Shaz…

    Citation: Trials 2020 21:927

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:499

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