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  1. Improving maternal antiretroviral therapy (ART) retention and adherence is a critical challenge facing prevention of mother-to-child transmission (PMTCT) of HIV programs. There is an urgent need for evidence-b...

    Authors: Maria H. Kim, Tapiwa A. Tembo, Alick Mazenga, Xiaoying Yu, Landon Myer, Rachael Sabelli, Robert Flick, Miriam Hartig, Elizabeth Wetzel, Katie Simon, Saeed Ahmed, Rose Nyirenda, Peter N. Kazembe, Mtisunge Mphande, Angella Mkandawire, Mike J. Chitani…

    Citation: Trials 2020 21:207

    Content type: Study protocol

    Published on:

  2. No conclusive treatment is available for irritable bowel disease (IBD). Adherence to a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) might alleviate clinical s...

    Authors: Alireza Milajerdi, Omid Sadeghi, Seyed Davar Siadat, Seyed Ali Keshavarz, Alireza Sima, Homayoon Vahedi, Peyman Adibi and Ahmad Esmaillzadeh

    Citation: Trials 2020 21:201

    Content type: Study protocol

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  3. Regulatory agencies, such as the European Medicines Agency and Health Canada, are requiring the public sharing of clinical trial reports that are used to make drug approval decisions. Both agencies have provid...

    Authors: Janice Branson, Nathan Good, Jung-Wei Chen, Will Monge, Christian Probst and Khaled El Emam

    Citation: Trials 2020 21:200

    Content type: Research

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  4. Recurrent bleeding from an intracranial aneurysm after subarachnoid hemorrhage (SAH) is associated with unfavorable outcome. Recurrent bleeding before aneurysm occlusion can be performed occurs in up to one in...

    Authors: René Post, Menno R. Germans, Bert A. Coert, Gabriël J. E. Rinkel, W. Peter Vandertop and Dagmar Verbaan

    Citation: Trials 2020 21:199

    Content type: Update

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    The Study protocol to this article has been published in Trials 2013 14:143

  6. The total ankle replacement versus ankle arthrodesis (TARVA) trial aims to determine which surgical procedure confers the greatest improvement in pain-free function for patients with end-stage ankle osteoarthr...

    Authors: Patrick Muller, Simon S. Skene, Kashfia Chowdhury, Suzie Cro, Andrew J. Goldberg and Caroline J. Doré

    Citation: Trials 2020 21:197

    Content type: Update

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  7. After publication of our article [1] the authors have notified us of missing to include one name to the authorship list:

    Authors: Benjamin Carrot, Jeanne Duclos, Caroline Barry, Leslie Radon, Anne-Solène Maria, Irène Kaganski, Zorica Jeremic, Vesper Barton-Clegg, Maurice Corcos, Malaïka Lasfar, Priscille Gerardin, Aurélie Harf, Marie-Rose Moro, Corinne Blanchet, Stéphane Bahrami and Nathalie Godart

    Citation: Trials 2020 21:196

    Content type: Correction

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    The original article was published in Trials 2019 20:249

  8. After publication of our article [1] the authors have notified us that the title for Figure 1 was incorrectly captioned.

    Authors: Bethany M. Kwan, L. Miriam Dickinson, Russell E. Glasgow, Martha Sajatovic, Mark Gritz, Jodi Summers Holtrop, Don E. Nease Jr, Natalie Ritchie, Andrea Nederveld, Dennis Gurfinkel and Jeanette A. Waxmonsky

    Citation: Trials 2020 21:195

    Content type: Correction

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    The original article was published in Trials 2020 21:65

  9. Total knee arthroplasty (TKA) with mechanical alignment (MA) aims to achieve neutral limb alignment in all patients, whereas TKA with functional alignment (FA) aims to restore native, patient-specific anatomy ...

    Authors: Babar Kayani, Sujith Konan, Jenni Tahmassebi, Sam Oussedik, Peter D. Moriarty and Fares S. Haddad

    Citation: Trials 2020 21:194

    Content type: Study protocol

    Published on:

  10. Shoulder pain is an uncomfortable feeling in the muscle around the shoulder. The cause of myalgia is the accumulation of lactic acid in muscles and impaired blood circulation, which is called blood stasis in t...

    Authors: Soobin Jang, Hyun Kyung Sung, Mi Mi Ko, Seon Mi Shin, Ho-Yeon Go and Jeeyoun Jung

    Citation: Trials 2020 21:193

    Content type: Study protocol

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    The Correction to this article has been published in Trials 2020 21:250

  11. Ticagrelor is a reversibly binding, direct-acting, oral, P2Y12 antagonist used for the prevention of atherothrombotic events in patients with coronary artery disease (CAD). Ticagrelor blocks adenosine reuptake th...

    Authors: D. D’Amario, A. Restivo, A. M. Leone, R. Vergallo, S. Migliaro, F. Canonico, M. Galli, C. Trani, F. Burzotta, C. Aurigemma, G. Niccoli, A. Buffon, R. A. Montone, A. Flex, F. Franceschi, G. Tinelli…

    Citation: Trials 2020 21:192

    Content type: Study protocol

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  12. Unhealthy alcohol use is a leading cause of morbidity and mortality among young people, including university students. Delivering secondary prevention interventions against unhealthy alcohol use is challenging...

    Authors: Nicolas Bertholet, Elodie Schmutz, Véronique S. Grazioli, Mohamed Faouzi, Jennifer McNeely, Gerhard Gmel, Jean-Bernard Daeppen and John A. Cunningham

    Citation: Trials 2020 21:191

    Content type: Study protocol

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  13. Approximately one in four pregnant women undergo an induction of labour. The purpose of this study is to investigate the clinical effectiveness, safety, and cost-effectiveness for mothers and babies of two met...

    Authors: Michelle R. Wise, Joy Marriott, Malcolm Battin, John M. D. Thompson, Michael Stitely and Lynn Sadler

    Citation: Trials 2020 21:190

    Content type: Study protocol

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  14. Informal caregivers report substantial burden and depressive symptoms which predict higher rates of patient institutionalization. While caregiver education interventions may reduce caregiver distress and decre...

    Authors: Megan Shepherd-Banigan, Valerie A. Smith, Jennifer H. Lindquist, Michael Paul Cary Jr., Katherine E. M. Miller, Jennifer G. Chapman and Courtney H. Van Houtven

    Citation: Trials 2020 21:189

    Content type: Research

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  15. Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dem...

    Authors: Amanda Timler, Caroline Bulsara, Max Bulsara, Alistair Vickery, Jill Smith and Jim Codde

    Citation: Trials 2020 21:188

    Content type: Study protocol

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  16. Earlier, we designed and evaluated an educational mass media intervention for improving people’s ability to think more critically and to assess the trustworthiness of claims (assertions) about the benefits and...

    Authors: Daniel Semakula, Allen Nsangi, Andrew D. Oxman, Matt Oxman, Astrid Austvoll-Dahlgren, Sarah Rosenbaum, Angela Morelli, Claire Glenton, Simon Lewin, Laetitia Nyirazinyoye, Margaret Kaseje, Iain Chalmers, Atle Fretheim, Christopher J. Rose and Nelson K. Sewankambo

    Citation: Trials 2020 21:187

    Content type: Research

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  17. Mexico has one of the highest prevalence rates of obesity worldwide. New pharmacological strategies that focus on people with class III obesity are required. Metformin and dapagliflozin are two drugs approved ...

    Authors: Aldo Ferreira-Hermosillo, Mario Antonio Molina-Ayala, Diana Molina-Guerrero, Ana Pamela Garrido-Mendoza, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta, Etual Espinosa and Moisés Mercado

    Citation: Trials 2020 21:186

    Content type: Study protocol

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  18. Germany hosts a large number of refugees from war-affected countries. The integration of refugees, in particular young refugees from the Middle East, is one of the major current social challenges in Germany. M...

    Authors: Sarah Wilker, Claudia Catani, Jasmin Wittmann, Melissa Preusse, Telja Schmidt, Theodor May, Verena Ertl, Bettina Doering, Rita Rosner, Areej Zindler and Frank Neuner

    Citation: Trials 2020 21:185

    Content type: Study protocol

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  19. Individuals affected by stroke present with changes in cardiovascular and respiratory functions. Cardiorespiratory training (CRT) is one of the classic intervention guidelines for cardiorespiratory fitness. CR...

    Authors: Renata Janaína Pereira de Souza, Daniella Cunha Brandão, José Vicente Martins, Juliana Fernandes and Armele Dornelas de Andrade

    Citation: Trials 2020 21:184

    Content type: Study protocol

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  20. Eighty per cent of UK women have at least one baby, making pregnancy an opportunity to help women stop smoking before their health is irreparably compromised. Smoking cessation during pregnancy helps protect i...

    Authors: Lesley Sinclair, Margaret McFadden, Helen Tilbrook, Alex Mitchell, Ada Keding, Judith Watson, Linda Bauld, Frank Kee, David Torgerson, Catherine Hewitt, Jennifer McKell, Pat Hoddinott, Fiona M. Harris, Isabelle Uny, Kathleen Boyd, Nicola McMeekin…

    Citation: Trials 2020 21:183

    Content type: Study protocol

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  21. Dengue is increasing in its global presence with an estimated 4 billion people at-risk of infection in at least 128 countries. Despite the promising results of EcoHealth and community mobilization approaches to A...

    Authors: Kate Zinszer, Andrea Caprara, Antonio Lima, Stéphanie Degroote, Monica Zahreddine, Kellyanne Abreu, Mabel Carabali, Katia Charland, Mayana Azevedo Dantas, José Wellington, Beatriz Parra, Florence Fournet, Emmanuel Bonnet, Denis Pérez, Emilie Robert, Christian Dagenais…

    Citation: Trials 2020 21:182

    Content type: Study protocol

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  22. Tuberculosis (TB) is a significant public health problem that causes substantial morbidity and mortality. Current first-line anti-TB chemotherapy, although very effective, has limitations including long-treatm...

    Authors: Ruth Nabisere, Joseph Musaazi, Paolo Denti, Florence Aber, Mohammed Lamorde, Kelly E. Dooley, Rob Aarnoutse, Derek J. Sloan and Christine Sekaggya-Wiltshire

    Citation: Trials 2020 21:181

    Content type: Study protocol

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  23. This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals’ f...

    Authors: E. Q. Silva, E. Y. Suda, D. P. Santos, J. L. Veríssimo, J. S. S. P. Ferreira, R. H. Cruvinel Júnior, R. L. Monteiro, C. D. Sartor and I. C. N. Sacco

    Citation: Trials 2020 21:180

    Content type: Study protocol

    Published on:

  24. Septoplasty (surgery to straighten a deviation in the nasal septum) is a frequently performed operation worldwide, with approximately 250,000 performed annually in the US and 22,000 in the UK. Most septoplasti...

    Authors: Katherine J. Rennie, James O’Hara, Nikki Rousseau, Deborah Stocken, Denise Howel, Laura Ternent, Mike Drinnan, Alison Bray, Leila Rooshenas, David W. Hamilton, Alison Steel, Tony Fouweather, Ann-Marie Hynes, Eva-Maria Holstein, Yemi Oluboyede, Alaa Abouhajar…

    Citation: Trials 2020 21:179

    Content type: Study protocol

    Published on:

  25. The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood phenylalanine (Phe) levels in adults outside preg...

    Authors: Roman Trepp, Raphaela Muri, Stephanie Abgottspon, Lenka Bosanska, Michel Hochuli, Johannes Slotboom, Christian Rummel, Roland Kreis and Regula Everts

    Citation: Trials 2020 21:178

    Content type: Study protocol

    Published on:

  26. Medication is generally recommended to reduce the morbidity and mortality caused by cardiovascular disease in hypertensive patients. However, considering the difficulties and economic factors associated with l...

    Authors: Sang-Hyun Lee, Byung-Jun Kim, In-Hwa Park, Eui-Hyoung Hwang, Eun Ju Park, Insoo Jang and Man-Suk Hwang

    Citation: Trials 2020 21:177

    Content type: Study protocol

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  27. Evidence for the add-on effect of kinesiotape (KT) with acupuncture for treating ankle sprains remains insufficient. We assessed the add-on effect of KT on ankle sprains by comparing acupuncture combined with ...

    Authors: Jeong-Cheol Shin, Jae-Hong Kim, Dongwoo Nam, Gwang-Cheon Park and Jeong-Soon Lee

    Citation: Trials 2020 21:176

    Content type: Research

    Published on:

  28. SABATO (Staphylococcus aureus bacteremia antibiotic treatment options) is a randomized, parallel-group, clinical non-inferiority trial designed to examine the efficacy and safety of early oral switch therapy in l...

    Authors: Achim J. Kaasch, Anna Rommerskirchen, Martin Hellmich, Gerd Fätkenheuer, Reinhild Prinz-Langenohl, Siegbert Rieg, Winfried V. Kern and Harald Seifert

    Citation: Trials 2020 21:175

    Content type: Update

    Published on:

    The Study protocol to this article has been published in Trials 2015 16:450

  29. Multimorbidity affects four of ten US adults and eight of ten adults ages 65 years and older, and frequently includes both cardiometabolic conditions and behavioral health concerns. Hispanics/Latinos (hereafte...

    Authors: Linda C. Gallo, Addie L. Fortmann, Julia I. Bravin, Taylor L. Clark, Kimberly L. Savin, Duvia Lara Ledesma, Johanna Euyoque, Haley Sandoval, Scott C. Roesch, Todd Gilmer, Gregory A. Talavera and Athena Philis-Tsimikas

    Citation: Trials 2020 21:174

    Content type: Study protocol

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  30. Sexual concerns are distressing for breast cancer survivors and interfere with their intimate relationships. This study evaluates the efficacy of a four-session couple-based intervention delivered via telephon...

    Authors: Jennifer Barsky Reese, Lauren A. Zimmaro, Stephen J. Lepore, Kristen A. Sorice, Elizabeth Handorf, Mary B. Daly, Leslie R. Schover, Deborah Kashy, Kelly Westbrook and Laura S. Porter

    Citation: Trials 2020 21:173

    Content type: Study protocol

    Published on:

  31. After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled.

    Authors: Frank Tegtmeier, Reinhard Schinzel, Ronny Beer, Diederik Bulters, Jean-Yves LeFrant, Joan Sahuquillo, Andreas Unterberg, Peter Andrews, Antonio Belli, Javier Ibanez, Alfonso Lagares, Michael Mokry, Harald Willschke, Charlotte Flüh and Erich Schmutzhard

    Citation: Trials 2020 21:172

    Content type: Correction

    Published on:

    The original article was published in Trials 2020 21:80

  32. Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reduc...

    Authors: Ana Jessica Pinto, Tiago Peçanha, Kamila Meireles, Fabiana Braga Benatti, Karina Bonfiglioli, Ana Lúcia de Sá Pinto, Fernanda Rodrigues Lima, Rosa Maria Rodrigues Pereira, Maria Claudia Costa Irigoyen, James Edward Turner, John P. Kirwan, Neville Owen, David W. Dunstan, Hamilton Roschel and Bruno Gualano

    Citation: Trials 2020 21:171

    Content type: Study protocol

    Published on:

  33. Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks’ gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal int...

    Authors: Huiqing Sun, Yun Cao, Shuping Han, Rui Cheng, Ling Liu, Jiangqin Liu, Shiwen Xia, Jiajie Zhang, Zhankui Li, Xiuyong Cheng, Chuanzhong Yang, Xinnian Pan, Long Li, Xin Ding, Rensheng Wang, Mingyuan Wu…

    Citation: Trials 2020 21:170

    Content type: Study protocol

    Published on:

  34. Polycystic ovary syndrome (PCOS) is a complex endocrine syndrome with poorly understood mechanisms. To provide patients with PCOS with individualized therapy, it is critical to precisely diagnose the phenotype...

    Authors: Cheng-Ming Ni, Wen-Long Huang, Yan-Min Jiang, Juan Xu, Ru Duan, Yun-Long Zhu, Xu-Ping Zhu, Xue-Mei Fan, Guo-An Luo, Yi-Ming Wang, Yan-Yu Li, Qing He and Lan Xu

    Citation: Trials 2020 21:169

    Content type: Study protocol

    Published on:

  35. The treatment and management of long-term health conditions is the greatest challenge facing health systems around the world today. Innovative approaches to patient care in the community such as Anticipatory C...

    Authors: Kevin Brazil, David Scott, Emma Wallace, Mike Clarke, Tom Fahey, Patrick Gillespie, Peter O’Halloran, Christopher Cardwell, Gillian Carter, Kieran McGlade and Frank Doyle

    Citation: Trials 2020 21:168

    Content type: Study protocol

    Published on:

  36. Unemployment is highly prevalent in populations with alcohol and drug dependence and the employment support offered in addiction-treatment programmes is ineffective. Individual Placement and Support (IPS) is a...

    Authors: John Marsden, Paul Anders, Helen Clark, Kyriacos Colocassis, Brian Eastwood, Jonathan Knight, Alexandra Melaugh, David Quinn, Virginia Wright and Jez Stannard

    Citation: Trials 2020 21:167

    Content type: Study protocol

    Published on:

  37. Urgency is a complaint of sudden, compelling desire to pass urine, which is difficult to defer, caused by involuntary contraction of the detrusor muscle during the bladder-filling stage. To enable detrusor inh...

    Authors: Juliana Falcão Padilha, Mariana Arias Avila, Enio Júnior Seidel and Patricia Driusso

    Citation: Trials 2020 21:166

    Content type: Study protocol

    Published on:

  38. Prophylactic augmentation of the wound with mesh proposed by Kniepeiss et al is the world's first attempt to significantly reduce the risk of postoperative hernia in liver transplantation. Similar technique ha...

    Authors: Janusz Maciej Strzelczyk

    Citation: Trials 2020 21:165

    Content type: Letter

    Published on:

    The original article was published in Trials 2019 20:371

  39. Primary dysmenorrhoea (PDM) is defined as a series of pain-dominated symptoms during and after menstruation without organic lesions. Nonsteroidal anti-inflammatory drugs and oral contraceptives are usually rec...

    Authors: Shanshan Liu, Lezheng Wang and Jian Yang

    Citation: Trials 2020 21:164

    Content type: Study protocol

    Published on:

  40. Postoperative pain is common after nasal endoscopic surgery. It interferes with the quality of sleep and delays postoperative recovery. Acupuncture is an effective tool for pain management. However, electroacu...

    Authors: Shanshan Li, Qing Zhang, Xuan Yin, Hongyu Yue, Wei Zhang, Lixing Lao, Zhangjin Zhang, Huangan Wu and Shifen Xu

    Citation: Trials 2020 21:163

    Content type: Study protocol

    Published on:

  41. Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. Immune-enhancing enteral formula has been proven to significantly reduce infection rate in TBI patients. One of ...

    Authors: Mahsa Malekahmadi, Omid Moradi Moghaddam, Sheikh Mohammed Shariful Islam, Kiarash Tanha, Mohsen Nematy, Naseh Pahlavani, Safieh Firouzi, Mohammad Reza Zali and Abdolreza Norouzy

    Citation: Trials 2020 21:162

    Content type: Study protocol

    Published on:

  42. Impulsivity and compulsivity are related to emotional and social maladjustment and often underlie psychiatric disorders. Recently, alterations in microbiota composition have been shown to have implications for...

    Authors: Gara Arteaga-Henríquez, Silvia Karina Rosales-Ortiz, Alejandro Arias-Vásquez, Istvan Bitter, Ylva Ginsberg, Pol Ibañez-Jimenez, Tünde Kilencz, Catharina Lavebratt, Silke Matura, Andreas Reif, Janos Rethelyi, Vanesa Richarte, Nanda Rommelse, Anne Siegl and J. Antoni Ramos-Quiroga

    Citation: Trials 2020 21:161

    Content type: Study protocol

    Published on:

  43. Skin-sparing mastectomy followed by immediate implant-based breast reconstruction is a commonly used treatment for breast cancer. However, when placing the implant in a subpectoral pocket, a high incidence of ...

    Authors: Diana L. Dyrberg, Gudjon L. Gunnarsson, Camilla Bille, Jens A. Sørensen and Jørn B. Thomsen

    Citation: Trials 2020 21:160

    Content type: Study protocol

    Published on:

  44. Whether they are injected peri- or intraocularly, corticosteroids are still essential tools in the therapeutic arsenal for treating inflammatory macular oedema. A few years ago, however, only triamcinolone ace...

    Authors: Chloé Couret, Alexandra Poinas, Christelle Volteau, Valery-Pierre Riche, Marie-Laure Le Lez, Marie-Hélène Errera, Catherine Creuzot-Garcher, Stéphanie Baillif, Laurent Kodjikian, Catherine Ivan, Laurence Mathilde Le Jumeau de Kergaradec, Anne Chiffoleau, Alexandra Jobert, Julie Jaulin, Laetitia Biron, Elisabeth Hervouet…

    Citation: Trials 2020 21:159

    Content type: Study protocol

    Published on:

  45. Current treatment options for Palmoplantar Pustulosis (PPP), a debilitating chronic skin disease which affects the hands and feet, are limited. The Anakinra for Pustular psoriasis: Response in a Controlled Tri...

    Authors: Suzie Cro, Prakash Patel, Jonathan Barker, David A. Burden, Christopher E. M. Griffiths, Helen J. Lachmann, Nick J. Reynolds, Richard B. Warren, Francesca Capon, Catherine Smith and Victoria Cornelius

    Citation: Trials 2020 21:158

    Content type: Update

    Published on:

    The Study protocol to this article has been published in Trials 2018 19:465

  46. Retrospective exploratory analyses of randomised controlled trials (RCTs) seeking to identify treatment effect heterogeneity (TEH) are prone to bias and false positives. Yet the desire to learn all we can from...

    Authors: James A. Watson and Chris C. Holmes

    Citation: Trials 2020 21:156

    Content type: Methodology

    Published on:

  47. Both methotrexate (MTX) and leflunomide (LEF) are registered and regularly prescribed as first-line treatments for the use in patients with psoriatic arthritis (PsA) and they are occasionally used in combinati...

    Authors: Michelle L. M. Mulder, Johanna E. Vriezekolk, Nathan den Broeder, Elien A. M. Mahler, Philip S. Helliwell, Frank H. J. van den Hoogen, Alfons A. den Broeder and Mark H. Wenink

    Citation: Trials 2020 21:155

    Content type: Study protocol

    Published on:

  48. With 7.7 million South Africans currently infected with human immunodeficiency virus (HIV) and 4.8 million currently receiving antiretroviral treatment (ART), the epidemic represents a considerable burden for ...

    Authors: Caroline Masquillier, Lucia Knight, Linda Campbell, Neo Sematlane, Anton Delport, Tanyaradzwa Dube and Edwin Wouters

    Citation: Trials 2020 21:154

    Content type: Study protocol

    Published on:

  49. The prevalence rates of childhood obesity are increasing. The current multidisciplinary treatments for (childhood) obesity are effective but only moderately and in the short term. A possible explanation for th...

    Authors: Taaike Debeuf, Sandra Verbeken, Elisa Boelens, Brenda Volkaert, Eva Van Malderen, Nathalie Michels and Caroline Braet

    Citation: Trials 2020 21:153

    Content type: Study protocol

    Published on:

  50. Thanks to advancements in medical care, a majority of patients with sickle cell disease (SCD) worldwide live beyond 18 years of age, and therefore, patients initially followed in paediatric departments are the...

    Authors: Delphine Hoegy, Nathalie Bleyzac, Alexandra Gauthier-Vasserot, Giovanna Cannas, Angélique Denis, Arnaud Hot, Yves Bertrand, Pauline Occelli, Sandrine Touzet, Claude Dussart and Audrey Janoly-Dumenil

    Citation: Trials 2020 21:152

    Content type: Study protocol

    Published on:

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