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  1. People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is...

    Authors: Fiona E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. Smith, Katherine Lloyd, Edward W. Richfield, Danielle E. Brazier, Mícheál Ó Breasail, Agnes J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh…
    Citation: Trials 2023 24:147
  2. Postoperative cognitive dysfunction (POCD) refers to a neurological dysfunction after a major surgery and anesthesia. It is common in elderly patients and is characterized by impairment in consciousness, orien...

    Authors: Xiaoyi Zhang, Yuwen Chen, Ying Tang, Yizhe Zhang, Xiao Zhang and Diansan Su
    Citation: Trials 2023 24:146
  3. The seemingly simple tasks of standing and walking require continuous integration of complex spinal reflex circuits between descending motor commands and ascending sensory inputs. Spinal cord injury greatly im...

    Authors: Andreas Skiadopoulos, Grace O. Famodimu, Shammah K. Solomon, Parul Agarwal, Noam Y. Harel and Maria Knikou
    Citation: Trials 2023 24:145
  4. Perioperative pain management is one of the most challenging issues for patients with spinal neoplasms. Inadequate postoperative analgesia usually leads to severe postsurgical pain, which could cause patients ...

    Authors: Wanchen Sun, Juan Wang, Jing Wang, Jingyi Fan, Yang Zhou, Yunzhen Wang and Ruquan Han
    Citation: Trials 2023 24:144
  5. To explore the effects of Ving Tsun (VT) sticking-hand training on knee joint proprioception and leg muscular performance among community-dwelling middle-aged and older adults.

    Authors: Shirley S. M. Fong, Louisa M. Y. Chung, Timothy T. T. Yam, Joanne W. Y. Chung, Young-Hyeon Bae, Yang Gao, Jessie S. M. Chan and Hsing-Kuo Wang
    Citation: Trials 2023 24:143
  6. In parallel to the traditional symptomatology, deficits in cognition (memory, attention, reasoning, social functioning) contribute significantly to disability and suffering in individuals with schizophrenia. C...

    Authors: Clément Dondé, Julien Bastin, Arnaud Pouchon, Nicolas Costes, Eric Fakra, Filipe Galvão, Aurélia Gay, Frédéric Haesebaert, Laurent Lamalle, Inès Mérida, Maxence Rigon, Fabien Schneider, Irène Troprès, Jérôme Brunelin and Mircea Polosan
    Citation: Trials 2023 24:141
  7. Haemorrhoids are common and frequently occurring diseases in the clinical setting, and severe haemorrhoids require surgical treatment. There are various surgical methods to treat haemorrhoids, but each has adv...

    Authors: Keqiang Yu, Haijun Li, Ping Xue, Zhidi Xie, Minghui Tang, Hongbo He and Jing Wu
    Citation: Trials 2023 24:140
  8. Periodontal disease and lung function impairment were found to be associated with low-grade systemic or local inflammation, and it might be that gingival/periodontal inflammation triggers lung function due to ...

    Authors: Jan Kühnisch, Tianyu Zhao, Randi J. Bertelsen, Rudolf A. Jörres, Dennis Nowak and Joachim Heinrich
    Citation: Trials 2023 24:139
  9. Child maltreatment (CM) is a pervasive public health problem and there is a critical need for brief, effective, scalable prevention programs. Problematic parent-child relationships lie at the heart of CM. Pare...

    Authors: Samantha Schilling, Byron J. Powell, Paul W. Stewart and Joanne N. Wood
    Citation: Trials 2023 24:138
  10. The OPTIMIZE trial is a multi-site, comparative effectiveness research (CER) study that uses a Sequential Multiple Assessment Randomized Trial (SMART) designed to examine the effectiveness of complex health in...

    Authors: Julie M. Fritz, Tom Greene, Gerard P. Brennan, Kate Minick, Elizabeth Lane, Stephen T. Wegener and Richard L. Skolasky
    Citation: Trials 2023 24:137

    The Study protocol to this article has been published in BMC Musculoskeletal Disorders 2020 21:293

  11. Adults with intellectual disabilities have a higher prevalence of unhealthy eating habits, stress, low levels of mobility, and comparable drug consumption as the general population. Consequently, they suffer f...

    Authors: Stephan Nadolny, Dirk Bruland, Marie Grunwald, Annika Gröndahl, Jessica Grammatico, Miriam Tariba Richter, Christian Grebe and Änne-Dörte Latteck
    Citation: Trials 2023 24:136
  12. Induction of labour (IOL) at 39 weeks has been shown to decrease maternal and neonatal adverse outcomes. Given the growing demand for 39-week IOL, it is imperative that effective methods be assessed for induct...

    Authors: Sarah M. Nicholson, Orla Smith, Susan Hatt, Zara Molphy, Patrick Dicker, Karen Flood and Fergal Malone
    Citation: Trials 2023 24:135
  13. Breast cancer (BC) is the most common invasive cancer in women, and exercise can significantly improve the outcomes of BC survivors. MoviS (Movement and Health Beyond Care) is a randomized controlled trial aim...

    Authors: Valentina Natalucci, Carlo Ferri Marini, Mauro De Santi, Giosuè Annibalini, Francesco Lucertini, Luciana Vallorani, Andrea Rocco Panico, Davide Sisti, Roberta Saltarelli, Sabrina Donati Zeppa, Deborah Agostini, Marco Gervasi, Giulia Baldelli, Eugenio Grassi, Alessandra Nart, Massimo Rossato…
    Citation: Trials 2023 24:134
  14. Healthcare-associated infections (HAIs) are a common, costly, yet largely preventable complication impacting patients in healthcare settings globally. Improving routine cleaning and disinfection of the hospita...

    Authors: Katrina Browne, Nicole White, Peta Tehan, Philip L Russo, Maham Amin, Andrew J. Stewardson, Allen C. Cheng, Kirsty Graham, Gabrielle O’Kane, Jennie King, Martin Kiernan, David Brain and Brett G. Mitchell
    Citation: Trials 2023 24:133
  15. Deep inspiration breath hold (DIBH) reduces radiotherapy cardiac dose for left-sided breast cancer patients. The primary aim of the BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Hear...

    Authors: Hilary L. Byrne, Elisabeth Steiner, Jeremy Booth, Gillian Lamoury, Marita Morgia, Kylie Richardson, Leigh Ambrose, Kuldeep Makhija, Cameron Stanton, Benjamin Zwan, Regina Bromley, John Atyeo, Shona Silvester, Natalie Plant and Paul Keall
    Citation: Trials 2023 24:132
  16. Too little sleep and the consequences thereof are a heavy burden in modern societies. In contrast to alcohol or illicit drug use, there are no quick roadside or workplace tests for objective biomarkers for sle...

    Authors: Michael Scholz, Stefan Lakaemper, Kristina Keller, Akos Dobay, Andrea Eva Steuer, Hans-Peter Landolt and Thomas Kraemer
    Citation: Trials 2023 24:131
  17. Cleansing of the vulva and perineum is recommended during preparation for vaginal delivery, and special attention is paid to cleansing before episiotomy because episiotomy is known to increase the risk of peri...

    Authors: Young Mi Jung, Seung Mi Lee, So Yeon Kim, Jin Hoon Chung, Hye-Sung Won, Kyung A Lee, Mi Hye Park, Geum Joon Cho, Min-Jeong Oh, Eun Saem Choi, Ki Hoon Ahn, Soon-Cheol Hong, Ji-Hee Sung, Cheong-Rae Roh, Sun Min Kim, Byoung Jae Kim…
    Citation: Trials 2023 24:130
  18. N-acetylcysteine (NAC) has broadly been used as an anti-oxidant agent in various types of diseases. This study aimed to assess the effect of NAC on the systemic lupus erythematosus (SLE) disease activity and o...

    Authors: Mitra Abbasifard, Hossein Khorramdelazad, Abdolrahman Rostamian, Mohsen Rezaian, Pooya Saeed Askari, Gholamhosein Taghipur Khajeh Sharifi, Moein Kardoust Parizi, Mobina Taghipour Khajeh Sharifi and Seyed Reza Najafizadeh
    Citation: Trials 2023 24:129
  19. Residual malaria transmission is the result of adaptive mosquito behavior that allows malaria vectors to thrive and sustain transmission in the presence of good access to bed nets or insecticide residual spray...

    Authors: Carlos Chaccour, Aina Casellas, Felix Hammann, Paula Ruiz-Castillo, Patricia Nicolas, Julia Montaña, Mary Mael, Prashant Selvaraj, Urs Duthaler, Sigilbert Mrema, Mwaka Kakolwa, Issa Lyimo, Fredros Okumu, Achla Marathe, Roger Schürch, Eldo Elobolobo…
    Citation: Trials 2023 24:128
  20. Enrolment is one of the most challenging aspects of conducting clinical trials, preceded by the process of informed consent (IC). Different strategies to improve recruitment in clinical trials have been used, ...

    Authors: Ana Teresita Mazzochi, Martin Dennis and Ho-Yan Yvonne Chun
    Citation: Trials 2023 24:127
  21. Sexual assault and rape are the traumatic life events with the highest probability for posttraumatic stress disorder (PTSD), which can have devastating consequences for those afflicted by the condition. Studie...

    Authors: Tina Haugen, Joar Øveraas Halvorsen, Oddgeir Friborg, Melanie Rae Simpson, Paul Jarle Mork, Gustav Mikkelsen, Ask Elklit, Barbara O. Rothbaum, Berit Schei and Cecilie Hagemann
    Citation: Trials 2023 24:126
  22. The efficacy of interventions based on mindfulness and compassion has been demonstrated in both clinical and general population, and in different social contexts. These interventions include so-called attentio...

    Authors: Javier García-Campayo, Rinchen Hijar-Aguinaga, Yolanda López-Del-Hoyo, Rosa Magallón-Botaya, Selene Fernández-Martínez, Alberto Barceló-Soler, Joaquim Soler-Ribaudi and Jesus Montero-Marin
    Citation: Trials 2023 24:125
  23. Post-stroke gait deviations contribute to significant functional disability, impaired walking ability and poor quality of life. Prior studies suggest that gait training with paretic lower limb loading may impr...

    Authors: Abdulhamid U. Maje and Aminu A. Ibrahim
    Citation: Trials 2023 24:124
  24. The present study aimed to determine the impact of vitamin D supplementation (VDs) on recovery delay among COVID-19 patients.

    Authors: Hela Abroug, Amani Maatouk, Cyrine Bennasrallah, Wafa Dhouib, Manel Ben Fredj, Imen Zemni, Meriem Kacem, Salma Mhalla, Sarra Nouira, Manel Ben Belgacem, Aymen Nasri, Rim Klii, Chawki Loussaief, Nissaf Ben Alya, Ines Bouanene and Asma Belguith Sriha
    Citation: Trials 2023 24:123
  25. New patient-centered models of care are needed to individualize care and reduce high-cost care, including emergency department (ED) visits and hospitalizations for low- and intermediate-acuity conditions that ...

    Authors: Jennifer L. Ridgeway, Erin O. Wissler Gerdes, Andrew Dodge, Chad P. Liedl, Michael B. Juntunen, Wendy J. S. Sundt, Amy Glasgow, Michelle A. Lampman, Angela L. Fink, Sara B. Severson, Grace Lin, Richard R. Sampson, Robert P. Peterson, Brian M. Murley, Aaron B. Klassen, Anuradha Luke…
    Citation: Trials 2023 24:122
  26. Authors: F. L. Vissers, A. Balduzzi, E. A. van Bodegraven, J. van Hilst, S. Festen, M. Abu Hilal, H. J. Asbun, J. S. D. Mieog, B. Groot Koerkamp, O. R. Busch, F. Daams, M. Luyer, M. De Pastena, G. Malleo, G. Marchegiani, J. Klaase…
    Citation: Trials 2023 24:121

    The original article was published in Trials 2022 23:809

  27. Integrating information on bodily functions, pain intensity and quality of life into one composite measure of a holistic responder has recently been proposed as a useful method to evaluate treatment efficacy o...

    Authors: Lisa Goudman, Koen Putman, Leen Van Doorslaer, Maxime Billot, Manuel Roulaud, Philippe Rigoard and Maarten Moens
    Citation: Trials 2023 24:120
  28. Peer support is effective in improving psychological well-being of family caregivers of people with conditions such as dementia, cancer, and brain injury. However, there are limited data on effective psycholog...

    Authors: Louise Rose, Thilipan Thaventhiran, Esther Hobson, Rebecca Rogers, Kirsty James, Petrina Chu, Ben Carter, Christina Faull, Sian Saha, Jeong Su Lee, Georgios Kaltsakas, Christopher McDermott and Michelle Ramsay
    Citation: Trials 2023 24:119
  29. Dental caries is one of the most common diseases affecting children world widely as well as in the Kingdom of Saudi Arabia. Supervised tooth brushing programs are implemented throughout the world to provide yo...

    Authors: Haya Alayadi, Areej Alsiwat, Haifa AlAkeel, Munirah Alaskar, Maram Alwadi and Wael Sabbah
    Citation: Trials 2023 24:118
  30. Few studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected residual implants. We perform two similar randomized-clinical trials (RCT) t...

    Authors: Ilker Uçkay, Stephan Wirth, Björn Zörner, Sandro Fucentese, Karl Wieser, Andreas Schweizer, Daniel Müller, Patrick Zingg and Mazda Farshad
    Citation: Trials 2023 24:117
  31. Regular exercise has been shown to have beneficial health effects in cancer survivors, including improving quality of life and other important health outcomes. However, providing people with cancer with easily...

    Authors: Melissa Kotte, Kate A. Bolam, Sara Mijwel, Renske Altena, Prue Cormie and Yvonne Wengström
    Citation: Trials 2023 24:116
  32. Mindfulness-based interventions have been shown to improve psychological outcomes including stress, anxiety, and depression in general population studies. However, effectiveness has not been sufficiently exami...

    Authors: Inger Burnett-Zeigler, Elayne Zhou, Jennifer H. Martinez, Katelyn Zumpf, Lynette Lartey, Judith T. Moskowitz, Katherine L. Wisner, Thomas McDade, C. Hendricks Brown, Jacqueline Gollan, Jody D. Ciolino, Jacob M. Schauer and Lucia C. Petito
    Citation: Trials 2023 24:115
  33. A healthy lifestyle is indispensable for the prevention of noncommunicable diseases. However, lifestyle medicine is hampered by time constraints and competing priorities of treating physicians. A dedicated lif...

    Authors: Marlinde L. van Dijk, Leonie M. te Loo, Joyce Vrijsen, Inge van den Akker-Scheek, Sanne Westerveld, Marjan Annema, André van Beek, Jip van den Berg, Alexander L. Boerboom, Adrie Bouma, Martine de Bruijne, Jeroen Crasborn, Johanna M. van Dongen, Anouk Driessen, Karin Eijkelenkamp, Nies Goelema…
    Citation: Trials 2023 24:114
  34. Among all racial/ethnic groups, people who identify as African American/Blacks have the second highest colorectal cancer (CRC) incidence in the USA. This disparity may exist because African American/Blacks, co...

    Authors: Andrew McLeod, Patricia Wolf, Robert S. Chapkin, Laurie A. Davidson, Ivan Ivanov, Michael Berbaum, Lauren R. Williams, H. Rex Gaskins, Jason Ridlon, Jen Sanchez-Flack, Lara Blumstein, Linda Schiffer, Alyshia Hamm, Kate Cares, Mirjana Antonic, Beatriz Penalver Bernabe…
    Citation: Trials 2023 24:113
  35. Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease involving multiple organ systems. The Janus kinase/signal transduction and activator of transcription (JAK/STAT) signaling pathway is a key pat...

    Authors: Wei Bai, Fan Yang, Huji Xu, Wei Wei, Hongbin Li, Liyun Zhang, Yi Zhao, Xiaofei Shi, Yan Zhang, Xiaofeng Zeng and Xiaomei Leng
    Citation: Trials 2023 24:112
  36. Authors: Stefan J. Schaller, Jörn Kiselev, Verena Loidl, Wilm Quentin, Katrin Schmidt, Rudolf Mörgeli, Tanja Rombey, Reinhard Busse, Ulrich Mansmann and Claudia Spies
    Citation: Trials 2023 24:111

    The original article was published in Trials 2022 23:468

  37. This study aimed to assess the different impacts of aerobic and resistance exercise intervention on pre-diabetes and its possible influencing factor (obesity) to identify which exercise intervention mode was b...

    Authors: Xijuan Luo, Zhengzhen Wang, Bowen Li, Xianbo Zhang and Xin Li
    Citation: Trials 2023 24:110
  38. Appropriate positioning is crucial to successful breastfeeding and its continuation. Positioning can create, prevent, or correct breastfeeding problems. This study aimed to determine and compare the effects of...

    Authors: Asefe Bashiri, Leila Amiri-Farahani, Hamid Salehiniya and Sally Pezaro
    Citation: Trials 2023 24:109
  39. Authors: Regina Wing Shan Sit, Ricky Wing Keung Wu, Samuel Ka Kin Ling, Bo Wang, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Samuel Yeung Shan Wong, Kenneth Dean Reeves and David Rabago
    Citation: Trials 2023 24:108

    The original article was published in Trials 2022 23:1063

  40. Adjustment for baseline prognostic factors in randomized clinical trials is usually performed by means of sample-based regression models. Sample-based models may be incorrect due to overfitting. To assess whet...

    Authors: Thomas Perneger, Christophe Combescure and Antoine Poncet
    Citation: Trials 2023 24:107
  41. Cervical spondylotic myelopathy (CSM) is the predominant cause of spinal cord dysfunction in the elderly. The patients are often frail and susceptible to complications. Posterior surgical techniques involving ...

    Authors: Anna MacDowall, Håkan Löfgren, Erik Edström, Helena Brisby, Catharina Parai and Adrian Elmi-Terander
    Citation: Trials 2023 24:106
  42. Although most cancers are sporadic, germline genetic variants are implicated in 5–10% of cancer cases. Clinical genetic testing identifies pathogenic germline genetic variants for hereditary cancers. The Michi...

    Authors: Lynette Hammond Gerido, Jennifer J. Griggs, Ken Resnicow, Kelley M. Kidwell, Emerson Delacroix, Sarah Austin, Erika N. Hanson, Elizabeth Bacon, Erika Koeppe, Stefanie Goodall, Matthew Demerath, Elizabeth A. Rizzo, Shayna Weiner, Sarah T. Hawley, Wendy R. Uhlmann, J. Scott Roberts…
    Citation: Trials 2023 24:105
  43. Specific blends of essential amino acids (EAA) containing a high percentage of branched-chain amino acids preserves mitochondrial metabolism and higher physical resistance in elderly mice, increasing their sur...

    Authors: Riccardo Dalle Grave, Simona Calugi, Chiara Ruocco, Mirko Chimini, Agnese Segala, Maurizio Ragni, Michele Carruba, Alessandra Valerio and Enzo Nisoli
    Citation: Trials 2023 24:104
  44. Taiwan has a high national caesarean rate coupled with a low vaginal birth after caesarean (VBAC) rate. This study aims to develop and evaluate a web-based decision-aid with communication support tools, to inc...

    Authors: Shu Wen Chen, Allison Shorten, Chang Ching Yeh, Chien Huei Kao, Yu Ying Lu and Hsiang Wei Hu
    Citation: Trials 2023 24:103
  45. The majority of surgical interventions are performed in day care and patients are discharged after the first critical postoperative period. At home, patients have limited options to contact healthcare provider...

    Authors: B. Thiel, M. B. Godfried, M. E. van Emst, L. M. Vernooij, L. M. van Vliet, E. Rumke, R. T. M. van Dongen, W. Gerrits, J. S. H. A. Koopman and C. J. Kalkman
    Citation: Trials 2023 24:102
  46. Falling and gait difficulties in people with Parkinson’s disease (PD) are associated with impaired reactive postural adjustments and impairments in attentional resources. Combined intensive balance motor and c...

    Authors: Josefa Domingos, John Dean, Júlio B. Fernandes, Catarina Ramos, Miguel Grunho, Luís Proença, João R. Vaz and Catarina Godinho
    Citation: Trials 2023 24:101
  47. The effectiveness of biologic therapies, primarily tumor necrosis factor inhibitors (TNFi), for children with spondyloarthritis (SpA) has made inactive disease a realistic patient outcome. However, biologic th...

    Authors: Pamela F. Weiss, Cora E. Sears, Timothy G. Brandon, Christopher B. Forrest, Emily Neu, Melanie Kohlheim, Jenny Leal, Rui Xiao and Daniel Lovell
    Citation: Trials 2023 24:100
  48. Clinical trials commonly use multiple endpoints to measure the impact of an intervention. While this improves the comprehensiveness of outcomes, it can make trial results difficult to interpret. We examined th...

    Authors: Rebecca K. Metcalfe, Mark Harrison, Joel Singer, Mary Lewisch, Terry Lee, Peter von Dadelszen, Laura A. Magee and Nick Bansback
    Citation: Trials 2023 24:99
  49. Authors: Enya Daynes, Molly Baldwin, Neil J. Greening, Thomas Yates, Nicolette C. Bishop, George Mills, Matthew Roberts, Malik Hamrouni, Tatiana Plekhanova, Ioannis Vogiatzis, Carlos Echevarria, Rashmita Nathu, Hamish J. C. McAuley, Lorna Latimer, Jennifer Glennie, Francesca Chambers…
    Citation: Trials 2023 24:98

    The original article was published in Trials 2023 24:61

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