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  1. The management of small gastric submucosal tumors (SMTs) originating from the muscularis propria layer (SMT-MPs) remains a subject of debate. Endoscopic submucosal dissection (ESD) is currently considered the ...

    Authors: Mingfeng Liu, Rui Yuan, Ke Zhan, Yichun Yang, Shan Li and Liang Deng
    Citation: Trials 2024 25:49
  2. Patients with hematological malignancies received multiple hypodermic injections of recombinant human granulocyte colony-stimulating factor. Procedural pain is one of the most common iatrogenic causes of pain ...

    Authors: Jun-Jun Zhang, Ping Yu, Hui Dang, Cheng-Shuang Feng, Xiu-Jiang Long, Wen-Fa Huang, Lei Wang, Jie-Ling Li, Guo-Liang Tian, Jia-Quan Wen, Jun-Hui Mei and Yu-Xiang Li
    Citation: Trials 2024 25:47
  3. Children in Malawi face high rates of malnutrition and are at risk of not reaching their developmental potential. Community-based childcare centres (CBCCs) can be cost-effective platforms for scaling-up early ...

    Authors:
    Citation: Trials 2024 25:46
  4. Anhedonia, which is defined as the inability to feel pleasure, is considered a core symptom of major depressive disorder (MDD). It can lead to several adverse outcomes in adolescents, including heightened dise...

    Authors: Runxin Lv, Min Cai, Nailong Tang, Yifan Shi, Yuyu Zhang, Nian Liu, Tianle Han, Yaochi Zhang and Huaning Wang
    Citation: Trials 2024 25:44
  5. Patients with obsessive–compulsive disorder (OCD) suffer from repetitive fearful intrusions which they try to neutralize by performing compulsions. OCD is considered to be the most resistant anxiety disorder w...

    Authors: Elena Hoogerwerf, Anja Greeven, Rutger Goekoop and Philip Spinhoven
    Citation: Trials 2024 25:43
  6. Mandibular distraction osteogenesis (MDO) is a major part of the treatment for hemifacial microsomia patients. Due to the narrow surgical field of the intraoral approach, osteotomy accuracy is highly dependent...

    Authors: Xiangqi Liu, Ziwei Zhang, Wenqing Han, Zhijie Zhao, Byeong Seop Kim, Yingjie Yan, Xiaojun Chen, Xuetong Wang, Xin Li, Xianxian Yang, Bingshun Wang, Haisong Xu, Li Lin and Gang Chai
    Citation: Trials 2024 25:42
  7. Early palliative/pre-emptive intervention improves clinical outcomes and quality of life for patients with metastatic cancer. A previous signal-seeking randomized controlled trial (RCT) demonstrated that early...

    Authors: Robert J. Rothrock, Ahmad Ozair, Maria C. Avendano, Susana Herrera, Haley Appel, Suyen Ramos, Amy K. Starosciak, Daniel S. Leon-Ariza, Muni Rubens, Michael W. McDermott, Manmeet S. Ahluwalia, Minesh P. Mehta and Rupesh R. Kotecha
    Citation: Trials 2024 25:41
  8. A growing body of literature indicates that adolescent girls who talk with close friends about interpersonal problems or worries in an excessive, speculative way, and with an intense focus on distress (i.e., co-r...

    Authors: Patricia Vuijk, Kim Bul, Marieke Buil, Marloes Rauws, Keshia Curie, Charlotte Amesz, Ron Weerheijm and Heleen Riper
    Citation: Trials 2024 25:40
  9. In February 2021, the UK Department of Health and Social Care sought evidence on the safety and immunogenicity of COVID-19 and influenza vaccine co-administration to inform the 2021/2022 influenza vaccine poli...

    Authors: Sarah Baos, Rachel Todd, Russell Thirard, Rosie Harris, Jana Kirwan, Katherine Joyce, David Hutton, Adam Finn, Madeleine Clout, Heike Cappel-Porter, Chris A Rogers, Rajeka Lazarus and Lucy Culliford
    Citation: Trials 2024 25:39
  10. Adequately selecting the initial follicle-stimulating hormone (FSH) dose during controlled ovarian stimulation (COS) is key for success in assisted reproduction. The objective of COS is to obtain an optimal nu...

    Authors: Nuria Correa, Jesus Cerquides, Josep Lluis Arcos, Rita Vassena and Mina Popovic
    Citation: Trials 2024 25:38
  11. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to manage anxiety in adults with an autism diagnosis. However, their effectiveness and adverse effect profile in the autistic population ...

    Authors: Dheeraj Rai, Doug Webb, Amanda Lewis, Leonora Cotton, Jade Eloise Norris, Regi Alexander, David S. Baldwin, Traolach Brugha, Madeleine Cochrane, Maria Chiara Del Piccolo, Emma J. Glasson, Katherine K. Hatch, David Kessler, Peter E. Langdon, Helen Leonard, Stephanie J. MacNeill…
    Citation: Trials 2024 25:37
  12. Authors: Annie O’Brien, Suzanne Hamilton, Neil Humphrey, Pamela Qualter, Jan R. Boehnke, Joao Santos, Ola Demkowicz, Margarita Panayiotou, Alex Thompson, Jennifer Lau, Lauren Burke and Yizhuo Lu
    Citation: Trials 2024 25:36

    The original article was published in Trials 2023 24:703

  13. In-stent reocclusion after endovascular therapy has a negative impact on outcomes in acute ischemic stroke (AIS) due to tandem lesions (TL). Optimal antiplatelet therapy approach in these patients to avoid in-...

    Authors: Elena Zapata-Arriaza, Manuel Medina-Rodríguez, Francisco Moniche Álvarez, Asier de Albóniga-Chindurza, Marta Aguilar-Pérez, Leire Ainz-Gómez, Pablo Baena-Palomino, Aynara Zamora, Blanca Pardo-Galiana, Fernando Delgado-Acosta, Roberto Valverde Moyano, Elvira Jiménez-Gómez, Isabel Bravo Rey, Rafael Oteros Fernández, Irene Escudero-Martínez, Isabel Vielba-Gomez…
    Citation: Trials 2024 25:35
  14. Stroke is one of the leading causes of death in the USA and is a major cause of serious disability for adults. This randomized crossover study examines the effect of targeted high-definition transcranial direc...

    Authors: Rita Huan-Ting Peng, Dorothy He, Shirley A. James, Jordan N. Williamson, Carly Skadden, Sanjiv Jain, Wael Hassaneen, Amrendra Miranpuri, Amandeep Kaur, Jesus N. Sarol and Yuan Yang
    Citation: Trials 2024 25:34
  15. Patients undergoing carotid endarterectomy (CEA) have a high restenosis rate, which increases the risk of stroke, and there is still a lack of effective treatment for restenosis. The cause of stenosis is relat...

    Authors: Zhi Zhang, Xiang Ji, Yihao Tao, Ning Huang, Rong Wen, Jun Tang, Yuan Cheng, Zongyi Xie, Guodong Liu and Guanjian Zhao
    Citation: Trials 2024 25:33
  16. Research on intermittent fasting has shown that it can improve a variety of health outcomes, including blood sugar control, blood lipid levels and blood pressure. Only few studies document longer periods of fa...

    Authors: Claudia Pieper, Florian Tim Hitesh Kaistha, Sarah Schroeer, Maria Borgert, Andreas Michalsen and Wolfgang Mayer-Berger
    Citation: Trials 2024 25:32
  17. The spleen plays a significant role in the clearance of circulating microorganisms. Sequelae of splenectomy, especially immunodeficiency, can have a deleterious effect on a patient’s health and even lead to de...

    Authors: Mohammed Abu Hilal, Christoph Kuemmerli, Jasper P. Sijberden, Alma Moekotte, Giuseppe Zimmitti, Adnan Alseidi, Horacio J. Asbun, Ravi Marudanayagam, Morgan Bonds, Filipe Kunzler, Robert Sutcliffe, Efrem Eren, John N. Primrose and Anthony P. Williams
    Citation: Trials 2024 25:31
  18. Admission criteria that treat children with low mid-upper-arm circumference (MUAC), and low weight-for-height z-score (WHZ) are not aligned with the evidence on which children are at risk of mortality. An analysi...

    Authors: Suvi T. Kangas, Césaire T. Ouédraogo, Moctar Tounkara, Bareye Ouoluoguem, Issa Niamanto Coulibaly, Alhousseyni Haidara, Niele Hawa Diarra, Koniba Diassana, Zachary Tausanovitch, Christian Ritz, Jonathan C. Wells, André Briend, Mark Myatt, Elizabeth Radin and Jeanette Bailey
    Citation: Trials 2024 25:30
  19. This protocol paper presents an updated statistical analysis plan of the protocol of a randomised controlled trial. The randomised controlled trial investigates the effect of integrating smoking cessation inte...

    Authors: Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Jan Tore Daltveit, Jørn Henrik Vold, Einar Furulund, Torgeir Gilje Lid and Lars Thore Fadnes
    Citation: Trials 2024 25:29

    The Study protocol to this article has been published in Trials 2022 23:663

  20. Globally, women with disabilities are less likely to have access to family planning services compared to their peers without disabilities. However, evidence of effective interventions for promoting their sexua...

    Authors: Sarah Marks, Ekundayo Arogundade, Mark T. Carew, Shanquan Chen, Lena Morgon Banks, Hannah Kuper, Femi Adegoke and Calum Davey
    Citation: Trials 2024 25:28
  21. The gliding surface of total knee endoprostheses is exposed to high loads due to patient weight and activity. These implant components are typically manufactured from ultra-high molecular weight polyethylene (...

    Authors: Kristin Maier, Marius Selig, Andréa Haddouche, Martin Haunschild, Oliver Hauschild, Iman Khalili, Julia Kirschberg, Christoph Lutter, Michael Menges, Patrice Mertl, Andreas Niemeier, Brice Rubens-Duval and Wolfram Mittelmeier
    Citation: Trials 2024 25:27
  22. Motivation and a therapeutic alliance are crucial for successful therapy. It is assumed that dogs can increase motivation and help support therapeutic relationships. This is one of the reasons for including do...

    Authors: Wanda Arnskötter, Suzanne Martin, Susanne Walitza and Karin Hediger
    Citation: Trials 2024 25:26
  23. Entecavir and tenofovir disoproxil fumarate (TDF) are standard first-line treatments to prevent viral reactivation and hepatocellular carcinoma (HCC) in individuals chronically infected with the hepatitis B vi...

    Authors: Li-Xin Pan, Yi-Yang Wang, Zhong-Hai Li, Jia-Xi Luo, Kun-Jun Wu, Zhen-Xiu Liu, Pei-Sheng Wu, Kang Chen, Liang Ma, Xiao-Hui Fan and Jian-Hong Zhong
    Citation: Trials 2024 25:25
  24. Tussis, which increases the incidence of airway spasm, aspiration, nausea, and vomiting, is a common complication faced during upper gastrointestinal (GI) endoscopy. However, sedatives and analgesics exhibit i...

    Authors: Hai-jun Hou, Lu Liu, Ming Tian and Fu-shan Xue
    Citation: Trials 2024 25:24
  25. Attention-deficit hyperactivity disorder (ADHD) is characterized by difficulty paying attention, poor impulse control, and hyperactive behavior. It is associated with several adverse health and social outcomes...

    Authors: Stéphanie Baggio, Joël Billieux, Anja Dirkzwager, Katia Iglesias, Karine Moschetti, Nader Perroud, Marie Schneider, Nathalie Vernaz, Hans Wolff and Patrick Heller
    Citation: Trials 2024 25:23
  26. The main contributors to death and disability from chronic illnesses in developing nations are elevated blood pressure (hypertension), blood sugar (diabetes mellitus), and blood cholesterol (dyslipidaemia). Ev...

    Authors: Priyamadhaba Behera, Binod Kumar Patro, Arvind Kumar Singh, Susmita Dora, Debapriya Bandhopadhyay, Gautom Kumar Saharia, Anupam Dey, Surama Manjari Behera and Sonu H. Subba
    Citation: Trials 2024 25:22
  27. Breast cancer is the most common cancer in women. Radiotherapy is an important part of breast cancer treatment after surgery. Breast cancer radiotherapy is usually delivered in 3–5 weeks. This is a long durati...

    Authors: Budhi Singh Yadav, Divya Dahiya, P. Kannan, Shikha Goyal, Ishita Laroiya, Santhosh Irrinki, Ngangom Robert Singh and Reena Sharma
    Citation: Trials 2024 25:21
  28. The prolonged air leak is probably the most common complication following lung resections. Around 10–20% of the patients who undergo a lung resection will eventually develop a prolonged air leak. The definitio...

    Authors: Ioannis Karampinis, Christian Ruckes, Fabian Doerr, Servet Bölükbas, Sara Ricciardi, Giuseppe Cardillo, Carlos Galvez, Bogdan Vidmar, Tomaz Stupnik, Vincent Fang, Rene Horsleben Petersen and Eric Dominic Roessner
    Citation: Trials 2024 25:20
  29. Intraoperative hypoxemia and postoperative pulmonary complications (PPCs) often occur in patients with one-lung ventilation (OLV), due to both pulmonary shunt and atelectasis. It has been demonstrated that ind...

    Authors: Xu-Ming Liu, Xin-Lu Chang, Jing-Yi Sun, Wen-Wen Hao and Li-Xin An
    Citation: Trials 2024 25:19
  30. Authors: Alexandra Burton, Penny Rapaport, Marina Palomo, Kathryn Lord, Jessica Budgett, Julie Barber, Rachael Hunter, Laurie Butler, Victoria Vickerstaff, Kenneth Rockwood, Margaret Ogden, Debs Smith, Iain Lang, Gill Livingston, Briony Dow, Helen Kales…
    Citation: Trials 2024 25:18

    The original article was published in Trials 2021 22:865

  31. Beyond a certain threshold diameter, abdominal aortic aneurysms (AAA) are to be treated by open surgical or endovascular aortic aneurysm repair (EVAR). In a quarter of patients who undergo EVAR, inversion of b...

    Authors: Christoph Knappich, Felix Kirchhoff, Marie-Kristin Fritsche, Silvia Egert-Schwender, Heiko Wendorff, Michael Kallmayer, Bernhard Haller, Alexander Hyhlik-Duerr, Christian Reeps, Hans-Henning Eckstein and Matthias Trenner
    Citation: Trials 2024 25:17
  32. Polycystic ovary syndrome (PCOS), an incidence of 10–15% in women of reproductive age, shows sex hormone disorders, luteal insufficiency, and the tendency of placental villus space thrombus. The incidence of e...

    Authors: Ou Huang, Haixia Ding, Dandan Wu, Qing Zhang and Wen Li
    Citation: Trials 2024 25:16
  33. The problem of suicide has become increasingly common in individuals with major depressive disorder (MDD). Transcranial direct current stimulation (tDCS) is an effective treatment for MDD with 2 milliamperes (...

    Authors: Yiming Chen, Dongbin Lyu, Fan Wang, Qinte Huang, Weichieh Yang, Mengke Zhang, Zheyi Wei, Shuxiang Shi, Shuqi Kong, Shentse Chen, Shuang He, Vivien Yang, Yiru Fang, Abdel Douiri and Wu Hong
    Citation: Trials 2024 25:15
  34. Primary aldosteronism (P.A.) is the most common form of secondary hypertension, accounting for 5% of hypertensive patients and 17–23% of patients with resistant hypertension. Compared to primary hypertension, ...

    Authors: Minzhi He, Yuhao Zhang, Xiaoxiao Song, Tianyue Zhang, Hailan Yu, Yongli Ji, Siyuan Gong, Peifei Chai, Jinyi Chen, Siwei Wang, Bing Chen, Xiaohong Xu and Zhenjie Liu
    Citation: Trials 2024 25:14
  35. Refugee populations have an increased risk for mental disorders, such as depression, anxiety, and posttraumatic stress disorders. Comorbidity is common. At the same time, refugees face multiple barriers to acc...

    Authors: Johanna Boettcher, Manuel Heinrich, Maria Boettche, Sebastian Burchert, Heide Glaesmer, Euphrosyne Gouzoulis-Mayfrank, Carina Heeke, Martina Hernek, Christine Knaevelsrud, Alexander Konnopka, Louisa Muntendorf, Hannah Nilles, Laura Nohr, Steffi Pohl, Sophia Paskuy, Isabelle Reinhardt…
    Citation: Trials 2024 25:13
  36. Keloid is a skin disorder that results from excessive fibrous tissue growth in the area of the initial trauma. Treating keloids can be challenging since the success of various treatments varies from one study ...

    Authors: Yuni Eka Anggraini, Niken Trisnowati, Ronny Martien and Retno Danarti
    Citation: Trials 2024 25:12
  37. Establishment of effective evidence-based interventions in rehabilitation of working memory (WM) deficits after acquired brain injury (ABI) is sorely needed. Despite robust evidence for the efficiency of clini...

    Authors: Line Sophie Eide, Per-Ola Rike, Silje Endresen Reme, Hildegun Snekkevik, Stephan Rossner, Gunnar Rosen, Jonas Kristoffer Lindeløv and Marianne Løvstad
    Citation: Trials 2024 25:11
  38. Laparoscopic nephrectomy is a commonly utilized surgical approach for the management of renal cancer. Despite its widespread acceptance, postoperative pain management remains a significant challenge for many p...

    Authors: Ming Yang, Lei Cao, Tong Lu, Cheng Xiao, Zhuoxi Wu, Xuetao Jiang, Wei Wang and Hong Li
    Citation: Trials 2024 25:10
  39. Frailty is common in older age and is characterised by loss of biological reserves across multiple organ systems. These changes associated with frailty mean older people can be vulnerable to sudden, dramatic c...

    Authors: Anne Heaven, Peter Bower, Florence Day, Amanda Farrin, Catherine Fernadez, Marilyn Foster, Robbie Foy, Rebecca Hawkins, Claire Hulme, Sara Humphrey, Rebecca Lawton, Catriona Parker, Ellen Thompson, Robert West and Andrew Clegg
    Citation: Trials 2024 25:8
  40. Petersen’s hernia, which occurs after Billroth-II (B-II) or Roux-en-Y (REY) anastomosis, can be reduced by defect closure. This study aims to compare the incidence of bowel obstruction above Clavien–Dindo clas...

    Authors: Jae Kyun Park, Dae Hwan Kim, Tae-Yong Jeon, Sang-Ho Jeong, Tae Han Kim, Jae-Seok Min, Rock Bum Kim, Young Joon Lee, Ji Ho Park, Young Gil Son, Ki Young Yoon, Kyung Won Seo, Ki Hyun Kim, Yoonhong Kim, Hyun Dong Chae, Sun Hwi Hwang…
    Citation: Trials 2024 25:7
  41. The surgical techniques for treatment of chronic subdural hematoma (CSDH), a common neurosurgical condition, have been discussed in a lot of clinical literature. However, the recurrence proportion after CSDH s...

    Authors: Yoshitaka Nagashima, Yoshio Araki, Kazuki Nishida, Shunichiro Kuramitsu, Kenichi Wakabayashi, Shinji Shimato, Takeshi Kinkori, Toshihisa Nishizawa, Takahisa Kano, Toshinori Hasegawa, Atsushi Noda, Kenko Maeda, Yu Yamamoto, Osamu Suzuki, Naoki Koketsu, Takeshi Okada…
    Citation: Trials 2024 25:6
  42. Individuals’ comprehension of the information provided in consent forms should fundamentally influence whether to participate initially in a study and later whether to remain a participant. Existing evidence, ...

    Authors: Katarina Ulfsdotter Gunnarsson, Elizabeth S. Collier, Jim McCambridge and Marcus Bendtsen
    Citation: Trials 2024 25:5
  43. Disseminated intravascular coagulation (DIC) occurs in 30–50% of septic patients and contributes to high mortality in the intensive care unit (ICU). However, there are few proven interventions for coagulation ...

    Authors: Yini Sun, Renyu Ding, Hao Sun, Yingjian Liang and Xiaochun Ma
    Citation: Trials 2024 25:4
  44. The new European Medicines Agency (EMA) Clinical Trials Information System (CTIS), based on the Clinical Trials Regulation (CTR EU 536/2014), came into full effect on 31 January 2022 and was intended to provid...

    Authors: Thale D. J. H. Patrick-Brown, Josephine Bourner, Sabrina Kali, Marius Trøseid, Yazdan Yazdanpanah, Piero Olliaro and Inge Christoffer Olsen
    Citation: Trials 2024 25:3
  45. Dreaming sometimes occurs during sedation. It has been reported that factors such as different anesthetics, depth of anesthesia, age, sex, and preoperative psychological state may affect dreams. Ciprofol and r...

    Authors: Le-Qiang Xia, Rui Zhou, Rui Deng, Dan Zhou, Jia Han, Zhi-Fu Zhao, San-Jie Gao, Xian-Jie Zhang, Yu-Kai Zhou and Li-Ze Xiong
    Citation: Trials 2024 25:2
  46. The emergence of new problematic alcohol consumption practices among young people requires new dynamics in prevention strategies. In this context, the ADUC project (Alcohol and Drugs at the University of Caen)...

    Authors: Jessica Mange, Nicolas Mauny, Charlotte Montcharmont, Eve Legrand, Maud Lemercier-Dugarin, Arnaud Mortier, Martin Duvivier, Johnny Leveneur, Cédric Lacherez, Nicolas Cabé and Anne-Pascale Le Berre
    Citation: Trials 2024 25:1
  47. Since birth, during the exploration of the environment to interact with objects, we exploit both the motor and sensory components of the upper limb (UL). This ability to integrate sensory and motor information...

    Authors: Alex Martino Cinnera, Sonia Bonnì, Alessia D’Acunto, Michele Maiella, Matteo Ferraresi, Elias Paolo Casula, Valentina Pezzopane, Marco Tramontano, Marco Iosa, Stefano Paolucci, Giovanni Morone, Giuseppe Vannozzi and Giacomo Koch
    Citation: Trials 2023 24:823
  48. Postoperative delirium (POD) is a complication after surgery which leads to worse outcomes. The frequency of this syndrome is increasing as more elderly patients undergo major surgery. The frequency is around ...

    Authors: Yosuke Nakadate, Mariko Yamada, Natsuyo Kusuyama, Ryota Ishii, Hiroaki Sato, Thomas Schricker and Makoto Tanaka
    Citation: Trials 2023 24:822
  49. Significant lower genital tract (LGT) dysbiosis and an associated lower rate of clinical pregnancy after in vitro fertilization–frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients ...

    Authors: Huixi Chen, Yaoyao Tu, Chen Zhang, Jie Li, Ting Wu, Suying Liu, Liying He, Aijun Zhang, Yan Li, Lu Li, Yilun Sui, Li Wang, Xiaojun Chen, Ji Xi, Yanting Wu, Li Jin…
    Citation: Trials 2023 24:821

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