Skip to main content

Articles

Page 3 of 184

  1. In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and re...

    Authors: Julia M. Neuhann, Jannik Stemler, Antonio Carcas, Jesús Frías-Iniesta, Ullrich Bethe, Sarah Heringer, Lea Tischmann, Marouan Zarrouk, Arnd Cüppers, Franz König, Martin Posch and Oliver A. Cornely
    Citation: Trials 2022 23:865
  2. The way information about potential harms of trial intervention is shared within participant information leaflets (PILs) varies widely and can cause subjective ‘nocebo’ harms. This study aimed to develop princ...

    Authors: Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek and Jeremy Howick
    Citation: Trials 2022 23:863
  3. Bariatric surgery has adverse effects on the muscular-skeletal system with loss of bone mass and muscle mass and an increase in the risk of fracture. Zoledronic acid is widely used in osteoporosis and prevents...

    Authors: Søren Gam, Bibi Gram, Claus Bogh Juhl, Anne Pernille Hermann and Stinus Gadegaard Hansen
    Citation: Trials 2022 23:861
  4. The clinical trial landscape has evolved over the last two decades, shaped by advances in therapeutics and drug development and innovation in trial design and methods. The tracking of such changes became possi...

    Authors: Gillian Gresham, Jill L. Meinert, Arthur G. Gresham, Steven Piantadosi and Curtis L. Meinert
    Citation: Trials 2022 23:858
  5. For the design and analysis of clinical trials with time-to-event outcomes, the Cox proportional hazards model and the logrank test have been the cornerstone methods for many decades. Increasingly, the key ass...

    Authors: Kim M. Jachno, Stephane Heritier, Robyn L. Woods, Suzanne Mahady, Andrew Chan, Andrew Tonkin, Anne Murray, John J. McNeil and Rory Wolfe
    Citation: Trials 2022 23:857
  6. The COVID-19 pandemic significantly impacted the conduct of clinical trials through delay, interruption or cancellation. Decentralised methods in clinical trials could help to continue trials during a pandemic...

    Authors: Arnela Suman, Jasmijn van Es, Helga Gardarsdottir, Diederick E. Grobbee, Kimberly Hawkins, Megan A. Heath, Isla S. Mackenzie, Ghislaine van Thiel and Mira G. P. Zuidgeest
    Citation: Trials 2022 23:856
  7. To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with P...

    Authors: Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman…
    Citation: Trials 2022 23:855
  8. Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural th...

    Authors: Markus Harboe Olsen, Julie Hagstrøm, Nicole Nadine Lønfeldt, Camilla Uhre, Valdemar Uhre, Linea Pretzmann, Sofie Heidenheim Christensen, Christine Thoustrup, Nicoline Løcke Jepsen Korsbjerg, Anna-Rosa Cecilie Mora-Jensen, Melanie Ritter, Janus Engstrøm, Jane Lindschou, Hartwig Roman Siebner, Frank Verhulst, Pia Jeppesen…
    Citation: Trials 2022 23:854
  9. Authors: Susanne G. R. Klotz, Gesche Ketels, Christian A. Behrendt, Hans-Helmut Konig, Sebastian Kohlmann, Bernd Lowe, Johannes Petersen, Sina Stock, Eik Vettorazzi, Antonia Zapf, Inke Zastrow, Christian Zollner, Hermann Reichenspurner and Evaldas Girdauskas
    Citation: Trials 2022 23:853

    The original article was published in Trials 2022 23:528

  10. Authors: Alaa Abouhajar, Lisa Alcock, Theophile Bigirumurame, Penny Bradley, Laura Brown, Ian Campbell, Silvia Del Din, Julie Faitg, Gavin Falkous, Grainne S. Gorman, Rachel Lakey, Robert McFarland, Jane Newman, Lynn Rochester, Vicky Ryan, Hesther Smith…
    Citation: Trials 2022 23:852

    The original article was published in Trials 2022 23:789

  11. Many people with psychotic disorders experience symptoms of post-traumatic stress disorder (PTSD). In recent years, several trauma-focused therapies (TFTs), including cognitive restructuring (CR), prolonged ex...

    Authors: Simone R. Burger, Tineke van der Linden, Amy Hardy, Paul de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Catherine van Zelst, Jennifer D. Gottlieb, Kim T. Mueser, Agnes van Minnen, Ad de Jongh, Machteld Marcelis, Mark van der Gaag and David van den Berg
    Citation: Trials 2022 23:851
  12. Self-management support is increasingly viewed as an integral part of chronic condition management in adolescence. It is well recognized that markers of chronic illness control deteriorate during adolescence. ...

    Authors: Jaunna Gauci, Jacqueline Bloomfield, Sharon Lawn, Susan Towns, Annabelle Hobbs and Katharine Steinbeck
    Citation: Trials 2022 23:850
  13. Men who present to the emergency department (ED) with self-harm are at high risk of dying by suicide, with 2.7% of men dying in the year following their presentation, more than double the rate for women (1.2%)...

    Authors: Simon Hatcher, Marnin J. Heisel, Oydeji Ayonrinde, Daniel Corsi, Nicole E. Edgar, Sidney H. Kennedy, Sakina J. Rizvi, Ayal Schaffer and Mark Sinyor
    Citation: Trials 2022 23:849

    The Study protocol to this article has been published in Trials 2020 21:925

  14. Cardiotocography (CTG) is a screening test used to detect fetal hypoxia in labour. It has a high false positive rate resulting in many potentially unnecessary caesarean sections. Fetal blood sampling (FBS) is ...

    Authors: D. J. Murphy, Y. Shahabuddin, S. Yambasu, K. O’Donoghue, D. Devane, A. Cotter, G. Gaffney, L. A. Burke, E. J. Molloy and F. Boland
    Citation: Trials 2022 23:848
  15. Acute and everyday stress is substantial for the development of mental and physical diseases, therefore it is crucial to get a better understanding of its pathogenesis. Different methods (e.g., Ambulatory Asse...

    Authors: Daniel Schleicher, Angelika Ecker, Martin Kocur, Irina Jarvers, Colin Nash, Leonie Götz, Alexandra H. Otto, Stephanie Kandsperger and Romuald Brunner
    Citation: Trials 2022 23:847
  16. Enteral feeding intolerance, energy-protein malnutrition, and muscle wasting are common conditions in the critical care setting. The primary aim of this study was to investigate the effect of synbiotic supplem...

    Authors: Najmeh Seifi, Reza Rezvani, Alireza Sedaghat, Mohsen Nematy, Majid Khadem-Rezaiyan and Mohammad Safarian
    Citation: Trials 2022 23:846
  17. Plantar fasciopathy is the most common reason for complaints of plantar heel pain and one of the most prevalent musculoskeletal conditions with a reported lifetime incidence of 10%. The condition is normally c...

    Authors: Stefan Møller, Henrik Riel, Jens Wester, Ane Simony, Bjarke Viberg and Carsten Jensen
    Citation: Trials 2022 23:845
  18. Different coping strategies have been associated with various effects on infertile couples’ mental health. Considering the close interaction between couples, the present study aims to develop coping strategies...

    Authors: Marzie Reisi, Ashraf Kazemi and Mohammad Reza Abedi
    Citation: Trials 2022 23:844
  19. Recruitment of adults lacking the capacity to consent to trials requires the involvement of an alternative ‘proxy’ decision-maker, usually a family member. This can be challenging for family members, with some...

    Authors: Victoria Shepherd, Kerenza Hood, Katie Gillies and Fiona Wood
    Citation: Trials 2022 23:843
  20. Physical activity (PA) is a key behaviour for patients with type 2 diabetes (T2DM). However, healthcare professionals’ (HCP) recommendations (walking advice), which are short-term and individually focused, did...

    Authors: Guillem Jabardo-Camprubí, Judit Bort-Roig, Rafel Donat-Roca, Raimon Milà-Villarroel, Mercè Sitjà-Rabert, Jim McKenna and Anna Puig-Ribera
    Citation: Trials 2022 23:842
  21. Diabetes self-management education and support (DSMES) programs have struggled to deliver sustainable, effective support for adults with diabetes (AWDs) to improve self-management behaviors, achieve glycemic g...

    Authors: Denise J. Deverts, Michele Heisler, Edith C. Kieffer, Gretchen A. Piatt, Felix Valbuena, Jonathan G. Yabes, Claudia Guajardo, Deliana Ilarraza-Montalvo, Gloria Palmisano, Glory Koerbel and Ann-Marie Rosland
    Citation: Trials 2022 23:841
  22. Job loss after a cancer diagnosis can lead to long-term financial toxicity and its attendant adverse clinical consequences, including decreased treatment adherence. Among women undergoing (neo)adjuvant chemoth...

    Authors: Victoria S. Blinder, Sujata Patil, Jackie Finik, Della Makower, Monica Muppidi, Wendy G. Lichtenthal, Patricia A. Parker, Maria Claros, Jennifer Suarez, Bharat Narang and Francesca Gany
    Citation: Trials 2022 23:840
  23. Almost half of the patients with cancer report cancer-related financial hardship, termed “financial toxicity” (FT), which affects health-related quality of life, care retention, and, in extreme cases, mortalit...

    Authors: Stephanie B. Wheeler, Caitlin B. Biddell, Michelle L. Manning, Mindy S. Gellin, Neda R. Padilla, Lisa P. Spees, Cynthia D. Rogers, Julia Rodriguez-O’Donnell, Cleo Samuel-Ryals, Sarah A. Birken, Katherine E. Reeder-Hayes, Victoria M. Petermann, Allison M. Deal and Donald L. Rosenstein
    Citation: Trials 2022 23:839
  24. International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to...

    Authors: Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L. J. DeKoninck, Enrico Lopriore, Wes Onland, Marijn J. Vermeulen, M. Elske van den Akker–van Marle, Leti van Bodegom–Vos, Willem P. de Boode, Anton H. van Kaam, Irwin K. M. Reiss, Graeme R. Polglase, G. Jeroen Hutten, Sandra A. Prins, Estelle E. M. Mulder…
    Citation: Trials 2022 23:838
  25. The purpose of this study is to explore whether electrical impedance tomography (EIT)-guided individualized positive end-expiratory pressure (PEEP) can reduce the incidence of pulmonary complications within 1 ...

    Authors: Zihao Zhang, Lianqin Zhang, Jiang Zhu, Jun Dong and Hairui Liu
    Citation: Trials 2022 23:837
  26. The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitor...

    Authors: Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood and Garry Meakin
    Citation: Trials 2022 23:836
  27. Neurosyphilis may cause irreversible neurological sequelae. First-line treatment consists of penicillin G, with ceftriaxone being an alternative treatment in patients allergic to penicillin. The lack of clinic...

    Authors: Fang-Zhi Du, Min-Zhi Wu, Xu Zhang, Rui-Li Zhang and Qian-Qiu Wang
    Citation: Trials 2022 23:835
  28. Cervical cancer is considered preventable disease, though it is the second largest killer of women’s cancer in low and middle-income countries. Despite the government’s attempts to broaden screening facilities...

    Authors: Gerezgiher Buruh Abera, Solomon Mekonen Abebe and Abebaw Gebeyehu Worku
    Citation: Trials 2022 23:834
  29. The COVID-19 pandemic has had a devastating impact on individuals and multiple aspects of our society including healthcare and clinical research. The silver lining is that the pandemic also served as a catalys...

    Authors: Lada Leyens, Tracy Simkins and Nafsika Kronidou Horst
    Citation: Trials 2022 23:833
  30. Authors: E. Bailin Xie, Kaeley M. Simpson, Kristin A. Reynolds, Ryan J. Giuliano, Jennifer L. P. Protudjer, Melanie Soderstrom, Shannon Sauer-Zavala, Gerald F. Giesbrecht, Catherine Lebel, Anna L. Mackinnon, Charlie Rioux, Lara Penner-Goeke, Makayla Freeman, Marlee R. Salisbury, Lianne Tomfohr-Madsen and Leslie E. Roos
    Citation: Trials 2022 23:832

    The original article was published in Trials 2022 23:741

  31. Around one fourth of patients with colorectal cancer present themselves with distant metastases at the time of diagnosis, and one additional one fifth of the patients will develop distant metastases during the...

    Authors: Veronica Reivell, Helga Hagman, Johan Haux, Carl Jorns, Per Lindnér and Helena Taflin
    Citation: Trials 2022 23:831
  32. In blended therapy, face-to-face psychotherapy and Internet-based interventions are combined. Blended therapy may be advantageous for patients and psychotherapists. However, most blended interventions focus on...

    Authors: Carmen Schaeuffele, Manuel Heinrich, Solveig Behr, Friederike Fenski, Leona Hammelrath, Pavle Zagorscak, Alessa Jansen, Steffi Pohl, Johanna Boettcher and Christine Knaevelsrud
    Citation: Trials 2022 23:830
  33. Advance care planning (ACP) is a process involving conversations between patients, loved ones, and healthcare providers that consider patient preferences for the types of medical therapies received at the end ...

    Authors: Lauren J. Van Scoy, Benjamin H. Levi, Cindy Bramble, William Calo, Vernon M. Chinchilli, Lindsey Currin, Denise Grant, Christopher Hollenbeak, Maria Katsaros, Sara Marlin, Allison M. Scott, Amy Tucci, Erika VanDyke, Emily Wasserman, Pamela Witt and Michael J. Green
    Citation: Trials 2022 23:829
  34. Dyspnea is common and severe in intensive care unit (ICU) patients managed for acute respiratory failure. Dyspnea appears to be associated with impaired prognosis and neuropsychological sequels. Pain and dyspn...

    Authors: Alexandre Demoule, Robin Deleris, Côme Bureau, Said Lebbah, Maxens Decavèle, Martin Dres, Thomas Similowski and Agnes Dechartres
    Citation: Trials 2022 23:828
  35. The Center for Disease Control and Prevention’s National Diabetes Prevention Program (NDPP) aims to help individuals with prediabetes avoid progression to type 2 diabetes mellitus (T2DM) through weight loss. S...

    Authors: Dina H. Griauzde, Alison O’Brien, William S. Yancy Jr., Caroline R. Richardson, Jamie Krinock, Melissa DeJonckheere, Deanna J. M. Isaman, Kaitlyn Vanias, Samuel Shopinski and Laura R. Saslow
    Citation: Trials 2022 23:827
  36. Working memory deficits are one of the core and most characteristic clinical features of cognitive impairment in schizophrenia. Cognitive training can improve the cognitive function of patients with schizophre...

    Authors: Xiaolin Zhu, Chao Huang, Hongzhen Fan, Fengmei Fan, Yanli Zhao, Meihong Xiu, Yunhui Wang, Yajun Li, Yunlong Tan, Zhiren Wang and Shuping Tan
    Citation: Trials 2022 23:826
  37. Traumatic hemorrhagic shock (THS) is the main cause of death in trauma patients with high mortality. Rapid control of the source of bleeding and early resuscitation are crucial to clinical treatment. Guideline...

    Authors: Jizhe Zhang, Dong Han, Kun Zhang, Weiqiang Guan, Li Li and Zhengtao Gu
    Citation: Trials 2022 23:825
  38. This update summarises key changes made to the protocol since the publication of the original protocol for the NAVKIDS2 trial of patient navigators for children with chronic kidney disease (CKD) experiencing soci...

    Authors: Anita van Zwieten, Elizabeth G. Ryan, Patrina Caldwell, Kirsten Howard, Allison Tong, Jonathan C. Craig, Stephen I. Alexander, Martin Howell, Armando Teixeira-Pinto, Carmel M. Hawley, Shilpanjali Jesudason, Amanda Walker, Fiona Mackie, Sean E. Kennedy, Steven McTaggart, Hugh J. McCarthy…
    Citation: Trials 2022 23:824

    The Study protocol to this article has been published in BMC Nephrology 2019 20:134

  39. Understanding public and patient attitudes to clinical research is paramount to successful recruitment. The COVID-19 pandemic has led to additional hurdles in achieving this. Our aim is to understand the curre...

    Authors: Dalia Abdulhussein, Timothy E. Yap, Haider Manzar, Serge Miodragovic and Francesca Cordeiro
    Citation: Trials 2022 23:823
  40. Major depressive disorder (MDD) is a leading cause of disability worldwide. The current treatments are ineffective in approximately one-third of patients, resulting in a large economic burden and reduced quali...

    Authors: Julia R. Plank, Stephanie C. Glover, Ben D. Moloney, Nicholas R. Hoeh, Frederick Sundram, Rachael L. Sumner, Suresh Muthukumaraswamy and Joanne C. Lin
    Citation: Trials 2022 23:822
  41. Sri Lanka is faced with the challenge of managing a large population with diabetes mellitus by 2030. Psychological stress plays a major role in disease outcome by exerting physiological, psychological and soci...

    Authors: K. P. C. Dalpatadu, P. Galappatthy, P. Katulanda and S. Jayasinghe
    Citation: Trials 2022 23:821
  42. Mental illness has an estimated financial burden on the Danish economy of 3.4% of the gross national product every year due to lost productivity, social benefits, and healthcare costs, and approximately 50% of...

    Authors: Thomas Nordahl Christensen, Chalotte Heinsvig Poulsen, Bea Kolbe Ebersbach and Lene Falgaard Eplov
    Citation: Trials 2022 23:820
  43. Cancer survivors frequently develop cognitive impairment, which negatively affects their quality of life and emotional well-being. This study compares the effectiveness of a well-established treatment (neurops...

    Authors: Francisco García-Torres, Adrián Tejero-Perea, Ángel Gómez-Solís, Rosario Castillo-Mayén, Maria José Jaén-Moreno, Bárbara Luque, Mario Gálvez-Lara, Araceli Sánchez-Raya, Marcin Jablonski, Beatriz Rodríguez-Alonso and Enrique Aranda
    Citation: Trials 2022 23:819
  44. Pseudomonas aeruginosa infection is seen in chronic pulmonary disease and is associated with exacerbations and poor long-term prognosis. However, evidence-based guidelines for the management and treatment of P. ...

    Authors: Josefin Eklöf, Imane Achir Alispahic, Pradeesh Sivapalan, Torgny Wilcke, Niels Seersholm, Karin Armbruster, Jakob Lyngby Kjærgaard, Mohamad Isam Saeed, Thyge Lynghøj Nielsen, Andrea Browatzki, Rikke Holmen Overgaard, Camilla Sund Fenlev, Zitta Barella Harboe, Helle Frost Andreassen, Therese Sophie Lapperre, Lars Pedersen…
    Citation: Trials 2022 23:817
  45. High-grade glioma (HGG) is the most malignant brain tumor with poor outcomes. Whether anesthetic methods have an impact on the outcome of these patients is still unknown. Retrospective study has found no diffe...

    Authors: Jia Dong, Dexiang Wang, Huizhong Sun, Min Zeng, Xiaoyuan Liu, Xiang Yan, Ruowen Li, Shu Li and Yuming Peng
    Citation: Trials 2022 23:816
  46. Authors: Valérie Martel-Laferrière, Daniel J. Feaster, Lisa R. Metsch, Bruce R. Schackman, Christine Loignon, Bohdan Nosyk, Hansel Tookes, Czarina N. Behrends, Nelson Arruda, Oluleye Adigun, Marie-Eve Goyer, Michael A. Kolber, Jean-Francois Mary, Allan E. Rodriguez, Iveth G. Yanez, Yue Pan…
    Citation: Trials 2022 23:815

    The original article was published in Trials 2022 23:341

  47. Cholinesterase inhibitors (ChEIs) decrease long-term cognitive decline in patients with Alzheimer’s disease (AD); however, there is little evidence that ChEIs affect cognitive test scores in patients with mild...

    Authors: Ko Woon Kim, Qi Wang, Se Hee Koo and Byoung-Soo Shin
    Citation: Trials 2022 23:813
  48. Bacterial infection is a major cause of mortality in patients with cirrhosis. Spontaneous bacterial peritonitis (SBP) is a serious and common infection in patients with cirrhosis and ascites. Secondary prophyl...

    Authors: Dominic Crocombe, Norin Ahmed, Indran Balakrishnan, Ekaterina Bordea, Marisa Chau, Louise China, Lynsey Corless, Victoria Danquah, Hakim-Moulay Dehbi, John F. Dillon, Ewan H. Forrest, Nick Freemantle, David Peter Gear, Coral Hollywood, Rachael Hunter, Tasheeka Jeyapalan…
    Citation: Trials 2022 23:812
  49. Paediatric cancer patients often experience anxiety and depression. Evidence suggests that cognitive-behavioural interventions may help reduce anxiety and depression in children undergoing cancer treatment. Ho...

    Authors: Tenaw Gualu Melesse, Janita Pak Chun Chau and William Ho Cheung Li
    Citation: Trials 2022 23:811
  50. Polygenic risk scores (PRSs) can predict the risk of colorectal cancer (CRC) and target screening more precisely than current guidelines using age and family history alone. Primary care, as a far-reaching poin...

    Authors: Sibel Saya, Lucy Boyd, Patty Chondros, Mairead McNamara, Michelle King, Shakira Milton, Richard De Abreu Lourenco, Malcolm Clark, George Fishman, Julie Marker, Cheri Ostroff, Richard Allman, Fiona M. Walter, Daniel Buchanan, Ingrid Winship, Jennifer McIntosh…
    Citation: Trials 2022 23:810

Annual Journal Metrics