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  1. Vitamin A supplementation of 6-59 month old children is currently recommended by the World Health Organization based on evidence that it reduces mortality. There has been considerable interest in determining t...

    Authors: Rajiv Bahl, Nita Bhandari, Brinda Dube, Karen Edmond, Wafaie Fawzi, Olivier Fontaine, Jasmine Kaur, Betty R Kirkwood, Jose Martines, Honorati Masanja, Sarmila Mazumder, Salum Msham, Sam Newton, Maureen Oleary, Julia Ruben, Caitlin Shannon…
    Citation: Trials 2012 13:22
  2. Central sensitization has recently been documented in patients with knee osteoarthritis (OAk). So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing...

    Authors: David Beckwée, Willem De Hertogh, Pierre Lievens, Ivan Bautmans and Peter Vaes
    Citation: Trials 2012 13:21
  3. Heart failure patients with stable angina, acute coronary syndromes and valvular heart disease may benefit from revascularisation and/or valve surgery. However, the mortality rate is increased- 5-30%. Biventri...

    Authors: Stuart J Russell, Christine Tan, Peter O'Keefe, Saeed Ashraf, Afzal Zaidi, Alan G Fraser and Zaheer R Yousef
    Citation: Trials 2012 13:20
  4. Alcohol dependence is a significant and costly problem in the UK yet only 6% of people a year receive treatment. Current service provision based on the treatment of acute episodes of illness and emphasising pe...

    Authors: Helen Gilburt, Tom Burns, Alex Copello, Simon Coulton, Michael Crawford, Ed Day, Paolo Deluca, Christine Godfrey, Steve Parrott, Abigail K Rose, Julia M A Sinclair, Christine Wright and Colin Drummond
    Citation: Trials 2012 13:19
  5. The success and cost-effectiveness of bowel cancer screening depends on achieving and maintaining high screening uptake rates. The involvement of GPs in screening has been found to improve patient compliance. ...

    Authors: Sarah Damery, Steve Smith, Alison Clements, Roger Holder, Linda Nichols, Heather Draper, Sue Clifford, Laura Parker, Richard Hobbs and Sue Wilson
    Citation: Trials 2012 13:18
  6. Cricoid pressure is considered to be the gold standard means of preventing aspiration of gastric content during Rapid Sequence Intubation (RSI). Its effectiveness has only been demonstrated in cadaveric studie...

    Authors: Christopher E Trethewy, Julie M Burrows, Don Clausen and Steven R Doherty
    Citation: Trials 2012 13:17
  7. Internet-administered cognitive behavioural therapy (ICBT) has been found to be effective for a range of anxiety disorders. However, most studies have focused on one specific primary diagnosis and co-morbidity...

    Authors: Lise Bergman Nordgren, Gerhard Andersson, Åsa Kadowaki and Per Carlbring
    Citation: Trials 2012 13:16
  8. Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system in young adults. Despite the fact that numerous lines of evidence link both the risk of disease development and ...

    Authors: Jan Dörr, Stephanie Ohlraun, Horst Skarabis and Friedemann Paul
    Citation: Trials 2012 13:15
  9. Incisional hernia is a frequent complication in abdominal surgery. This article describes the development of a prospective randomized clinical trial designed to determine whether watchful waiting is an accepta...

    Authors: Johannes C Lauscher, Peter Martus, Andrea Stroux, Jens Neudecker, Uwe Behrens, Ralf Hammerich, Heinz J Buhr and Jörg-Peter Ritz
    Citation: Trials 2012 13:14
  10. MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR.

    Authors: Nicholas C Harvey, Kassim Javaid, Nicholas Bishop, Stephen Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice and Cyrus Cooper
    Citation: Trials 2012 13:13
  11. Children who witness interparental violence are at a heightened risk for developing psychosocial, behavioral and cognitive problems, as well as posttraumatic stress symptoms. For these children the psycho-educ...

    Authors: Mathilde M Overbeek, J Clasien de Schipper, Francien Lamers-Winkelman and Carlo Schuengel
    Citation: Trials 2012 13:12
  12. Motor imagery (MI) when combined with physiotherapy can offer functional benefits after stroke. Two MI integration strategies exist: added and embedded MI. Both approaches were compared when learning a complex...

    Authors: Corina Schuster, Jenny Butler, Brian Andrews, Udo Kischka and Thierry Ettlin
    Citation: Trials 2012 13:11
  13. Hand hygiene is considered as an important means of infection control. We explored whether guided hand hygiene together with transmission-limiting behaviour reduces infection episodes and lost days of work in ...

    Authors: Carita Savolainen-Kopra, Jaason Haapakoski, Piia A Peltola, Thedi Ziegler, Terttu Korpela, Pirjo Anttila, Ali Amiryousefi, Pentti Huovinen, Markku Huvinen, Heikki Noronen, Pia Riikkala, Merja Roivainen, Petri Ruutu, Juha Teirilä, Erkki Vartiainen and Tapani Hovi
    Citation: Trials 2012 13:10
  14. We aimed to establish levels of consumer involvement in randomised controlled trials (RCTs), meta-analyses and other studies carried out by the UK Medical Research Council (MRC) Clinical Trials Unit across the...

    Authors: Claire L Vale, Lindsay C Thompson, Claire Murphy, Silvia Forcat and Bec Hanley
    Citation: Trials 2012 13:9
  15. Executive function is critical for children's healthy development. We propose an intervention program to enhance children's executive function using the game, GO. Many neuroimaging studies have revealed that p...

    Authors: Yoshiyuki Tachibana, Jiro Yoshida, Masahito Ichinomiya, Rui Nouchi, Carlos Miyauchi, Hikaru Takeuchi, Naoki Tomita, Hiroyuki Arai and Ryuta Kawashima
    Citation: Trials 2012 13:8
  16. Laparoscopic cholecystectomy in acute calculous cholecystitis in high risk patients can lead to significant morbidity and mortality. Percutaneous cholecystostomy may be an alternative treatment option but the ...

    Authors: Kirsten Kortram, Bert van Ramshorst, Thomas L Bollen, Marc G H Besselink, Dirk J Gouma, Tom Karsten, Philip M Kruyt, Grard A P Nieuwenhuijzen, Johannes C Kelder, Ellen Tromp and Djamila Boerma
    Citation: Trials 2012 13:7
  17. Chronic Obstructive Pulmonary Disease (COPD) and asthma are common chronic diseases that are frequently accompanied by depression and/or anxiety. However, symptoms of depression and anxiety are often not recog...

    Authors: Antoinette M Pommer, François Pouwer, Johan Denollet and Victor J M Pop
    Citation: Trials 2012 13:6
  18. Surgeons in the Netherlands, Canada and the US participate in the FAITH trial (Fixation using Alternative Implants for the Treatment of Hip fractures). Dutch sites are managed and visited by a financed central...

    Authors: Stephanie M Zielinski, Helena Viveiros, Martin J Heetveld, Marc F Swiontkowski, Mohit Bhandari, Peter Patka and Esther MM Van Lieshout
    Citation: Trials 2012 13:5
  19. Governments and donors all over Africa are searching for sustainable, affordable and cost-effective ways to improve the quality of malaria case management. Widespread deficiencies have been reported in the pre...

    Authors: Virginia Wiseman, Lindsay J Mangham, Bonnie Cundill, Olivia A Achonduh, Akindeh Mbuh Nji, Abanda Ngu Njei, Clare Chandler and Wilfred F Mbacham
    Citation: Trials 2012 13:4
  20. Gyejibongnyeong-hwan (GJBNH) is one of the most popular Korean medicine formulas for menstrual pain of dysmenorrhea. The concept of blood stagnation in Korean medicine is considered the main factor of causing ...

    Authors: Jeong-Su Park, Sunju Park, Chun-Hoo Cheon, Ho-Yeon Go, Seung-Ho Sun, Yong-Cheol Shin, Bo-Hyoung Jang and Seong-Gyu Ko
    Citation: Trials 2012 13:3
  21. Randomised trials evaluation of surgical interventions are often designed and analysed as if the outcome of individual patients is independent of the surgeon providing the intervention. There is reason to expe...

    Authors: Jonathan A Cook, Thomas Bruckner, Graeme S MacLennan and Christoph M Seiler
    Citation: Trials 2012 13:2
  22. Patients with ST-elevation myocardial infarction (STEMI) not treated with primary or rescue percutaneous coronary intervention (PCI) are at risk for recurrent ischemia, especially when viability in the infarct...

    Authors: Ramon B van Loon, Gerrit Veen, Leo H B Baur, Otto Kamp, Jean G F Bronzwaer, Jos W R Twisk, Freek W A Verheugt and Albert C van Rossum
    Citation: Trials 2012 13:1
  23. Fresh frozen plasma (FFP) is an effective therapy to correct for a deficiency of multiple coagulation factors during bleeding. In past years, use of FFP has increased, in particular in patients on the Intensiv...

    Authors: Marcella CA Müller, Evert de Jonge, M Sesmu Arbous, Angelique ME Spoelstra -de Man, Atilla Karakus, Margreeth B Vroom and Nicole P Juffermans
    Citation: Trials 2011 12:266
  24. Poorly controlled hypertension (HTN) remains one of the most significant public health problems in the United States, in terms of morbidity, mortality, and economic burden. Despite compelling evidence supporti...

    Authors: Antoinette Schoenthaler, Leanne Luerassi, Jeanne A Teresi, Stephanie Silver, Jian Kong, Taiye Odedosu, Samantha Trilling, Anna Errico, Oshevire Uvwo, Kimberly Sebek, Adetutu Adekoya and Gbenga Ogedegbe
    Citation: Trials 2011 12:265
  25. Exercise programmes can be administered successfully as therapeutic agents to patients with a number of chronic diseases and help to improve physical functioning in older adults. Usually, such programmes targe...

    Authors: Timo Hinrichs, Anna Moschny, Michael Brach, Stefan Wilm, Renate Klaaßen-Mielke, Matthias Trampisch and Petra Platen
    Citation: Trials 2011 12:263
  26. The aim of this study was to evaluate the antiplaque effect of a new alcohol free essential oil mouthwash with respect to a control of an essential oil with alcohol mouthwash, using an in vivo plaque regrowth mod...

    Authors: Enrico Marchetti, Stefano Mummolo, Jonathan Di Mattia, Fabio Casalena, Salvatore Di Martino, Antonella Mattei and Giuseppe Marzo
    Citation: Trials 2011 12:262
  27. High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to prevent colorectal cancer. However the role of Aspirin ...

    Authors: Raghib Ali, Han-Chong Toh and Whay-Kuang Chia
    Citation: Trials 2011 12:261
  28. Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key as...

    Authors: Sara Ahmed, Susan J Bartlett, Pierre Ernst, Guy Paré, Maria Kanter, Robert Perreault, Roland Grad, Laurel Taylor and Robyn Tamblyn
    Citation: Trials 2011 12:260
  29. People with multiple sclerosis (MS) are at high risk of depression. We undertook a pilot trial of computerised cognitive behavioural therapy (CCBT) for the treatment of depression in people with MS to test the...

    Authors: Cindy L Cooper, Daniel Hind, Glenys D Parry, Claire L Isaac, Munyaradzi Dimairo, Alicia O'Cathain, Anita Rose, Jennifer V Freeman, Leonie Martin, Eva C Kaltenthaler, Anna Thake and Basil Sharrack
    Citation: Trials 2011 12:259
  30. Authors: Kimberley Goldsmith, Trudie Chalder, Peter White, Michael Sharpe and Andrew Pickles
    Citation: Trials 2011 12(Suppl 1):A144

    This article is part of a Supplement: Volume 12 Supplement 1

  31. Authors: Sarah Meredith, Martyn Ward, Gillian Booth, Andrew Fisher, Carrol Gamble, Heather House and Martin Landray
    Citation: Trials 2011 12(Suppl 1):A39

    This article is part of a Supplement: Volume 12 Supplement 1

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