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  1. The effectiveness of biologic therapies, primarily tumor necrosis factor inhibitors (TNFi), for children with spondyloarthritis (SpA) has made inactive disease a realistic patient outcome. However, biologic th...

    Authors: Pamela F. Weiss, Cora E. Sears, Timothy G. Brandon, Christopher B. Forrest, Emily Neu, Melanie Kohlheim, Jenny Leal, Rui Xiao and Daniel Lovell
    Citation: Trials 2023 24:100
  2. Clinical trials commonly use multiple endpoints to measure the impact of an intervention. While this improves the comprehensiveness of outcomes, it can make trial results difficult to interpret. We examined th...

    Authors: Rebecca K. Metcalfe, Mark Harrison, Joel Singer, Mary Lewisch, Terry Lee, Peter von Dadelszen, Laura A. Magee and Nick Bansback
    Citation: Trials 2023 24:99
  3. Authors: Enya Daynes, Molly Baldwin, Neil J. Greening, Thomas Yates, Nicolette C. Bishop, George Mills, Matthew Roberts, Malik Hamrouni, Tatiana Plekhanova, Ioannis Vogiatzis, Carlos Echevarria, Rashmita Nathu, Hamish J. C. McAuley, Lorna Latimer, Jennifer Glennie, Francesca Chambers…
    Citation: Trials 2023 24:98

    The original article was published in Trials 2023 24:61

  4. While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...

    Authors: Grace E. Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C. Blyth, Claire Waddington, Julie A. Marsh and Thomas L. Snelling
    Citation: Trials 2023 24:97
  5. The resurgence of HIV outbreaks and rising prevalence among people who inject drugs (PWID) remain exigent obstacles to Ending the HIV Epidemic in the USA. Adapting a low threshold, comprehensive treatment mode...

    Authors: Hansel E. Tookes, Asa Oxner, David P. Serota, Elizabeth Alonso, Lisa R. Metsch, Daniel J. Feaster, Jessica Ucha, Edward Suarez Jr., David W. Forrest, Kathryn McCollister, Allan Rodriguez, Michael A. Kolber, Teresa A. Chueng, Sheryl Zayas, Bernice McCoy, Kyle Sutherland…
    Citation: Trials 2023 24:96
  6. Mental well-being is associated with many mental health symptoms, including depression and health-related quality of life. Digital divide could impact mental health, particularly during the COVID-19 pandemic....

    Authors: Rick Yiu Cho Kwan, Fowie Ng, Manfred Lai, David Wong and Sally Chan
    Citation: Trials 2023 24:95
  7. There is no evidence of the use of beetroot juice with a previously recommended dose of nitrate (NO3) (> 300 mg) on the cardiovascular performance during and recovery following exercise in postmenopausal women...

    Authors: Cicero Jonas R. Benjamim, Yaritza Brito Alves Sousa, Andrey Alves Porto, Yasmim Mota de Moraes Pontes, Simone Sakagute Tavares, Guilherme da Silva Rodrigues, Leonardo Santos Lopes da Silva, Leonardo da Silva Goncalves, Carolina Scoqui Guimaraes, Macário Arosti Rebelo, Andressa Crystine da Silva Sobrinho, Jose E. Tanus-Santos, Vitor Engracia Valenti, Bruno Gualano and Carlos Roberto Bueno Júnior
    Citation: Trials 2023 24:94
  8. Randomised controlled trials (RCTs) are considered the “gold standard” for evaluating the effectiveness of interventions in clinical research. However, conventional RCTs are typically complex, expensive, and h...

    Authors: Khic-Houy Prang, Bill Karanatsios, Angela Zhang, Ebony Verbunt, Hui-li Wong, Vanessa Wong, Lucy Gately, Ben Tran, Peter Gibbs and Margaret Kelaher
    Citation: Trials 2023 24:92
  9. Vertigo, dizziness or balance disorders (VDB) are common leading symptoms in older people, which can have a negative impact on their mobility and participation in daily live, yet, diagnosis is challenging and ...

    Authors: Caren Horstmannshoff, Stefanie Skudlik, Jenny Petermann, Theresia Kiesel, Tobias Döringer, Alexander Crispin, Joachim Hermsdörfer, Juliane Köberlein-Neu, Klaus Jahn, Stefan Schädler, Petra Bauer, Karen Voigt and Martin Müller
    Citation: Trials 2023 24:91
  10. A common challenge for randomised controlled trials (RCTs) is recruiting enough participants to be adequately powered to answer the research question. Recruitment has been set as a priority research area in tr...

    Authors: Keith R. Moffat, Wen Shi, Paul Cannon and Frank Sullivan
    Citation: Trials 2023 24:90
  11. A cancer diagnosis is a known precipitant of psychological distress, with fear of recurrence being a well-documented distressing consequence of cancer. Cancer recurrence often results in an additional psycholo...

    Authors: Sinead Lynch, Damien Lowry, Clodagh Finnerty, Yvonne O’Meara and Donal Brennan
    Citation: Trials 2023 24:89
  12. Acute pancreatitis is a serious threat to human health and gastrointestinal dysmotility is a common complication for acute pancreatitis patients, resulting in delayed feeding, oral feeding intolerance, paralyt...

    Authors: Han Sun, Yaqi Sheng, Tiekuan Du and Huadong Zhu
    Citation: Trials 2023 24:88
  13. This study aims to evaluate the effect of vitamin D and magnesium supplementation on clinical symptoms and serum inflammatory and oxidative stress markers in patients with COVID-19.

    Authors: Nahid Ramezani-Jolfaie, Ebrahim Eftekhar, Mohadese Dadinasab, Zahra Ghaeini Hesarooeyeh, Pooria Pakdaman, Farkhondeh Razmpour, Gholamali Javedan, Mahmood Khayatian, Mehdi Hassani Azad, Parivash Davoodian, Elham Brahimi, Shideh Rafati, Sara Nikoofal-Sahlabadi and Mohammad Mohammadi
    Citation: Trials 2023 24:87
  14. Individuals with severe chronic obstructive pulmonary disease (COPD) are often at risk of undernutrition with low health-related quality of life (HRQoL). Undernutrition can worsen COPD and other comorbidities,...

    Authors: Maria H. Hegelund, Christian Ritz, Thyge L. Nielsen, Mette F. Olsen, Christian Søborg, Lone Braagaard, Christian Mølgaard, Rikke Krogh-Madsen, Birgitte Lindegaard and Daniel Faurholt-Jepsen
    Citation: Trials 2023 24:86
  15. Multisite practical clinical trials evaluate treatments in real-world practice. A multisite randomized Veterans Health Administration (VHA) cooperative study (CSP#555) published in 2011 compared the first long...

    Authors: Robert Rosenheck, Sonia T. Anand, Stephen G. Kurtz, Cynthia Hau, Diane Smedberg, James F. Pontzer, Ryan E. Ferguson and Cynthia R. Davis
    Citation: Trials 2023 24:85
  16. Advanced practice physiotherapy (APP) models of care where physiotherapists are primary contact emergency department (ED) providers are promising models of care to improve access, alleviate physicians’ burden,...

    Authors: E. Matifat, E. Berger Pelletier, R. Brison, L. J. Hébert, J.-S. Roy, L. Woodhouse, S. Berthelot, R. Daoust, M.-J. Sirois, R. Booth, R. Gagnon, J. Miller, Y. Tousignant-Laflamme, M. Emond, K. Perreault and F. Desmeules
    Citation: Trials 2023 24:84
  17. In paediatric epilepsy, the evidence of effectiveness of antiseizure treatment is inconclusive for some types of epilepsy. As with other paediatric clinical trials, researchers undertaking paediatric epilepsy ...

    Authors: Bernie Carter, Lucy Bray, Nadia al-Najjar, Agnès Tort Piella, Catrin Tudur-Smith, Catherine Spowart, Amber Collingwood, Holly Crudgington, Janet Currier, Dyfrig A. Hughes, Eifiona Wood, Rachael Martin, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Heather Sutherland…
    Citation: Trials 2023 24:83
  18. Urinary continence care for residents of nursing homes who are unable to communicate their toileting needs usually involves care aides manually checking continence products (pads) to determine the level of uri...

    Authors: Muyibat Omotunde, Fredrik Agholme, Arne Böhling, Nicole Huige, Hardy Schweigel, Daniela Hayder-Beichel, Robert Reidy and Adrian Wagg
    Citation: Trials 2023 24:80
  19. Peripheral neuropathy is a common dose-limiting side effect of paclitaxel. To date, there is no effective strategy to prevent paclitaxel-induced peripheral neuropathy. A recent small phase II study demonstrate...

    Authors: Praful Pandey, Akash Kumar, Deepam Pushpam, Sachin Khurana, Prabhat Singh Malik, Ajay Gogia, Elavarasi Arunmozhimaran, Mamta Bhushan Singh, Dinu Santha Chandran and Atul Batra
    Citation: Trials 2023 24:79
  20. Lateral compression type1 (LC-1) fragility fractures are a common, painful injury in older adults resulting in reduced mobility. The incidence of these fractures is increasing with the growing older adult popu...

    Authors: Elizabeth Cook, Joanne Laycock, Mehool Acharya, Michael Ross Backhouse, Belen Corbacho, Laura Doherty, Daren Forward, Catherine Hewitt, Catherine Hilton, Peter Hull, Jamila Kassam, Camila Maturana, Catriona Mcdaid, Jenny Roche, Dhanupriya Sivapathasuntharam, David Torgerson…
    Citation: Trials 2023 24:78
  21. Young people are vulnerable to experiencing problematic levels of loneliness which can lead to poor mental health outcomes. Loneliness is a malleable treatment target and preliminary evidence has shown that it...

    Authors: Michelle H. Lim, Lily Thurston, Robert Eres, Thomas L. Rodebaugh, Mario Alvarez-Jimenez, David L. Penn, Vassilis Kostakos and John F. M. Gleeson
    Citation: Trials 2023 24:77
  22. Incisional hernia is a frequent complication following loop ileostomy reversal. Incisional hernias are associated with morbidity, loss of health-related quality of life and costs and warrant the investigation ...

    Authors: Sven Müller, Dirk Weyhe, Florian Herrle, Philipp Horvath, Robert Bachmann, Viktor von Ehrlich-Treuenstätt, Patrick Heger, Nadir Nasir, Christina Klose, Alexander Ritz, Anja Sander, Erich Grohmann, Colette Dörr-Harim and André L. Mihaljevic
    Citation: Trials 2023 24:76
  23. Individuals living with long COVID experience multiple, interacting and fluctuating symptoms which can have a dramatic impact on daily living. The aim of the Long Covid Personalised Self-managemenT support Eva...

    Authors: Claire Potter, Fiona Leggat, Rachel Lowe, Philip Pallmann, Muhammad Riaz, Christy Barlow, Adrian Edwards, Aloysius Niroshan Siriwardena, Nick Sevdalis, Bernadette Sewell, Jackie McRae, Jessica Fish, Maria Ines de Sousa de Abreu, Fiona Jones and Monica Busse
    Citation: Trials 2023 24:75
  24. Follow-up programs for gynecological cancer patients are currently under revision. There is limited evidence that traditional follow-up and clinical examinations improve survival in an early-stage gynecologica...

    Authors: Stinne Holm Bergholdt, Dorte Gilsaa Hansen, Anna Thit Johnsen, Bo Snedker Boman and Pernille Tine Jensen
    Citation: Trials 2023 24:74
  25. Obstructive sleep apnea (OSA) is quite common among the adult population, according to recent epidemiological studies. The most frequently suggested alternate treatment for mild to moderate OSA is oral applian...

    Authors: Vikram Belkhode, Surekha Godbole, Sharayu Nimonkar, Sweta Pisulkar and Pranali Nimonkar
    Citation: Trials 2023 24:73
  26. The high incidence of intraoperative glucose dysregulations in liver transplantation (LT) is related to the lack of highly orchestrated control of intraoperative blood glucose. Glucose monitoring based on a si...

    Authors: Yi Duan, Zuo-Zhi Li, Pan Liu, Lei Cui, Zhifeng Gao and Huan Zhang
    Citation: Trials 2023 24:72
  27. Existing guidelines recommend statisticians remain blinded to treatment allocation prior to the final analysis and that any interim analyses should be conducted by a separate team from the one undertaking the ...

    Authors: Mais Iflaifel, Kirsty Sprange, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven A. Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery and Christopher Partlett
    Citation: Trials 2023 24:71
  28. Prophylactic dressings are increasingly used to prevent pressure injuries in hospitalised patients. However, evidence regarding the effectiveness of these dressings is still emerging. This trial aims to determ...

    Authors: R. M. Walker, W. Chaboyer, M. Cooke, J. A. Whitty, L. Thalib, I. Lockwood, S. Latimer, J. Campbell, R. Probert and B. M. Gillespie
    Citation: Trials 2023 24:70
  29. Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease creating an immense burden on social health care systems. Pulmonary rehabilitation (PR) has proven to be effective in patien...

    Authors: Yuting Jing, Yuying Ma, Hongxing Zhang, Zhenhu Wu, Yongwen Li, Haoxuan Li, Minling Huang, Lin Lin and Yinji Xu
    Citation: Trials 2023 24:69
  30. Diarrhoeal disease remains a significant cause of morbidity and mortality among the under-fives in many low- and middle-income countries. Changes to food safety practices and feeding methods around the weaning...

    Authors: Evans A. Asamane, Laura Quinn, Samuel I. Watson, Richard J. Lilford, Karla Hemming, Cheick Sidibe, Ryan T. Rego, Sami Bensassi, Youssouf Diarra, Samba Diop, Om Prasad Gautam, Mohammad Sirajul Islam, Louise Jackson, Kate Jolly, Kassoum Kayentao, Ousmane Koita…
    Citation: Trials 2023 24:68
  31. The double-lumen tube (DLT) is an essential equipment for thoracic anesthesia and the precise position of DLT placement is particularly important for anesthesia and surgery. However, the incidence of DLT malpo...

    Authors: Xi Zhang, Dong-Xu Wang, Qin Zhang, Qi-Bin Shen, Fei Tong, Yong-He Hu, Zhen-Duo Zhang, Fei-Fan Liu, Ya-Wen Tang, Juan-Li Chen, He Liu, Feng Zhou and Si-Ping Hu
    Citation: Trials 2023 24:67
  32. For children and young people with eye and vision conditions, research is essential to advancing evidence-based recommendations in diagnosis, prevention, treatments and cures. Patient ‘experience’ reflects a k...

    Authors: Jacqueline Miller, Katherine Curtis-Tyler, Michelle Maden, Annegret Dahlmann-Noor and Jane Chudleigh
    Citation: Trials 2023 24:66
  33. Foot and ankle involvement is common in rheumatic and musculoskeletal diseases (RMDs). High-quality evidence is lacking to determine the effectiveness of treatments for these disorders. Heterogeneity in the ou...

    Authors: Lara S. Chapman, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Toby O. Smith, John B. Arnold, Dorcas Beaton, Philip G. Conaghan, Yvonne M. Golightly, Marian T. Hannan, Catherine Hofstetter, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Peter Tugwell, Philip Helliwell…
    Citation: Trials 2023 24:65
  34. Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are di...

    Authors: Cornelis Jan van Dam, Monique van Velzen, Cornelis Kramers, Arnt Schellekens, Erik Olofsen, Marieke Niesters and Albert Dahan
    Citation: Trials 2023 24:64
  35. Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patien...

    Authors: Sarah E. Rowan, Jason Haukoos, Kevin F. Kamis, Emily Hopkins, Stephanie Gravitz, Carolynn Lyle, Alia A. Al-Tayyib, Edward M. Gardner, James W. Galbraith, Yu-Hsiang Hsieh, Michael S. Lyons, Richard E. Rothman, Douglas A. E. White, Jake R. Morgan, Benjamin P. Linas, Allison L. Sabel…
    Citation: Trials 2023 24:63
  36. This trial aims to assess whether dexmedetomidine can reduce the incidence of postoperative cognitive dysfunction in elderly orthopaedic patients and explore the specific mechanism.

    Authors: Weihong Zhao, Huanhuan Zhang and Jianli Li
    Citation: Trials 2023 24:62
  37. Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited con...

    Authors: Enya Daynes, Molly Baldwin, Neil J. Greening, Thomas Yates, Nicolette C. Bishop, George Mills, Matthew Roberts, Malik Hamrouni, Tatiana Plekhanova, Ioannis Vogiatzis, Carlos Echevarria, Rashmita Nathu, Hamish J. C. McAuley, Lorna Latimer, Jennifer Glennie, Francesca Chambers…
    Citation: Trials 2023 24:61

    The Correction to this article has been published in Trials 2023 24:98

  38. Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predominantly medium-sized arteries, particularly the coronary arteries. A number of recent studies conducted in different Eur...

    Authors: Despina Eleftheriou, Yolanda Collaco Moraes, Cara Purvis, Molly Pursell, Marta Merida Morillas, Robin Kahn, Maria Mossberg, Filip Kucera, Robert Tulloh, Joseph F. Standing, Veronica Swallow, Rachael McCormack, Jethro Herberg, Michael Levin, Mandy Wan, Nigel Klein…
    Citation: Trials 2023 24:60
  39. Severe mental illness (SMI) presents a major challenge worldwide, affecting approximately 5–8% of the world’s population. It causes significant distress to affected people, families and wider communities, gene...

    Authors: Victoria Jane Bird, Sana Zehra Sajun, Renata Peppl, Sara Evans-Lacko, Stefan Priebe, Swaran Singh, Lakshmi Venkatraman, Padmavati Ramachandran, Aneeta Pasha, Ashar Malik and Onaiza Qureshi
    Citation: Trials 2023 24:59
  40. Trials evaluating drug discontinuation (drug discontinuation trials, DDTs) show a broad methodological spectrum. There are several specific methodological aspects in drug discontinuation trials (e.g., determin...

    Authors: Nina Grede, Katrin Kuss, Ina Staudt, Norbert Donner-Banzhoff and Annika Viniol
    Citation: Trials 2023 24:58
  41. Dysarthria after stroke is when speech intelligibility is impaired, and this occurs in half of all stroke survivors. Dysarthria often leads to social isolation, poor psychological well-being and can prevent re...

    Authors: C. Mitchell, A. Bowen, P. Conroy, B. M. Whelan, S. J. Wallace, A. Dancer, K. Woodward-Nutt and J. J. Kirkham
    Citation: Trials 2023 24:57
  42. A “mismatch” sequence of less prenatal weight gain and more postnatal weight gain may lead to ectopic lipid accumulation, and trigger the development of early adrenarche/pubarche and the activation of the gona...

    Authors: Judit Bassols, Francis de Zegher, Marta Diaz, Gemma Carreras-Badosa, Cristina Garcia-Beltran, Elsa Puerto-Carranza, Cora Oliver-Vila, Paula Casano, Céline Alicia Franco, Rita Malpique, Abel López-Bermejo and Lourdes Ibáñez
    Citation: Trials 2023 24:56
  43. Authors: I. W. J. M. van Goor, L. A. Daamen, M. G. Besselink, A. M. E. Bruynzeel, O. R. Busch, G. A. Cirkel, B. Groot Koerkamp, N. Haj Mohammed, H. D. Heerkens, H. W. M. van Laarhoven, G. J. Meijer, J. Nuyttens, H. C. van Santvoort, G. van Tienhoven, H. M. Verkooijen, J. W. Wilmink…
    Citation: Trials 2023 24:55

    The original article was published in Trials 2022 23:913

  44. Children < 5 years old in contact with TB cases are at high risk for developing severe and fatal forms of TB. Contact investigation, BCG vaccination, and isoniazid preventive therapy (IPT) are the most effecti...

    Authors: L. Otero, N. Zetola, M. Campos, J. Zunt, A. Bayer, M. Curisinche, T. Ochoa, M. Reyes, V. Vega, P. Van der Stuyft and TR. Sterling
    Citation: Trials 2023 24:54
  45. External randomised pilot trials aim to determine whether a future definitive randomised controlled trial (RCT) should be conducted, and if so, how. However, not every pilot trial that suggests that a definiti...

    Authors: Katie Mellor, Susan J. Dutton and Sally Hopewell
    Citation: Trials 2023 24:53
  46. We unfortunately need to make an update to our published study protocol that describes a significant change in the design of the study. The Committee on Health Research Ethics of the Capital Region Denmark rec...

    Authors: U. N. Jeppesen, A. S. Due, L. Mariegaard, A. Pinkham, M. Vos, W. Veling, M. Nordentoft and L. B. Glenthøj
    Citation: Trials 2023 24:52

    The Study protocol to this article has been published in Trials 2022 23:658

  47. Design and implementation of multi-country clinical trials for multidrug-resistant tuberculosis (MDR-TB) are complex for several reasons, including trial duration, varying levels of experience and infrastructu...

    Authors: Leena N. Patel, Meera Gurumurthy, Gay Bronson, Karen Sanders and I. D. Rusen
    Citation: Trials 2023 24:51

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