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  1. Immunocompromised hosts (ICH) experience more breakthrough infections and worse clinical outcomes following infection with COVID-19 than immunocompetent people. Prophylactic monoclonal antibody therapies can b...

    Authors: David W. J. Griffin, Michael Dymock, Germaine Wong, C. Orla Morrissey, Sharon R. Lewin, Allen C. Cheng, Kirsten Howard, Julie A. Marsh, Kanta Subbarao, Michelle Hagenauer, Janine Roney, Anthony Cunningham, Tom Snelling and James H. McMahon
    Citation: Trials 2024 25:485
  2. High flow nasal cannula (HFNC) has been increasingly adopted in the past 2 decades as a mode of respiratory support for children hospitalized with bronchiolitis. The growing use of HFNC despite a paucity of hi...

    Authors: Christopher M. Horvat, Srinivasan Suresh, Nathan James, Rajesh K. Aneja, Alicia K. Au, Scott Berry, Arthur Blumer, Kelly Bricker, Robert S. B. Clark, Heidilyn Dolinich, Sheila Hahner, Christina Jockel, Jordan Kalivoda, India Loar, Denee Marasco, Adrienne Marcinick…
    Citation: Trials 2024 25:484
  3. Diarrheal disease is a significant cause of morbidity and mortality in under-fives in many low- and middle-income countries. Changes in food safety, hygiene practices, and nutrition around the weaning period m...

    Authors: Laura Quinn, James Martin, Evans Asamane, Semira Manaseki-Holland, Richard J. Lilford, Lacina Traore, Jacqueline Thompson, Samuel I. Watson and Karla Hemming
    Citation: Trials 2024 25:483

    The Study protocol to this article has been published in Trials 2023 24:68

  4. Narrowband ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, as current...

    Authors: Eva Knöps, Phyllis Spuls, Ruben Duijnhoven, Marcel Dijkgraaf, Marit van Barreveld, Bernd Arents, Annefloor van Enst, Floor Garritsen, Maruschka Merkus, Pina Middelkamp-Hup, Annelie Musters, Angela Bosma, Ariënna Hyseni, Jitske Dijkstra, Dirk Jan Hijnen and Louise Gerbens
    Citation: Trials 2024 25:482
  5. In standard weaning from mechanical ventilation, a successful spontaneous breathing test (SBT) consisting of 30 min 8 cmH2O pressure-support ventilation (PSV8) without positive end-expiratory pressure (PEEP) is f...

    Authors: Carles Subirà, Gina Rognoni, Herbert Baquerizo, Carolina García, Sara Cabañes, Maria de la Torre, Beatriz Quevedo, Cristina Pedrós, Ana I. Tizón, Natalia Murillo, Laura Parro, Fernando Eiras, Gemma Rialp, Susana Altaba, Alejandro González-Castro, Andrés F. Pacheco…
    Citation: Trials 2024 25:481
  6. Postoperative sleep disturbance has a potentially detrimental effect on postoperative recovery. Perioperative patients are affected by several factors. General anesthesia induces a non-physiological state that...

    Authors: Xueru Li, Lijuan Yan, Linhong Wang, Hanshen Chen and Bin Yang
    Citation: Trials 2024 25:480
  7. Insertion of an external ventricular drain (EVD) is a first-line treatment of acute hydrocephalus caused by aneurysmal subarachnoid haemorrhage (aSAH). Once the patient is clinically stable, the EVD is either ...

    Authors: Tenna Capion, Alexander Lilja-Cyron, Marianne Juhler, Kirsten Møller, Angelika Sorteberg, Pål André Rønning, Frantz Rom Poulsen, Joakim Wismann, Anders Emil Schack, Celina Ravlo, Jørgen Isaksen, Jane Lindschou, Christian Gluud, Tiit Mathiesen and Markus Harboe Olsen
    Citation: Trials 2024 25:479
  8. Postpartum depression (PPD) affects 30–50% of women with a history of previous depression or bipolar disorder and 8% of women with no history of depression. Negative cognitive biases in the perception of infan...

    Authors: Anne J. Bjertrup, Jeanne Kofoed, Ida Egmose, Katrine Wendelboe, Victoria Southgate, Mette S. Væver and Kamilla W. Miskowiak
    Citation: Trials 2024 25:478
  9. Digitally delivered weight loss programmes can provide a convenient, potentially cheaper, and scalable treatment option for people who may need to lose weight. However, outcomes are often inferior to in-person...

    Authors: Gina M. Wren, Dimitrios A. Koutoukidis, Jadine Scragg, Grace Preston, Marianne Hennessy, Daisy Estephane, Michael Whitman and Susan A. Jebb
    Citation: Trials 2024 25:477
  10. Participants in research trials often disclose severe depression symptoms, including thoughts of self-harm and suicidal ideation, in validated self-administered questionnaires such as the Patient Health Questi...

    Authors: Vari Wileman, Serena McGuinness, Louise Sweeney, Christine Norton, Laura Miller, Imogen Stagg, Ronan O’Carroll and Rona Moss-Morris
    Citation: Trials 2024 25:476
  11. Infertility produces infertility-related stress in both members of infertile couples, especially for infertile women. Some studies verified the negative relationship between infertility-related stress and outc...

    Authors: Li Liu, Huiyan Yang, Anjiang Lei and Huaxuan You
    Citation: Trials 2024 25:475
  12. Social jetlag is a chronic disruption of sleep timing that is characterized by different sleep timing during workdays and free days. Social jetlag has been associated with disturbed glucose metabolism, insulin...

    Authors: Emma J. Bouman, Romy Slebe, Dirk Jan Stenvers, Petra J. M. Elders, Joline W. J. Beulens and Femke Rutters
    Citation: Trials 2024 25:474
  13. n-of-1 trials are undertaken to optimise the evaluation of health technologies in individual patients. They involve a single patient receiving treatments, both interventional and control, consecutively over se...

    Authors: Robin Chatters, Olivia Hawksworth, Steven Julious and Andrew Cook
    Citation: Trials 2024 25:473
  14. Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women, The standard treatment recommendation for women with early cervical cancer is radical hyste...

    Authors: Xin Zhao, Yansong Liu, Jumin Niu and Yulin Shi
    Citation: Trials 2024 25:471
  15. Gay, bisexual, and other men who have sex with men (GBMSM) represent a high-risk group for HIV transmission in Romania, yet they possess few resources for prevention. Despite having no formal access to pre-exp...

    Authors: Corina Lelutiu-Weinberger, Mircea L. Filimon, Anna M. Zavodszky, Mihai Lixandru, Lucian Hanu, Cristina Fierbinteanu, Raluca Patrascu, Adrian Streinu-Cercel, Sergiu Luculescu, Maria Bora, Irina Filipescu, Cristian Jianu, Lisa B. Heightow-Weidman, Aimee Rochelle, Brian Yi, Nickie Buckner…
    Citation: Trials 2024 25:470
  16. Postpartum depression constitutes a significant public health issue, with prevalence rates ranging between 8 and 19% in high-income nations. Nevertheless, numerous barriers, including time constraints, societa...

    Authors: Daria Daehn, Caroline Meyer, Viola Loew, Jessica Wabiszczewicz, Steffi Pohl, Maria Böttche, Silke Pawils and Babette Renneberg
    Citation: Trials 2024 25:469
  17. With the increasing number of joint replacement surgeries, periprosthetic joint infection (PJI) has become a significant concern in orthopedic practice, making research on PJI prevention paramount. Therefore, ...

    Authors: Michał Kułakowski, Karol Elster, Mateusz Szymczak, Paweł Ślęczka, Mariusz Baumgart, Aleksandra Królikowska and Paweł Reichert
    Citation: Trials 2024 25:468
  18. Sharing trial results with participants is a moral imperative, but too often does not happen in appropriate ways.

    Authors: Annabelle South, Claire Snowdon, Eva Burnett, Barbara E. Bierer, Katie Gillies, Talia Isaacs and Matthew R. Sydes
    Citation: Trials 2024 25:467
  19. More than 50% of people who die by suicide have not been in contact with formal mental health services. The rate of people who fly ‘under the radar’ of mental health services is higher among men than women, in...

    Authors: Jin Han, Aimy Slade, Hiroko Fujimoto, Wu Yi Zheng, Artur Shvetcov, Leonard Hoon, Joost Funke Kupper, Manisha Senadeera, Sunil Gupta, Svetha Venkatesh, Kon Mouzakis, Yuanyuan Gu, Anam Bilgrami, Noura Saba, Henry Cutler, Philip Batterham…
    Citation: Trials 2024 25:466
  20. Mental and neuropsychological disorders make up approximately 14% of the total health burden globally, with 80% of the affected living in low- and middle-income countries (LMICs) of whom 90% cannot access ment...

    Authors: Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen and Juliet Ndimwibo Babirye
    Citation: Trials 2024 25:465
  21. Authors: Jaideep C. Menon, Denny John, Aswathy Sreedevi, Chandrasekhar Janakiram, R Akshaya, S Sumithra, M. S Aravind, Mathews Numpeli, Bipin Gopal, B. A Renjini, P. K Sajeev, Ravivarman Lakshmanasamy and Abhishek Kunwar
    Citation: Trials 2024 25:463

    The original article was published in Trials 2024 25:437

  22. This update outlines amendments to the CHAMPION2/STRIPES2 cluster randomised trial protocol primarily made due to the COVID-19 pandemic and nationwide lockdown in India in 2020. These amendments were in line w...

    Authors: Siddharudha Shivalli, Ila Fazzio, Chris Frost, Diana Elbourne, Nicholas Magill, Dropti Sharma, Sajjan Singh Shekhawat, Rukmini Banerji, Sridevi Karnati, Harshavardhan Reddy, Padmanabh Reddy, Rakhi Nair, Madan Gopal and Peter Boone
    Citation: Trials 2024 25:462

    The Update to this article has been published in Trials 2024 25:280

  23. The preoperative body surface and nasal decolonization may reduce the risk of surgical site infections (SSI) but yields conflicting results in the current orthopedic literature.

    Authors: Ines Unterfrauner, Nadja Bragatto-Hess, Thorsten Studhalter, Mazda Farshad and Ilker Uçkay
    Citation: Trials 2024 25:461
  24. People with serious mental health problems (SMHP) are more likely to be admitted to psychiatric hospital following contact with crisis services. Admissions can have significant personal costs, be traumatic and...

    Authors: Melissa Pyle, Lucy Loftus, Richard Emsley, Daniel Freeman, Steven Gillard, Andrew Gumley, Justyna Sierpatowska, Lisa Wood, Rory C. O’Connor, Paul Pfeiffer, Sharon Anne Simpson, Nicole Cockayne, Gemma Shields, Ariane Beckley, Helen Beckwith, Maria Filippidou…
    Citation: Trials 2024 25:460
  25. Particulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk for infants in neonatal intensive care units (NICUs). This particulate...

    Authors: Francesco Cresi, Elena Maggiora, Cecilia Capetti, Martina Capitanio, Mattia Ferroglio, Elena Spada, Francesca De Matteis, Sara Cosimi, Fabio Mosca and Alessandra Coscia
    Citation: Trials 2024 25:459
  26. Despite progress in reducing the infant mortality in India, the neonatal mortality decline has been slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A promising strategy aimin...

    Authors: Anju Pradhan Sinha, Dilip Raja, Kamlesh S. Mahajan, Piyu Sharma, Subodh S. Gupta, Ramesh Poluru, Anand S. Kawade, Girish Dayma, Sunil Sazawal, Ashish Bavdekar, Sailajanandan Parida, Sushma Nangia, Abhishek V. Raut, Adhisivam Bethou, Prabhabati Devi, Makrand Gorpade…
    Citation: Trials 2024 25:458
  27. This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October 2019.

    Authors: Rindra Vatosoa Randremanana, Mihaja Raberahona, Mamy Jean de Dieu Randria, Josephine Bourner, Gabriella Zadonirina, Hanitra Razananaivo, Théodora Mayouya-Gamana, Reziky Mangahasimbola, Elise Pesonel, Annelies Gillesen, Minoarisoa Rajerison, Voahangy Andrianaivoarimanana, Tansy Edwards, Peter Horby and Piero Olliaro
    Citation: Trials 2024 25:457

    The Research to this article has been published in Trials 2023 24:815

  28. Authors: L. A. Daamen, I. W. J. M. van Goor, V. P. Groot, P. C. M. Andel, L. A. A. Brosens, O. R. Busch, G. A. Cirkel, N. Haj Mohammad, H. D. Heerkens, I. H. J. T. de Hingh, F. Hoogwater, H. W. M. van Laarhoven, M. Los, G. J. Meijer, V. E. de Meijer, R. Pande…
    Citation: Trials 2024 25:456

    The original article was published in Trials 2024 25:401

  29. Lithiasis is a common and recurrent disease. Flexible ureteroscopy (fURS) is the cornerstone of laser treatment of kidney stones. Kidney stones destruction requires its laser pulverization into small fragments...

    Authors: ML. Letouche, B. Giraudeau, MS. Agier and F. Bruyere
    Citation: Trials 2024 25:455
  30. Challenges to recruitment of family caregivers exist and are amplified when consent must occur in the context of chaotic healthcare circumstances, such as the transition from hospital to home. The onset of the...

    Authors: Allison M. Gustavson, Molly J. Horstman, Jodie A. Cogswell, Diane E. Holland, Catherine E. Vanderboom, Jay Mandrekar, William S. Harmsen, Brystana G. Kaufman, Cory Ingram and Joan M. Griffin
    Citation: Trials 2024 25:454
  31. Cleft lip and palate (CLP) are among the most common congenital anomaly that affects up to 33,000 newborns in India every year. Nasoalveolar moulding (NAM) is a non-surgical treatment performed between 0 and 6...

    Authors: Badri Thiruvenkatachari, Krishnamurthy Bonanthaya, Anne Marie Kuijpers Jagtman, Jonathan Sandler, Rajesh S Powar, Syed Altaf Hussain, B. Subramaniyan, Nitin Bhola, Hari Kishore Bhat, Varun Ramachandra, Sylvia Jayakumar, Puneet Batra, Subhiksha Chakkaravarthi, V. Thailavathy, Manoj Prathap, Thulasiram Elumalai…
    Citation: Trials 2024 25:453
  32. Despite the low-risk nature of participation in most clinical anesthesia trials, subject recruitment on the same day as surgery is often restricted due to the concerns of researchers and local research ethics ...

    Authors: Connor T. A. Brenna, Nancy Walton, Melanie Cohn, Urooj Siddiqui, Ella Huszti and Richard Brull
    Citation: Trials 2024 25:452
  33. Many stroke survivors remain with residual cognitive and motor impairments despite receiving timely acute and sub-acute rehabilitation. This indicates that rehabilitation following stroke should be continuous ...

    Authors: S.K. Huber, R.H. Knols, J.P.O. Held, M. Betschart and E.D. de Bruin
    Citation: Trials 2024 25:451
  34. Patients with language barriers encounter healthcare disparities, which may be alleviated by leveraging interpreter skills to reduce cultural, language, and literacy barriers through improved bidirectional com...

    Authors: Inna Strechen, Patrick Wilson, Targ Eltalhi, Kimberly Piche, Dan Tschida-Reuter, Diane Howard, Bruce Sutor, Ing Tiong, Svetlana Herasevich, Brian Pickering and Amelia Barwise
    Citation: Trials 2024 25:450
  35. One single-center randomized clinical trial showed that INTELLiVENT-adaptive support ventilation (ASV) is superior to conventional ventilation with respect to the quality of ventilation in post-cardiac surgery...

    Authors: Martin H. Bernardi, Dominique Bettex, Laura A. Buiteman–Kruizinga, Ashley de Bie, Matthias Hoffmann, Janine de Kleijn, Simon Corrado Serafini, Manon A. Molenaar, Frederique Paulus, Jasminka Peršec, Ary Serpa Neto, Reto Schuepbach, Paolo Severgnini, Andrej Šribar, Marcus J. Schultz and Edda Tschernko
    Citation: Trials 2024 25:449
  36. Combination prevention interventions, when integrated with community-based support, have been shown to be particularly beneficial to adolescent and young peoples’ sexual and reproductive health. Between 2020 a...

    Authors: Thembelihle Zuma, Jacob Busang, Sphesihle Hlongwane, Glory Chidumwa, Dumsani Gumede, Manono Luthuli, Jaco Dreyer, Carina Herbst, Nonhlanhla Okesola, Natsayi Chimbindi, Nuala McGrath, Lorraine Sherr, Janet Seeley and Maryam Shahmanesh
    Citation: Trials 2024 25:448
  37. The role of cytoreductive nephrectomy (CN) in the treatment of metastatic renal cell carcinoma (mRCC) remains unclear in the immuno-oncology (IO) era. The results of two randomized trials, CARMENA and SURTIME,...

    Authors: Jee Soo Park, Jongchan Kim, Jinhyung Jeon, Jongsoo Lee, Won Sik Jang, Seung Hwan Lee, Woong Kyu Han, Young Deuk Choi, Kyo Chul Koo, Kang Su Cho, Byung Ha Chung and Won Sik Ham
    Citation: Trials 2024 25:447
  38. Globally, violence against children poses substantial health and economic challenges, with estimated costs nearing USD 7 trillion. This prompts the urgent call for effective evidence-based interventions in pre...

    Authors: Jonathan Klapwijk, G. J. Melendez-Torres, Abigail Ornellas, Mwita Wambura, Angelique N. Chetty, Lauren Baerecke, Joyce Wamoyi and Lucie D. Cluver
    Citation: Trials 2024 25:446

    The Study protocol to this article has been published in Trials 2024 25:119

  39. Body weight loss (BWL) after gastrectomy impact on the short- and long-term outcomes. Oral nutritional supplement (ONS) has potential to prevent BWL in patients after gastrectomy. However, there is no consiste...

    Authors: Kohei Ueno, Tatsuto Nishigori, Yukinari Tokoro, Akiyoshi Nakakura, Shigeru Tsunoda, Shigeo Hisamori, Kyoichi Hashimoto, Seiichiro Kanaya, Kenjiro Hirai, Eiji Tanaka, Hiroaki Hata, Dai Manaka, Masazumi Sakaguchi, Masato Kondo, Takatsugu Kan, Atsushi Itami…
    Citation: Trials 2024 25:445
  40. Mild cognitive impairment (MCI) involves cognitive decline beyond typical age-related changes, but without significant daily activity disruption. It can encompass various cognitive domains as the causes of MCI...

    Authors: Drin Ferizaj, Oskar Stamm, Luis Perotti, Eva Maria Martin, Anja Ophey, Sophia Rekers, Daniel Scharfenberg, Tobias Oelgeschläger, Katharina Barcatta, Sigrid Seiler, Johanna Funk, Charles Benoy, Carsten Finke, Elke Kalbe, Kathrin Finke and Anika Heimann-Steinert
    Citation: Trials 2024 25:444
  41. Women with a history of gestational diabetes mellitus (GDM) are 12-fold more likely to develop type 2 diabetes (T2D) 4–6 years after delivery than women without GDM. Similarly, GDM is associated with the devel...

    Authors: Alicia Salamanca-Sanabria, Seaw Jia Liew, Jacqueline Mair, Maria De Iorio, Young Doris Yee Ling, Mya Thway Tint, Yew Tong Wei, Karen Lim, Desmond Ong, Yu Chung Chooi, Vicky Tay and Johan Gunnar Eriksson
    Citation: Trials 2024 25:443
  42. Neck pain is a prevalent global musculoskeletal issue, significantly contributing to the loss of years of healthy life due to disability. Chronic nonspecific neck pain (CNNP) involves diverse symptoms impactin...

    Authors: Aron Charles Barbosa da Silva, Gabriela Nascimento Santana, Inaê Silva Santos, Patrícia Gabrielle dos Santos, Adriano Rodrigues de Oliveira, Almir Vieria Dibai Filho and Cid André Fidelis de Paula Gomes
    Citation: Trials 2024 25:442
  43. Major depressive disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall quality of life. Approximately one third of individuals with depression do n...

    Authors: Joshua M. Poulin, Gregory E. Bigford, Krista L. Lanctôt, Peter Giacobbe, Ayal Schaffer, Mark Sinyor, Jennifer S. Rabin, Mario Masellis, Amit Singnurkar, Christopher B. Pople, Nir Lipsman, Muhammad I. Husain, Joshua D. Rosenblat, Xingshan Cao, Bradley J. MacIntosh and Sean M. Nestor
    Citation: Trials 2024 25:441
  44. Low anterior resection syndrome (LARS) is a distressing condition that affects approximately 25–80% of patients following surgery for rectal cancer. LARS is characterized by debilitating bowel dysfunction symp...

    Authors: Gaoyang Cao, Xinjie Zhang, Fei Wang, Da Man, Lijie Wu, Xuchu Pan and Shan Chen
    Citation: Trials 2024 25:440
  45. Moderately severe or major trauma (injury severity score (ISS) > 8) is common, often resulting in physical and psychological problems and leading to difficulties in returning to work. Vocational rehabilitation...

    Authors: Denise Kendrick, Rebecca Lindley, Lauren Blackburn, Cristina Roadevin, Ellen Thompson, Isabel Andrews, Fahim Anwar, Adam Brooks, Edd Carlton, Robert Crouch, Florence Day, Steve Fallon, Amanda Farrin, Laura Graham, Karen Hoffman, Rebekah Howell…
    Citation: Trials 2024 25:439
  46. Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and at present, India has the highest burden of acute coronary syndrome and ST-elevation myocardial infarction (MI). A key reason for p...

    Authors: Jaideep C. Menon, Denny John, Aswathy Sreedevi, Chandrasekhar Janakiram, Akshaya R, Sumithra S, Aravind M S, Mathews Numpeli, Bipin Gopal, Renjini B A, Sajeev P K, Ravivarman Lakshmanasamy and Abhishek Kunwar
    Citation: Trials 2024 25:437

    The Correction to this article has been published in Trials 2024 25:463

  47. Norepinephrine and phenylephrine are commonly used vasoactive drugs to treat hypotension during the perioperative period. The increased release of endogenous norepinephrine elicits prothrombotic changes, while...

    Authors: Wenhui Tao, Yufang Xie, Wei Ding, Jinfeng Bao, Ye Zhang and Xianwen Hu
    Citation: Trials 2024 25:432
  48. Use of sedatives and analgesics is associated with the occurrence of delirium in critically ill patients receiving mechanical ventilation. Dexmedetomidine reduces the occurrence of delirium but may cause hypot...

    Authors: Wenhui Zhang, Jinjin You, Jing Hu, Xiangding Chen, Han Wang, Nan Li, Chen Wei, Wanchun Tang and Xiangrong Zuo
    Citation: Trials 2024 25:431

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