Skip to main content

Effectiveness of self-administered mirror therapy on upper extremity impairments and function of acute stroke patients: study protocol



Many therapeutic interventions are performed by physiotherapists to improve upper extremity function and/or activities of daily living (ADL) in stroke patients. Mirror therapy (MT) is a simple technique that can be self-administered by the patients with intact cognition following patient education by a skilled physiotherapist. However, the effectiveness of self-administered MT in post-stroke patients in upper extremity function remains unclear. Therefore, the objective of this study is to examine the effectiveness of MT in improving upper extremity function and recovery in acute stroke patients.


This study is a single-center, prospective, randomized, open-label, controlled trial with blinded outcome evaluation (PROBE design), in which a total of 36 eligible acute stroke patients will be randomly assigned to control (n=18) and experimental group (n=18). Participants in the control group will receive regular rehabilitation interventions whereas participants in the experimental group will receive MT education in addition to their regular interventions for 4 weeks.

Study outcome

The primary outcome measure will be upper extremity function that will be measured using the Fugl-Meyer Assessment scale and the Wolf Motor Function Test. The secondary outcome measure will be behaviors related to ADL as estimated using the Modified Barthel Index. Outcome measures will be assessed at baseline and at 4 weeks post-rehabilitation intervention/MT.


A two-way repeated analysis of variance (ANOVA) with time and group effects will be used to analyze between-group differences. The level of significance will be set at P < 0.05.


The results of the study will provide critical information to include self-administered MT as an adjuvant to regular interventions and may facilitate recovery of the upper extremity function of stroke patients.

Trial registration NCT04542772. Registered on 9 September 2020. Protocol version: Final 1.0.

Peer Review reports


Stroke is a sudden loss of brain function caused by focal cerebral ischemia or hemorrhage resulting in neurological impairments [1]. According to available statistics from 2012 to 2013, the number of stroke survivors in Canada is equivalent to the population of New Brunswick. It is the third leading cause of death and physical disability in Canadian adults [2]. Unfortunately, up to 78% of stroke survivors have impaired upper extremity function resulting in diminished activities of daily living [3]. Evidence shows that stroke survivors with initial upper extremity weakness can regain function using therapeutic interventions [4]. The Canadian Stroke Best Practice Guidelines (CSBPG) outlined specific therapies, such as range-of-motion exercises, mental imagery, functional electrical stimulation, mirror therapy (MT), constraint-induced movement therapy, virtual reality, strength training, and bilateral arm training, to improve upper extremity function [5]. While the majority of these therapeutic procedures are administered by skilled professionals, mirror therapy is a simple and inexpensive technique that can be self-administered by the patients with intact cognition.

In MT, the patient is seated with a lap tray and a mirror is placed in between the arms in midsagittal plane with the mirror facing the unaffected arm. The patient is asked to move the unaffected arm while looking at the mirror. The patient perceives the reflection in the mirror as his paralyzed arm and the brain receives a stimulus as if the patient is moving his affected arm. This visual stimulus supports motor rehabilitation by capitalizing on the strong connection between visual input and the premotor cortex [5, 6]. The effectiveness of MT in upper extremity function has been well explored in the past [7,8,9,10,11].

Critical review

In an effort to identify gaps in the literature and to identify the parameters that can be used for our study, published systematic reviews and meta-analyses on the use of mirror therapy on upper extremity function in post-stroke patients were reviewed. A total of 49 studies were identified in six systematic reviews [12,13,14,15,16,17]. We categorized those 49 studies as acute/early sub-acute stroke (< 4 weeks), sub-acute stroke (< 3 months), and chronic stroke (> 3 months) based on the initiation of intervention from stroke onset [7]. Of these 49 studies, five studies (Table 1) were conducted on acute/early sub-acute stroke patients and were included for critical analysis (Table 2) [8,9,10,11, 18]. We found that the included five studies had limited sample sizes, weak methodology, and MT intervention were therapist guided. The frequency and duration of the MT intervention ranged from 5 days/week, 30 min/session for 2 weeks to 5 days/week, and 30 min/session for 6 weeks. The type of exercise training varied across all 5 trials. Bilateral arm training was included in one study [7], unilateral movement in two studies [8, 11], MT combined with constraint-induced movement therapy in one study [10], and MT combined with neuro-muscular electrical stimulation in one study [9]. In all five studies, it was concluded that MT was effective in improving the upper extremity function of stroke patients.

Table 1 Primary studies included in systematic reviews
Table 2 Sample size, risk of bias, and PEDro scores

The effectiveness of MT was summarized in one of the recent Cochrane reviews which included randomized controlled trials (RCTs) and randomized cross-over trials comparing MT and other interventions. The results suggested moderate-quality evidence that MT has a significant effect on motor function with SMD 0.47, 95% CI 0.27–0.67 for all outcome measures and mean difference of 4.32, 95% CI 2.46–6.19 for Fugl-Meyer Assessment upper extremity [19]. The authors suggested that MT should be considered, at least, as an adjuvant to conventional rehabilitation to improve upper extremity motor impairments and ADL of stroke survivors [17].

Morkisch et al. performed a secondary meta-analysis on a Cochrane review for MT to detect which parameters of the therapeutic protocols influence the effect of MT in upper extremity rehabilitation in post-stroke individuals. They found that unilateral arm movement execution without manipulation of objects with a larger mirror was found to be more effective in improving motor function than bilateral movement including manipulation of objects with using a smaller mirror [12]. The use of a larger mirror (50 x 40 cm) lessens the distraction and increases unilateral visual feedback. In addition, the larger mirror allows incorporation of shoulder movements and shaping (adaptation of the content of the therapy) [18]. Evidence shows that mirrored movements of the unaffected limb resulted in sufficient neural activation, without movement of the paretic limb [20, 21].

Patient self-managed education program has been shown to be effective in improving patient outcomes and in reducing treatment costs in other clinical conditions [22]. In addition, there is evidence that self-delivered MT intervention is feasible and improves patient outcomes in other clinical conditions [23]. Although the effect of patient education and effectiveness of MT are extensively explored in separate studies, the effectiveness of self-administered MT has not been explored in acute stroke patients. Also, literature shows that rehabilitation interventions are crucial during the first 4 weeks post-stroke as it is a critical time for neural plasticity and recovery [7]. Therefore, the objective of the present study is to examine the effectiveness of MT in improving upper extremity function and recovery in acute care settings.

Material and methods

Study design

A single-center, prospective, randomized, open-label, controlled trial with blinded outcome evaluation (PROBE design) will be used to evaluate the effectiveness of self-administered MT on upper extremity functions of acute/or early sub-acute stroke patients.

Study setting

The study will be conducted at the acute stroke and intensive rehabilitation units at one of the Ontario hospitals between July 2021 and June 2022. We assessed feasibility of single-center study by reviewing The Discharge Abstract Database (DAD) which revealed approximately 300 stroke annual stroke admissions for the last two fiscal years. This will allow sufficient patient recruitment (calculated below) over 1 year period for the study.

Study participants

A stroke team member at the hospital will identify potential patients, and a physiotherapist will assess patient eligibility based on the following inclusion: (1) > 18 years of age; (2) any gender; (3) admitted with a diagnosis of stroke with onset within 2 weeks; (4) Brunnstrom stages of stroke recovery between 2 and 4 for the upper extremity; (5) able to follow directions; (6) no severe cognitive impairments that could interfere with patient participation; (7) consent to treatment by the patient; and (8) Alpha-Functional Independence Measure (Alpha-FIM) score of > 40. Patients will be excluded based on several criteria: (1) medically unstable patients; (2) lack of motivation; (3) recurrent/chronic stroke; (4) recent upper extremity musculoskeletal injuries with movement restrictions; (5) receptive or global aphasia; (6) delirium; (7) unilateral neglect; and (8) visual field defect.

Group assignment

Sample size estimates

The sample size and effect size were calculated based on a previously published study [24], using the G* power software. A sample of 18 will be required in each group to detect a difference in the primary outcome measure (FMA-UE) with an effect size (Cohen’s d) of 1.15 and a statistical power of 0.80 at a one-sided type one error of 0.05.

Based on the above calculation, a total of 36 patients will be recruited and assigned to the MT (n = 18) or control group (n =18) using a random sampling method. Randomization will be done prior to the baseline assessment with a statistical software program that generates this sequence. Random numbers will be assigned according to the order of patients’ admission to the hospital. To conceal allocation, random group allotment will be managed by a social worker who will not be involved in the assessment or intervention to minimize the confounding and contamination. Refer to Fig. 1 for the study process.

Fig. 1
figure 1

Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) used to identify studies


Pre- and post-test assessments will be performed by a physiotherapist who will be blinded to group allocation (assessor blinding). Patient education will be provided by a research assistant who will neither be involved in outcome assessment nor with implementing regular rehabilitation interventions. The research assistant will ensure that the patient understands the parameters of the exercise intervention, mirror placement, and unilateral arm execution (nonparalytic arm should be moved and not the paralyzed arm) and masters the MT technique.


Both the experimental and the control groups will receive the standard-of-care, multidisciplinary rehabilitation intervention based on their needs and tolerance, whereas patients in the experimental group will self-administer MT for an additional 30 min. During MT education, the patients will be educated or shown how to perform MT and the patients will complete the recommended exercises on their own for 5 days a week for 4 weeks. The research assistant will aid with setup if needed. As recommended in the standard MT procedures, patients will be asked to remove all jewelry and to sit on the chair or wheelchair in front of the table. A mirror will be placed on the table at a perpendicular angle, and its reflecting surface will face the non-paretic limb. The paretic limb will be positioned behind the mirror, and the non-paretic limb will be placed in front of the reflecting surface of the mirror. Patients will be asked to look at the mirror while doing exercises with the non-paretic limb. This activity will provide visual feedback to the brain like the patient moving the paretic limb. The patients in the MT group will be educated to perform the following several movements on the non-paretic side while looking at the mirror: (1) metacarpophalangeal (MCP) flexion, extension, and abduction; (2) fist and release; (3) wrist ulnar and radial deviations; (4) wrist flexion and extension; (5) forearm pronation and supination; (6) elbow flexion and extension; (7) shoulder flexion; and (8) shoulder abduction. Each movement will be performed for 10 repetitions and 2–3 sets (depending on patient tolerance) for a total of 30 min/session for 5 days a week for a period of 4 weeks. Patients in the experimental group will be given an exercise logbook to record exercise compliance. The logbook will include date, duration of MT, types of exercises (e.g., shoulder movements, elbow movement, wrist movement, and finger movements). Patients will be asked to record the above every single time they do the exercises. Exercise compliance will be considered as adequate if patients complete 80% of MT protocol (e.g., 25 min per day for 4 days a week for 3 weeks).

Participant bias will be minimized by assuring the participant that the quality of rehabilitation will not be affected by group assignment and by explaining that the trial aims to analyze whether the addition of MT education will have an additional beneficial impact on functional outcomes. The research will be initiated in an acute stroke unit and will be carried over in an intensive rehabilitation unit of the same hospital. We are not anticipating any confounding variables at this time during the patient transfer process as this happens within the same hospital and the patients in the experimental group will be self-administering MT only after the regular rehabilitation hours without interrupting any of the exercises or education that are regularly provided by therapists at intensive rehabilitation unit. The mirror for MT will be provided to the patient during the initial assessment (pre-test assessment) that the patient will take it with them to the rehabilitation unit and will be returned at the end of 4 weeks post-assessment.

Outcome measures and data collection

The primary outcome measures of interest are the level of upper limb motor impairment and functional performance. These variables will be measured using the Fugl-Meyer Assessment-upper extremity (FMA-UE) and the Wolf Motor Function Test (WMFT), respectively. Both FMA-UE and WMFT are reliable and valid outcome measures and are used consistently in MT research [25]. Moreover, the Stroke Edge Task Force of the Academy of Neurological Physical Therapy (American Physical Therapy Association) recommends FMA-UE and WMFT for patients who have had a stroke and who are undergoing acute care [26]. The secondary outcome measure will be ADL measured by the Modified Barthel Index (MBI), a reliable and valid tool for assessing ADL in stroke survivors and used in MT research.

A physiotherapist will assess the above outcome measures twice: (1) pre-test assessment at the beginning of the trial and (2) post-test assessment at the end of the trial. Before the study, the assessor will be trained in assessing all outcome measures and will be tested with two patients to assure standardization. The assessors will be trained by one of the investigators of this study (VR) who is a physiotherapist specialized in stroke rehabilitation and experienced in administering the above outcome measures. In addition, demographic characteristics, such as age, gender, handedness, Alpha-FIM score, Brunnstrom stages of motor recovery, type of lesion, side of hemiplegia, and the onset of stroke, will be collected during the initial assessments (Fig. 2).

Fig. 2
figure 2

Flow chart representing study process

Participant timeline

Participant timeline was developed according to the SPIRIT guideline and is presented in Table 3.

Table 3 Timeline of screening, recruitment, randomization, interventions, and assessments

Rehabilitation interventions are crucial during the first 4 weeks post-stroke as it is a critical time for neural plasticity and recovery [17]. Therefore, the present study will be initiated within 48 to 72 h of patient admission in the acute care unit and will be continued for 4 weeks following the initial assessment. Following admission to an acute stroke unit, screening and informed consent and baseline outcome assessments will be completed within 48 to 72 h. The mirror therapy education will commence immediately after the baseline assessment and end in 4 weeks.

Statistical analysis

Data analysis

Data will be analyzed using the SPSS software version 23. Demographic characteristics and baseline scores will be compared using the independent t-test and the chi-squared test for continuous variables (such as age and time since stroke) and dichotomous variables (gender, dominance, affected side, and type of lesion), respectively. A two-way repeated analysis of variance (ANOVA) with time and group effects will be used to analyze between-group differences. We will administer both intention-to-treat and per-protocol analyses to determine the effectiveness of the proposed intervention [27]. The level of significance will be set at P < 0.05. Patients will be considered as being compliant if they perform at least 80% of the original MT protocol. The compliance will be reported using the four ways recommended by Hawley-Hague et al. (i.e., completion, attendance, duration adherence, and intensity adherence) [28]. In addition, CONSORT will be used to report this RCT to facilitate reading and quality assessment.


A limitation of this study is having two primary outcome measures which affects the power of the study. However, we decided to include both the outcome measures as we are interested in exploring the effectiveness of MT in improving motor impairment and motor function.

Safety and adverse event monitoring

A data safety monitoring board will be notified outlining adverse events that occur from this study, from baseline assessment through to completion of the final evaluation.

Stopping rules and early termination

Participants will be removed from the study if they want to withdraw themselves from the study. Participants’ data will be removed and will not be included for analysis if they request the withdrawal of their data before entering it for data analysis.


This will be the first study exploring the benefits of patient education on MT in acute stroke patients. We expect that the results of the study will provide critical information to plan MT as an adjuvant to regular interventions for acute stroke patients. This inexpensive treatment technique may improve patient participation and therapy time which may promote robust recovery of the upper extremity function of stroke patients.

Trial status

The current protocol version is “Final 1.0.”, as of September 9, 2020. A total of 36 patients will be recruited for the study. As of May 19, no patients were recruited for the study. Recruitment is estimated to begin in July 2021 and end in June 2022.

Availability of data and materials

Additional data and documents are available on request.


  1. Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064–89.

    Article  PubMed  Google Scholar 

  2. Stroke in Canada, (2016, October 27). In Public Health Agency of Canada. Retrieved September 30, 2019, from Accessed 30 Dec 2020.

  3. Lawrence ES, Coshall C, Dundas R, Stewart J, Rudd AG, Howard R, et al. Estimates of the prevalence of acute stroke impairments and disability in a multiethnic population. Stroke. 2001;32(6):1279–84.

    Article  CAS  PubMed  Google Scholar 

  4. Hatem SM, Saussez G, Della Faille M, Prist V, Zhang X, Dispa D, et al. Rehabilitation of motor function after stroke: a multiple systematic review focused on techniques to stimulate upper extremity recovery. Front Hum Neurosci. 2016;10:442.

    Article  CAS  Google Scholar 

  5. Hebert D, Lindsay MP, McIntyre A, Kirton A, Rumney PG, Bagg S, et al. Canadian stroke best practice recommendations: stroke rehabilitation practice guidelines, update 2015. Int J Stroke. 2016;11(4):459–84.

    Article  PubMed  Google Scholar 

  6. Seitz RJ, Höflich P, Binkofski F, Tellmann L, Herzog H, Freund HJ. Role of the premotor cortex in recovery from middle cerebral artery infarction. Arch Neurol. 1998;55(8):1081–8.

    Article  CAS  PubMed  Google Scholar 

  7. Bernhardt J, Hayward KS, Kwakkel G, Ward NS, Wolf SL, Borschmann K, et al. Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce. Int J Stroke. 2017;12(5):444–50.

    Article  PubMed  Google Scholar 

  8. Dohle C, Püllen J, Nakaten A, Küst J, Rietz C, Karbe H. Mirror therapy promotes recovery from severe hemiparesis: a randomized controlled trial. Neurorehabil Neural Repair. 2009;23(3):209–17.

    Article  PubMed  Google Scholar 

  9. Invernizzi M, Negrini S, Carda S, Lanzotti L, Cisari C, Baricich A. The value of adding mirror therapy for upper limb motor recovery of subacute stroke patients: a randomized controlled trial. Eur J Phys Rehabil Med. 2013;49(3):311–7.

    CAS  PubMed  Google Scholar 

  10. Yun GJ, Chun MH, Park JY, Kim BR. The synergic effects of mirror therapy and neuromuscular electrical stimulation for hand function in stroke patients. Ann Rehabil Med. 2011;35(3):316–21.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Yoon JA, Koo BI, Shin MJ, Shin YB, Ko HY, Shin YI. Effect of constraint-induced movement therapy and mirror therapy for patients with subacute stroke. Ann Rehabil Med. 2014;38(4):458–66.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Morkisch N, Thieme H, Dohle C. How to perform mirror therapy after stroke? Evidence from a meta-analysis. Restor Neurol Neurosci. 2019;37(5):421–35.

    Article  PubMed  Google Scholar 

  13. Pérez-Cruzado D, Merchán-Baeza JA, González-Sánchez M, Cuesta-Vargas AI. Systematic review of mirror therapy compared with conventional rehabilitation in upper extremity function in stroke survivors. Aust Occup Ther J. 2017;64(2):91–112.

    Article  PubMed  Google Scholar 

  14. Zeng W, Guo Y, Wu G, Liu X, Fang Q. Mirror therapy for motor function of the upper extremity in patients with stroke: a meta-analysis. J Rehabil Med. 2018;50(1):8–15.

    Article  PubMed  Google Scholar 

  15. Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C. Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev. 2012;2012(3):CD008449. Published 2012 Mar 14.

    Article  PubMed Central  Google Scholar 

  16. Mirela Cristina L, Matei D, Ignat B, Popescu CD. Mirror therapy enhances upper extremity motor recovery in stroke patients. Acta Neurol Belg. 2015;115(4):597–603.

    Article  PubMed  Google Scholar 

  17. Yang Y, Zhao Q, Zhang Y, Wu Q, Jiang X, Cheng G. Effect of mirror therapy on recovery of stroke survivors: a systematic review and network meta-analysis. Neuroscience. 2018;390:318–36.

    Article  CAS  PubMed  Google Scholar 

  18. Morkisch N, Jettkowski K, Ferreira dos Santos L, Dohle C. Modelling of therapeutic action during mirror therapy-Aqualitative analysis as basis for technical solutions. Curr Direct Biomed Eng. 2017;3(1):45–8.

    Article  Google Scholar 

  19. Thieme H, Morkisch N, Mehrholz J, et al. Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev. 2018;7(7):CD008449. Published 2018 Jul 11.

    Article  PubMed  Google Scholar 

  20. di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G. Understanding motor events: a neurophysiological study. Exp Brain Res. 1992;91(1):176–80.

    Article  PubMed  Google Scholar 

  21. Wang J, Fritzsch C, Bernarding J, Krause T, Mauritz K-H, Brunetti M, et al. Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects. NeuroRehabilitation. 2013;4:593–603.

    Article  Google Scholar 

  22. Bodenheimer T, Lorig K, Holman H, Grumbach K. Patient self-management of chronic disease in primary care. JAMA. 2002;288(19):2469–75.

    Article  PubMed  Google Scholar 

  23. Darnall BD, Li H. Home-based self-delivered mirror therapy for phantom pain: a pilot study. J Rehabil Med. 2012;44(3):254–60. Accessed 30 Dec 2020.

  24. Samuelkamaleshkumar S, Reethajanetsureka S, Pauljebaraj P, Benshamir B, Padankatti SM, David JA. Mirror therapy enhances motor performance in the paretic upper limb after stroke: a pilot randomized controlled trial. Arch Phys Med Rehabil. 2014;95(11):2000–5.

  25. Cantero-Téllez R, Naughton N, Algar L, Valdes K. Outcome measurement of hand function following mirror therapy for stroke rehabilitation: a systematic review. J Hand Ther. 2019;32(2):277–91. e1.

    Article  PubMed  Google Scholar 

  26. Rose, D., Pinto-Zipp, G., Anderson, H., Bland, M., Byl, N., Capo-Lugo, C., Sulwer M., Yoshida, R. (2018). StrokeEDGE II outcome measures in acute care. Academy of Neurological Physical Therapy, division of American Physical Therapy Association, United States. Retrieved November 10, 2019, from

  27. Shah PB. Intention-to-treat and per-protocol analysis. CMAJ. 2011;183(6):696.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Hawley-Hague H, Horne M, Skelton DA, Todd C. Review of how we should define (and measure) adherence in studies examining older adults' participation in exercise classes. BMJ Open. 2016;6(6):e011560.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references


This study was reviewed and funded by the Northern Ontario Academic Medicine Association (Project C-20-15). The funding body played no role in the design of the study, data collection, analysis, or data interpretation and in writing the manuscript.

Author information

Authors and Affiliations



VR conceived the idea for the study. VR and DJ drafted the protocol. All authors were involved in the critical revision of the protocol and approved the protocol.

Authors information

V. Rajendran, PT, PhD, is a registered physiotherapist at Health Sciences North and an adjunct professor in the School of Kinesiology and Health Sciences at Laurentian University, Sudbury, Ontario. He is also a clinical lecturer at Northern Ontario School of Medicine

D. Jeevanantham, PT, PhD, is a registered physiotherapist at Health Sciences North and assistant clinical professor at Northern Ontario School of Medicine. She is also an adjunct professor in the School of Kinesiology and Health Sciences at Laurentian University, Sudbury, Ontario.

C. Larivière, PhD, is the Dean of the Faculty of Education and Health and a Full Professor in the School of Kinesiology and Health Sciences at Laurentian University.

Ravinder-Jeet Singh, MMBS, DM, is a Stroke Neurologist at Health Sciences North, and an assistant clinical professor at Northern Ontario School of Medicine.

Lisa Zeman, RN, is a clinical manager of Medicine and acute Stroke Program, Health Sciences North, Sudbury, Ontario

Padma Papuri, MD, FRCPC, is an assistant professor at Northern Ontario School of Medicine and a medical director for the Northeastern Ontario Stroke Network, Sudbury, Ontario.

Corresponding author

Correspondence to Venkadesan Rajendran.

Ethics declarations

Ethics approval and consent to participate

The research study information package will be explained to all potential study participants, and baseline measurements will be taken after receiving a signed informed consent from the potential participant. Participants will be given options to withdraw from the study at any time. Ethics approval was obtained from an institutional review board at the Health Sciences North Research Institute.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rajendran, V., Jeevanantham, D., Larivière, C. et al. Effectiveness of self-administered mirror therapy on upper extremity impairments and function of acute stroke patients: study protocol. Trials 22, 439 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: