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Controlling Hypertension After Severe Cerebrovascular Event (CHASE): study protocol for a randomized controlled trial
Trials volume 19, Article number: 130 (2018)
No ideal blood pressure (BP) range has been scientifically determined for acute stroke, and no studies on BP management have been carried out for patients with severe stroke. This trial aims to investigate whether individualized lowering of elevated BP would improve the outcome in patients with severe stroke.
The CHASE trial is a multicenter, randomized, controlled study. A total of 500 adult patients with acute severe stroke will be enrolled in 18 study sites in China and randomized to individualized BP lowering (10–15% reduction from admission level) or guideline-recommended BP lowering. The primary outcome measurement is the proportion of participants with a poor outcome (modified Rankin Scale ≥ 3) at day 90 of enrollment. Secondary outcomes include disability at hospital discharge and the ability of activities of daily living at day 90 of enrollment. The relationship between intervention and the primary outcome will be analyzed using multivariate logistic regression adjusted for study site, demographics, and baseline characteristics.
The CHASE trial will be the first study to explore the optimum BP management for acute severe stroke. This trial potentially offers a strong argument for individualized target for lowering elevated BP in patients with severe stroke.
ClinicalTrials.gov, NCT02982655. Registered on 30 November 2016.
Elevated blood pressure (BP) is one of the most common clinical manifestations in acute stroke; 70–84% [1,2,3] of stroke patients have a systolic blood pressure (SBP) > 140 mmHg on admission. Despite efforts by a few multicenter studies, the optimum management of BP in acute stroke is still an ongoing dilemma. The ACCESS study and CHHIPS study indicated that modest BP reduction brought down the mortality and the number of vascular events , whereas the SCAST study suggested that a careful BP-lowering treatment was associated with a higher risk of poor outcome. The results from the COSSACS study, CATIS study, ATACH-2 study, and INTERACT2 study are neutral: intensive lowering of BP did not reduce the mortality or severe disability significantly [5,6,7,8].
However, none of the above studies were targeted at patients with severe stroke. Acute severe strokes account for 13–24% of all strokes [9, 10] and are associated with cerebral hernia, acute cardiac failure , systemic complications , and death. Given the paucity, we initiated a multicenter randomized controlled trial (RCT) called CHASE, dedicated to test whether individualized antihypertensive treatment would lower the mortality and major disability in patients with severe stroke.
The study aims at assessing the effect of individualized BP-lowering regimens vs guideline-recommended BP-lowering regimens on mortality and morbidity in patients with acute severe stroke.
This study has a multicenter, randomized, controlled, single-blind design. Patients will be randomized to two different arms: (1) intervention group (individualized BP lowering), with an individualized target for BP lowering during the first week of hospitalization; and (2) control group (guideline-recommended BP lowering), with a fixed target recommended by the guideline for BP lowering during the first week of hospitalization. The participants are blind to the grouping results; the researchers are informed of the grouping results because they have to follow a specified strategy of BP management. Figure 1 shows a flowchart of the study design. Recommendations for Interventional Trials (SPIRIT) Figure are outlined in Additional file 1.
This is a Chinese multicenter trial involving 18 tertiary and district general hospitals in Shaanxi province, an administrative region with a population of 38 million located at the very center of China. The study will be conducted according to Good Clinical Practice guidelines and the Declaration of Helsinki. The study has been approved by the ethics committees of Xijing hospital (KY20162085-2).
Training of investigators
All CHASE investigators are required to be trained in the protocol, Good Clinical Practice, and use of the Glasgow Coma Scale (GCS), National Institute of Health stroke scale (NIHSS), Barthel index, and modified Rankin Scale (mRS) if they had no recent certifications.
The study will include patients with acute severe stroke who have elevated BP on admission. In order to be eligible for inclusion in the study, the patients have to comply with the following criteria: (1) age ≥ 18 years; (2) the randomly assigned BP-lowering regimen is able to be commenced within 72 h after the onset of stroke (ischemic or hemorrhagic), confirmed by a computed tomography (CT) or magnetic resonance imaging (MRI) scan of the brain (if the precise timing of the onset of symptoms or signs of the qualifying event is unknown, then the time of onset will be taken as the last time the patient was known to be well); (3) GCS on admission ≤ 12 or NIHSS on admission ≥ 11; (4) there are at least two SBP measurements of ≥ 150 and ≤ 210 mmHg, recorded ≥ 5 min apart (patients with an initial SBP < 150 mmHg may be randomized when the SBP fulfils entry criteria on rechecking up to 72 h after the onset of stroke); and (5) written informed consent is able to be obtained directly from the patient or an appropriate surrogate, based on local ethics committee recommendations.
Exclusion criteria are: (1) patients who have received thrombolytic therapy, embolectomy, or decompressive craniectomy for the current stroke; (2) patients with subarachnoid hemorrhage; (3) known definite contraindication to acute BP lowering (e.g. known severe carotid, vertebral, or cerebral arterial stenosis, Moyamoya disease or Takayasu’s arteritis, high grade stenotic valvular heart disease); (4) secondary to a structural abnormality in the brain (e.g. an arteriovenous malformation, intracranial aneurysm, tumor, or trauma); (5) unstable vital signs and requiring the use of vasoactive agents; (6) known existing dementia or pre-stroke disability (e.g. score 3–5 on the modified Rankin scale); (7) concomitant medical illness that would interfere with the outcome assessments and/or follow-up (advanced cancer; severe pulmonary dysfunction [forced expiratory volume in 1 s < 50%]; severe cardiac dysfunction [ejection fraction ≤ 50%]; severe hepatic failure [Child-Pugh score ≥ 7]; severe renal failure [glomerular filtration rate ≤ 30 mL/min or serum creatinine ≥ 4 mg/dL]); (8) patients who are currently participating in other investigational trials; and (9) patients who are considered to have a high likelihood of not adhering to the study treatment or the follow-up regimen.
A secure website (http://traillogin.applinzi.com) will be used to perform the centralized randomization (computerized random numbers). Patients will be randomized into one of the two intervention arms (1:1).
In patients who are assigned to receive individualized regimen to lower BP (individualized BP-lowering group), antihypertensive treatments are to be initiated to reduce SBP to a range of 130–180 mmHg and by 10–15% from the admission level within 2 h after randomization. SBP in the individualized BP-lowering group is to be maintained around the target level for one week with or without the use of hypertensive agents. In participants who were assigned to receive guideline-recommended treatment [13, 14] (guideline-recommended BP-lowering group), antihypertensive agents are to be administered if the SBP was > 200 mmHg in acute ischemic stroke (AIS) or the SBP was > 180 mmHg in intracerebral hemorrhage (ICH). The goal is to maintain the SBP < 200 mmHg in ischemic stroke and < 180 mmHg in ICH for one week with or without the use of hypertensive agents. Table 1 presents the detailed management of BP in the first week after randomization.
The selection of antihypertensive agents is based on the local availability; no specific agent is stipulated (both intravenous and oral agents can be used). Patients who take antihypertensive agents before stroke continue to take the same antihypertensive medication (same drug with same dosage). The rest of the medical care for stroke is based on the guideline [15, 16]. The management of BP after the first week of hospitalization adheres to the guideline as well.
Table 2 presents all the variables measured at each time point of the study. At the time point of baseline screening, demographics, subtypes of stroke, medical history (e.g. AIS, ICH, coronary event, diabetes mellitus, and hypertension), physical examination, clinical scores (NIHSS, GCS, Barthel index, mRS), and vital signs are recorded. On day 1 and day 7, routine laboratory tests for stroke patients are assessed, including blood routine, liver and renal function test, serum lipid, fasting glucose, urine routine, and electrocardiography. Co-morbidities on the day of screening and hospital discharge are recorded. Clinical scores on day 7, the day of hospital discharge, and day 90 are collected. During the whole hospitalization, BP, vital signs, and adverse events (AEs) are monitored, and concomitant treatments are documented.
Blood pressure monitoring
An automatic BP cuff on the unaffected arm (right arm is chosen when both sides are affected or unaffected) is used to monitor the BP (SBP, diastolic BP, and mean arterial pressure). During the first 24 h after randomization, BP is recorded every 2 h. On days 2 and 3, BP is recorded every 4 h. During days 4–7, BP is recorded every 8 h. On the day of hospital discharge, BP at 08:00 is recorded. Three measurements of BP are required for each time point and the average is recorded.
The following procedures to minimize bias and ensure data quality and protocol standardization are required: (1) a training session will be held for research coordinators from all the participating centers before the commencement of CHASE study; (2) the principal investigator in each research site takes charge of quality control by supervising the conduct of the trial in accordance with the prespecified protocol, applicable guidelines, and regulations; (3) all participating sites will have monitoring visits via video conferencing after every ten patients are randomized, to verify consent, eligibility criteria, anomalous data, and reported serious AEs; (4) the Shaanxi Cerebrovascular Disease Clinical Research Center (SCRC) will prepare monthly reports on recruitment, randomization, data completeness, and protocol adherence. Case report forms and informed consent forms will be securely stored in a locked cabinet in a secure office with limited access. All digital data will be password-protected and stored in a firewall-protected secure environment. The trial sponsor has access to the final trial dataset.
The primary outcome measurement is the proportion of participants with a poor outcome at day 90 of enrollment. Poor outcome is defined as major disability (mRS ≥ 3, unable to live independently) or all-cause death. The proportion of participants with a poor outcome at hospital discharge is the key secondary outcome. Other secondary outcomes are the disability (evaluated by NIHSS, GCS, and Barthel index) at hospital discharge and the ability of activities of daily living at day 90 of enrollment evaluated by Barthel index. Outcomes are assessed independently by trained research assistants who are blind to the grouping results and clinical data. The 90-day outcomes are evaluated via telephone interviews at day 90 of enrollment (a delay of up to three days is acceptable). In cases when the patient is incapable to complete the interview, the first choice for a proxy is the spouse/live-in companion.
Determination of the sample size
The sample size was set at 500 to provide at least 80% power to detect a 6% absolute risk reduction in the primary outcome for patients in the individualized BP-lowering group compared to those in the guideline-recommended control group, using a two-sided significance test with 5% type I error. The following assumptions were made: a primary outcome of 60% in the control group will be reduced to 54% in the individualized group; and there will be 10% non-adherence to the treatment protocol and 5% overall loss to follow-up. The 60% incidence of unfavorable 90-day outcome is extrapolated from one Chinese study on severe stroke (NIHSS > 10) in 2013 . The 10% non-adherence rate and the absolute risk reduction in primary outcome are extrapolated from the INTERACT1&2 studies which were designed to compare the effects of two different BP-lowering strategies in acute stroke patients [8, 18].
Statistical and analytical plan
Patients will be analyzed according to the intention-to-treat principle. Analyses will be conducted at the Shaanxi Cerebrovascular Disease Clinical Research Center by blinded biostatisticians. Baseline characteristics will be summarized using univariate analyses. Categorical variables will be presented as the number and percent, whereas the continuous variables will be presented as mean (± standard deviation) or median (interquartile range). We will compare the proportions for the primary and secondary outcomes between patients randomized to the individualized BP-lowering group vs the guideline-recommended BP-lowering group using the Chi-square test. We will calculate the relative risk reduction, absolute risk reduction, and the number needed to treat with individualized BP-lowering target to prevent one death. Logistic multivariate analyses will be used to adjust for potential confounding effects of different variables and estimate adjusted odds ratios and associated 95% confidential intervals. Two-sided p values ≤ 0.05 will be considered significant. Statistical analysis will be performed with SPSS version 22 software (SPSS Inc., Chicago, IL, USA).
Protocol amendments will be agreed upon with the CHASE Study Group, Sponsor and Funding Body before submission for ethical approval. Following ethical approval, protocol modifications will be communicated with relevant parties such as the trial investigators, the trial registry, and, if required, trial participants.
The results of this trial will be disseminated to a wide clinical audience (patients, health professionals, policy makers, and the general public) through publication in a high-impact international scientific journal.
A few multicenter, randomized studies have been carried out to search for the ideal BP range for patients with acute stroke; however, none of them aimed at severe stroke, which has a much higher rate of mortality and disability. No clinical evidence can be used to guide the BP management in critical care for those stroke patients with an initial presentation of severe neurological deficits. Our study aims to test the superiority of individualized BP lowering compared to guideline-recommended BP lowering in improving three-month outcome. Our study will provide the first evidence on the optimum BP-lowering target for patients with acute severe stroke.
Factors that contribute to raised BP in acute stroke are multifaceted, such as history of hypertension, stroke severity, pressure response to hospital admission, infarct area related to BP adjustment, and increased intracranial pressure . Raised BP later falls into the following types: without antihypertensive medications BP declines spontaneously; with antihypertensive medications BP does not decline, declines modestly (10–15% from baseline), or intensively (≥ 20% from baseline value) . Elevated BP raises the risk of cerebral edema, hemorrhagic transformation of the infarct , hematoma expansion , cardiac complications, and renal insufficiency. On the other hand, a decrease in BP might reduce the blood perfusion of the brain and aggravate the cerebral ischemic injury, especially in large territorial ischemia . One clinical study indicated that both large increase and reduction in BP (> 20 mmHg) were associated with a higher risk of early neurological deterioration, increased infarct volume, and poorer outcome at three months . Therefore, a proper management of BP is essential for stroke patients.
However, no ideal BP range has been scientifically determined yet. Guidelines for AIS from the American Heart Association (AHA)/American Stroke Association suggest that BP targets are based on best clinical judgment and a reasonable estimate might be to lower the SBP by 15% if the BP is > 220/120 mmHg . For ICH patients presenting with SBP < 180 mmHg, guidelines from AHA in 1999 suggest to defer antihypertensive therapy; guidelines from AHA in 2015 suggest to lower SBP to 140 mmHg. Chinese guidelines for AIS recommend the use of hypertensive therapy when SBP is > 200 mmHg . Also, Chinese guidelines for ICH suggest that antihypertensive therapy should be initiated when SBP is > 180 mmHg and a target around 160/90 mmHg can be considered although evidence is lacking . None of the above guidelines mentioned any BP-lowering regimen specifically for severe stroke due to the lack of clinical evidence.
Given the paucity of studies on BP management for severe stroke, we performed a retrospective preliminary study in stroke patients admitted to neurological intensive care unit (NICU) in Xijing Hospital (a tertiary teaching hospital) in the last three years and found that NICU mortality was significantly higher in patients with SBP reduced by > 15% than those with SBP reduced by < 15%. This difference of mortality remained significant in patients with AIS. For ICH, the NICU mortality was also higher in patients with SBP reduced by > 15% than those with SBP reduced by < 15%, albeit insignificant.
Based on the above result and previous studies, we designed a multicenter RCT to investigate whether individualized lowering (10–15% reduction from admission level) of elevated BP would improve the outcomes in patients with severe stroke, hoping to provide evidence of BP management for acute severe stroke, help improve the quality of life, and reduce family and social burdens.
The CHASE study trial was conceived and designed in 2016. At the time this manuscript was submitted, full approval by the Medical Ethics Committee has been obtained for all centers and recruitment was started. The patients’ follow-up is currently ongoing.
American Heart Association
Acute ischemic stroke
Glasgow Coma Scale
National Institute of Health stroke scale
Systolic blood pressure
Wallace JD, Levy LL. Blood pressure after stroke. JAMA. 1981;246:2177–80.
CAST Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet. 1997;349:1641–9.
Qureshi AI, Ezzeddine MA, Nasar A, Suri MF, Kirmani JF, Hussein HM, et al. Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med. 2007;25:32–8.
Schrader J, Luders S, Kulschewski A, Berger J, Zidek W, Treib J, et al. The ACCESS study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors. Stroke. 2003;34:1699–703.
Robinson TG, Potter JF, Ford GA, Bulpitt CJ, Chernova J, Jagger C, et al. Effects of antihypertensive treatment after acute stroke in the Continue Or Stop post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial. Lancet Neurol. 2010;9:767–75.
He J, Zhang Y, Xu T, Zhao Q, Wang D, Chen CS, et al. Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial. JAMA. 2014;311:479–89.
Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, et al. Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med. 2016;375:1033–43.
Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013;368:2355–65.
Appelros P, Nydevik I, Seiger A, Terént A. Predictors of severe stroke: influence of preexisting dementia and cardiac disorders. Stroke. 2002;33:2357–62.
Bill O, Zufferey P, Faouzi M, Michel P. Severe stroke patient profile and predictors of favorable outcome. J Thromb Haemost. 2013;11(1):92–9.
Kasner SE, Demchuk AM, Berrouschot J, Schmutzhard E, Harms L, Verro P, et al. Predictors of fatal brain edema in massive hemispheric ischemic stroke. Stroke. 2001;32(9):2117–23.
Berrouschot J, Rössler A, Köster J, Schneider D. Mechanical ventilation in patients with hemispheric ischemic stroke. Crit Care Med. 2000;28:2956–61.
Broderick JP, Adams HP, Barsan W, Feinberg W, Feldmann E, Grotta J, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council. Am Heart Assoc Stroke. 1999;30:905–15.
Cerebrovascular Disease Group from Chinese Medical Association’s Neurology Chapter. Chinese Guidelines for the early management of patients with acute ischemic stroke 2014. Chin J Neurol. 2015;48:246–57.
Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870–947.
Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46:2032–60.
Sung SF, Chen YW, Tseng MC, Ong CT, Lin HJ. Atrial fibrillation predicts good functional outcome following intravenous tissue plasminogen activator in patients with severe stroke. Clin Neurol Neurosurg. 2013;115:892–5.
Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, et al. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008;7:391–9.
Vemmos KN, Spengos K, Tsivgoulis G, Zakopoulos N, Manios E, Kotsis V, et al. Factors influencing acute blood pressure values in stroke subtypes. J Hum Hypertens. 2004;18:253–9.
AlSibai A, Qureshi AI. Management of acute hypertensive response in patients with ischemic stroke. Neurohospitalist. 2016;6:122–9.
Strandgaard S, Paulson OB. Cerebral blood flow and its pathophysiology in hypertension. Am J Hypertens. 1989;2:486–92.
Ohwaki K, Yano E, Nagashima H, Hirata M, Nakagomi T, Tamura A. Blood pressure management in acute intracerebral hemorrhage: relationship between elevated blood pressure and hematoma enlargement. Stroke. 2004;35:1364–7.
Semplicini A, Maresca A, Boscolo G, Sartori M, Rocchi R, Giantin V, et al. Hypertension in acute ischemic stroke a compensatory mechanism or an additional damaging factor. Arch Intern Med. 2003;163:211–6.
Castillo J, Leira R, Garcia MM, Serena J, Blanco M, Davalos A. Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome. Stroke. 2004;35:520–6.
Cerebrovascular Disease Group from Chinese Medical Association’s Neurology Chapter. Chinese Guidelines for the early management of patients with acute intracranial hemorrhage 2014. Chin J Neurol. 2015;48:435–44.
We thank all recruiting sites, particularly the principal investigators, co-investigators, and research nurses (the CHASE collaborative group).
The CHASE trial is funded by the Shaanxi Province Key Research and Development Project (2017ZDCXL-SF-02-02).
Availability of data and materials
Ethics approval and consent to participate
The study has been approved by the ethics committees of Xijing Hospital, the Fourth Military Medical University, on 22 November 2016 (KY20162085-2). Written informed consent to participate will be obtained from each participant. A copy of the case report form and consent form can be obtained from the corresponding author. Potential protocol modifications will be formally approved by the Research Ethics Committee before being implemented.
Consent for publication
The authors declare that they have no competing interests.
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Yuan, F., Yang, F., Xue, C. et al. Controlling Hypertension After Severe Cerebrovascular Event (CHASE): study protocol for a randomized controlled trial. Trials 19, 130 (2018). https://doi.org/10.1186/s13063-018-2530-x
- Blood pressure
- Severe stroke
- Critical care