Table 1 Inclusion and exclusion criteria for patient selection

1) Age > 18 years

1) Motor unit loss in the median nerve less than 2 standard deviations below the mean for the age group

2) One or more of the following symptoms of CTS

2) Presence of other neurologic conditions

 a) Numbness and paresthesias in the median nerve distributions

3) Previous carpal tunnel release

 b) Precipitation of those symptoms by repetitive motions that are relieved by rubbing and/or shaking

4) Cognitive impairment that renders the patient incapable of providing consent

 c) Nocturnal awakening of the above symptoms

5) History of seizures

 d) Weakness of thumb abduction and thenar atrophy

6) Kidney disease/renal impairment

7) Sensitivity to any of the drug components of the formulation or are

8) Pregnant/breast feeding

9) For women of child-bearing potential, those that are not willing to use adequate contraceptive prevention methods for at least 30 days after the last dose of the medication.