- Paper Report
- Open Access
Intravenous dofetilide vs amiodarone
- Niall Mulvahill1
© Biomed Central Ltd 2001
- Received: 5 October 2000
- Published: 17 October 2001
- Class III drugs, medical cardioversion, torsades de pointes
This paper describes acute chemical cardioversion of atrial fibrillation and flutter to sinus rhythm.
This research was undertaken to investigate further the use of dofetilide for acute cardioversion of atrial fibrillation and flutter.
Dofetilide, a class III antiarrhythmic, restored sinus rhythm in 35% of patients, 3 h after a 15 min infusion in comparison to conversion rates of 4% for amiodarone and 4% for placebo. The duration of atrial arrhythmia did not influence conversion rates. Treatment with dofetilide was associated with an 8% incidence of torsadea de pointes.
A meta-analysis of the published data to date reveals a 25% success rate for dofetilide in converting atrial fibrillation and a 65% success rate in converting atrial flutter.