Skip to content

Advertisement

  • Paper Report
  • Open Access

Intravenous dofetilide vs amiodarone

  • 1
Current Controlled Trials in Cardiovascular Medicine20012:72003

https://doi.org/10.1186/cvm-2001-72003

  • Received: 5 October 2000
  • Published:

Keywords

  • Class III drugs, medical cardioversion, torsades de pointes

Context

This paper describes acute chemical cardioversion of atrial fibrillation and flutter to sinus rhythm.

This research was undertaken to investigate further the use of dofetilide for acute cardioversion of atrial fibrillation and flutter.

Significant findings

Dofetilide, a class III antiarrhythmic, restored sinus rhythm in 35% of patients, 3 h after a 15 min infusion in comparison to conversion rates of 4% for amiodarone and 4% for placebo. The duration of atrial arrhythmia did not influence conversion rates. Treatment with dofetilide was associated with an 8% incidence of torsadea de pointes.

Comments

I found this article interesting because the effectiveness of dofetilide in cardioverting atrial fibrillation or flutter is not dependent on the duration of flutter, in contrast to flecainide and propfenone.

Possible implications of these findings are that a short intravenous infusion of dofetilide may be used for the conversion of long-standing atrial fibrillation or the conversion of atrial flutter; however, because of the incidence of torsades de pointes, continuous ECG monitoring is required.

Methods

A meta-analysis of the published data to date reveals a 25% success rate for dofetilide in converting atrial fibrillation and a 65% success rate in converting atrial flutter.

Additional information

Authors’ Affiliations

(1)
Freeman Hospital, Newcastle Upon Tyne, UK

References

  1. Bianconi L, Castro A, Dinelli M, Alboni P, Pappalardo A, Santini M: Intravenous dofetilide versus amiodarone for acute termination of atrial fibrillation and flutter. Eur Heart J 2000, 21:1265-1273. Eur Heart J. 2000, 21: 1265-1273.View ArticlePubMedGoogle Scholar

Copyright

© Biomed Central Ltd 2001

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.

Advertisement