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  • Poster presentation
  • Open Access

Exploring the reasons for the sensitivity to change of a patient preference measure, compared with the KOOS questionnaire in patellofemoral osteoarthritis

  • 1, 2,
  • 1, 2 and
  • 1, 3
Trials201516 (Suppl 2) :P66

  • Published:


  • Public Health
  • Arthritis
  • Osteoarthritis
  • Visual Analogue Scale
  • Analogue Scale


We have previously found that one patient preference measure has increased sensitivity to change (Parkes et al. 2014, Arthritis Rheum 66 (11): S562). We explored the reasons why this particular measure has increased sensitivity, using data from the BRACE trial (ISRCTN50380458).


The ‘pain on nominated aggravating activity’ visual analogue scale (VASNA), was compared to the Knee Osteoarthritis Outcome Score (KOOS) questionnaire. The distribution of painful activities selected by patients using the VASNA in the BRACE trial was compared to activities covered by the KOOS. We also compared the standardised between-groups change in pain in the VASNA and the KOOS to see whether the magnitude in change was comparable.


Two-thirds of patients nominated pain using stairs, an activity captured by the KOOS. A further 28 subjects (22.2%) nominated squatting, bending or kneeling, and others nominated running (3.2%), activities not captured by KOOS. Standardised changes were generally higher for the VASNA than for the KOOS total score (for example, stairs subgroup change - 0.26 vs. -0.11), especially for patients choosing activities not covered by the KOOS (squatting, bending and kneeling subgroup change -0.26 vs. -0.16). In this subgroup, many of the individual KOOS items change little following treatment.


The VASNA was more sensitive to change than the KOOS both in subgroups whose painful activity overlapped with KOOS items and those that did not. Questions which have less relevance may add ‘noise’ to the signal for change in pain, which could explain the KOOS's decreased sensitivity to change.

Authors’ Affiliations

University of Manchester, Manchester, UK
NIHR Manchester Musculoskeletal Biomedical Research Unit (BRU), Manchester, UK
Boston University, Boston, MA, USA


© Parkes et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


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