Volume 16 Supplement 2

3rd International Clinical Trials Methodology Conference

Open Access

Trials within trials of interventions to improve recruitment and retention: the experience of York Trials Unit

  • David Torgerson1 and
  • Caroline Fairhurst1
Trials201516(Suppl 2):O9

https://doi.org/10.1186/1745-6215-16-S2-O9

Published: 16 November 2015

Background

Few trials of interventions have been undertaken to improve trial recruitment and retention with two recent Cochrane finding only 57 trials. This could be improved if all of the UK Trials Units agreed to conduct at least two embedded trials per year. At the York Trials Unit (YTU) we have a policy of routinely embedding a recruitment or retention trial in most of our existing studies.

Method

A review of all YTU ‘trials within trials’.

Results

Of the 20 trials undertaken 8 were of interventions to enhance recruitment and 12 were of attrition reduction. For the recruitment strategies different information methods (6) were the most common with trial co-ordinator visit and different envelope colours being the other interventions. For the 12 attrition prevention trials 4 were of electronic reminders, 2 of newsletters, 4 were of post-it notes, 1 was of a free pen, and 1 was of offer of trial results. Currently, we have found that electronic reminders and participant newsletters for retention are effective and these are now being routinely included in our trials. Most of our trials were ‘unfunded’ and consequently the interventions tended to be inexpensive. The benefits of doing embedded trials include: improved knowledge and early publications for the trial co-ordinators. Some Chief Investigators can be hostile viewing them as a ‘nuisance’ but with discussion most reasonable investigators can be persuaded.

Conclusion

If all trials units did two ‘trials within a trial’ per year then the evidence base would be doubled within a year.

Authors’ Affiliations

(1)
University of York

Copyright

© Torgerson and Fairhurst 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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