Volume 16 Supplement 2

3rd International Clinical Trials Methodology Conference

Open Access

Good practice principles for sharing individual participant data from publicly funded clinical trials

  • Catrin Tudur Smith1,
  • Carolyn Hopkins1,
  • Matt Sydes4,
  • Kerry Woolfall1,
  • Mike Clarke3,
  • Gordon Murray2 and
  • Paula Williamson1
Trials201516(Suppl 2):O1

https://doi.org/10.1186/1745-6215-16-S2-O1

Published: 16 November 2015

Sharing Individual Participant Data (IPD) from completed clinical trials offers numerous well recognised advantages that can advance clinical research and benefit patients. The clinical trial community, including publicly funded trials, has a duty to facilitate this process.

In our recent survey, publicly funded clinical trials units (CTUs) from the UKCRC registered CTUs network were supportive of the principle of sharing IPD. However, concerns were also raised including complex and varied sponsorship arrangements of the trials they coordinate, inappropriate reuse of clinical trial data, additional resource required for CTUs to prepare and share data, potential loss of ability to publish further research, and the potential risk to trial participant privacy. The CTUs preferred the use of a controlled access approach, with systems in place to review data access requests from researchers.

We have used the results of this survey, input from an expert committee and an open consultation involving the UKCRC registered CTUs to inform the development of a guidance document summarising good practice principles for sharing IPD and associated documentation from publicly-funded clinical trials. The guidance has been endorsed by Cancer Research UK, MRC Methodology Research Programme Advisory Group, Wellcome Trust and the Executive Group of the UK CRC Registered CTUs Network. The National Institute for Health Research (NIHR) has confirmed it is supportive of the application of this guidance.

Authors’ Affiliations

(1)
North West HTMR, University of Liverpool
(2)
University of Edinburgh
(3)
All Ireland HTMR, Queen's University
(4)
MRC Clinical Trials Unit, London HTMR

Copyright

© Smith et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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