Skip to main content

A Randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial



The financial costs associated with asthma care continue to increase while care remains suboptimal. Promoting optimal self-management, including the use of asthma action plans, along with regular health professional review has been shown to be an effective strategy and is recommended in asthma guidelines internationally. Despite evidence of benefit, guided self-management remains underused, however the potential for online resources to promote self-management behaviors is gaining increasing recognition. The aim of this paper is to describe the protocol for a pilot evaluation of a website ‘Living well with asthma’ which has been developed with the aim of promoting self-management behaviors shown to improve outcomes.


The study is a parallel randomized controlled trial, where adults with asthma are randomly assigned to either access to the website for 12 weeks, or usual asthma care for 12 weeks (followed by access to the website if desired). Individuals are included if they are over 16-years-old, have a diagnosis of asthma with an Asthma Control Questionnaire (ACQ) score of greater than, or equal to 1, and have access to the internet. Primary outcomes for this evaluation include recruitment and retention rates, changes at 12 weeks from baseline for both ACQ and Asthma Quality of Life Questionnaire (AQLQ) scores, and quantitative data describing website usage (number of times logged on, length of time logged on, number of times individual pages looked at, and for how long). Secondary outcomes include clinical outcomes (medication use, health services use, lung function) and patient reported outcomes (including adherence, patient activation measures, and health status).


Piloting of complex interventions is considered best practice and will maximise the potential of any future large-scale randomized controlled trial to successfully recruit and be able to report on necessary outcomes. Here we will provide results across a range of outcomes which will provide estimates of efficacy to inform the design of a future full-scale randomized controlled trial of the ‘Living well with asthma’ website.

Trial registration

This trial is registered with Current Controlled Trials ISRCTN78556552 on 18/06/13.

Peer Review reports


Asthma is common, affecting an estimated 300 million people worldwide[1]. The financial costs associated with asthma care continue to increase[2], while care remains suboptimal - patients continue to overestimate their asthma control, tolerating more symptoms and greater limitations than necessary[3, 4]. Promoting self-management, including the use of asthma action plans, along with regular health professional review has been shown to be an effective strategy leading to improved outcomes including improved quality of life, lower rates of healthcare contacts, and fewer days off work and school, and is a recommendation in worldwide asthma guidelines[59]. Self-management support aims to improve outcomes in a number of ways: better recognition of deterioration of symptoms, more appropriate responses to exacerbations, and optimizing adherence to medication[10]. Improving adherence to inhaled corticosteroids is crucial to avoid exacerbations, improve day to day control, and reduce the risk of hospitalization and death[11]. Adherence to treatments in many chronic illnesses is low and asthma is no exception[12, 13]. Research into non-adherence suggests several rationales, but in common with other chronic conditions recurring themes relate to doubts about the need for the medications in the first place, and concerns about potential side-effects of treatments[12, 14].

Despite evidence of benefits, guided self-management remains underused[911]. Online interactive tools to support asthma self-management in general have been trialed out with the UK and there is increasing evidence that they may be safe and effective, enabling patients to take a more proactive role, improving asthma quality of life scores and symptoms (and in some cases forced expiratory volume in 1 second (FEV1))[1518], and potentially demonstrating cost-effectiveness[19]. This suggests that making effective use of available technologies may have the potential to increase uptake of self-management behaviors in those with asthma, without additional cost. How best to achieve this is still not clear[20].

‘Living well with asthma’ resource development

We developed an online resource ‘Living well with asthma’ which aims to promote optimal self-management behaviors known to lead to improved outcomes. Exploratory focus group discussions with adults with asthma and primary care nurses clarified the key features deemed most important in a website. These data, along with a preceding literature review[20], informed the initial development of a prototype of the website. The actual content of the pages within the website was developed and refined iteratively with input from adults with asthma, practice nurses, general practitioners, a sociologist, human computer interactions researchers, respiratory physicians, and a health psychologist. Further refinement of the content was undertaken using ‘Think aloud’ studies with adults with asthma. These were undertaken by DM, and participants fed back in real time their views on the contents and usability. Initially this was on paper mock-ups of proposed web pages, and latterly on actual ‘Living well with asthma’ webpages. ‘Think aloud’ studies are a recognized method of gaining information about users’ views in real time as they navigate around a website, providing information about usability and feeding into further development and refinement of the website[21, 22]. The ‘Living well with asthma’ website was developed as a standalone resource which should complement face-to-face asthma reviews, but does not require health professional involvement.

A full description of the website development will be available in a forthcoming publication.

Rationale for the evaluation methods

Guidance for the development of complex interventions recommends pilot and feasibility studies prior to formal evaluations[23, 24]. A pilot study is a version of the main study that is run in miniature to test whether the components of the main study can all work together[25], whereas a feasibility study is used to estimate important parameters that are needed to design the main study, such as ease of recruitment, standard deviations of outcome measures, and follow-up rates[25, 26]. This study aims to address both issues. Feasibility and piloting are essential to ensure that planned progression to a full-scale randomized controlled trial (RCT) is appropriate in the first place and if it can be undertaken with appropriate power to achieve definitive results. This early evaluation must be broad enough to provide information both about how a full-scale RCT may work in practice but should also have consideration for how the resource may be used beyond the evaluation. Feasibility is investigated through measuring recruitment and retention rates and collecting usability data about the website itself. Measuring clinical outcomes will allow for the collection of important data on the efficacy of the intervention and for the estimation of effect sizes in any future larger RCT.

Study aims

This study aims firstly to assess the feasibility of conducting a RCT of the clinical effectiveness of an online asthma resource aimed at promoting adherence in adults with poorly controlled asthma, using the ‘Living well with asthma’ resource. Secondly, as a pilot study the aim is to provide estimates of recruitment and retention rates, as well as estimates of the variability of clinical and behavioral outcome measures to inform power calculations for a definitive trial. The study will collect a range of information about the way the intervention was used, including but not limited to: the most and least visited pages, the length of time the intervention was accessed, and how often it was accessed. Finally, this pilot and feasibility study also aims to identify any potential problems to be addressed, and allow for further development of the resource, before a further evaluation.

We hypothesize that this intervention, which has been designed with end user involvement and aims to improve adherence to therapy using multiple strategies (educational information, attitudinal arguments, self-monitoring, and reminders), will result in improved symptom control and quality of life measures in adults with asthma.


Ethical approval and trial registration

Ethical approval for this study was granted by the West of Scotland Research Ethics Committee (ref 13/WOS/004) in March 2013. All participants provided written informed consent. The trial was conducted in accordance with national laws, Good Clinical Practice guidelines and the Declaration of Helsinki 2002. This trial is registered with Current Controlled Trials ISRCTN78556552.

Recruitment, randomization and blinding

Participants are primarily being recruited from primary care practices within the Greater Glasgow and Clyde health board area and from posters in public places. We aim to recruit 50 participants in total. See Table 1 for full eligibility criteria.

Table 1 Inclusion and exclusion criteria

Consenting participants fulfilling our inclusion and exclusion criteria are being randomized using a third party automated telephone interactive voice response system. Participants will self-complete all questionnaires. Due to the nature of the intervention the blinding of the researcher is not practical, however data will be entered and managed by the Robertson Centre for Biostatistics (RCB), University of Glasgow, and the researcher will take no role in this. The data will be analyzed by a researcher blinded to the allocation of the groups.


This is a parallel, two arm RCT. See study flow chart (Figure1) and SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist (Additional file1) for further details. The duration of participation is 12 weeks from randomization. Those randomized to the intervention arm will have access to a purpose-built website with the aim of facilitating adherence to asthma medications for 12 weeks. This will include the following five areas: a) allow users to gain understanding of their current degree of asthma control and how they can improve it, specifically by optimizing their use of prescribed medication; b) challenge attitudes and concerns around taking medications for asthma; c) learn how to get the most out of their annual asthma review; d) prompt those who do not have one to seek an asthma action plan to be filled in with a health professional; e) send reminders to participants such as to get the flu vaccine or to order inhalers (participants can opt out of this aspect).

Figure 1
figure 1

Study flow chart. ACQ, Asthma Control Questionnaire; AQLQ, Asthma Quality of Life Questionnaire; FeNO, Fractional Exhaled Nitric Oxide; GP, General Practitioner; MMAS, Morisky Medication Adherence Scale; PAM, Patient Activation Measure; PETS, Problems of Experienced Therapy Scale.

This resource will not advise medication changes directly, but if indicated, may suggest making an appointment with a nurse or doctor for review. Clear advice will be presented for seeking help in an emergency.

Control group

Those randomized to usual care will be advised to continue to manage their asthma as they would usually. After the follow-up visit at 12 weeks, participants in the control group will be offered 12 weeks of access to the website if they choose.


Primary endpoints

The primary endpoints for this study are: recruitment and retention rates at 12 weeks from baseline, web usability, and changes at 12 weeks from baseline for ACQ[27] and AQLQ[28] scores. Recruitment and retention rates will be measured as well as usage data at 12 weeks, including number of times users logged in and total length of time logged in, number of times individual pages were viewed, and length of time spent on each page.

Secondary endpoints

The first secondary endpoint for this study will be changes at 12 weeks from baseline for Patient Activation Measure (PAM) score[29], EQ-5D score (generic measure of health related quality of life)[30], the Morisky Medication Adherence Scale (MMAS)[31], lung function (via pre bronchodilator spirometry FEV1, FEV1/FVC (forced vital capacity), peak expiratory flow (PEF) performed to American Thoracic Society (ATS) s tandards[32], and fractional exhaled nitric oxide levels (FeNO) performed to ATS standards[33].

The second secondary endpoint will be changes in the Problematic Experiences of Therapy Scale (PETS)[34] score at 12 weeks in the intervention group only. The third secondary endpoint will be self-reported healthcare utilization including: routine visit to GP or practice nurse because of asthma, visit to GP because of asthma requiring oral steroids, hospital admission (and length of stay) because of asthma requiring oral steroids, emergency or out of hours’ visit because of asthma requiring oral steroids, and emergency or out of hours’ visit of patients to the GP or GP visit to patient at home because of asthma requiring oral steroids. The fourth secondary endpoint will be self-reported medication utilization including: changes in the level of adherence to prescribed preventer medications, changes to the average number of reliever puffs taken per week, intensification of treatment, or step-up of asthma medications (as defined by British Thoracic Society/Scottish Intercollegiate Guidelines Network (BTS/SIGN) guidelines, and step-down of asthma medications (as defined by BTS/SIGN guidelines).

Statistical considerations and data handling

While this study is not powered to detect differences in clinical measures, we will report estimates of effect sizes with a 95% confidence interval. The primary objectives include determining recruitment and retention rates to inform the feasibility of running a full-scale trial. We shall recruit 50 participants to estimate these quantities with reasonable precision. For example, if we invite 100 participants to recruit 50, the recruitment rate would be estimated with a confidence interval of ± 10%. Patient characteristics and outcomes will be summarized at baseline, at follow-up, and as changes over baseline. Study groups will be compared using baseline-adjusted linear regression (analysis of covariance (ANCOVA). The effects of baseline and intermediate data on patient outcomes will be explored using linear regression. The variability of outcome data will be used to estimate the sample size required for a definitive study.

Data management

The RCB, part of the Glasgow Clinical Trials Unit (a fully registered UKCRN Clinical Trials Unit) are managing the randomization procedures and the trial data. Case report forms (CRF) will be used to collect study data. The CRF has been developed by the researcher and the RCB. The RCB are responsible for collating study data.

Trial management group and patient safety

The routine management of the trial will be coordinated by the trial management group. This will comprise the chief investigator (DM) and four co-investigators (FM, SW, NT, and AM). This group will monitor the progress of the trial to ensure that the protocol is adhered to. This group will meet bimonthly, with monthly recruitment reports via email. Any changes to the study protocol will be following agreement with the trial management group, and subject to approval from Research and Development at NHS Greater Glasgow and Clyde, and the West of Scotland Research Ethics Committee, where required.

The study will end when the trial management group agrees that either the planned sample size has been achieved or the recruitment is so poor that completion of the trial is not feasible.

Only adverse events that are outcome measures will be recorded. All serious adverse events (SAEs) will be recorded at follow-up. All SAEs will be assessed for causality, expectedness, and severity. This assessment is the responsibility of the chief investigator (CI). The trial team will record all SAEs. The CI will endeavor to obtain sufficient information to determine the causality of the adverse event and must provide an opinion of the causal relationship between each SAE and the study intervention. The accumulated SAEs will be sent to the sponsor and the West of Scotland Research Ethics Committee in an annual safety report. Detailed records of all SAEs will be held in the trial master file.

Annual safety reports

It shall be the responsibility of the trial management group on behalf of the sponsor to submit, once a year throughout the clinical trial, or on request, a safety report to the West of Scotland Research Ethics Committee.


The increasing burden of chronic disease on healthcare providers is well known, and promoting self-care is a strategy for shifting this burden away from healthcare providers. The Internet may provide a cost-effective medium for doing this. Piloting of complex interventions is considered best practice and will maximize the potential of any future full-scale RCT to successfully recruit and be able to report on necessary outcomes. Here we report on feasibility outcomes such as recruitment, retention, and usability of the intervention being investigated, and undertake piloting of an intervention which will aim to determine clinical efficacy.

Trial status

Recruitment was initiated in June 2013, with the first patient randomized in September 2013, and is ongoing as of February 2014.



Asthma Control Questionnaire


Asthma Quality of Life Questionnaire


American Thoracic Society


British Thoracic Society/Scottish Intercollegiate Network


Chief Investigator


Case Report Form


Controlled Trial of Investigational Medicinal Product


Fractional Exhaled Nitric Oxide

FEV1 :

Forced Expiratory Volume in 1 second


Forced Vital Capacity


General Practitioner


Morisky Medication Adherence Scale


Patient Activation Measure


Peak Expiratory Flow


Problems of Experienced Therapy Scale


Robertson Centre for Biostatistics


Randomized Controlled Trial


Serious Adverse Event.


  1. Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma (GINA) Program: The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004, 59: 469-478. 10.1111/j.1398-9995.2004.00526.x.

    Article  PubMed  Google Scholar 

  2. Bahadori K, Doyle-Waters MM, Marra C, Lynd L, Alasaly K, Swiston J, Fitzgerald JM: Economic burden of asthma: a systematic review. BMC Pulm Med. 2009, 9: 24-10.1186/1471-2466-9-24.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Rabe KF, Adachi M, Lai CKW, Soriano JB, Vermeire PA, Weiss KB, Weiss ST: Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004, 114: 40-47. 10.1016/j.jaci.2004.04.042.

    Article  PubMed  Google Scholar 

  4. Haughney J, Barnes G, Partridge M, Cleland J: The living & breathing study: a study of patients’ views of asthma and its treatment. Prim Care Respir J. 2004, 13: 28-35. 10.1016/j.pcrj.2003.11.007.

    Article  PubMed  Google Scholar 

  5. British Thoracic Society: British guideline on the management of Asthma. Thorax. 2008, SupplIV: iv1-iv121.

    Google Scholar 

  6. Powell H, Gibson PG: Options for self-management education for adults with asthma [Systematic Review]. Cochrane Database Syst Rev. 2002, CD004107:

    Google Scholar 

  7. Thoonen BP, Schermer TR, van den Boom G, Molema J, Folgering H, Akkermans RP, Grol R, van Weel C, van Schayck CP: Self-management of asthma in general practice, asthma control and quality of life: a randomised controlled trial. Thorax. 2003, 58: 30-36. 10.1136/thorax.58.1.30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gibson PG, Powell H, Wilson A, Abramson MJ, Haywood P, Bauman A, Hensley MJ, Walters EH, Roberts JJL: Self-management education and regular practitioner review for adults with asthma [Systematic Review]. Cochrane Database Syst Rev. 2002, CD001117-

    Google Scholar 

  9. GINA: From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2012, Available from:

    Google Scholar 

  10. Aarne L: Guided self management of asthma − how to do it. BMJ. 1999, 319: 759-760. 10.1136/bmj.319.7212.759.

    Article  Google Scholar 

  11. Sims EJ, Price D, Haughney J, Ryan D, Thomas M: Current control and future risk in Asthma management. Allergy Asthma Immunol Res. 2011, 3: 217-225. 10.4168/aair.2011.3.4.217.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Horne R: Compliance, adherence, and concordance: implications for asthma treatment. Chest. 2006, 130: 65S-72S. 10.1378/chest.130.1_suppl.65S.

    Article  PubMed  Google Scholar 

  13. Heaney LG, Horne R: Non-adherence in difficult asthma: time to take it seriously. Thorax. 2012, 67: 268-270. 10.1136/thoraxjnl-2011-200257.

    Article  PubMed  Google Scholar 

  14. Pound P, Britten N, Morgan M, Yardley L, Pope C, Daker-White G, Campbell R: Resisting medicines: a synthesis of qualitative studies of medicine taking. Soc Sci Med. 2005, 61: 133-155. 10.1016/j.socscimed.2004.11.063.

    Article  PubMed  Google Scholar 

  15. van der Meer V, Bakker MJ, van den Hout WB, Rabe KF, Sterk PJ, Kievit J, Assendelft WJ, Sont JK, SMASHING (Self-Management in Asthma Supported by Hospitals, ICT, Nurses and General Practitioners) Study Group: Internet-Based Self-management plus education compared with usual care in Asthma. Ann Intern Med. 2009, 151: 110-120. 10.7326/0003-4819-151-2-200907210-00008.

    Article  PubMed  Google Scholar 

  16. Chan DS, Callahan CW, Hatch-Pigott VB, Lawless A, Proffitt HL, Manning NE, Schweikert M, Malone FJ: Internet-based home monitoring and education of children with Asthma is comparable to ideal office-based care: results of a 1-year Asthma in-home monitoring trial. Pediatrics. 2007, 119: 569-578. 10.1542/peds.2006-1884.

    Article  PubMed  Google Scholar 

  17. Rasmussen LM, Phanareth K, Nolte H, Backer V: Internet-based monitoring of asthma: a long-term, randomized clinical study of 300 asthmatic subjects. J Allergy Clin Immunol. 2005, 115: 1137-1142. 10.1016/j.jaci.2005.03.030.

    Article  PubMed  Google Scholar 

  18. Hashimoto S, Brinke AT, Roldaan AC, van Veen IH, Moller GM, Sont JK, Weersink EJ, van der Zee JS, Braunstahl GJ, Swinderman AH, Sterk PJ, Bel EH: Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial. Thorax. 2011, 66: 514-520. 10.1136/thx.2010.153411.

    Article  PubMed  Google Scholar 

  19. Van DMV, Van den Hout WB, RABE KF, Bakker MJ, Sterk PJ, Assendelft WJ, Kievit J, Sont JK: Cost-effectiveness of internet-based self-management compared with usual care in asthma. PLoS One. 2011, 6: e27108-10.1371/journal.pone.0027108.

    Article  Google Scholar 

  20. Morrison D, Wyke S, Agur K, Cameron EJ, Docking RI, MacKenzie AM, McConnachie A, Raghuvir V, Thomson NC, Mair FS: Digital Asthma self-management interventions: a systematic review. J Med Internet Res. 2014, 16: e51-10.2196/jmir.2814.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hinchliffe A, Mummery WK: Applying usability testing techniques to improve a health promotion website. Health Promot J Austr. 2008, 19: 29-35.

    PubMed  Google Scholar 

  22. Vizri RA: Refining the test phase of usability evaluation: how many subjects is enough?. Hum Factors. 1992, 34: 457-468.

    Google Scholar 

  23. Medical Research Council: Developing and evaluating complex interventions: new guidance. 2008, London: MRC

    Google Scholar 

  24. Public Health Guidance NICE: Behaviour Change at Population, Community and Individual Levels. 2007, London: NICE

    Google Scholar 

  25. Arain M, Campbell MJ, Cooper CL, Lancaster GA: What is a pilot or feasibility study? a review of current practice and editorial policy. BMC Med Res Methodol. 2010, 10: 67-10.1186/1471-2288-10-67.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lancaster GA, Dodd S, Williamson PR: Design and analysis of pilot studies: recommendations for good practice. J Eval Clin Pract. 2004, 10: 307-312. 10.1111/j..2002.384.doc.x.

    Article  PubMed  Google Scholar 

  27. Juniper EF, O’Byrne PM, Guyatt GH, Ferrie PJ, King DR: Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999, 14: 902-907. 10.1034/j.1399-3003.1999.14d29.x.

    Article  CAS  PubMed  Google Scholar 

  28. Juniper EF, Guyatt GH, Cox FM, Ferrie PJ, King DR: Development and validation of the mini Asthma quality of life questionnaire. Eur Respir J. 1999, 14: 32-38. 10.1034/j.1399-3003.1999.14a08.x.

    Article  CAS  PubMed  Google Scholar 

  29. Hibbard JH, Mahoney ER, Stockard J, Tusler M: Development and testing of a short form of the patient activation measure. Health Serv Res. 2005, 40: 1918-1930. 10.1111/j.1475-6773.2005.00438.x.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Group EQ: EuroQol–a new facility for the measurement of health-related quality of life: the EuroQol group. Health Pol. 1990, 16: 199-208.

    Article  Google Scholar 

  31. Morisky DE, Ang A, Krousel-Wood M, Ward HJ: Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008, 10: 348-354. 10.1111/j.1751-7176.2008.07572.x.

    Article  Google Scholar 

  32. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J: Standardisation of spirometry. Eur Respir J. 2005, 26: 319-338. 10.1183/09031936.05.00034805.

    Article  CAS  PubMed  Google Scholar 

  33. ATS/ERS: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005, 171: 912-930.

    Article  Google Scholar 

  34. Yardley L, Kirby S: Evaluation of booklet-based self-management of symptoms in meniere disease: a randomized controlled trial. Psychosom Med. 2006, 68: 762-769. 10.1097/01.psy.0000232269.17906.92.

    Article  PubMed  Google Scholar 

Download references


Thanks to the Chief Scientist Office who funded this project (ref CAF 11/08). The authors would also like to thank Professor Mike Thomas who provided feedback during protocol development, and Professor Lucy Yardley for her assistance in modifying the PETS questionnaire for use in this study.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Frances S Mair.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DM developed and designed the trial in collaboration with FM, SW, NT, AM, RC. Recruitment of practices or patients was undertaken by DM, KA, KS and FM. Data collection was undertaken by DM, KA and KS. DM wrote the first draft of the protocol and refined it based on comments and feedback from all other authors. All authors read and approved the final manuscript.

Electronic supplementary material


Additional file 1: SPIRIT Checklist as appropriate to a non-CTIMP (Controlled Trial of Investigational Medicinal Product).(PDF 428 KB)

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morrison, D., Wyke, S., Thomson, N.C. et al. A Randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials 15, 185 (2014).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: