Volume 12 Supplement 1

Clinical Trials Methodology Conference 2011

Open Access

What parents think about being approached about children’s trials, how this differs from what practitioners expect, and what this tells us about enhancing recruitment

  • Bridget Young1Email author,
  • Valerie Shilling2,
  • Helen Hickey3,
  • Emma Sowden1,
  • Rosalind L Smyth4 and
  • Paula R Williamson3
Trials201112(Suppl 1):A116

https://doi.org/10.1186/1745-6215-12-S1-A116

Published: 13 December 2011

Objectives

Recruiting to clinical trials that involve vulnerable patient groups such as children is regarded as challenging. We compared how parents and practitioners described their experiences of recruitment to clinical trials of medicines for children in order to identify strategies to optimise recruitment and its conduct.

Methods

Qualitative study of recruitment within four randomised controlled trials at 11 research sites in the UK. We compared i) audio-recording of practitioner-family dialogue during trial recruitment discussions with ii) audio-recordings of interviews that we subsequently conducted with parents and practitioners. Analyses of transcribed audio-recordings were informed by the principles of the constant comparative method.

Results

Parents from 59 families were interviewed, 41 of whom had participated in audio-recorded recruitment discussions. Thirty one practitioners (doctors and nurses) were interviewed. While parents said little in the recruitment discussions and asked few questions, they reported a positive experience of the trial approach describing a sense of comfort and safety. Parents wanted to be told about a trial if their child was eligible - they did not want practitioners to exclude their child without discussing it. Even if parents declined or if the discussion took place at a difficult time, they understood the need to approach them and spoke of the value of research. Some parents viewed research participation as an ‘exciting’ opportunity. By contrast, practitioners often worried about approaching families about research in case it burdened them. Some practitioners were particularly apprehensive about approaching families and implied that recruiting to clinical trials was something which they found aversive. Many were also concerned about the amount of information they had to provide and believed this overwhelmed families.

Conclusions

The concerns of some practitioners, that parents would be overburdened, stood in sharp contrast to the perspectives of parents. Contrary to what practitioners often expected, parents were positive about being approached to enter their child into a clinical trial. Helping practitioners to understand how families perceive clinical trials and providing them with ‘moral’ support in approaching families may enhance recruitment to children’s clinical trials. This strategy may also potentially benefit recruitment in trials with other vulnerable patient groups [1].

Authors’ Affiliations

(1)
Mental and Behavioural Health Science, University of Liverpool
(2)
Child Health Research Group, Peninsula Medical School, University of Exeter
(3)
Biostatistics, University of Liverpool
(4)
Reproductive and Developmental Medicine, University of Liverpool

References

  1. Shilling V, Williamson PR, Hickey H, Sowden E, Beresford MW, Smyth RL, Young B: Communication about Children's Clinical Trials as observed and experienced: qualitative study of parents and practitioners. PLoS ONE. 2011, 6 (7): e21604-10.1371/journal.pone.0021604. doi:10.1371/journal.pone.0021604PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Young et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement