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  1. Venous thromboembolism (VTE) remains a priority challenge among orthopedic trauma patients. It is crucial to further improve the prophylaxis against VTE in routine orthopedic treatment. This study aims to comp...

    Authors: Qin Tan, Lu Zhou, Yihan Lu and Weifeng Huang
    Citation: Trials 2023 24:816
  2. Conducting clinical research on treatments for emerging infectious diseases is often complicated by methodological challenges, such as the identification of appropriate outcome measures to assess treatment res...

    Authors: Josephine Bourner, Ravaka Randriamparany, Tsinjo Fehizoro Rasoanaivo, Emmanuelle Denis, Rindra Vatosoa Randremanana, Michel Vaillant, Alex Paddy Salam, Bronner P. Gonçalves and Piero Olliaro
    Citation: Trials 2023 24:815
  3. Violence against health care workers (HCWs) is a multifaceted issue entwined with broader social, cultural, and economic contexts. While it is a global phenomenon, in crisis settings, HCWs are exposed to excep...

    Authors: Giovanfrancesco Ferrari, Samuel Makali Lwamushi, Ghislain Bisimwa Balaluka, Riyadh K. Lafta, Christian Schindler, Daniella Bugugu, Emmanuel Lurhangire, Fabrizio Tediosi, Jessica Ramirez Mendoza and Sonja Merten
    Citation: Trials 2023 24:814
  4. Authors: Eva Tolmeijer, Felicity Waite, Louise Isham, Laura Bringmann, Robin Timmers, Arjan van den Berg, Hanneke Schuurmans, Anton B. P. Staring, Paul de Bont, Rob van Grunsven, Gert Stulp, Ben Wijnen, Mark van der Gaag, Daniel Freeman and David van den Berg
    Citation: Trials 2023 24:813

    The original article was published in Trials 2023 24:644

  5. Participants with prediabetes are at a high risk of developing type 2 diabetes (T2D). Recent studies have suggested that blocking the receptor activator of nuclear factor-κB ligand (RANKL) may improve glucose ...

    Authors: Yilin Wang, Yu Jiang, Jia Li, Xisheng Lin, Yan Luo, Shuhuai Tan, Haohan Yang, Zefu Gao, Xiang Cui, Pengbin Yin, Dan Kong, Yuan Gao, Yu Cheng, Licheng Zhang, Peifu Tang and Houchen Lyu
    Citation: Trials 2023 24:812
  6. Acute-on-chronic liver failure (ACLF) is a common clinical type of liver failure, and patients with acute-on-chronic liver failure are prone to fungal infections, especially the increasing incidence of invasiv...

    Authors: Xue Yu, Lejia Xu, Jiaxing Zheng, Ziying Lei, Yihua Pang, Xiaojie Li, Jianyun Zhu and Jing Liu
    Citation: Trials 2023 24:811
  7. The results of germline genetic testing for hereditary cancer are of importance not only to the patients under investigation but also to their genetic at-risk relatives. Standard care is to encourage the prob...

    Authors: Carolina Hawranek, Hans Ehrencrona, Anna Öfverholm, Barbro Numan Hellquist and Anna Rosén
    Citation: Trials 2023 24:810
  8. Prostate cancer remains the most prevalent malignancy and the second-leading cause of cancer-related death in men in the USA. Radiation therapy, typically with androgen suppression, remains a mainstay in the t...

    Authors: Emerson Lee, Jonathan Coulter, Alok Mishra, Fernanda Caramella-Pereira, Angelo Demarzo, Michelle Rudek, Chen Hu, Misop Han, Theodore L. DeWeese, Srinivasan Yegnasubramanian and Daniel Y. Song
    Citation: Trials 2023 24:809
  9. Inflammation in ST-segment elevation myocardial infarction (STEMI) is an important contributor to both acute myocardial ischemia and reperfusion injury after primary percutaneous coronary intervention (PCI). M...

    Authors: Jasmine Melissa Madsen, Laust Emil Roelsgaard Obling, Laura Rytoft, Fredrik Folke, Christian Hassager, Lars Bredevang Andersen, Niels Vejlstrup, Lia Evi Bang, Thomas Engstrøm and Jacob Thomsen Lønborg
    Citation: Trials 2023 24:808
  10. Full pulpotomy has been proposed as an alternative to root canal treatment in teeth with signs and symptoms indicative of irreversible pulpitis (IRP), but the evidence is limited, relying on underpowered studi...

    Authors: I. A. El Karim, H. F. Duncan, A. F. Fouad, N. A. Taha, V. Yu, S. Saber, V. Ballal, P. Chompu-inwai, H. M. A. Ahmed, B. P. F. A. Gomes, S. Abushouk, S. Cushley, C. O’Neill and M. Clarke
    Citation: Trials 2023 24:807
  11. Studies have shown that the wet suction technique in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) generates better histological diagnostic accuracy and specimen quality than the dry suction te...

    Authors: Shenglin Xu, Junfen Wang, Jianian Guo, Fang Xie, Weiguang Qiao, Yiteng Meng, Peng Peng, Haiyan Hu, Ying Huang, Side Liu, Mengbin Qin, Jun Yao and Yue Li
    Citation: Trials 2023 24:805
  12. Sexual violence (SV) is a significant, global public health problem, particularly among young adults. Promising interventions exist, including prosocial bystander intervention programs that train bystanders to...

    Authors: Laura F. Salazar, Dominic J. Parrott, David DiLillo, Sarah Gervais, Anne Marie Schipani-McLaughlin, Ruschelle Leone, Kevin Swartout, Lauren Simpson, Renita Moore, Tiffany Wilson, Nyla Flowers, Haley Church and Amanda Baildon
    Citation: Trials 2023 24:804
  13. The global prevalence of diabetes mellitus (DM) continues to rise and 70% of diabetic individuals have dry eye disease (DED) that leads to subsequent abnormalities of the corneal epithelium, corneal nerves, te...

    Authors: Jiayan Chen, Yimeng Chen, Guanghao Qin, Liangzhe Li, Mingze Li, Yuan Cheng, Shuting Zhuang, Zhihui Li, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan E. Moore, Ling Xu, Wei He, Sile Yu…
    Citation: Trials 2023 24:803
  14. There is a lack of evidence on the effectiveness of livelihood interventions amongst people with disabilities. In many countries, self-employment or microentrepreneurship is a dominant source of livelihoods fo...

    Authors: Lena Morgon Banks, Stella Kepha, Anja Zinke-Allmang, Paul M. Gichuki, Nathaniel Scherer, Charles Mwandawiro, Mark Carew, Doris Njomo, Shanquan Chen, Collins Okoyo, Calum Davey, Tom Shakespeare, Maria Antonella Pereira, Divya Goyal and Hannah Kuper
    Citation: Trials 2023 24:802
  15. Clinical research nurses (CRNs) have first-hand experience with ethical challenges and play a crucial role in upholding ethical conduct and adherence to the principles of informed consent in clinical research....

    Authors: Tove Godskesen, Joar Björk and Niklas Juth
    Citation: Trials 2023 24:801
  16. Physical restraints remain to be commonly used in agitated intensive care unit (ICU) patients worldwide, despite a lack of evidence on efficacy and safety and reports of detrimental short and long-term consequ...

    Authors: Rens W. J. Kooken, Bram Tilburgs, Rob ter Heine, Bart Ramakers and Mark van den Boogaard
    Citation: Trials 2023 24:800
  17. Red blood cell (RBC) transfusion is a critical supportive therapy in cardiovascular surgery (CVS). Donor selection and testing have reduced the risk of transfusion-transmitted infections; however, risks remain...

    Authors: Edward L. Snyder, Michael E. Sekela, Ian J. Welsby, Yoshiya Toyoda, Mohamed Alsammak, Neel R. Sodha, Thomas M. Beaver, J. Peter R. Pelletier, James D. Gorham, John S. McNeil, Roman M. Sniecinski, Ronald G. Pearl, Gregory A. Nuttall, Ravi Sarode, T. Brett Reece, Alesia Kaplan…
    Citation: Trials 2023 24:799
  18. Following SARS-CoV-2 infection, a relevant proportion of patients suffer from persistent or recurring sequela, even after initially mild primary illness. Many patients experience exhaustion and fatigue, rende...

    Authors: Adrian Krotz, Nadia Sosnowsky-Waschek, Stephanie Bechtel, Christine Neumann, Monika Lohkamp, Gabor Kovacs, Bernd Genser and Joachim E. Fischer
    Citation: Trials 2023 24:798
  19. The use of remote consultation modalities has exponentially grown in the past few years, particularly since the onset of the COVID-19 pandemic. Although a huge body of the literature has described the use of p...

    Authors: Alejandro Rodríguez-Molinero, Gerard Carot-Sans, Roser Escrig, Cristian Tebé, Jacobo Arce, Carlos Pérez-López, Silvia Ballesta, Guillermo Verdejo, Ángel Cedeño, Mar Riera-Pagespetit, Sofia Vivas-Angeles, Jose L. Alarcon, Itziar Navarro, Silvia Toro, Llorenç Mateo, Ana J. Torres…
    Citation: Trials 2023 24:797
  20. The REVISE (Re-Evaluating the Inhibition of Stress Erosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically ill patient...

    Authors: Diane Heels-Ansdell, Laurent Billot, Lehana Thabane, Waleed Alhazzani, Adam Deane, Gordon Guyatt, Simon Finfer, François Lauzier, John Myburgh, Paul Young, Yaseen Arabi, John Marshall, Shane English, John Muscedere, Marlies Ostermann, Bala Venkatesh…
    Citation: Trials 2023 24:796
  21. The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and sever...

    Authors: Robert K. Mahar, Anna McGlothlin, Michael Dymock, Todd C. Lee, Roger J. Lewis, Thomas Lumley, Jocelyn Mora, David J. Price, Benjamin R. Saville, Tom Snelling, Rebecca Turner, Steven A. Webb, Joshua S. Davis, Steven Y. C. Tong and Julie A. Marsh
    Citation: Trials 2023 24:795
  22. Although placebo-controlled trials are considered the gold standard for evaluating the efficacy of healthcare interventions, they can be perceived to be controversial and challenging to conduct for surgical tr...

    Authors: Emma Kwan-Yee Ho, Ralph Jasper Mobbs, James Montague van Gelder, Ian Andrew Harris, Gavin Davis, Ralph Stanford, David John Beard, Christopher Gerard Maher, Joanna Prior, Michael Knox, David Barrett Anderson, Rachelle Buchbinder and Manuela Loureiro Ferreira
    Citation: Trials 2023 24:794
  23. The Live Well with Parkinson’s Self-Management Toolkit is designed for use in the NHS to support people with Parkinson’s, their carers and health professionals in managing motor and non-motor symptoms and prom...

    Authors: Kate Walters, Megan Armstrong, Benjamin Gardner, Gareth Ambler, Rachael Hunter, Bev Maydon, Nathan Davies, Catherine Atkinson, Richard Brown, Tasmin Rookes, Daniel Davis and Anette Schrag
    Citation: Trials 2023 24:793
  24. Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant im...

    Authors: Flavia L. Lombardo, Stefania Spila Alegiani, Flavia Mayer, Marta Cipriani, Maria Lo Giudice, Albert Christian Ludolph, Christopher J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gabriele Nicolini, Nicola Vanacore, Brian Dickie, Alberto Albanese and Maria Puopolo
    Citation: Trials 2023 24:792
  25. Family caregiver interventions are essential to support dementia caregiving. However, such interventions are typically complex and consist of multiple components. Existing evidence rarely delineates the effect...

    Authors: Jojo Yan Yan Kwok, Daphne Sze Ki Cheung, Steven Zarit, Karen Siu-Lan Cheung, Bobo Hi Po Lau, Vivian Weiqun Lou, Sheung-Tak Cheng, Dolores Gallagher-Thompson and Kee-Lee Chou
    Citation: Trials 2023 24:791
  26. Throughout the COVID-19 pandemic, underserved populations, such as racial and ethnic minorities, were disproportionately impacted by illness, hospitalization, and death. Equity in clinical trials means that th...

    Authors: Qing Xu, Tiana J. McMann, Jiawei Li, Christine Wenzel and Tim K. Mackey
    Citation: Trials 2023 24:790
  27. Alopecia is one of the most common adverse effects of chemotherapy. It reduces the patient’s self-esteem and quality of life and the effect of therapy. Scalp cooling is the only verified current method for pre...

    Authors: Cong-Xian Wu, Cheng-Hsin Li, Yi-Hsien Shiao, Huan-Yu Cheng, Tsung-Han Wu, Chun-Hui Lee, Zi-Yu Chang and Yuan-Chieh Yeh
    Citation: Trials 2023 24:789
  28. Upper limb dysfunction seriously affects the ability of stroke patients to perform activities of daily living. As a popular exercise therapy, Tai Chi may become an alternative intervention. However, the neurop...

    Authors: Qiurong Xie, Jinsong Wu, Qi Zhang, Yanxin Zhang, Bo Sheng, Xiaoling Wang and Jia Huang
    Citation: Trials 2023 24:788
  29. Oblique lumbar interbody fusion (OLIF) is an internationally popular minimally invasive technology for the treatment of various lumbar diseases. Since its introduction to China in 2014, OLIF technology has cle...

    Authors: Nian-rong Han, Akram Osman, Wei Hu, Yi-fei Huang, Yan-lu Liu and Zhan-jun Ma
    Citation: Trials 2023 24:787
  30. Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colo...

    Authors: Rui Qi Gao, Zhen Chang Mo, Hai Kun Zhou, Peng Fei Yu, Wei Dong Wang, Dan Hong Dong, Xi Sheng Yang, Xiao Hua Li and Gang Ji
    Citation: Trials 2023 24:786
  31. Irritable bowel syndrome (IBS) is a highly prevalent disorder for which treatment options such as medication, diets, and hypnotherapy either have shown limited effect or relieve symptoms in only a limited subs...

    Authors: B. Wertheim, E. E. Aarts, C. de Roos and Y. R. van Rood
    Citation: Trials 2023 24:785
  32. Focal brain lesions following a stroke of the middle cerebral artery induce large-scale network disarray with a potential to impact multiple cognitive and behavioral domains. Over the last 20 years, non-invasi...

    Authors: Xavier Corominas-Teruel, Martina Bracco, Montserrat Fibla, Rosa Maria San Segundo, Marc Villalobos-Llaó, Cecile Gallea, Benoit Beranger, Monica Toba, Antoni Valero-Cabré and Maria Teresa Colomina
    Citation: Trials 2023 24:783
  33. Postpartum haemorrhage (PPH) causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a life-saving treatment for women with PPH. Intravenous (IV) TXA reduces deaths due to PPH by one-third whe...

    Authors: Amy Brenner, Haleema Shakur-Still, Rizwana Chaudhri, Projestine Muganyizi, Oladapo Olayemi, Monica Arribas, Aasia Kayani, Kiran Javid, Adenike Bello and Ian Roberts
    Citation: Trials 2023 24:782
  34. Antiviral therapy has been reported to be associated with lower recurrence rate of hepatocellular carcinoma (HCC) for patients with hepatitis B virus (HBV) infection. While entecavir (ETV) and tenofovir disopr...

    Authors: Wei Peng, Mengshi Yi, Xin Qi, Weili Qi, Chuan Li and Tianfu Wen
    Citation: Trials 2023 24:781
  35. Low back pain (LBP) is the leading cause of years lived with disability worldwide. Public safety workers are highly exposed to physically demanding activities and inappropriate postures, increasing the risk of...

    Authors: Eduardo F. Marins, Eduardo L. Caputo, Vitor L. Krüger, Dirceu M. Junior, Fabrício G. Scaglioni, Fabricio B. Del Vecchio, Tiago T. Primo and Cristine L. Alberton
    Citation: Trials 2023 24:780
  36. The findings from multi-centre trials are central to the practice of evidence-based medicine, enabling the development and implementation of new treatments. The time it takes to commence clinical trials at sit...

    Authors: Sam Crosby, Adriana Malavisi, Liping Huang, Stephen Jan, Richard Holden and Bruce Neal
    Citation: Trials 2023 24:779
  37. Vonoprazan results in more potent acid suppression for gastroesophageal reflux disease (GERD) than proton pump inhibitors. It has only been approved for treating erosive esophagitis in China, but 30–40% of GER...

    Authors: Dongke Wang, Dan Zhou, Xinghuang Liu, Zhiyue Xu, Tao Bai and Xiaohua Hou
    Citation: Trials 2023 24:778
  38. Adjustment problems and disorders are highly prevalent among university students worldwide. These problems can cause significant interference in academic and social functioning and increase vulnerability to ot...

    Authors: A. Juszczyk-Kalina, P. Holas and T. J. Farchione
    Citation: Trials 2023 24:777
  39. Highly effective, short-course, bedaquiline-containing treatment regimens for multidrug-resistant tuberculosis (MDR-TB) and integrase strand transfer inhibitor (INSTI)-containing fixed dose combination antiret...

    Authors: Jesse Ross, Rubeshan Perumal, Allison Wolf, Mbali Zulu, Kevin Guzman, Boitumelo Seepamore, Karl Reis, Hlengiwe Nyilana, Senzo Hlathi, Radhamoney Narasimmulu, Ying Kuen K. Cheung, K. Rivet Amico, Gerald Friedland, Amrita Daftary, Jennifer R. Zelnick, Kogieleum Naidoo…
    Citation: Trials 2023 24:776
  40. Our previous randomized controlled trial (RCT) have demonstrated that intermittent Pringle’s maneuver (IPM) with a 25-min ischemic interval can be applied safely and efficiently in open or laparoscopic hepatec...

    Authors: Yang Huang, Liangliang Xu, Ning Wang, Xingyu Pu, Wentao Wang, Tianfu Wen, Mingqing Xu and Li Jiang
    Citation: Trials 2023 24:774
  41. Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yields worse efficacy results, and cause...

    Authors: S. B. Patil, M. Tamirat, K. Khazhidinov, E. Ardizzoni, M. Atger, A. Austin, E. Baudin, M. Bekhit, S. Bektasov, E. Berikova, M. Bonnet, R. Caboclo, M. Chaudhry, V. Chavan, S. Cloez, J. Coit…
    Citation: Trials 2023 24:773
  42. The Active Connected Engaged [ACE] study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial [RCT] with an internal pilot phase. The ACE study incorporates a multi-level mixed met...

    Authors: Afroditi Stathi, Janet Withall, Diane Crone, Helen Hawley-Hague, Rebecca Playle, Emma Frew, Sally Fenton, Melvyn Hillsdon, Christopher Pugh, Chris Todd, Kate Jolly, Nick Cavill, Max Western, Sarah Roche, Nigel Kirby, Elisabeth Boulton…
    Citation: Trials 2023 24:772
  43. This manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate the efficacy of attractive targeted sugar baits (ATSB) described in an already published...

    Authors: Joshua Yukich, Thomas P. Eisele, Feiko terKuile, Ruth Ashton, Sarah Staedke, Angela F. Harris, Paul C. D. Johnson, Sophie Sarrassat, Maia Lesosky, John Bradley, Immo Kleinschmidt and Megan Littrell
    Citation: Trials 2023 24:771
  44. Hypertension increases the risk of cardiovascular disease. Uncontrolled nocturnal blood pressure is prevalent in patients taking antihypertensive medication, with an incidence rate of 30–60%. Although chronoth...

    Authors: Mengzhuo Xu, Xin Zhang, Runyu Ye, Xueting Liu, Lirong Sun, Shanshan Jia, Zhipeng Zhang, Xinran Li, Ziqiong Wang, Hang Liao, Rufeng Shi, Kai Liu, Si Wang, Qingtao Meng and Xiaoping Chen
    Citation: Trials 2023 24:770
  45. Limited mobility in older adults consistently predicts both morbidity and mortality. As individuals age, the rates of mobility disability increase from 1.0% in people aged 15–24 to 20.6% in adults over 65 year...

    Authors: Jordyn Rice, Linda C. Li, Jennifer C. Davis, Marco Pahor, Kenneth Madden, Nathan Wei, Hubert Wong, Dawn A. Skelton, Sioban McCormick, Ryan S. Falck, Cindy K. Barha, Ryan E. Rhodes, Sohail Loomba, Mohsen Sadatsafavi and Teresa Liu-Ambrose
    Citation: Trials 2023 24:769
  46. Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collag...

    Authors: L. van Dam, R. Terink, M. Mensink, R. J. de Vos and J. Zwerver
    Citation: Trials 2023 24:768
  47. Post-traumatic stress symptoms develop in a quarter to half of injured children affecting their longer-term psychologic and physical health. Evidence-based care exists for post-traumatic stress; however, it is...

    Authors: Heather T. Keenan, Shari L. Wade, Devi Miron, Angela P. Presson, Amy E. Clark and Linda Ewing-Cobbs
    Citation: Trials 2023 24:766

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