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  1. Prospective, international, multi-centre, randomised (1:1) trial to evaluate the clinical impact of percutaneous transluminal renal artery stenting (PTRAS) on the impaired renal function measured by the estima...

    Authors: Uwe Schwarzwälder, Michael Hauk and Thomas Zeller
    Citation: Trials 2009 10:60
  2. Internet-based self-help is an effective preventive intervention for highly prevalent disorders, such as depression and anxiety. It is not clear, however, whether it is necessary to offer these interventions w...

    Authors: Tara Donker, Annemieke van Straten, Heleen Riper, Isaac Marks, Gerhard Andersson and Pim Cuijpers
    Citation: Trials 2009 10:59
  3. Concomitant treatment in addition to intervention may influence the primary outcome, especially in complex interventions such as surgical trials. Evidence-based standards for perioperative care after distal pa...

    Authors: Helge Bruns, Nuh N Rahbari, Thorsten Löffler, Markus K Diener, Christoph M Seiler, Matthias Glanemann, Giovanni Butturini, Christoph Schuhmacher, Inga Rossion, Markus W Büchler and Tido Junghans
    Citation: Trials 2009 10:58
  4. Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glu...

    Authors: Rob Jones, Bart Sheehan, Patrick Phillips, Ed Juszczak, Jessica Adams, Ashley Baldwin, Clive Ballard, Sube Banerjee, Bob Barber, Peter Bentham, Richard Brown, Alistair Burns, Tom Dening, David Findlay, Richard Gray, Mary Griffin…
    Citation: Trials 2009 10:57
  5. Since September 2005 the International Committee of Medical Journal Editors has required that trials be registered in accordance with the World Health Organization (WHO) minimum dataset, in order to be conside...

    Authors: Lorenzo P Moja, Ivan Moschetti, Munira Nurbhai, Anna Compagnoni, Alessandro Liberati, Jeremy M Grimshaw, An-Wen Chan, Kay Dickersin, Karmela Krleza-Jeric, David Moher, Ida Sim and Jimmy Volmink
    Citation: Trials 2009 10:56
  6. The number of reports of clinical trials grows by hundreds every week. However, this does not mean that people making decisions about healthcare are finding it easier to obtain reliable knowledge for these dec...

    Authors: Mike Clarke
    Citation: Trials 2009 10:55
  7. Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects ...

    Authors: Jong-In Kim, Myeong Soo Lee, So-Young Jung, Jun-Yong Choi, Sanghoon Lee, Jeong-Min Ko, Hong Zhao, Jiping Zhao, Ae-Ran Kim, Mi-Suk Shin, Kyung-Won Kang, Hee-Jung Jung, Tae-Hun Kim, Baoyan Liu and Sun-Mi Choi
    Citation: Trials 2009 10:54
  8. In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin and many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting ...

    Authors: Laura Sheard, Nat MJ Wright, Clive E Adams, Nicole Bound, Bruno Rushforth, Roger Hart and Charlotte NE Tompkins
    Citation: Trials 2009 10:53
  9. Poor recruitment and retention of participants in randomised controlled trials (RCTs) is problematic but common. Clear and detailed reporting of participant flow is essential to assess the generalisability and...

    Authors: Merran Toerien, Sara T Brookes, Chris Metcalfe, Isabel de Salis, Zelda Tomlin, Tim J Peters, Jonathan Sterne and Jenny L Donovan
    Citation: Trials 2009 10:52
  10. Fractures of the proximal humerus are common injuries and account for 4–5 percent of all fractures, second only to hip and wrist fractures. The incidence is positively correlated with age and osteoporosis, and...

    Authors: Stig Brorson, Bo Sanderhoff Olsen, Lars Henrik Frich, Steen Lund Jensen, Hans Viggo Johannsen, Anne Kathrine Sørensen and Asbjørn Hrobjartsson
    Citation: Trials 2009 10:51
  11. Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect clinical practice, but pose interpretational challenges for clinicians, researchers, and policy makers. Beca...

    Authors: Matthias Briel, Melanie Lane, Victor M Montori, Dirk Bassler, Paul Glasziou, German Malaga, Elie A Akl, Ignacio Ferreira-Gonzalez, Pablo Alonso-Coello, Gerard Urrutia, Regina Kunz, Carolina Ruiz Culebro, Suzana Alves da Silva, David N Flynn, Mohamed B Elamin, Brigitte Strahm…
    Citation: Trials 2009 10:49
  12. Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be ...

    Authors: Kim Houlind, Bo Juul Kjeldsen, Susanne Nørgaard Madsen, Bodil Steen Rasmussen, Susanne Juel Holme, Thomas Andersen Schmidt, Poul Erik Haahr and Poul Erik Mortensen
    Citation: Trials 2009 10:47
  13. Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) constitute to be a high-risk population for the development of contrast-induced nephropathy (CIN), in which the incidence of CIN is estimat...

    Authors: Manouchehr Amini, Mojtaba Salarifar, Alireza Amirbaigloo, Farzad Masoudkabir and Fatemeh Esfahani
    Citation: Trials 2009 10:45
  14. Sending a monetary incentive with postal questionnaires has been found to improve the proportion of responders, in research in non-healthcare settings. However, there is little research on use of incentives to...

    Authors: Simon Gates, Mark A Williams, Emma Withers, Esther Williamson, Shahrul Mt-Isa and Sarah E Lamb
    Citation: Trials 2009 10:44
  15. Some patients will experience more or less benefit from treatment than the averages reported from clinical trials; such variation in therapeutic outcome is termed heterogeneity of treatment effects (HTE). Iden...

    Authors: Nicole B Gabler, Naihua Duan, Diana Liao, Joann G Elmore, Theodore G Ganiats and Richard L Kravitz
    Citation: Trials 2009 10:43
  16. Heart failure patients with implantable defibrillators (ICD) frequently visit the clinic for routine device monitoring. Moreover, in the case of clinical events, such as ICD shocks or alert notifications for c...

    Authors: Maurizio Marzegalli, Maurizio Landolina, Maurizio Lunati, Giovanni B Perego, Alessia Pappone, Giuseppe Guenzati, Carlo Campana, Maria Frigerio, Gianfranco Parati, Antonio Curnis, Irene Colangelo and Sergio Valsecchi
    Citation: Trials 2009 10:42
  17. Highly active antiretroviral therapy produces a significant decrease in HIV-1 replication and allows an increase in the CD4 T-cell count, leading to a decrease in the incidence of opportunistic infections and ...

    Authors: Carlos J Montoya, Fabian Jaimes, Edwin A Higuita, Sandra Convers-Páez, Santiago Estrada, Francisco Gutierrez, Pedro Amariles, Newar Giraldo, Cristina Peñaloza and Maria T Rugeles
    Citation: Trials 2009 10:41
  18. Incomplete ascertainment of outcomes in randomized controlled trials (RCTs) is likely to bias final study results if reasons for unavailability of patient data are associated with the outcome of interest. The ...

    Authors: Elie A Akl, Matthias Briel, John J You, Francois Lamontagne, Azim Gangji, Tali Cukierman-Yaffe, Mohamad Alshurafa, Xin Sun, Kara A Nerenberg, Bradley C Johnston, Claudio Vera, Edward J Mills, Dirk Bassler, Arturo Salazar, Neera Bhatnagar, Jason W Busse…
    Citation: Trials 2009 10:40
  19. The multi-arm multi-stage (MAMS) trial is a new paradigm for conducting randomised controlled trials that allows the simultaneous assessment of a number of research treatments against a single control arm. MAM...

    Authors: Matthew R Sydes, Mahesh KB Parmar, Nicholas D James, Noel W Clarke, David P Dearnaley, Malcolm D Mason, Rachel C Morgan, Karen Sanders and Patrick Royston
    Citation: Trials 2009 10:39
  20. Aceltylcysteine has been evaluated in several small trials as a means of reducing the risk of contrast-induced nephropathy (CIN), however systematic reviews of these studies do not provide conclusive answers. ...

    Authors:
    Citation: Trials 2009 10:38
  21. Vitamin D does not only regulate calcium homeostasis but also plays an important role as an immune modulator. It influences the immune system through the induction of immune shifts and regulatory cells resulti...

    Authors: Ursula Thiem, Georg Heinze, Rudolf Segel, Thomas Perkmann, Franz Kainberger, Ferdinand Mühlbacher, Walter Hörl and Kyra Borchhardt
    Citation: Trials 2009 10:36
  22. Randomised controlled trials are the gold standard for evaluating mental health care interventions. We assessed the content and quality of trials published in Acta Psychiatrica Scandinavica and Supplementum si...

    Authors: Hosam E Matar, Muhammad Q Almerie, Muhammad O Al Marhi and Clive E Adams
    Citation: Trials 2009 10:35
  23. In the developmental stage of laparoscopic cholecystectomy (LC) it was considered 'unsafe' or 'technically difficult' to perform laparoscopic cholecystectomy for acute cholecystitis (AC). With increasing exper...

    Authors: Fausto Catena, Luca Ansaloni, Salomone Di Saverio, Filippo Gazzotti, Federico Coccolini and Antonio Daniele Pinna
    Citation: Trials 2009 10:34
  24. A subgroup of clinical trial subjects identified by baseline characteristics is a proper subgroup while a subgroup determined by post randomization events or measures is an improper subgroup. Both types of sub...

    Authors: Karim F Hirji and Morten W Fagerland
    Citation: Trials 2009 10:33
  25. The incidence of gallstones and gallbladder sludge is known to be higher in patients after gastrectomy than in general population. This higher incidence is probably related to surgical dissection of the vagus ...

    Authors: Marco Farsi, Marco Bernini, Lapo Bencini, Egidio Miranda, Roberto Manetti, Giovanni de Manzoni, Giuseppe Verlato, Daniele Marrelli, Corrado Pedrazzani, Francesco Roviello, Alberto Marchet, Luigi Cristadoro, Leonardo Gerard and Renato Moretti
    Citation: Trials 2009 10:32
  26. One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to p...

    Authors: Michela Nosè, Simone Accordini, Paola Artioli, Francesco Barale, Corrado Barbui, Rossella Beneduce, Domenico Berardi, Gerardo Bertolazzi, Bruno Biancosino, Alfredo Bisogno, Raffaella Bivi, Filippo Bogetto, Marianna Boso, Alberto Bozzani, Piera Bucolo, Marcello Casale…
    Citation: Trials 2009 10:31
  27. Amlexanox has been developed as a 5 percent topical oral paste for the treatment of patients with recurrent aphthous stomatitis (RAS) in most European countries. However, it is not yet available in China and h...

    Authors: Wenxia Meng, Yi Dong, Jie Liu, Zhi Wang, Xiaobo Zhong, Ruiyang Chen, Hongmei Zhou, Mei Lin, Lu Jiang, Feng Gao, Tao Xu, Qianming Chen and Xin Zeng
    Citation: Trials 2009 10:30
  28. Medication errors are an important cause of morbidity and mortality in primary care.

    Authors: Anthony J Avery, Sarah Rodgers, Judith A Cantrill, Sarah Armstrong, Rachel Elliott, Rachel Howard, Denise Kendrick, Caroline J Morris, Scott A Murray, Robin J Prescott, Kathrin Cresswell and Aziz Sheikh
    Citation: Trials 2009 10:28

    The Erratum to this article has been published in Trials 2010 11:23

  29. Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published cro...

    Authors: Edward J Mills, An-Wen Chan, Ping Wu, Andy Vail, Gordon H Guyatt and Douglas G Altman
    Citation: Trials 2009 10:27
  30. Telephone quit lines are accessible to many smokers and are used to engage motivated smokers to make quit attempts. Smoking cessation counselling provided via telephone can either be reactive (i.e. primarily i...

    Authors: Tim Coleman, Andy McEwen, Linda Bauld, Janet Ferguson, Paula Lorgelly and Sarah Lewis
    Citation: Trials 2009 10:26
  31. Many studies have already reported encouraging results in the prophylactic therapy of migraine by acupuncture, but there seems to be a lack of high quality randomized controlled trials from China. We design an...

    Authors: Yan Zhang, Linpeng Wang, Huilin Liu, Nan Li, Jingdao Li and Jinghong Yi
    Citation: Trials 2009 10:25
  32. Fibromyalgia is a prevalent and disabling disorder characterized by widespread pain and other symptoms such as insomnia, fatigue or depression. Catastrophization is considered a key clinical symptom in fibromy...

    Authors: Javier García-Campayo, Antoni Serrano-Blanco, Baltasar Rodero, Rosa Magallón, Marta Alda, Eva Andrés, Juan V Luciano and Yolanda López del Hoyo
    Citation: Trials 2009 10:24
  33. Anorexia nervosa is a serious eating disorder leading to high morbidity and mortality as a result of both malnutrition and suicide. The seriousness of the disorder requires extensive knowledge of effective tre...

    Authors: Beate Wild, Hans-Christoph Friederich, Gaby Gross, Martin Teufel, Wolfgang Herzog, Katrin E Giel, Martina de Zwaan, Henning Schauenburg, Carmen Schade-Brittinger, Helmut Schäfer and Stephan Zipfel
    Citation: Trials 2009 10:23
  34. Older adults who live in rural areas experience significant disparities in health status and access to mental health care. "Telepsychology," (also referred to as "telepsychiatry," or "telemental health") repre...

    Authors: Leonard E Egede, Christopher B Frueh, Lisa K Richardson, Ronald Acierno, Patrick D Mauldin, Rebecca G Knapp and Carl Lejuez
    Citation: Trials 2009 10:22
  35. The prevalence of depression in patients with acute coronary syndrome, i.e. myocardial infarction and unstable angina, is higher than in the general population. The prevalence of anxiety is higher as well. Bot...

    Authors: Baiba Hedegaard Hansen, Jamal Abed Hanash, Alice Rasmussen, Jørgen Fischer Hansen and Morten Birket-Smith
    Citation: Trials 2009 10:20
  36. Many studies have attempted to determine the "best" anaesthetic technique for neurosurgical procedures in patients without intracranial hypertension. So far, no study comparing intravenous (IA) with volatile-base...

    Authors: Giuseppe Citerio, Maria Grazia Franzosi, Roberto Latini, Serge Masson, Simona Barlera, Stefano Guzzetti and Antonio Pesenti
    Citation: Trials 2009 10:19
  37. Depression Care for People with Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depressio...

    Authors: Jane Walker, Jim Cassidy and Michael Sharpe
    Citation: Trials 2009 10:18
  38. Tourette Syndrome (TS) is a neurological condition presenting chronic motor and phonic tics, and important degree of comorbidity. Considered an uncommon illness, it first becomes apparent during childhood. Cur...

    Authors: Rafael Garcia-Lopez, Emilio Perea-Milla, Cesar Ruiz Garcia, Francisco Rivas-Ruiz, Julio Romero-Gonzalez, Jose L Moreno, Vicente Faus, Guadalupe del Castillo Aguas and Juan C Ramos Diaz
    Citation: Trials 2009 10:16
  39. Hypertension affects 29% of the adult U.S. population and is a leading cause of heart disease, stroke, and kidney failure. Despite numerous effective treatments, only 53% of people with hypertension are at goa...

    Authors: Rowena J Dolor, William S Yancy Jr, William F Owen, David B Matchar, Gregory P Samsa, Kathryn I Pollak, Pao-Hwa Lin, Jamy D Ard, Maxwell Prempeh, Heather L McGuire, Bryan C Batch, William Fan and Laura P Svetkey
    Citation: Trials 2009 10:13
  40. Metformin has had a 'black box' contraindication in diabetic patients with heart failure (HF), but many believe it to be the treatment of choice in this setting. Therefore, we attempted to conduct a pilot stud...

    Authors: Dean T Eurich, Ross T Tsuyuki, Sumit R Majumdar, Finlay A McAlister, Richard Lewanczuk, Marcelo C Shibata and Jeffrey A Johnson
    Citation: Trials 2009 10:12
  41. Non-pharmacological, non-surgical interventions are recommended as the first line of treatment for osteoarthritis (OA) of the hip and knee. There is evidence that exercise therapy is effective for reducing pai...

    Authors: J Haxby Abbott, M Clare Robertson, Joanne E McKenzie, G David Baxter, Jean-Claude Theis and A John Campbell
    Citation: Trials 2009 10:11

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