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  1. Emotional problems such as anxiety and low mood in children are common, impair everyday functioning and increase the risk of severe mental health disorders in adulthood. Relatively few children with emotional ...

    Authors: Paul Stallard, Gordon Taylor, Rob Anderson, Harry Daniels, Neil Simpson, Rhiannon Phillips and Elena Skryabina
    Citation: Trials 2012 13:227
  2. Parastomal hernia is a common complication of a colostomy. Ultimately, one-third of patients with a parastomal hernia will need surgical correction due to frequent leakage or life-threatening bowel obstruction...

    Authors: Henk-Thijs Brandsma, Birgitta ME Hansson, Hilde V-Haaren-de Haan, Theo J Aufenacker, Camiel Rosman and Rob P Bleichrodt
    Citation: Trials 2012 13:226
  3. After an initial attack of biliary pancreatitis, cholecystectomy minimizes the risk of recurrent biliary pancreatitis and other gallstone-related complications. Guidelines advocate performing cholecystectomy w...

    Authors: Stefan A Bouwense, Marc G Besselink, Sandra van Brunschot, Olaf J Bakker, Hjalmar C van Santvoort, Nicolien J Schepers, Marja A Boermeester, Thomas L Bollen, Koop Bosscha, Menno A Brink, Marco J Bruno, Esther C Consten, Cornelis H Dejong, Peter van Duijvendijk, Casper H van Eijck, Jos J Gerritsen…
    Citation: Trials 2012 13:225
  4. Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patien...

    Authors: Guang-Xia Shi, Li-Li Han, Li-Ying Liu, Qian-Qian Li, Cun-Zhi Liu and Lin-Peng Wang
    Citation: Trials 2012 13:224
  5. Our approach to advancing the treatment of psychosis is to focus on key single symptoms and develop interventions that target the mechanisms that maintain them. In our theoretical research we have found worry ...

    Authors: Daniel Freeman, Graham Dunn, Helen Startup and David Kingdon
    Citation: Trials 2012 13:223
  6. Previous studies had suggested that the outcome for patients with spontaneous lobar intracerebral haemorrhage (ICH) and no intraventricular haemorrhage (IVH) might be improved with early evacuation of the haem...

    Authors: Barbara A Gregson, Gordon D Murray, Patrick M Mitchell, Elise N Rowan, Anil R Gholkar and A David Mendelow
    Citation: Trials 2012 13:222
  7. Low-level laser therapy (LLLT) has been widely used as adjuvant strategy for treatment of musculoskeletal disorders. The light-tissue interaction (photobiostimulation) promotes analgesic and anti-inflammatory ...

    Authors: Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior, Ana Carolina Araruna Alves, Caroline Sobral de Melo Rambo, Luciana Maria Malosa Sampaio, Claudia Santos Oliveira, Regiane Albertini and Luis Vicente Franco de Oliveira
    Citation: Trials 2012 13:221
  8. Binge eating disorder (BED) is a prevalent clinical eating disorder associated with increased psychopathology, psychiatric comorbidity, overweight and obesity, and increased health care costs. Since its inclus...

    Authors: Martina de Zwaan, Stephan Herpertz, Stephan Zipfel, Brunna Tuschen-Caffier, Hans-Christoph Friederich, Frauke Schmidt, Olaf Gefeller, Andreas Mayr, Tony Lam, Carmen Schade-Brittinger and Anja Hilbert
    Citation: Trials 2012 13:220
  9. To improve risk factor management in diabetes, we need to support effective interactions between patients and healthcare providers. Our aim is to develop and evaluate a treatment decision aid that offers perso...

    Authors: Petra Denig, Mathijs Dun, Jan Schuling, Flora M Haaijer-Ruskamp and Jaco Voorham
    Citation: Trials 2012 13:219
  10. Practice effects are a known threat to reliability and validity in clinical trials. Few studies have investigated the potential influence of practice on repeated screening measures in longitudinal clinical tri...

    Authors: Erin L Abner, Brandon C Dennis, Melissa J Mathews, Marta S Mendiondo, Allison Caban-Holt, Richard J Kryscio, Frederick A Schmitt and John J Crowley
    Citation: Trials 2012 13:217
  11. Long-standing randomised controlled trial (RCT) evidence indicates that asthma action plans can improve patient outcomes. Internationally, however, these plans are seldom issued by professionals or used by pat...

    Authors: Nicola Ring, Ruth Jepson, Hilary Pinnock, Caroline Wilson, Gaylor Hoskins, Sally Wyke and Aziz Sheikh
    Citation: Trials 2012 13:216
  12. Iliac artery atherosclerotic disease may cause intermittent claudication and critical limb ischemia. It can lead to serious complications such as infection, amputation and even death. Revascularization relieve...

    Authors: Joost A Bekken, Jan Albert Vos, Ruud A Aarts, Jean-Paul PM de Vries and Bram Fioole
    Citation: Trials 2012 13:215
  13. Non-inferiority and equivalence trials require tailored methodology and therefore adequate conduct and reporting is an ambitious task. The aim of our review was to assess whether the criteria recommended by th...

    Authors: Petra Schiller, Nicole Burchardi, Michael Niestroj and Meinhard Kieser
    Citation: Trials 2012 13:214
  14. Reducing neonatal-related deaths is one of the major bottlenecks to achieving Millennium Development Goal 4. Studies in Asia and South America have shown that neonatal mortality can be reduced through communit...

    Authors: Peter Waiswa, Stefan S Peterson, Gertrude Namazzi, Elizabeth Kiracho Ekirapa, Sarah Naikoba, Romano Byaruhanga, Juliet Kiguli, Karin Kallander, Abner Tagoola, Margaret Nakakeeto and George Pariyo
    Citation: Trials 2012 13:213
  15. There is an urgent need to protect children against dengue since this age group is particularly sensitive to the disease. Since dengue vectors are active mainly during the day, a potential target for control s...

    Authors: Annelies Wilder-Smith, Peter Byass, Phanthip Olanratmanee, Pongsri Maskhao, Luechai Sringernyuang, James G Logan, Steve W Lindsay, Sarah Banks, Duane Gubler, Valérie R Louis, Yesim Tozan and Pattamaporn Kittayapong
    Citation: Trials 2012 13:212
  16. Cellular therapy after organ transplantation is emerging as an intriguing strategy to achieve dose reduction of classical immunosuppressive pharmacotherapy. Here, we introduce a new scoring system to assess tr...

    Authors: Johannes Dillmann, Felix C Popp, Barbara Fillenberg, Florian Zeman, Elke Eggenhofer, Stefan Farkas, Marcus N Scherer, Michael Koller, Edward K Geissler, Robert Deans, Deborah Ladenheim, Martin Loss, Hans J Schlitt and Marc H Dahlke
    Citation: Trials 2012 13:211
  17. The evidence on the effect of acupuncture or counseling for depression is not conclusive yet is sufficient to warrant further research. Our aim is to conduct a full-scale RCT to determine the clinical and cost...

    Authors: Hugh MacPherson, Stewart Richmond, J Martin Bland, Harriet Lansdown, Ann Hopton, Arthur Kang’ombe, Stephen Morley, Sara Perren, Eldon Spackman, Karen Spilsbury, David Torgerson and Ian Watt
    Citation: Trials 2012 13:209
  18. The severe iatrogenic hypogonadal state induced by medical castration used for treatment of prostate cancer is associated with adverse effects including fatigue, increased fracture risk, and a decrease in skel...

    Authors: Liam Bourke, Ratna Sohanpal, Veronica Nanton, Helen Crank, Derek J Rosario and John M Saxton
    Citation: Trials 2012 13:208
  19. Although cigarette smoking is a leading cause of death and disability in the United States (US), over 40 million adults in the US currently smoke. Quitting smoking is particularly difficult for smokers with ce...

    Authors: Jasper AJ Smits, Michael J Zvolensky, David Rosenfield, Bess H Marcus, Timothy S Church, Georita M Frierson, Mark B Powers, Michael W Otto, Michelle L Davis, Lindsey B DeBoer and Nicole F Briceno
    Citation: Trials 2012 13:207
  20. Having a ‘theory of mind’, or having the ability to attribute mental states to oneself or others, is considered one of the most central domains of impairment among children with an autism spectrum disorder (AS...

    Authors: Elske Hoddenbach, Hans M Koot, Pamela Clifford, Carolien Gevers, Cassandra Clauser, Frits Boer and Sander Begeer
    Citation: Trials 2012 13:206
  21. In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German a...

    Authors: Eva Hummers-Pradier, Jutta Bleidorn, Guido Schmiemann, Stefanie Joos, Annette Becker, Attila Altiner, Jean-François Chenot and Martin Scherer
    Citation: Trials 2012 13:205
  22. In 2009, 665 patients underwent total knee replacements (TKRs) at the Norfolk and Norwich University Hospitals NHS Foundation Trust (NNUH), representing nearly 1% of the national total. Pain control following ...

    Authors: Simon Donell, Katherine Deane, Louise Swift, Garry Barton, Paula Balls, Clare Darrah and Richard Gray
    Citation: Trials 2012 13:204
  23. Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through...

    Authors: James Whitehorn, Nguyen Van Vinh Chau, Nguyen Thanh Truong, Luong Thi Hue Tai, Nguyen Van Hao, Tran Tinh Hien, Marcel Wolbers, Laura Merson, Nguyen Thi Phuong Dung, Rosanna Peeling, Cameron Simmons, Bridget Wills and Jeremy Farrar
    Citation: Trials 2012 13:203
  24. Social anxiety disorder (SAD) is one of the most common anxiety disorders and is associated with marked impairments. However, a small proportion of individuals with SAD seek and receive treatment. Internet-adm...

    Authors: Bogdan Tudor Tulbure, Kristoffer NT Månsson and Gerhard Andersson
    Citation: Trials 2012 13:202
  25. Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic sur...

    Authors: Momin Malik, Kirsty McCormack, Zygmunt H Krukowski, Alison McDonald, Gladys McPherson, Jonathan A Cook and Irfan Ahmed
    Citation: Trials 2012 13:201
  26. Results of previous studies have shown that exercise training can improve cognitive functions in healthy older people. Some studies have demonstrated that long-term combination exercise training can facilitate...

    Authors: Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi and Ryuta Kawashima
    Citation: Trials 2012 13:200
  27. Acute kidney allograft rejection is a major cause for declining graft function and has a negative impact on the long-term graft survival. The majority (90%) of acute rejections are T-cell mediated and, therefo...

    Authors: Lena Schiffer, Mario Schiffer, Saskia Merkel, Anke Schwarz, Michael Mengel, Christopher Jürgens, Christoph Schroeder, Alexander A Zoerner, Kerstin Püllmann, Verena Bröcker, Jan U Becker, Maximilian E Dämmrich, Jana Träder, Anika Großhennig, Frank Biertz, Hermann Haller…
    Citation: Trials 2012 13:199
  28. In healthcare research the randomised controlled trial is seen as the gold standard because it ensures selection bias is minimised. However, there is uncertainty as to which is the most preferred method of ran...

    Authors: Gladys C McPherson, Marion K Campbell and Diana R Elbourne
    Citation: Trials 2012 13:198
  29. Many people with dementia experience anxiety, which can lead to decreased independence, relationship difficulties and increased admittance to care homes. Anxiety is often treated with antipsychotic medication,...

    Authors: Aimee Spector, Martin Orrell, Miles Lattimer, Juanita Hoe, Michael King, Kate Harwood, Afifa Qazi and Georgina Charlesworth
    Citation: Trials 2012 13:197
  30. Cervical dilation using mechanical dilators is associated with various complications, such as uterine perforation, cervical laceration, infections and intraperitoneal hemorrhage. To achieve safe and painless c...

    Authors: Slobodan Arsenijevic, Gordana Vukcevic-Globarevic, Vladislav Volarevic, Ivan Macuzic, Petar Todorovic, Irena Tanaskovic, Milan Mijailovic, Sasa Raicevic and Branislav Jeremic
    Citation: Trials 2012 13:196
  31. Although government-funded specialist smoking cessation services in England offer advice and support to smokers motivated to quit, only a small proportion of smokers make use of this service. Evidence suggests...

    Authors: Hazel Gilbert, Stephen Sutton, Richard Morris, Steve Parrot, Simon Galton and Irwin Nazareth
    Citation: Trials 2012 13:195
  32. Intracranial hemorrhage occurs in over 60% of severe head injuries in one of three types: extradural (EDH); subdural (SDH); and intraparenchymal (TICH). Prompt surgical removal of significant SDH and EDH is es...

    Authors: Barbara A Gregson, Elise N Rowan, Patrick M Mitchell, Andy Unterberg, Elaine M McColl, Iain R Chambers, Paul McNamee and A David Mendelow
    Citation: Trials 2012 13:193
  33. Childhood intermittent exotropia [X(T)] is a type of strabismus (squint) in which one eye deviates outward at times, usually when the child is tired. It may progress to a permanent squint, loss of stereovision...

    Authors: Deborah Buck, Elaine McColl, Christine J Powell, Jing Shen, John Sloper, Nick Steen, Robert Taylor, Peter Tiffin, Luke Vale and Michael P Clarke
    Citation: Trials 2012 13:192
  34. Nutritional support is an essential part of the management of critically ill patients. However, optimal caloric intake has not been systematically evaluated. We aim to compare two strategies of enteral feeding...

    Authors: Yaseen M Arabi, Samir H Haddad, Abdulaziz S Aldawood, Hasan M Al-Dorzi, Hani M Tamim, Maram Sakkijha, Gwynne Jones, Lauralyn McIntyre, Sangeeta Mehta, Othman Solaiman, Musharaf Sadat, Lara Afesh and Bushra Sami
    Citation: Trials 2012 13:191
  35. Alcohol abuse comes with risks for increased morbidity and mortality among patients with HIV. This study aims to determine the prevalence of alcohol use and other risk factors in a sample of primary care patie...

    Authors: Diana Huis in ’t Veld, Linda Skaal, Karl Peltzer, Robert Colebunders, John V Ndimande and Supa Pengpid
    Citation: Trials 2012 13:190
  36. Maintenance of the blind-to-treatment allocation is one of the most important means of avoiding bias in randomised controlled clinical trials. Commonly used methodologies to determine whether patients have bec...

    Authors: Stephen Wright, Paul Duncombe and Douglas G Altman
    Citation: Trials 2012 13:189
  37. Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have adverse side effects and poor adherence. The pu...

    Authors: Kyung-Min Shin, Ji-Eun Park, Yan Liu, Hee-Jung Jung, So-Young Jung, Min-Hee Lee, Kyung-Won Kang, Tae-Han Yook and Sun-Mi Choi
    Citation: Trials 2012 13:188
  38. Living with HIV makes considerable demands on a person in terms of self-management, especially as regards adherence to treatment and coping with adverse side-effects. The online HIV Treatment, Virtual Nursing ...

    Authors: José Côté, Gaston Godin, Yann-Gaël Guéhéneuc, Geneviève Rouleau, Pilar Ramirez-Garcìa, Joanne Otis, Cécile Tremblay and Ghayas Fadel
    Citation: Trials 2012 13:187
  39. Many women try to stop smoking in pregnancy but fail. One difficulty is that there is insufficient evidence that medications for smoking cessation are effective and safe in pregnancy and thus many women prefer...

    Authors: Michael Ussher, Paul Aveyard, Isaac Manyonda, Sarah Lewis, Robert West, Beth Lewis, Bess Marcus, Adrian H Taylor, Pelham Barton and Tim Coleman
    Citation: Trials 2012 13:186
  40. Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues...

    Authors: David E Newby, Michelle C Williams, Andrew D Flapan, John F Forbes, Allister D Hargreaves, Stephen J Leslie, Steff C Lewis, Graham McKillop, Scott McLean, John H Reid, James C Sprat, Neal G Uren, Edwin J van Beek, Nicholas A Boon, Liz Clark, Peter Craig…
    Citation: Trials 2012 13:184
  41. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a disabling progressive course. Chronic cerebrospinal venous insufficiency (CCSVI) has recently been d...

    Authors: Paolo Zamboni, Antonio Bertolotto, Paolo Boldrini, Patrizia Cenni, Roberto D’Alessandro, Roberto D’Amico, Massimo Del Sette, Roberto Galeotti, Stefania Galimberti, Alessandro Liberati, Luca Massacesi, Donato Papini, Fabrizio Salvi, Silvana Simi, Andrea Stella, Luigi Tesio…
    Citation: Trials 2012 13:183
  42. Diarrheal diseases and dengue fever are major global health problems. Where provision of clean water is inadequate, water storage is crucial. Fecal contamination of stored water is a common source of diarrheal...

    Authors: Hans J Overgaard, Neal Alexander, Maria Ines Mátiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart, Razak Seidu and Thor Axel Stenström
    Citation: Trials 2012 13:182
  43. The purpose of this research is to develop and evaluate methods for conducting pragmatic cluster randomized trials in a primary care electronic database. The proposal describes one application, in a less frequ...

    Authors: Alex Dregan, Tjeerd van Staa, Lisa Mcdermott, Gerard McCann, Mark Ashworth, Judith Charlton, Charles Wolfe, Anthony Rudd, Lucy Yardley and Martin Gulliford
    Citation: Trials 2012 13:181
  44. Strategies to protect the brain from postoperative delirium (POD) after hip fracture are urgently needed. The development of delirium often is associated with the loss of independence, poor functional recovery...

    Authors: Mark Coburn, Robert D Sanders, Mervyn Maze and Rolf Rossaint
    Citation: Trials 2012 13:180
  45. Multiple chemical sensitivity (MCS) is a condition characterized by recurrent, self-reported symptoms from multiple organ systems, attributable to exposure to a wide range of chemically unrelated substances at...

    Authors: Christian Riise Hauge, Peter Jensa E Bonde, Alice Rasmussen and Sine Skovbjerg
    Citation: Trials 2012 13:179
  46. Prevalence of type 2 diabetes mellitus is increasing due to lifestyle changes, particularly affecting those genetically at risk. We developed DiAlert as a targeted group-based intervention aimed to promote int...

    Authors: Wieke H Heideman, Maartje de Wit, Barend JC Middelkoop, Vera Nierkens, Karien Stronks, Arnoud P Verhoeff and Frank J Snoek
    Citation: Trials 2012 13:178

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