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Volume 20 Supplement 2

The ethics of alternative clinical trial designs and methods in LMIC research: part one


'Funds were provided by the Global Forum on Bioethics in Research (GFBR). GFBR funding is provided by the Wellcome Trust, the Bill & Melinda Gates Foundation [OPP1151904], the National Institutes of Health and the UK Medical Research Council. The GFBR and its funders had no role in the conception of the research or in writing the manuscripts. Peer review and editorial decisions regarding papers co-authored by PY and RvdG in this supplement were handled by an independent supplement editor. The Supplement Editors declare no other competing interests.

Bangkok, Thailand28-29 November 2017

Edited by Ann-Margret Ervin, Phaik Yeong and Rieke van der Graaf

Conference website

  1. Stepped-wedge cluster randomized trials (SW-CRTs) are increasingly popular in health-related research in both high- and low-resource settings. There may be specific ethical issues that researchers face when de...

    Authors: Kaustubh Joag, Guillermo Ambrosio, Edgar Kestler, Charles Weijer, Karla Hemming and Rieke Van der Graaf
    Citation: Trials 2019 20(Suppl 2):703
  2. Human challenge trials (HCTs) deliberately infect participants in order to test vaccines and treatments in a controlled setting, rather than enrolling individuals with natural exposure to a disease. HCTs are t...

    Authors: Ricardo Palacios and Seema K. Shah
    Citation: Trials 2019 20(Suppl 2):702
  3. Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the de...

    Authors: Meriel Raymond, Malick M. Gibani, Nicholas P. J. Day and Phaik Yeong Cheah
    Citation: Trials 2019 20(Suppl 2):704
  4. Alternative clinical trial designs and methods are increasingly being used in place of the conventional individually randomised controlled trial (RCT) in high-income and in low-income and middle-income country...

    Authors: Adrienne Hunt, Carla Saenz and Katherine Littler
    Citation: Trials 2019 20(Suppl 2):701

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