Volume 16 Supplement 2

3rd International Clinical Trials Methodology Conference

Meeting abstracts

Publication of this supplement was funded by the 3rd Clinical Trials Methodology Conference.

3rd International Clinical Trials Methodology Conference. Go to conference site.

Glasgow, UK16-17 November 2015

Concatenated PDF V16 S2

Page 7 of 7

Innovative considerations on a phase 2a dose-finding strategy using Bayesian methods and MCP-MOD

Authors: Alun Bedding and Julian Zhou

Citation: Trials 2015 16(Suppl 2):P204

Content type: Poster presentation Published on: 16 November 2015
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Incorporating historical control data into the design and analysis of clinical trials

Authors: Maxine Bennett, William Powley, Jeffrey Wetherington and Adrian Mander

Citation: Trials 2015 16(Suppl 2):P205

Content type: Poster presentation Published on: 16 November 2015
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Feasibility work to inform trial design: using collaborative methods for efficient real-time data collection in the operating theatre

Authors: Natalie Blencowe

Citation: Trials 2015 16(Suppl 2):P206

Content type: Poster presentation Published on: 16 November 2015
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Design, method and application of stopping rules in a phase III 2x2 factorial randomised controlled trial

Authors: Megan Bowers, Louise Stanton and Mark Thursz

Citation: Trials 2015 16(Suppl 2):P207

Content type: Poster presentation Published on: 16 November 2015
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Smiley faces and the need for careful planning in trials

Authors: Mike Clarke, Lisa Maguire and Helen McAneney

Citation: Trials 2015 16(Suppl 2):P208

Content type: Poster presentation Published on: 16 November 2015
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The SWAT (study within a trial) programme; embedding trials to improve the methodological design and conduct of future research

Authors: Mike Clarke, Gerard Savage, Lisa Maguire and Helen McAneney

Citation: Trials 2015 16(Suppl 2):P209

Content type: Poster presentation Published on: 16 November 2015
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A pragmatic approach to the design and calibration of a Bayesian CRM dose finding trial

Authors: Michael Cole, Deborah Stocken and Christina Yap

Citation: Trials 2015 16(Suppl 2):P210

Content type: Poster presentation Published on: 16 November 2015
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Using an adaptive trial design for an infectious disease in primacy care - challenges in the design and set-up stages

Authors: Johanna Cook, Theo Verheij, Alike van der Velden, Herman Goossens, Menno de Jong, Philippe Beutels, Paul Little and Chris Butler

Citation: Trials 2015 16(Suppl 2):P211

Content type: Poster presentation Published on: 16 November 2015
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Practicalities of using an adaptive design for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests

Authors: Janet Dunn, Andrea Marshall, Amy Campbell, David Cameron, Helena Earl, Iain Macpherson, Christopher Poole, Daniel Rea, Adele Francis, Victoria Harmer, Adrienne Morgan, Nigel Stallard, Andreas Makris, Luke Hughes-Davies and Robert Stein

Citation: Trials 2015 16(Suppl 2):P212

Content type: Poster presentation Published on: 16 November 2015
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The use of Bayesian design in two trials in rare cancers

Authors: Peter Dutton, Sharon Love, Ade Faleti and Bass Hassan

Citation: Trials 2015 16(Suppl 2):P213

Content type: Poster presentation Published on: 16 November 2015
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How best to design a clinical trial that is relevant to practice? Applying PRECIS-2, a trial design tool, to primary care trials

Authors: Gordon Forbes, Kirsty Loudon, Shaun Treweek, Stephanie Taylor and Sandra Eldridge

Citation: Trials 2015 16(Suppl 2):P214

Content type: Poster presentation Published on: 16 November 2015
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NIHR statistics group imaging studies section: a network for statisticians and researchers using imaging in healthcare research

Authors: Julia Forman, Susan J Dutton, Thomas R Fanshawe and Sue Mallett

Citation: Trials 2015 16(Suppl 2):P215

Content type: Poster presentation Published on: 16 November 2015
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IntReALL HR and the benefits of adaptive design

Authors: Jane Holmes, Sharon Love, Vaskar Saha and Arend von Stackelberg

Citation: Trials 2015 16(Suppl 2):P216

Content type: Poster presentation Published on: 16 November 2015
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Simulation work in adaptive dose-finding designs to identify dose-intervals that achieve targets in multiple endpoints

Authors: James Howlett, Simon Bond, Adrian Mander, John Todd, Linda Wicker and Frank Waldron-Lynch

Citation: Trials 2015 16(Suppl 2):P217

Content type: Poster presentation Published on: 16 November 2015
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Adaptive two-stage bioequivalence trials with early stopping and sample size re-estimation

Authors: Franz Koenig, Martin Wolfsegger, Thomas Jaki, Helmut Schütz and Gernot Wassmer

Citation: Trials 2015 16(Suppl 2):P218

Content type: Poster presentation Published on: 16 November 2015
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Using re-randomisation to improve patient recruitment and increase statistical power in clinical trials

Authors: Brennan Kahan, Andrew Forbes, Caroline Dore and Tim Morris

Citation: Trials 2015 16(Suppl 2):P219

Content type: Poster presentation Published on: 16 November 2015
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Estimation bias in survival data within clinical trials that use adaptive seamless designs

Authors: Josephine Khan, Peter Kimani, Nigel Stallard and Ekkehard Glimm

Citation: Trials 2015 16(Suppl 2):P220

Content type: Poster presentation Published on: 16 November 2015
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Some small sample properties of the EWOC design in dose escalation trials

Authors: Nelson Kinnersley

Citation: Trials 2015 16(Suppl 2):P221

Content type: Poster presentation Published on: 16 November 2015
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Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth trials

Authors: Lisa Law and James Wason

Citation: Trials 2015 16(Suppl 2):P222

Content type: Poster presentation Published on: 16 November 2015
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Matching trial design decisions to the needs of those you hope will use the results: the PRECIS-2 tool

Authors: Kirsty Loudon, Merrick Zwarenstein, Frank Sullivan, Peter Donnan and Shaun Treweek

Citation: Trials 2015 16(Suppl 2):P223

Content type: Poster presentation Published on: 16 November 2015
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The paediatric hepatic international tumour trial (PHITT): clinical trial design in rare disease

Authors: Veronica Moroz, Bruce Morland, Gregory Tiao, Eiso Hiyama, Pamela Kearns and Keith Wheatley

Citation: Trials 2015 16(Suppl 2):P224

Content type: Poster presentation Published on: 16 November 2015
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The trials and tribulations of accessing data from routine sources

Authors: Graham Powell, Tony Marson, Dyfrig Hughes, Paula Williamson and Catrin Tudur-Smith

Citation: Trials 2015 16(Suppl 2):P225

Content type: Poster presentation Published on: 16 November 2015
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The 3+3 versus model-based approach: implementation in the CAPCISUM pancreatic cancer trial

Authors: Wendi Qian, Adrian Mander, Andrea Machin, Katy Dalchau and Pippa Corrie

Citation: Trials 2015 16(Suppl 2):P226

Content type: Poster presentation Published on: 16 November 2015
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A probability of benefit (AUC) approach to phase II cancer trials

Authors: Paul Silcocks

Citation: Trials 2015 16(Suppl 2):P227

Content type: Poster presentation Published on: 16 November 2015
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An adaptive trial design for updating the threshold of a continuous biomarker

Authors: Amy Spencer, Chris Harbron, Adrian Mander, James Wason and Ian Peers

Citation: Trials 2015 16(Suppl 2):P228

Content type: Poster presentation Published on: 16 November 2015
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Determining the sample size for a cluster-randomised trial: Bayesian hierarchical modelling of the ICC estimate

Authors: Svetlana Tishkovskaya, Chris Sutton, Lois Thomas, Michael Leathley and Caroline Watkins

Citation: Trials 2015 16(Suppl 2):P229

Content type: Poster presentation Published on: 16 November 2015
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A practical application of a novel software solution to aid identification of research participants in primary care - the CREAM study (children with eczema antibiotic management study)

Authors: Emma Thomas-Jones, Victoria Shepherd, Katy Addison, Kerenza Hood, Matthew Ridd, Chris Butler, Frank Sullivan and Nick Francis

Citation: Trials 2015 16(Suppl 2):P230

Content type: Poster presentation Published on: 16 November 2015
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Trial forge – working together to make trials more efficient

Authors: Shaun Treweek

Citation: Trials 2015 16(Suppl 2):P231

Content type: Poster presentation Published on: 16 November 2015
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Patient drift and response-adaptive randomisation: impact and solutions

Authors: Sofia S Villar, James Wason and Jack Bowden

Citation: Trials 2015 16(Suppl 2):P232

Content type: Poster presentation Published on: 16 November 2015
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A toxicity-dependent feasibility bound for the escalation with overdose control approach in phase I cancer trials

Authors: Graham Wheeler, Michael Sweeting and Adrian Mander

Citation: Trials 2015 16(Suppl 2):P233

Content type: Poster presentation Published on: 16 November 2015
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Phase II trial designs for complex interventions: a single-arm single-stage design for clustered continuous outcomes

Authors: Duncan T Wilson, Rebecca EA Walwyn, Sarah R Brown, Julia Brown and Amanda J Farrin

Citation: Trials 2015 16(Suppl 2):P234

Content type: Poster presentation Published on: 16 November 2015
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Addressing the barriers to implementing model based designs in dose escalation studies

Authors: Victoria Cornelius and Simon Bond

Citation: Trials 2015 16(Suppl 2):P235

Content type: Poster presentation Published on: 16 November 2015
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Two-arm randomised futility trials: PD-stat - a futility trial of a potential neuroprotective treatment in people with Parkinson's disease

Authors: Siobhan Creanor, Jane Vickery, Vicky Eyre, John Zajicek, Sue Ball, Jordan Elm and Camille Carroll

Citation: Trials 2015 16(Suppl 2):P236

Content type: Poster presentation Published on: 16 November 2015
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Comparison of analysis approaches for multi-level vascular imaging data

Authors: Julia Forman, Marie Fisk, Joseph Cheriyan, Simon Bond and Ian Wilkinson

Citation: Trials 2015 16(Suppl 2):P237

Content type: Poster presentation Published on: 16 November 2015
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Pragmatic approaches to mitigating missing data and research priorities to assess the effectiveness of interventions

Authors: Anna Kearney, Anne Daykin, Ali Heawood, Athene Lane, Jane Blazeby, Mike Clarke, Paula Williamson and Carrol Gamble

Citation: Trials 2015 16(Suppl 2):P238

Content type: Poster presentation Published on: 16 November 2015
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