Table 1 Schedule of activities

Screening/safety blood

X

X

X

Drug screening urine

X

Pregnancy test

X^A

Medical history

X

MINI

X

Physical/neurological examination

X

X

Vital parameters

X

X

X

Body weight

X

X

X

Concomitant medication/(concomitant diseases)

X

X

HAMD-21, PHQ-9, VAS, MADRS

X

X

X

X

X

X

X

X

X

X

X

X

HAM-A, C-SSRS, BDI, SSS, BHWSS, BENDEP-SRW

X

X

X

X

X

Study medication

X^B

X^C

Assessment of adverse events

X

X

X

X

X

Study blood

X

X

X

CANTAB, ARENA^D

X

X

fMRI

X

X

X

Cortisol Awakening Response

X

X

Microbiome

X

X

X