| Enrollment | Allocation | Post allocation | Follow-up | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Timepoint (week) |  − 1 | 0 | 1–2 | 3–4 | 5–6 | 7–8 | 9–10 | 11–12 | 13–14 | 15–16 | 17–18 | 19–20 |
Enrollment: | ||||||||||||
 Eligibility screen | x |  |  |  |  |  |  |  |  |  |  |  |
 Informed consent | x |  |  |  |  |  |  |  |  |  |  |  |
 Allocation |  | x |  |  |  |  |  |  |  |  |  |  |
Interventions: | ||||||||||||
 HFPDs: Plasmapheresis |  |  | xxx | xxx | xxx | xxx | xxx | xxx | xxx | xxx |  |  |
 RFPDs: Plasmapheresis |  |  | x | x | x | x | x | x | x | x |  |  |
 Controls: Blood donation |  |  | x |  |  |  |  |  |  | x |  |  |
Assessments: | ||||||||||||
Baseline variables: Outcome variables: | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Blood samples |  |  | x | x | x | x | x | x | x | x | x | x |
 FFQ |  |  |  |  |  |  |  |  |  |  | x |  |
 HSCL-25 |  | x |  |  |  |  |  |  |  |  | x |  |