Table 1 Inclusion criteria and exclusion criteria of the PPDET trial

Inclusion criteria

(1) 18 years to 80 years

(2) 2 ≤ NIHSS ≤ 25 [7, 30]

(3) mRS before stroke less than 3

(4) AIS (anterior circulation) scheduled for EVT

(5) mTICI after EVT reaches 2b–3

(6) Informed consent was signed by patients or legal representatives

Exclusion criteria

(1) Intracerebral hemorrhage occurred in the responsible vessel area in the past 6 weeks

(2) Patients who had received stent treatment at the responsible vessel in the past

(3) Neurological function was restored at or before angiography

(4) Patients who are allergic to heparin, aspirin, clopidogrel, rapamycin, lactic acid polymer, poly (n-butyl methacrylate), stainless steel, anesthetics, and contrast agents or have contraindications

(5) Hemoglobin was less than 70 g L⁻¹, platelet count was less than 50 × 10⁹ L⁻¹, international normalized ratio (INR) greater than 1.5 (irreversible), or uncorrectable bleeding factors

(6) Blood glucose < 2.7 mmol L⁻¹ or > 22.2 mmol L⁻¹

(7) Severe liver or kidney dysfunction, ALT > 3 times the upper limit of normal value or AST > 3 times the upper limit of normal value, creatinine > 1.5 times the upper limit of normal value

(8) Pregnant or lactating women

(9) Previous history of mental illness

(10) Stroke combined with other acute diseases or postoperative stroke of other operations

(11) Heart rate (HR) less than 50 bpm, a second or third degree of an atrioventricular block (except for pacemaker implantation), and one vasoactive drug cannot maintain the systolic blood pressure (SBP) above 90 mmHg