Table 4 Description of assessments
Category | Type | Assessment | Time of data collection (week) | Location of data collection | Data storage during data collection |
|---|---|---|---|---|---|
Home assessments (cognitive tests) | Verbal learning and memory | California Verbal Learning Test [37] | 1, 12 | Home | Amazon’s cloud storage system |
Working memory | N-back task [38] | ||||
Episodic memory | Face-name associative memory task [39] | ||||
Episodic memory | Pattern separation task [40] | ||||
Executive function | |||||
Executive function | Flanker task [43] | ||||
Visuospatial function | Spatial orientation task [44] | ||||
Verbal fluency | Thurstone Word Fluency Test [45] | ||||
Home assessments (emotion questionnaires) | Emotional memory | Emotional memory task [46] | |||
Emotional memory | Mood prediction and memory | ||||
Theory of mind | Reading the mind in the eyes test [47] | ||||
Mood | Positive and Negative Affect Schedule (PANAS) [48] | ||||
Stress | Daily Inventory of Stress Events [49] | ||||
Depression/anxiety/stress | Depression Anxiety Stress Scales-Short Form (DASS-21) [50] | ||||
Mindfulness | |||||
Home assessments (other questionnaires) | Sleep | Epworth Sleepiness Scale [53] | |||
Sleep | Karolinska Sleepiness Scale [54] | ||||
Demographics | Demographic information | 1 | |||
Physical activity | Physical activity ratings [55] | ||||
Survey | Post study survey | 12 | |||
Blood sample | N/A | Plasma amyloid beta levels | 2, 7, 12 | Lab | Lab freezer |
Plasma pTau | |||||
Plasma total tau | |||||
Urine sample | N/A | Amyloid beta levels | |||
MRI session | Structural MRI | T1-weighted sequence | 2, 7, 12 | Imaging center | Flywheel |
T2-weighted sequence | |||||
LC low resolution (proton density-weighted sequence) | |||||
LC high resolution (proton density-weighted sequence) | |||||
Hippocampal high resolution (T2-weighted sequence) | |||||
Fluid-attenuated inversion recovery (FLAIR) | 12 | ||||
Pulse | Pulse oximeter recording photoplethysmogram (PPG) signal from finger | 2, 7, 12 | Lab laptop and external hard drive | ||
EEG | N/A | 2, 12 | Lab | Lab computer and flywheel | |
Resting state EEG measure (with eyes open and closed) | |||||
Training mimicking EEG recording | 12 | ||||
Neuropsychological tests | Cognition | Trials A & B [58] | 2, 12 | Amazon’s cloud storage system | |
Animal fluency [59] | |||||
Multilingual naming test [60] | 2 | ||||
Montreal Cognitive Assessment (MoCA) [61] | |||||
Functional Activities Questionnaire [62] | |||||
Surveys | N/A | Profile of Mood States (POMS) [63] | 2, 7, 12 | Lab computer and flywheel | |
Daily Inventory of Stressful Events (DISE) [49] | |||||
Sleep survey | |||||
Baseline pulse measures | Pulse during rest and during 4-s paced breathing | Pulse oximeter recording photoplethysmogram (PPG) signal from earlobe | 2 | Lab after MRI | Amazon’s cloud storage system |
Pulse during rest | Home | ||||
Breathing training | Pulse during paced breathing | 3–11 | |||
Cognitive training | Brain games | Brain game performance | 2–11 |