Fig. 2
SPIRIT figure. Schedule of enrolment, interventions, and assessments “*” indicates the following: measurement from birth to 72 h after birth or discharge is done every 6 h then every 24 h till day 6 thereafter. “#” indicates the following: other neonatal secondary outcomes include cause-specific mortality; use of positive pressure ventilation > 1 min at birth; hypoglycaemia in first 36 h after birth; newborn severe respiratory distress from birth to 72 h or prior to discharge whichever is earlier; use of newborn respiratory support or high settings for continuous positive airway pressure (CPAP) or mechanical ventilation from birth to 72 h or prior to discharge whichever is earlier; admission to neonatal care unit in first 72 h after birth; and any parenteral antibiotic use till 7 days after birth and duration of birth hospitalization. Another composite secondary newborn outcome is stillbirth OR neonatal death within 72 h after birth OR invasive mechanical ventilation OR need for very high CPAP settings (≥ 8 cm water pressure and ≥ 0.7 FiO2) within 72 h after birth or prior to discharge, measured from enrolment till 72 h after birth or discharge, whichever is earlier