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Fig. 3 | Trials

Fig. 3

From: Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinational Experimentation

Fig. 3

Organization and advantages of the platform pragmatic clinical trials. The potential next step in developing the PRIME-9 collaboration will be the organization and advantages of platform pragmatic clinical trials (ppRCT). Platform trials can test multiple interventions simultaneously within a single trial, allowing for the streamlined development of effective therapies and the ability to adapt to changing scientific knowledge. These trials would follow the principles of pragmatic trials, focusing on patient-centered outcomes, efficiency, and flexibility. By conducting ppRCT, the PRIME-9 collaboration can evaluate the effectiveness of multiple interventions for a particular health condition or disease cost-effectively and adaptively. The addition of ppRCT would represent a significant advancement for the PRIME-9 collaboration in their mission to improve patient outcomes and advance healthcare practice worldwide

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