How many sites should an orthopedic trauma prospective multicenter trial have? A marginal analysis of the Major Extremity Trauma Research Consortium completed trials

Table 3 Major Extremity Trauma Research Consortium study design and study complexity rank

Study^a	Study design	Study complexity rank, 1–12, low to high
STREAM	Observational study	1
NERVE	Observational study	2
OUTLET	Observational study with heavy data collection	3
Bioburden	Observational study with tissue sample collection and shipment	4
VANCO	Unblinded pragmatic trial	5
OXYGEN	Blinded pragmatic trial	6
POvIV	Explanatory trial; randomization to medication	7
TAOS	Explanatory trial; randomization to standard surgical technique	8
CBPT	Explanatory trial; randomization to new psychosocial intervention	9
pTOG	Explanatory trial; randomization to surgical technique and a device	10
FIXIT	Explanatory trial; randomization to surgical technique and a device	11
PAIN	Explanatory trial; double blinded, placebo controlled	12

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