Table 2 Major Extremity Trauma Research Consortium study principal inclusion criteria and injury rarity rank

pTOG

Open diaphyseal tibia fracture with bone defect ≥ 1 cm comprising > 50% circumference and treated with intramedullary nail.

1

TAOS

Early or delayed transtibial amputation.

2

NERVE

Peripheral nerve injuries (excl. purely sensory nerves) resulting from upper extremity trauma.

3

PAIN

Patients with isolated orthopedic trauma associated with moderate/high rates of chronic pain and nonunion, i.e., those with fractures to the ankle and midfoot, the tibia, the humerus, and the femur.

4

OUTLET

Selected open type III pilon and foot/ankle or severe open or closed crush/blast foot injuries.

5

FIXIT

Gustilo type IIIB and severe Gustilo type IIIA diaphyseal or metaphyseal tibia fractures.

6

POvIV

Patients with post-op wound infection following fractures or joint fusion of bone proximal to and including the tarsal/metatarsal joint or proximal to the carpal joints.

7

Bioburden

Open type III tibia fracture (plateau, shaft, and pilon) requiring additional procedure or below-knee amputation and delayed closure, skin grafting, and/or flap.

8

CBPT

Patients treated surgically for a high-energy lower-extremity injury at high risk for poor outcomes (presence of pre-defined psychosocial risk factors).

9

VANCO

High-energy tibial plateau and pilon fractures treated operatively with plate and screw fixation.

10

OXYGEN

High-energy tibial plateau, pilon, and calcaneous fractures treated operatively with plate and screw fixation.

11

STREAM

Patients enrolled in METRC’s FIXIT, OUTLET, OXYGEN, PAIN, and TAOS studies are eligible for co-enrollment into STREAM.

12