Table 4 Plan for analysis of secondary outcomes
Outcome | Hypothesis | Outcome measure | Method of analysis |
|---|---|---|---|
Number of cigarettes smoked | Reduction in number of cigarettes | Self-reported daily number of cigarettes smoked | t-test and regression methods with secondary outcomes as dependent variable adjusted for variables defined in Table 2 |
Carbon monoxide in exhaled air | Reduced CO levels | Carbon monoxide in ppm in exhaled air | |
C-reactive protein | Reduced levels | CRP in mg/L | |
Leucocyte count | Levels within reference limit | Leucocyte count in 109/L | |
Psychological well-being | Increased score | Hopkins Symptom Checklist (SCL-10) | |
Physical fitness | Increased score | 4-min step test, number of steps | |
Quality of life | Increased score | EuroQoL EQ-5D-5L-questionaire | |
Fatigue | Less Fatigue | Fatigue Symptom Scale (FSS-3) | |
Dyspnoea | Less after intervention | Modified Medical Research Council (mMRC)-scale | |
Physical activity | Increased | Physical Activity Questionnaire (IPAQ) |