Effects of opioid-free anaesthesia on postoperative nausea and vomiting in patients undergoing video-assisted thoracoscopic surgery (OFA-PONV trial): study protocol for a randomised controlled trial

Table 1 Schedule of enrolment, intervention, and assessment

Time point	Study period
	Enrolment	Post-allocation		Follow-up
	Preoperation	Intraoperative	Postoperative anaesthesia care unit	24 h after operation	48 h after operation	discharge (3 days after operation)	6 months after operation
Enrolment
Eligibility screen	√
Informed consent	√
Assessment
Baseline variables	√
Lung imaging	√
Apfel’s PONV risk assessment	√
Karnofsky Performance Status	√					√
Intraoperative data		√
EEG monitoring		√
Blood gas		√
PONV^a			√	√	√
Complications and adverse events		√	√	√	√	√	√
Qor-15				√
Pain at rest and with movement				√	√
6-MWT	√				√
SF-36							√

According to SPIRIT statement of defining standard protocol items for clinical trials
PONV postoperative nausea and vomiting, QoR-15 quality of recovery-15 scale, 6-MWT 6-minute walk test, SF-36 36-item short-form survey
^aPrimary outcome

ISSN: 1745-6215