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Table 2 Operating characteristics of the stopping rule for feasibility

From: Induction of double-strand breaks with the non-steroidal androgen receptor ligand flutamide in patients on androgen suppression: a study protocol for a randomized, double-blind prospective trial

Underlying proportion without detectable DNA double-strand breaks

0.4

0.5

0.6

0.7

0.8

% of the time study stops

19.3%

44%

74.8%

92.4%

99.4%

Expected sample size

16.3

14.1

11.1

8.7

6.9