From: Induction of double-strand breaks with the non-steroidal androgen receptor ligand flutamide in patients on androgen suppression: a study protocol for a randomized, double-blind prospective trial
Underlying proportion without detectable DNA double-strand breaks
0.4
0.5
0.6
0.7
0.8
% of the time study stops
19.3%
44%
74.8%
92.4%
99.4%
Expected sample size
16.3
14.1
11.1
8.7
6.9