Pre-hospital pulse glucocorticoid therapy in patients with ST-segment elevation myocardial infarction transferred for primary percutaneous coronary intervention: a randomized controlled trial (PULSE-MI)

Table 1 Time schedule for the trial

	Study period
	Enrollment	Post-allocation				Follow-up
Timepoint	Ambulance	During primary PCI	Following Primary PCI	During admission at Rigshospitalet		Days 90
Enrolment:
Eligibility screen	X
Informed consent			X
Randomization	X
Interventions:
*Infusion of study medicine*	X
Assessments:
*CMR*				X	X
*Infarct size*^a				X	X
*Extent of MVO*^a				X	X
*IMH*^a				X
*AAR*^a				X
*MSI*^a				X	X
*LVEF*^a				X	X
*Mortality and hospitalization for heart failure*					X
*Biochemistry and biobank samples*		X		X	X
*Coronary physiology*		X

^aEvaluated on CMR. AAR, area at risk; CMR, cardiac magnetic resonance; IMH, intramyocardial hemorrhage; MSI, myocardial salvage index; MVO, microvascular obstruction; PCI, percutaneous coronary intervention

ISSN: 1745-6215