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Table 3 Schedule

From: Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial

 

1st visit on FET initial day

2nd visit after enrollment

3rd visit after 5 days

4th visit after 10 days

5th visit on ET

1st follow-up at 14 days after ET

2nd follow-up at 5 weeks after ET

3rd follow-up at mid-pregnancy

End of live birth

Enrollment

         

 Eligibility screen

X

        

 Written informed consent

X

        

 Allocation

 

X

       

Interventions

         

 Optimal endometrial preparation

X

X

X

X

X

    

Lactobacillus capsule

 

X

X

X

     

Assessments

         

 Baseline questionnaire

X

        

 Vaginal and cervical canal swabs

X

   

X

    

 Peripheral blood samples

X

   

X

    

 Medication diary (intervention group)

 

X

X

X

     

 HCG and P

     

X

X

  

 Clinical pregnancy

      

X

  

 Maternal and Fetal information

      

X

X

X

 Safety assessment

 

X

X

X

X

X

X

X

X

  1. HCG, human chorionic gonadotropin; P, progesterone