Early tirofiban versus heparin for bridging dual antiplatelet therapy in patients undergoing coronary endarterectomy combined with coronary artery bypass grafting: a multicenter randomized controlled trial protocol (the THACE-CABG trial)

Table 1 Bleeding categories according to the UDPB in adult cardiac surgery (if different categories indicate mixed definitions of bleeding, the worst definition applies)

Bleeding definition	Sternal closure delayed	Postoperative chest tube blood loss within 12 h (mL)	PRBC (unit)	FFP (unit)	PLT (unit)	Cryoprecipitate	PCCs	rFVIIa	Reexploration/tamponade
Class 0 (insignificant)	No	< 600	0^a	0	0	No	No	No	No
Class 1 (mild)	No	601–800	1	0	0	No	No	No	No
Class 2 (moderate)	No	801–1000	2–4	2–4	Yes	Yes	Yes	No	No
Class 3 (severe)	Yes	1001–2000	5–10	5–10	N/A	N/A	N/A	No	Yes
Class 4 (massive)	N/A	> 2000	> 10	> 10	N/A	N/A	N/A	Yes	N/A

UDPB Universal definition for perioperative bleeding, PRBC Packed red blood cells, FFP Fresh frozen plasma, PLT Platelet concentrates, PCCs Prothrombin complex concentrates, rFVIIa Recombinant activated factor VII, N/A Not applicable
^aCorrection of preoperative anemia or hemodilution only; the number of PRBCs used should only be considered in the UDPB when accompanied by other signs of perioperative bleeding

ISSN: 1745-6215