Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial

Table 1 Schedule of inclusion, interventions and assessments

Time points	Study period
	Enrolment	Post-allocation			Close-out
	Patients with acute pain caused by manual treatment after anterior ligament reconstruction	T0	T1	T2	Data collection measurements
Patients
Eligibility screen	√
Informed consent	√
Allocation	√	√
Interventions
Intervention group			√
Control group			√
Assessments
Pain score		√	√	√	Visual analogue scale
BP		√	√	√	Non-invasive electronic manometer
HR		√	√	√	Digital monitoring
SPO₂		√	√	√	Digital monitoring
Side effects			√	√	Yes/no
ROM				√	Goniometer
Satisfaction				√	Satisfied/dissatisfied
Adjuvant analgesia				√	Yes/no
Acceptance				√	Yes/no

Abbreviations: BP blood pressure(mm/Hg), HR heart rate(bpm), SPO₂ oxygen saturation(%), ROM range of motion(°)

ISSN: 1745-6215